ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Drug-induced osteoporosis with pathological fracture (finn-b-OSTPOPATFRACTURE)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Vegetable pieces (ukb-b-12566) (👉 📊) Drug-induced osteoporosis with pathological fracture Inverse variance weighted 13 -2.445645568 1.082599449 0.023880316
Lamb/mutton (ukb-b-14179) (👉 📊) Drug-induced osteoporosis with pathological fracture MR Egger 128 8.798748263 4.123916795 0.034814601
Mozzarella (ukb-b-14505) (👉 📊) Drug-induced osteoporosis with pathological fracture Simple mode 22 25.23146526 11.89584566 0.045989947
Rose wine (ukb-b-16124) (👉 📊) Drug-induced osteoporosis with pathological fracture Inverse variance weighted 14 4.232235312 1.859821992 0.022869176
Dark chocolate (ukb-b-16139) (👉 📊) Drug-induced osteoporosis with pathological fracture Weighted median 21 5.63837265 2.589640767 0.029459694
Dark chocolate (ukb-b-16139) (👉 📊) Drug-induced osteoporosis with pathological fracture Inverse variance weighted 21 4.20546501 1.70726358 0.013767308
Espresso (ukb-b-19142) (👉 📊) Drug-induced osteoporosis with pathological fracture Simple mode 33 -9.486761846 4.048703728 0.025499139
Espresso (ukb-b-19142) (👉 📊) Drug-induced osteoporosis with pathological fracture Weighted mode 33 -5.076123779 2.322148457 0.036248341
Oily fish (ukb-b-2209) (👉 📊) Drug-induced osteoporosis with pathological fracture MR Egger 168 -10.40890136 3.190950558 0.001342833
Vegetarian sausages/burgers (ukb-b-3383) (👉 📊) Drug-induced osteoporosis with pathological fracture MR Egger 34 -9.289382738 4.512546789 0.047754428
Drinking water (ukb-b-3975) (👉 📊) Drug-induced osteoporosis with pathological fracture MR Egger 24 1.670958064 0.619873821 0.013207091
Drinking water (ukb-b-3975) (👉 📊) Drug-induced osteoporosis with pathological fracture Inverse variance weighted 24 0.720662007 0.347405522 0.038041111
Beer/cider (ukb-b-4961) (👉 📊) Drug-induced osteoporosis with pathological fracture MR Egger 14 -6.4193526 2.705331797 0.035218141
Blue cheese (ukb-b-7429) (👉 📊) Drug-induced osteoporosis with pathological fracture Inverse variance weighted 20 7.878156902 3.663263077 0.031509007
Berry (ukb-b-8887) (👉 📊) Drug-induced osteoporosis with pathological fracture Weighted median 13 -3.772057963 1.850052398 0.041460757
Berry (ukb-b-8887) (👉 📊) Drug-induced osteoporosis with pathological fracture Inverse variance weighted 13 -2.728512543 1.328955316 0.040060371

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Vegetable pieces (ukb-b-12566) Drug-induced osteoporosis with pathological fracture All - Inverse variance weighted -2.4456455679554 1.08259944939665 0.023880316101134
Lamb/mutton (ukb-b-14179) Drug-induced osteoporosis with pathological fracture rs2135928 -39.5537245273261 17.1721660277315 0.0212584517037578
Lamb/mutton (ukb-b-14179) Drug-induced osteoporosis with pathological fracture rs660880 -28.0547765637438 12.4220439244359 0.0239165582680516
Lamb/mutton (ukb-b-14179) Drug-induced osteoporosis with pathological fracture All - MR Egger 8.79874826331169 4.123916795184 0.0348146007866959
Mozzarella (ukb-b-14505) Drug-induced osteoporosis with pathological fracture rs117549105 108.381803074366 46.1154964686332 0.018762054516912
Mozzarella (ukb-b-14505) Drug-induced osteoporosis with pathological fracture rs3781735 41.1165714336115 20.2569307956799 0.0423816255765067
Rose wine (ukb-b-16124) Drug-induced osteoporosis with pathological fracture rs13224220 5.439749067648 2.45539940889295 0.0267310233473148
Rose wine (ukb-b-16124) Drug-induced osteoporosis with pathological fracture rs9327014 20.9245577170745 7.88314241171287 0.0079463192044181
Rose wine (ukb-b-16124) Drug-induced osteoporosis with pathological fracture All - Inverse variance weighted 4.23223531211979 1.85982199246577 0.0228691758548765
