ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Osteoporosis (finn-b-M13_OSTEOPOROSIS)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Sweet pepper (ukb-b-10932) (👉 📊) Osteoporosis MR Egger 9 -3.858640408 1.125110365 0.010991682
Chocolate-covered raisin (ukb-b-1160) (👉 📊) Osteoporosis Weighted median 51 -1.254883042 0.63118441 0.046796196
Beetroot (ukb-b-11880) (👉 📊) Osteoporosis Inverse variance weighted 10 1.125443727 0.430236569 0.008899996
Avocado (ukb-b-12236) (👉 📊) Osteoporosis MR Egger 24 -2.531273155 1.137189205 0.036580663
Sweetcorn (ukb-b-13567) (👉 📊) Osteoporosis Weighted median 20 -1.22393152 0.571589852 0.032251803
Other sweets (ukb-b-139) (👉 📊) Osteoporosis MR Egger 26 1.615013781 0.586484274 0.011052493
Vegetarian alternatives (ukb-b-14425) (👉 📊) Osteoporosis MR Egger 6 109.7369103 37.45815782 0.042831484
White rice (ukb-b-14690) (👉 📊) Osteoporosis MR Egger 14 1.943085175 0.835823544 0.03843436
Broad bean (ukb-b-15212) (👉 📊) Osteoporosis Inverse variance weighted 21 0.999674281 0.45066765 0.0265407
Low calorie hot chocolate (ukb-b-1795) (👉 📊) Osteoporosis MR Egger 24 -4.344139697 1.527157216 0.009428263
Bran cereal (ukb-b-19498) (👉 📊) Osteoporosis Weighted median 4 -1.986957698 0.795252686 0.01247118
Bran cereal (ukb-b-19498) (👉 📊) Osteoporosis Inverse variance weighted 4 -1.54676333 0.745270882 0.037945982
Cheesy biscuits (ukb-b-19847) (👉 📊) Osteoporosis Weighted median 24 -2.192410453 1.053585314 0.037442646
Single crust pastry (ukb-b-2024) (👉 📊) Osteoporosis Inverse variance weighted 15 1.12543687 0.531680739 0.034280805
Parsnip (ukb-b-2468) (👉 📊) Osteoporosis MR Egger 20 -2.02611381 0.8430037 0.027233524
Mushroom (ukb-b-4043) (👉 📊) Osteoporosis Inverse variance weighted 9 1.224016313 0.425544952 0.004023031
Tea (ukb-b-6066) (👉 📊) Osteoporosis Weighted median 137 0.655159188 0.314387815 0.037167406
Watercress (ukb-b-6181) (👉 📊) Osteoporosis MR Egger 12 2.890126035 1.262784901 0.045113925
Watercress (ukb-b-6181) (👉 📊) Osteoporosis Inverse variance weighted 12 1.764493111 0.724694454 0.014899622
Pancake (ukb-b-6500) (👉 📊) Osteoporosis Inverse variance weighted 45 -1.424920348 0.563409336 0.01143544
Courgette (ukb-b-7420) (👉 📊) Osteoporosis Weighted median 19 1.113068996 0.557184106 0.045752639
Courgette (ukb-b-7420) (👉 📊) Osteoporosis Inverse variance weighted 19 0.848627361 0.40425366 0.035795334
Couscous (ukb-b-758) (👉 📊) Osteoporosis Inverse variance weighted 17 -2.357773876 0.984893609 0.016668583

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Sweet pepper (ukb-b-10932) Osteoporosis rs62188982 -3.02199789424615 1.01001170756276 0.0027711773521902
Sweet pepper (ukb-b-10932) Osteoporosis rs78836938 -3.98182372249354 1.82392490197247 0.0290279109648509
Sweet pepper (ukb-b-10932) Osteoporosis All - MR Egger -3.85864040758663 1.12511036498757 0.0109916823385005
Beetroot (ukb-b-11880) Osteoporosis rs28449718 3.70028928378421 1.65305019550498 0.0251909728677249
Beetroot (ukb-b-11880) Osteoporosis All - Inverse variance weighted 1.12544372737595 0.430236569219894 0.0088999955292141
Avocado (ukb-b-12236) Osteoporosis rs145012853 -6.36720924017643 2.42968977936652 0.0087778975787953
Avocado (ukb-b-12236) Osteoporosis rs2196281 8.73140857392826 3.40624088655585 0.0103665644292634
Avocado (ukb-b-12236) Osteoporosis All - MR Egger -2.53127315543157 1.13718920517711 0.036580662621553
Sweetcorn (ukb-b-13567) Osteoporosis rs76166697 -3.94379378486378 1.32469727216722 0.0029096218689991
Other sweets (ukb-b-139) Osteoporosis rs4849108 -4.57084432816858 1.96215521324342 0.0198324916334416
Other sweets (ukb-b-139) Osteoporosis All - MR Egger 1.61501378058845 0.586484273615504 0.0110524930252474
Vegetarian alternatives (ukb-b-14425) Osteoporosis rs9993067 9.98170560774166 4.95844466878076 0.0441070663808428
Vegetarian alternatives (ukb-b-14425) Osteoporosis All - MR Egger 109.736910309265 37.4581578201441 0.0428314839885648
