ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Other intervertebral disc disorders (finn-b-M13_INTERVERTEB)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Omelette (ukb-b-11272) (👉 📊) Other intervertebral disc disorders Weighted median 15 0.58215148 0.276959234 0.035558599
Lobster/crab (ukb-b-14746) (👉 📊) Other intervertebral disc disorders Inverse variance weighted 54 -0.938710163 0.471442934 0.0464652
Cheese (ukb-b-1489) (👉 📊) Other intervertebral disc disorders Inverse variance weighted 198 -0.307810357 0.080031711 0.00012001
Cereal (ukb-b-15926) (👉 📊) Other intervertebral disc disorders Inverse variance weighted 175 -0.302026147 0.100799644 0.002732759
Dried fruit (ukb-b-16576) (👉 📊) Other intervertebral disc disorders MR Egger 155 -1.265594858 0.479129551 0.00911249
Dried fruit (ukb-b-16576) (👉 📊) Other intervertebral disc disorders Inverse variance weighted 155 -0.274218923 0.123961258 0.026957403
Carrot (ukb-b-16710) (👉 📊) Other intervertebral disc disorders Inverse variance weighted 5 0.33530041 0.158486407 0.034375315
Non-oily fish (ukb-b-17627) (👉 📊) Other intervertebral disc disorders Weighted median 67 -0.48144479 0.242637863 0.047232289
Bran cereal (ukb-b-19498) (👉 📊) Other intervertebral disc disorders Inverse variance weighted 4 -0.792645662 0.282510324 0.005020386
Fizzy drink (ukb-b-2832) (👉 📊) Other intervertebral disc disorders Inverse variance weighted 12 0.355577212 0.173657295 0.040601167
Vegetarian sausages/burgers (ukb-b-3383) (👉 📊) Other intervertebral disc disorders Weighted mode 34 0.876996571 0.425652165 0.047319933
Hard cheese (ukb-b-3542) (👉 📊) Other intervertebral disc disorders Inverse variance weighted 12 -0.401183733 0.171683798 0.019451697
Apple (ukb-b-4070) (👉 📊) Other intervertebral disc disorders MR Egger 18 -0.81726488 0.319895632 0.021197104
Apple (ukb-b-4070) (👉 📊) Other intervertebral disc disorders Inverse variance weighted 18 -0.200626098 0.100837581 0.046635403
Breaded fish (ukb-b-5753) (👉 📊) Other intervertebral disc disorders Weighted median 20 -0.995168994 0.465013189 0.032347682
Breaded fish (ukb-b-5753) (👉 📊) Other intervertebral disc disorders Inverse variance weighted 20 -0.881276238 0.426854365 0.038962479
Processed meat (ukb-b-6324) (👉 📊) Other intervertebral disc disorders Inverse variance weighted 125 -0.271243433 0.102691099 0.008257566
Pancake (ukb-b-6500) (👉 📊) Other intervertebral disc disorders Inverse variance weighted 45 -0.540195873 0.25142672 0.0316723
Poultry (ukb-b-8006) (👉 📊) Other intervertebral disc disorders Weighted median 80 0.406889565 0.205883244 0.04811943
Poultry (ukb-b-8006) (👉 📊) Other intervertebral disc disorders Inverse variance weighted 80 0.335078482 0.155396001 0.031061209
Stewed fruit (ukb-b-8676) (👉 📊) Other intervertebral disc disorders MR Egger 9 2.277065114 0.640760303 0.009297634
Squash (ukb-b-8793) (👉 📊) Other intervertebral disc disorders MR Egger 18 1.040047372 0.316413577 0.004644887
Squash (ukb-b-8793) (👉 📊) Other intervertebral disc disorders Inverse variance weighted 18 0.260354055 0.125459774 0.037968054
Fortified wine (ukb-b-9524) (👉 📊) Other intervertebral disc disorders Inverse variance weighted 20 0.638648262 0.308168596 0.038228255
Sweet potato (ukb-b-9686) (👉 📊) Other intervertebral disc disorders Inverse variance weighted 24 0.56621878 0.258540264 0.028519861

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Omelette (ukb-b-11272) Other intervertebral disc disorders rs2447563 -1.69312616112143 0.662894781286945 0.0106450406406109
