ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Bread (ukb-b-11348) (👉 📊) Congenital malformations of eye, ear, face and neck MR Egger 113 2.928970636 1.450662846 0.04589139
Lamb/mutton (ukb-b-14179) (👉 📊) Congenital malformations of eye, ear, face and neck Inverse variance weighted 128 -1.085284433 0.530050202 0.040607787
Water (ukb-b-14898) (👉 📊) Congenital malformations of eye, ear, face and neck Weighted median 153 1.222643739 0.60367381 0.04283263
Rose wine (ukb-b-16124) (👉 📊) Congenital malformations of eye, ear, face and neck Inverse variance weighted 14 -1.90673109 0.748606218 0.010864052
Dried fruit (ukb-b-16576) (👉 📊) Congenital malformations of eye, ear, face and neck MR Egger 155 3.483208534 1.577113127 0.028689734
Fruit smoothie (ukb-b-1780) (👉 📊) Congenital malformations of eye, ear, face and neck Inverse variance weighted 24 -1.654415798 0.762161517 0.029954672
Cherry (ukb-b-2221) (👉 📊) Congenital malformations of eye, ear, face and neck Inverse variance weighted 17 2.911534402 1.48105246 0.049315361
Orange juice (ukb-b-2763) (👉 📊) Congenital malformations of eye, ear, face and neck Weighted median 12 -1.954761524 0.89444685 0.02885647
Orange juice (ukb-b-2763) (👉 📊) Congenital malformations of eye, ear, face and neck Inverse variance weighted 12 -1.268155187 0.630513808 0.044293316
Beef (ukb-b-2862) (👉 📊) Congenital malformations of eye, ear, face and neck MR Egger 98 -3.974081189 1.659590951 0.018579547
Standard tea (ukb-b-3291) (👉 📊) Congenital malformations of eye, ear, face and neck Inverse variance weighted 14 -0.008209059 0.003596467 0.022457805
Mushroom (ukb-b-4043) (👉 📊) Congenital malformations of eye, ear, face and neck Inverse variance weighted 9 -1.448287261 0.719257311 0.044052899
Apple (ukb-b-4070) (👉 📊) Congenital malformations of eye, ear, face and neck Inverse variance weighted 18 -0.901630679 0.393179526 0.021837753
Whole egg (ukb-b-4075) (👉 📊) Congenital malformations of eye, ear, face and neck Inverse variance weighted 6 2.055251415 0.860086688 0.016867358
Other cheese (ukb-b-4088) (👉 📊) Congenital malformations of eye, ear, face and neck Inverse variance weighted 17 3.325317844 1.584997092 0.035905483
Mango (ukb-b-6218) (👉 📊) Congenital malformations of eye, ear, face and neck Inverse variance weighted 25 -1.921730385 0.918121634 0.036339257
Poultry (ukb-b-8006) (👉 📊) Congenital malformations of eye, ear, face and neck Inverse variance weighted 80 -1.242321237 0.552019699 0.02441712
Other grain (ukb-b-8765) (👉 📊) Congenital malformations of eye, ear, face and neck MR Egger 70 -5.883247499 2.353513163 0.014845338
Other grain (ukb-b-8765) (👉 📊) Congenital malformations of eye, ear, face and neck Weighted median 70 -4.605152659 1.969779364 0.019392292
Other grain (ukb-b-8765) (👉 📊) Congenital malformations of eye, ear, face and neck Inverse variance weighted 70 -2.823244799 1.328301216 0.033548644
Other grain (ukb-b-8765) (👉 📊) Congenital malformations of eye, ear, face and neck Simple mode 70 -7.991080779 3.660432206 0.032433398

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Bread (ukb-b-11348) Congenital malformations of eye, ear, face and neck rs112611766 22.8686706096018 7.27519180773161 0.0016701058767278
Bread (ukb-b-11348) Congenital malformations of eye, ear, face and neck rs117398588 8.74212946215589 3.5912195991465 0.0149203521158944
Bread (ukb-b-11348) Congenital malformations of eye, ear, face and neck rs13023099 10.1649405446874 4.01018237612024 0.0112517127565525
Bread (ukb-b-11348) Congenital malformations of eye, ear, face and neck rs7923705 17.743170793975 4.94638754148583 0.0003343802486753
Bread (ukb-b-11348) Congenital malformations of eye, ear, face and neck All - MR Egger 2.92897063644492 1.45066284582254 0.0458913895195553
Lamb/mutton (ukb-b-14179) Congenital malformations of eye, ear, face and neck rs10883567 -12.980208982747 6.26201775206004 0.0381864572851383
Lamb/mutton (ukb-b-14179) Congenital malformations of eye, ear, face and neck rs10905778 -13.3613617857004 6.17091006166886 0.0303710411054834
Lamb/mutton (ukb-b-14179) Congenital malformations of eye, ear, face and neck rs11090045 -9.87251899101732 4.4679236799955 0.0271299064575689
Lamb/mutton (ukb-b-14179) Congenital malformations of eye, ear, face and neck rs2926119 11.0957551339443 5.58486341741861 0.0469495572706374