White rice (ukb-b-14690) Osteoporosis rs10453 -4.08465919623623 1.84097315886703 0.0265037373413258
White rice (ukb-b-14690) Osteoporosis All - MR Egger 1.94308517471367 0.835823544041652 0.0384343595024764
Broad bean (ukb-b-15212) Osteoporosis rs147717277 1.44238512689538 0.726225811647224 0.0470179347254351
Broad bean (ukb-b-15212) Osteoporosis All - Inverse variance weighted 0.999674281220267 0.450667649531154 0.0265406995488618
Low calorie hot chocolate (ukb-b-1795) Osteoporosis rs4969076 9.09158182952227 4.09649762667428 0.0264625935221249
Low calorie hot chocolate (ukb-b-1795) Osteoporosis rs62342194 8.92237587625599 4.15248356763904 0.0316594411649076
Low calorie hot chocolate (ukb-b-1795) Osteoporosis rs72785604 9.83178925697174 3.29285981658244 0.0028284642907337
Low calorie hot chocolate (ukb-b-1795) Osteoporosis All - MR Egger -4.34413969747183 1.52715721621084 0.0094282627019627
Bran cereal (ukb-b-19498) Osteoporosis rs185628064 -2.85245089333675 1.34619896119044 0.0340995522450592
Bran cereal (ukb-b-19498) Osteoporosis rs8176599 -2.00328243217782 0.791097934973339 0.0113323068499527
Bran cereal (ukb-b-19498) Osteoporosis All - Inverse variance weighted -1.54676332972055 0.745270881503678 0.0379459815468759
Cheesy biscuits (ukb-b-19847) Osteoporosis rs12123737 9.46154067822117 4.17844689850376 0.0235515017239316
Cheesy biscuits (ukb-b-19847) Osteoporosis rs78427380 8.71984897291759 4.32308005417886 0.0436907700231382
Single crust pastry (ukb-b-2024) Osteoporosis rs113141796 6.09512777421804 2.64281821560745 0.021093957051121
Single crust pastry (ukb-b-2024) Osteoporosis rs144508914 6.64112344676525 2.98023186783943 0.0258544175313145
Single crust pastry (ukb-b-2024) Osteoporosis rs4363561 5.69273528334093 2.47549085319535 0.0214686812712968
Single crust pastry (ukb-b-2024) Osteoporosis All - Inverse variance weighted 1.12543686991376 0.531680739164981 0.0342808049200641
Parsnip (ukb-b-2468) Osteoporosis rs151325351 -3.04307331962413 1.3688706919252 0.0262121662042563
Parsnip (ukb-b-2468) Osteoporosis All - MR Egger -2.02611380979541 0.843003699879492 0.0272335243131279
Mushroom (ukb-b-4043) Osteoporosis rs35350431 7.3682541360537 3.3392356889899 0.0273441809264352
Mushroom (ukb-b-4043) Osteoporosis rs61068241 2.63341410834891 1.00942233657389 0.0090851619150314
Mushroom (ukb-b-4043) Osteoporosis All - Inverse variance weighted 1.22401631304152 0.425544951627474 0.004023030802502
Tea (ukb-b-6066) Osteoporosis rs10752269 -4.68433195833042 2.10523044893457 0.0260750458519291
Tea (ukb-b-6066) Osteoporosis rs10807652 -4.86797462752618 2.43398731376309 0.0455002638963584
Tea (ukb-b-6066) Osteoporosis rs1950709 -6.91729899593776 2.49099409826014 0.0054876164587215
Tea (ukb-b-6066) Osteoporosis rs7172571 6.58447623090718 2.44318723304714 0.0070381140313964
Tea (ukb-b-6066) Osteoporosis rs984616 -4.44258872651357 2.26304801670146 0.0496345984318746
Watercress (ukb-b-6181) Osteoporosis rs191852210 4.11668221143023 1.06425591261406 0.0001096723536822
Watercress (ukb-b-6181) Osteoporosis All - Inverse variance weighted 1.76449311081511 0.724694454254804 0.0148996219925135
Watercress (ukb-b-6181) Osteoporosis All - MR Egger 2.8901260348008 1.26278490057171 0.0451139248501255
Pancake (ukb-b-6500) Osteoporosis rs116924241 -30.4835992000378 14.496952899863 0.0354868355506115
Pancake (ukb-b-6500) Osteoporosis rs56095783 -5.06035227490881 2.56767133806873 0.048747398369242
Pancake (ukb-b-6500) Osteoporosis All - Inverse variance weighted -1.4249203477158 0.563409336417254 0.0114354402015809
Courgette (ukb-b-7420) Osteoporosis All - Inverse variance weighted 0.848627360762758 0.404253660053542 0.0357953338382999
Couscous (ukb-b-758) Osteoporosis rs7912809 -12.4399580219919 5.75690568374558 0.030704936787553
Couscous (ukb-b-758) Osteoporosis All - Inverse variance weighted -2.35777387621675 0.984893609390363 0.0166685828174656