Omelette (ukb-b-11272) Other intervertebral disc disorders rs77529174 0.724318196132771 0.351661732905041 0.0394270866538407
Lobster/crab (ukb-b-14746) Other intervertebral disc disorders rs188857983 -6.89725271533949 3.25259917523378 0.0339608929706045
Lobster/crab (ukb-b-14746) Other intervertebral disc disorders rs217514 -11.341798735238 4.07227788416557 0.0053507262005622
Lobster/crab (ukb-b-14746) Other intervertebral disc disorders All - Inverse variance weighted -0.938710163302471 0.471442934379083 0.0464651998069518
Cheese (ukb-b-1489) Other intervertebral disc disorders rs10938397 -2.64419104280284 0.912875479062886 0.0037728844121744
Cheese (ukb-b-1489) Other intervertebral disc disorders rs11264431 2.21785278303249 1.09028897317144 0.0419326405383259
Cheese (ukb-b-1489) Other intervertebral disc disorders rs11735256 2.31903956599635 0.979522127153693 0.017907685938196
Cheese (ukb-b-1489) Other intervertebral disc disorders rs141547796 -1.61635121747745 0.748925197540871 0.0309101212574676
Cheese (ukb-b-1489) Other intervertebral disc disorders rs1473677 2.42711808784116 1.18962971066018 0.0413274345082965
Cheese (ukb-b-1489) Other intervertebral disc disorders rs1473781 -2.01953347079738 1.00976673539869 0.0455002638963584
Cheese (ukb-b-1489) Other intervertebral disc disorders rs2029401 -2.32022549154407 1.01402447408222 0.0221296260301262
Cheese (ukb-b-1489) Other intervertebral disc disorders rs34453616 -2.21993363085021 1.09852385856505 0.0432970209630816
Cheese (ukb-b-1489) Other intervertebral disc disorders rs35270670 -1.97809443569362 0.854732163571315 0.0206520548924176
Cheese (ukb-b-1489) Other intervertebral disc disorders rs59784053 -2.27265374785675 1.09184432726214 0.0373898573971982
Cheese (ukb-b-1489) Other intervertebral disc disorders rs61734410 -1.51915455746367 0.750570433529482 0.042970151746823
Cheese (ukb-b-1489) Other intervertebral disc disorders rs61953351 -2.90546281829893 0.890825864101088 0.00110809399022
Cheese (ukb-b-1489) Other intervertebral disc disorders rs62098037 -4.48987041430918 1.07683883920423 3.05279966629569e-05
Cheese (ukb-b-1489) Other intervertebral disc disorders rs66905828 -3.26176786059679 1.13414569815899 0.0040278927793661
Cheese (ukb-b-1489) Other intervertebral disc disorders rs67967503 -2.28423782285923 1.09531075932184 0.0370266508173513
Cheese (ukb-b-1489) Other intervertebral disc disorders rs71454634 -3.68936781183854 1.28036234994597 0.0039578360487455
Cheese (ukb-b-1489) Other intervertebral disc disorders rs72752436 -2.03647804089962 0.909825262531355 0.0252003409555088
Cheese (ukb-b-1489) Other intervertebral disc disorders rs7299943 -2.45835221732383 1.06437037342233 0.0209060198547708
Cheese (ukb-b-1489) Other intervertebral disc disorders rs75083733 -4.10517851503876 1.79377744788767 0.0221045671226504
Cheese (ukb-b-1489) Other intervertebral disc disorders rs75499503 -2.11413500767169 0.982825304569784 0.031469953943701
Cheese (ukb-b-1489) Other intervertebral disc disorders rs7607369 -2.7603193477153 1.00220825547817 0.0058829098670823
Cheese (ukb-b-1489) Other intervertebral disc disorders rs78370515 1.95617457613254 0.910510348163508 0.0316790164434888
Cheese (ukb-b-1489) Other intervertebral disc disorders rs975303 -2.14330030645434 0.766135855158021 0.0051492432384228