Lamb/mutton (ukb-b-14179) Congenital malformations of eye, ear, face and neck rs416769 13.5276673935135 5.92566410321051 0.0224365695913756
Lamb/mutton (ukb-b-14179) Congenital malformations of eye, ear, face and neck rs4449668 15.0118975649176 7.63316825334791 0.0492216521753002
Lamb/mutton (ukb-b-14179) Congenital malformations of eye, ear, face and neck rs4759074 -17.2237148486477 6.56277986745477 0.0086787977099846
Lamb/mutton (ukb-b-14179) Congenital malformations of eye, ear, face and neck rs77431173 -23.4022283891811 11.5791556788947 0.0432730179554182
Lamb/mutton (ukb-b-14179) Congenital malformations of eye, ear, face and neck rs942038 -16.9368342116347 5.99658951996466 0.0047367581421047
Lamb/mutton (ukb-b-14179) Congenital malformations of eye, ear, face and neck All - Inverse variance weighted -1.0852844326823 0.530050201884811 0.0406077873582879
Water (ukb-b-14898) Congenital malformations of eye, ear, face and neck rs11125629 -8.20803504058008 4.17763218433112 0.0494422870965603
Water (ukb-b-14898) Congenital malformations of eye, ear, face and neck rs113608681 -11.1012965708697 5.25253162560333 0.0345568396157097
Water (ukb-b-14898) Congenital malformations of eye, ear, face and neck rs12620738 10.2286511825804 4.94241548738126 0.0384930781161736
Water (ukb-b-14898) Congenital malformations of eye, ear, face and neck rs13171354 8.52937049855018 4.12145730053316 0.0384988589093931
Water (ukb-b-14898) Congenital malformations of eye, ear, face and neck rs14135 -12.1324127073761 4.37211769638167 0.0055210012434034
Water (ukb-b-14898) Congenital malformations of eye, ear, face and neck rs2917704 -13.2929629724226 5.32879476361745 0.0126115756842481
Water (ukb-b-14898) Congenital malformations of eye, ear, face and neck rs4410790 4.26932371061889 1.5515979191096 0.0059311109926676
Water (ukb-b-14898) Congenital malformations of eye, ear, face and neck rs654975 11.574062187734 5.20678751480135 0.0262239140138553
Water (ukb-b-14898) Congenital malformations of eye, ear, face and neck rs6933066 -10.1412161633377 4.94560916861592 0.0403108433966626
Water (ukb-b-14898) Congenital malformations of eye, ear, face and neck rs9343542 13.1449688917996 5.67900079524723 0.0206314219491539
Water (ukb-b-14898) Congenital malformations of eye, ear, face and neck rs9830293 -6.92788605147178 3.43774073355937 0.0438790995504291
Rose wine (ukb-b-16124) Congenital malformations of eye, ear, face and neck rs12456862 -10.4694974489603 3.45698105483409 0.0024576394220013
Rose wine (ukb-b-16124) Congenital malformations of eye, ear, face and neck All - Inverse variance weighted -1.90673109034742 0.748606217536615 0.010864051786082
Dried fruit (ukb-b-16576) Congenital malformations of eye, ear, face and neck rs11082011 11.3677522397308 5.60750926220888 0.0426381447229411
Dried fruit (ukb-b-16576) Congenital malformations of eye, ear, face and neck rs112887546 11.1312259202525 5.34744464559254 0.0373792753563067
Dried fruit (ukb-b-16576) Congenital malformations of eye, ear, face and neck rs13016580 10.8266999398896 5.52150312391847 0.0498994707444163
Dried fruit (ukb-b-16576) Congenital malformations of eye, ear, face and neck rs62007687 -14.8814736387745 5.55936600628479 0.0074322497089194
Dried fruit (ukb-b-16576) Congenital malformations of eye, ear, face and neck rs7810473 11.8226302320823 5.82289800960462 0.0423190693073295
Dried fruit (ukb-b-16576) Congenital malformations of eye, ear, face and neck rs9300104 -18.8323682729984 5.81276667778602 0.0011960153007513
Dried fruit (ukb-b-16576) Congenital malformations of eye, ear, face and neck All - MR Egger 3.48320853409922 1.57711312699203 0.0286897342613424
Fruit smoothie (ukb-b-1780) Congenital malformations of eye, ear, face and neck rs142521944 -10.0853889280652 4.58537845517954 0.0278447279568005
Fruit smoothie (ukb-b-1780) Congenital malformations of eye, ear, face and neck rs62438192 -12.0569460090448 5.50195098855529 0.0284232452961669
Fruit smoothie (ukb-b-1780) Congenital malformations of eye, ear, face and neck All - Inverse variance weighted -1.65441579832086 0.762161517494222 0.0299546717873767
Cherry (ukb-b-2221) Congenital malformations of eye, ear, face and neck rs2773155 11.0379699667561 4.92863232077922 0.0251194734215918