Dark chocolate (ukb-b-16139) Drug-induced osteoporosis with pathological fracture rs115832742 13.2634676504146 5.28886890395916 0.0121482663160216
Dark chocolate (ukb-b-16139) Drug-induced osteoporosis with pathological fracture rs75633229 8.2980540587039 3.43320081843821 0.0156489209457969
Dark chocolate (ukb-b-16139) Drug-induced osteoporosis with pathological fracture All - Inverse variance weighted 4.20546500955244 1.7072635802311 0.0137673080101065
Espresso (ukb-b-19142) Drug-induced osteoporosis with pathological fracture rs115032220 -8.01291023762083 3.70016631811221 0.0303452792157612
Espresso (ukb-b-19142) Drug-induced osteoporosis with pathological fracture rs17655875 56.1867963407014 22.9235901948786 0.0142441363873022
Espresso (ukb-b-19142) Drug-induced osteoporosis with pathological fracture rs76256974 20.9691334355828 10.5684432515337 0.0472416856555384
Espresso (ukb-b-19142) Drug-induced osteoporosis with pathological fracture rs77567794 18.1979494615433 8.30610427487941 0.0284581094942283
Oily fish (ukb-b-2209) Drug-induced osteoporosis with pathological fracture rs11859365 -15.8019045593325 5.39285413592474 0.003387917423746
Oily fish (ukb-b-2209) Drug-induced osteoporosis with pathological fracture rs12966327 27.7297145497205 10.6171922418401 0.0090073580471956
Oily fish (ukb-b-2209) Drug-induced osteoporosis with pathological fracture rs1925517 -21.9291519705567 10.9600656701877 0.0454114629946497
Oily fish (ukb-b-2209) Drug-induced osteoporosis with pathological fracture rs673604 -24.9872136945952 10.7589827646765 0.0202086468789416
Oily fish (ukb-b-2209) Drug-induced osteoporosis with pathological fracture rs7338243 32.4028994915071 11.4951855458185 0.0048200009420227
Oily fish (ukb-b-2209) Drug-induced osteoporosis with pathological fracture rs7683782 -24.9835952339838 11.0930754619237 0.0243109418515008
Oily fish (ukb-b-2209) Drug-induced osteoporosis with pathological fracture rs79059303 24.9440592788232 11.875939987528 0.0356948907252324
Oily fish (ukb-b-2209) Drug-induced osteoporosis with pathological fracture rs9889161 -22.207040487684 9.42935863844866 0.0185179438129846
Oily fish (ukb-b-2209) Drug-induced osteoporosis with pathological fracture All - MR Egger -10.4089013568085 3.19095055844394 0.0013428333995337
Vegetarian sausages/burgers (ukb-b-3383) Drug-induced osteoporosis with pathological fracture rs1532640 28.3880363408326 13.1121372783764 0.0303861718422543
Vegetarian sausages/burgers (ukb-b-3383) Drug-induced osteoporosis with pathological fracture All - MR Egger -9.28938273786311 4.51254678873651 0.0477544279570594
Drinking water (ukb-b-3975) Drug-induced osteoporosis with pathological fracture All - Inverse variance weighted 0.720662007386899 0.347405522318317 0.0380411110685716
Drinking water (ukb-b-3975) Drug-induced osteoporosis with pathological fracture All - MR Egger 1.67095806395131 0.619873821294263 0.0132070905186848
Beer/cider (ukb-b-4961) Drug-induced osteoporosis with pathological fracture rs72992184 -9.78272120538427 4.59152216666742 0.0331216772044894
Beer/cider (ukb-b-4961) Drug-induced osteoporosis with pathological fracture All - MR Egger -6.41935259965934 2.70533179678162 0.035218141315087
Blue cheese (ukb-b-7429) Drug-induced osteoporosis with pathological fracture rs118051920 54.9231345347565 18.9244953753448 0.0037052287894183
Blue cheese (ukb-b-7429) Drug-induced osteoporosis with pathological fracture All - Inverse variance weighted 7.87815690214723 3.66326307663796 0.0315090074500448
Berry (ukb-b-8887) Drug-induced osteoporosis with pathological fracture All - Inverse variance weighted -2.72851254315441 1.32895531627285 0.0400603713081463