Cheese (ukb-b-1489) Other intervertebral disc disorders All - Inverse variance weighted -0.30781035727735 0.0800317110781048 0.0001200103925405
Cereal (ukb-b-15926) Other intervertebral disc disorders rs10260232 -4.38283152066628 1.37477557082562 0.0014324359904531
Cereal (ukb-b-15926) Other intervertebral disc disorders rs10857964 -3.4145925915409 0.887368137094828 0.0001190860534106
Cereal (ukb-b-15926) Other intervertebral disc disorders rs117419440 -2.42618893685652 1.15400390692889 0.035517407596713
Cereal (ukb-b-15926) Other intervertebral disc disorders rs12523398 -3.19164139288947 1.36557790939549 0.0194283037216267
Cereal (ukb-b-15926) Other intervertebral disc disorders rs12892571 -3.53303441197126 1.27491761655232 0.0055852436665389
Cereal (ukb-b-15926) Other intervertebral disc disorders rs2339515 -3.60264224166433 1.33388969074281 0.0069161545827714
Cereal (ukb-b-15926) Other intervertebral disc disorders rs2927238 3.77689942907334 1.14185331576636 0.0009406810120566
Cereal (ukb-b-15926) Other intervertebral disc disorders rs6087577 -3.74165763069076 1.28721749394026 0.0036517031745103
Cereal (ukb-b-15926) Other intervertebral disc disorders rs62097852 -2.73637939790897 1.32440762858794 0.0388175559037619
Cereal (ukb-b-15926) Other intervertebral disc disorders rs6502045 -3.12885734817306 1.43262699092173 0.0289622480603975
Cereal (ukb-b-15926) Other intervertebral disc disorders rs8097544 -1.6276464475906 0.621022210676711 0.0087694115248212
Cereal (ukb-b-15926) Other intervertebral disc disorders All - Inverse variance weighted -0.302026146690728 0.100799643693858 0.0027327588604239
Dried fruit (ukb-b-16576) Other intervertebral disc disorders rs10026792 -2.55381920435163 1.12478679758447 0.0231777600631671
Dried fruit (ukb-b-16576) Other intervertebral disc disorders rs10740991 -1.89378099050122 0.7826035008065 0.0155270245538197
Dried fruit (ukb-b-16576) Other intervertebral disc disorders rs142119647 -5.58886211086104 2.00768817097218 0.005373772083997
Dried fruit (ukb-b-16576) Other intervertebral disc disorders rs1801140 -3.51818723911747 1.35658914728682 0.0095030349020935
Dried fruit (ukb-b-16576) Other intervertebral disc disorders rs193003548 -4.92517310699129 1.70873352691534 0.0039471733562835
Dried fruit (ukb-b-16576) Other intervertebral disc disorders rs1950826 3.44192036950681 1.49273249000116 0.0211226418556953
Dried fruit (ukb-b-16576) Other intervertebral disc disorders rs3764002 -3.36089623899707 0.929771748656785 0.0003006328321854
Dried fruit (ukb-b-16576) Other intervertebral disc disorders rs62007687 -4.06782878508644 1.42374007478025 0.0042747339601725
Dried fruit (ukb-b-16576) Other intervertebral disc disorders rs6533183 4.04499798274064 1.23655378746994 0.0010709727961888
Dried fruit (ukb-b-16576) Other intervertebral disc disorders rs7047847 -2.95921914192039 1.48430674420134 0.0461880330609749
Dried fruit (ukb-b-16576) Other intervertebral disc disorders rs7334175 -4.2844259963306 1.4742110955116 0.0036578906781473
Dried fruit (ukb-b-16576) Other intervertebral disc disorders rs75265668 8.112267522237 3.34207162793124 0.015210955483225
Dried fruit (ukb-b-16576) Other intervertebral disc disorders rs907237 3.66397016802992 1.45058204604598 0.0115414784731363
Dried fruit (ukb-b-16576) Other intervertebral disc disorders All - Inverse variance weighted -0.274218922629752 0.123961258254385 0.0269574027164291
Dried fruit (ukb-b-16576) Other intervertebral disc disorders All - MR Egger -1.26559485848419 0.479129550733425 0.0091124900775551