Cherry (ukb-b-2221) Congenital malformations of eye, ear, face and neck All - Inverse variance weighted 2.91153440215061 1.48105246046344 0.0493153610672342
Orange juice (ukb-b-2763) Congenital malformations of eye, ear, face and neck All - Inverse variance weighted -1.26815518659745 0.63051380811015 0.0442933156988488
Beef (ukb-b-2862) Congenital malformations of eye, ear, face and neck rs12829270 10.9620975071635 5.30759784365829 0.0388889997840788
Beef (ukb-b-2862) Congenital malformations of eye, ear, face and neck rs13145306 -11.0132158590308 5.22903907453171 0.0351900757745684
Beef (ukb-b-2862) Congenital malformations of eye, ear, face and neck rs144160011 -12.105991014553 4.26342980388223 0.0045184890163722
Beef (ukb-b-2862) Congenital malformations of eye, ear, face and neck rs1470610 -11.0020546992035 4.78884077309081 0.0215939159379788
Beef (ukb-b-2862) Congenital malformations of eye, ear, face and neck rs4759074 -13.6943850742596 5.21799364726363 0.0086787977099846
Beef (ukb-b-2862) Congenital malformations of eye, ear, face and neck rs7791463 -9.72931760723719 4.75469342700289 0.0407312387848121
Beef (ukb-b-2862) Congenital malformations of eye, ear, face and neck rs9615805 -10.4128972224889 4.83719693668811 0.0313444847581866
Beef (ukb-b-2862) Congenital malformations of eye, ear, face and neck All - MR Egger -3.9740811885463 1.65959095137592 0.0185795468559233
Standard tea (ukb-b-3291) Congenital malformations of eye, ear, face and neck rs2389763 -0.0319335951344684 0.0082935197130583 0.0001179119031977
Standard tea (ukb-b-3291) Congenital malformations of eye, ear, face and neck rs7233417 -0.0288405519952681 0.0107623956559058 0.0073676708567898
Standard tea (ukb-b-3291) Congenital malformations of eye, ear, face and neck rs908817 -0.0212127917712681 0.0090230670034261 0.0187254807485332
Standard tea (ukb-b-3291) Congenital malformations of eye, ear, face and neck All - Inverse variance weighted -0.0082090590054217 0.0035964666151556 0.0224578050293331
Mushroom (ukb-b-4043) Congenital malformations of eye, ear, face and neck All - Inverse variance weighted -1.44828726141111 0.719257310959124 0.0440528992244458
Apple (ukb-b-4070) Congenital malformations of eye, ear, face and neck rs1347300 -3.3748880776913 1.4013467763726 0.0160262331758464
Apple (ukb-b-4070) Congenital malformations of eye, ear, face and neck All - Inverse variance weighted -0.901630679451481 0.39317952615571 0.0218377533385981
Whole egg (ukb-b-4075) Congenital malformations of eye, ear, face and neck All - Inverse variance weighted 2.05525141453079 0.860086687589615 0.0168673579310129
Other cheese (ukb-b-4088) Congenital malformations of eye, ear, face and neck rs7214411 14.785221239891 7.47337475636152 0.0478851590399018
Other cheese (ukb-b-4088) Congenital malformations of eye, ear, face and neck All - Inverse variance weighted 3.32531784391786 1.58499709188801 0.0359054828312711
Mango (ukb-b-6218) Congenital malformations of eye, ear, face and neck All - Inverse variance weighted -1.92173038471461 0.918121634046449 0.0363392573807996
Poultry (ukb-b-8006) Congenital malformations of eye, ear, face and neck rs1062633 10.6466106661457 5.01400013023377 0.0337223044931005
Poultry (ukb-b-8006) Congenital malformations of eye, ear, face and neck rs61812638 -10.8930745466559 5.04211743721776 0.0307404283660449
Poultry (ukb-b-8006) Congenital malformations of eye, ear, face and neck rs7625597 -11.5707795684284 4.73723746096403 0.0145852722098294
Poultry (ukb-b-8006) Congenital malformations of eye, ear, face and neck rs77118273 -10.6338951901966 5.09248542749521 0.0367839209035852
Poultry (ukb-b-8006) Congenital malformations of eye, ear, face and neck All - Inverse variance weighted -1.24232123713876 0.552019698900982 0.0244171195808363
Other grain (ukb-b-8765) Congenital malformations of eye, ear, face and neck rs6573775 38.8252080722794 13.3996024971477 0.0037616228201506
Other grain (ukb-b-8765) Congenital malformations of eye, ear, face and neck rs72732838 -19.7260462082461 9.66047581448041 0.0411581588448199
Other grain (ukb-b-8765) Congenital malformations of eye, ear, face and neck All - Inverse variance weighted -2.82324479917659 1.32830121636911 0.0335486439792941
Other grain (ukb-b-8765) Congenital malformations of eye, ear, face and neck All - MR Egger -5.8832474991937 2.35351316343496 0.0148453377173165