Carrot (ukb-b-16710) Other intervertebral disc disorders All - Inverse variance weighted 0.335300410284545 0.158486407392369 0.0343753150349935
Non-oily fish (ukb-b-17627) Other intervertebral disc disorders rs11723103 -2.98365420476613 1.50468768085188 0.0473779322561446
Non-oily fish (ukb-b-17627) Other intervertebral disc disorders rs2702668 -3.13588968939922 1.38615413806777 0.0236791780819756
Non-oily fish (ukb-b-17627) Other intervertebral disc disorders rs4318925 -2.91267946560977 1.13714198314902 0.0104250195852144
Non-oily fish (ukb-b-17627) Other intervertebral disc disorders rs55858845 -3.35483623606545 1.57198040775638 0.0328308034705758
Non-oily fish (ukb-b-17627) Other intervertebral disc disorders rs7326846 -3.88789014273647 1.32123286187702 0.0032544452543791
Non-oily fish (ukb-b-17627) Other intervertebral disc disorders rs7432182 3.50310084823359 1.48579794597494 0.0183873791028408
Bran cereal (ukb-b-19498) Other intervertebral disc disorders rs185628064 -1.71234753858263 0.602939274148814 0.0045113533830846
Bran cereal (ukb-b-19498) Other intervertebral disc disorders All - Inverse variance weighted -0.792645662450935 0.282510324149836 0.0050203857901151
Fizzy drink (ukb-b-2832) Other intervertebral disc disorders rs7829588 0.950289699966786 0.412099740438671 0.0211123003516535
Fizzy drink (ukb-b-2832) Other intervertebral disc disorders All - Inverse variance weighted 0.355577212365511 0.173657295440934 0.0406011665381895
Vegetarian sausages/burgers (ukb-b-3383) Other intervertebral disc disorders rs11759837 -4.72869336744871 1.50286472841824 0.0016526377008945
Hard cheese (ukb-b-3542) Other intervertebral disc disorders rs148920910 -2.23123361737494 0.821072051584148 0.0065784341522019
Hard cheese (ukb-b-3542) Other intervertebral disc disorders rs760916 -1.15750757247945 0.439924996394057 0.0085097083795499
Hard cheese (ukb-b-3542) Other intervertebral disc disorders All - Inverse variance weighted -0.401183733038917 0.171683798113913 0.0194516967923188
Apple (ukb-b-4070) Other intervertebral disc disorders All - Inverse variance weighted -0.200626097673942 0.100837581075413 0.0466354027912554
Apple (ukb-b-4070) Other intervertebral disc disorders All - MR Egger -0.817264880112864 0.319895631549595 0.0211971043379109
Breaded fish (ukb-b-5753) Other intervertebral disc disorders rs117267390 -5.37537465339552 1.64086166273982 0.0010530859103889
Breaded fish (ukb-b-5753) Other intervertebral disc disorders rs150700219 4.62014372669938 2.10642572288133 0.0282816636608508
Breaded fish (ukb-b-5753) Other intervertebral disc disorders rs182530882 -4.36309804697609 1.48988476702236 0.0034062352189297
Breaded fish (ukb-b-5753) Other intervertebral disc disorders All - Inverse variance weighted -0.881276238456146 0.426854364608303 0.0389624789479739
Processed meat (ukb-b-6324) Other intervertebral disc disorders rs2029401 -1.84537153480234 0.806495707802504 0.0221296260301263
Processed meat (ukb-b-6324) Other intervertebral disc disorders rs35399883 -2.33777038269551 1.01497504159734 0.0212631679228043
Processed meat (ukb-b-6324) Other intervertebral disc disorders rs4077924 -2.27223631257651 1.03210733916327 0.0276970837150861
Processed meat (ukb-b-6324) Other intervertebral disc disorders rs4653392 -2.57905359946176 1.1213276519399 0.0214482200433516
Processed meat (ukb-b-6324) Other intervertebral disc disorders rs4963586 -2.20170655881769 1.11502735596776 0.0483162540733967
Processed meat (ukb-b-6324) Other intervertebral disc disorders rs56281131 3.64287636647913 1.77177715977393 0.0397769388487053
Processed meat (ukb-b-6324) Other intervertebral disc disorders rs62396185 2.31837372184396 0.96802271192783 0.0166222699573546
Processed meat (ukb-b-6324) Other intervertebral disc disorders rs73181005 -3.70163648947333 1.0091312986984 0.0002443198768354
Processed meat (ukb-b-6324) Other intervertebral disc disorders rs76900637 -3.34913661867687 1.48553112756497 0.0241644476119241
Processed meat (ukb-b-6324) Other intervertebral disc disorders rs78397471 3.05403094916556 1.30710046708709 0.0194655676840395
Processed meat (ukb-b-6324) Other intervertebral disc disorders All - Inverse variance weighted -0.271243432822673 0.10269109918881 0.0082575656599082
Pancake (ukb-b-6500) Other intervertebral disc disorders rs12959805 -4.35088778230471 1.54251127542209 0.0047926136502613
Pancake (ukb-b-6500) Other intervertebral disc disorders rs2195088 -6.90491559572013 2.26903741955676 0.0023415182417247
Pancake (ukb-b-6500) Other intervertebral disc disorders rs4334476 -10.4349049235428 4.86394645957261 0.0319242594968021
Pancake (ukb-b-6500) Other intervertebral disc disorders rs77299778 4.58085372125487 2.15267063404599 0.0333382154919935
Pancake (ukb-b-6500) Other intervertebral disc disorders All - Inverse variance weighted -0.540195872837986 0.251426719918373 0.0316722999740354
Poultry (ukb-b-8006) Other intervertebral disc disorders rs10133989 -2.81674324589888 1.1884597748477 0.0177842973347249
Poultry (ukb-b-8006) Other intervertebral disc disorders rs2965200 -2.97513364108372 1.26683109878403 0.0188499660989108
Poultry (ukb-b-8006) Other intervertebral disc disorders rs59154329 2.67307726807915 1.30065840225328 0.0398623546099712
Poultry (ukb-b-8006) Other intervertebral disc disorders rs7045589 2.87731636812797 1.19203106679587 0.0157874242343648
Poultry (ukb-b-8006) Other intervertebral disc disorders rs72904998 4.13810836219296 1.24545008959205 0.0008918888615616
Poultry (ukb-b-8006) Other intervertebral disc disorders All - Inverse variance weighted 0.33507848239207 0.155396001405139 0.0310612091559145
Stewed fruit (ukb-b-8676) Other intervertebral disc disorders rs2519958 -3.84099611046049 1.09829430646659 0.0004701029866695
Stewed fruit (ukb-b-8676) Other intervertebral disc disorders All - MR Egger 2.27706511351308 0.640760303091168 0.0092976336005698
Squash (ukb-b-8793) Other intervertebral disc disorders rs117062976 1.26753502274942 0.418908163168784 0.0024797097832326
Squash (ukb-b-8793) Other intervertebral disc disorders All - Inverse variance weighted 0.260354054831151 0.125459774454658 0.0379680536780832
Squash (ukb-b-8793) Other intervertebral disc disorders All - MR Egger 1.0400473722577 0.316413576761087 0.0046448870708897
Fortified wine (ukb-b-9524) Other intervertebral disc disorders rs182287655 5.47173408078398 2.41933016561115 0.0237176047053017
Fortified wine (ukb-b-9524) Other intervertebral disc disorders All - Inverse variance weighted 0.63864826239005 0.308168596307078 0.0382282551498033
Sweet potato (ukb-b-9686) Other intervertebral disc disorders rs116449159 2.15017132249114 0.787490989523161 0.0063256077324045
Sweet potato (ukb-b-9686) Other intervertebral disc disorders All - Inverse variance weighted 0.566218779708258 0.258540264329014 0.0285198608855978