ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Avocado (ukb-b-12236) (👉 📊) Seropositive rheumatoid arthritis, strict definition Weighted median 24 2.500469661 1.178627316 0.033878906
Scotch egg (ukb-b-13516) (👉 📊) Seropositive rheumatoid arthritis, strict definition Weighted median 106 -6.78126128 2.010882658 0.000745484
Scotch egg (ukb-b-13516) (👉 📊) Seropositive rheumatoid arthritis, strict definition Weighted mode 106 -8.87500994 3.537682266 0.013646447
Pea (ukb-b-15945) (👉 📊) Seropositive rheumatoid arthritis, strict definition Inverse variance weighted 11 1.467634747 0.509234993 0.003951117
Rose wine (ukb-b-16124) (👉 📊) Seropositive rheumatoid arthritis, strict definition Inverse variance weighted 14 -1.576962716 0.765811004 0.039474496
Hot chocolate (ukb-b-16449) (👉 📊) Seropositive rheumatoid arthritis, strict definition Weighted median 18 -2.676434965 1.251122853 0.032417342
Espresso (ukb-b-19142) (👉 📊) Seropositive rheumatoid arthritis, strict definition Weighted median 33 -1.871509927 0.857924547 0.029150974
Goat's cheese (ukb-b-20122) (👉 📊) Seropositive rheumatoid arthritis, strict definition Inverse variance weighted 35 -1.96129262 0.967544157 0.042653893
Oily fish (ukb-b-2209) (👉 📊) Seropositive rheumatoid arthritis, strict definition MR Egger 168 -2.798477236 1.344516816 0.038932156
Beef (ukb-b-2862) (👉 📊) Seropositive rheumatoid arthritis, strict definition MR Egger 98 3.3604246 1.532330023 0.030721572
Cabbage/kale (ukb-b-2975) (👉 📊) Seropositive rheumatoid arthritis, strict definition Inverse variance weighted 20 -0.920948355 0.415390636 0.026618598
Prune (ukb-b-3022) (👉 📊) Seropositive rheumatoid arthritis, strict definition MR Egger 15 4.808435604 1.635133384 0.011475087
Prune (ukb-b-3022) (👉 📊) Seropositive rheumatoid arthritis, strict definition Inverse variance weighted 15 1.947761314 0.906980795 0.031751739
Ham (ukb-b-4442) (👉 📊) Seropositive rheumatoid arthritis, strict definition Inverse variance weighted 9 0.926102954 0.465538724 0.046666495
Watercress (ukb-b-6181) (👉 📊) Seropositive rheumatoid arthritis, strict definition MR Egger 12 -3.964711812 1.755860006 0.047530587
Bread roll (ukb-b-6246) (👉 📊) Seropositive rheumatoid arthritis, strict definition Inverse variance weighted 18 1.073790188 0.39649858 0.006765298
Bread roll (ukb-b-6246) (👉 📊) Seropositive rheumatoid arthritis, strict definition Weighted mode 18 1.643839519 0.74469741 0.041319024
Fresh tomato (ukb-b-730) (👉 📊) Seropositive rheumatoid arthritis, strict definition Weighted median 10 1.155531024 0.49782594 0.020278496
Filtered coffee (ukb-b-748) (👉 📊) Seropositive rheumatoid arthritis, strict definition Inverse variance weighted 21 -0.566676311 0.284218571 0.046173406
Crispbread (ukb-b-8759) (👉 📊) Seropositive rheumatoid arthritis, strict definition Inverse variance weighted 14 0.651267218 0.320527123 0.042167522
Fortified wine (ukb-b-9524) (👉 📊) Seropositive rheumatoid arthritis, strict definition Weighted median 20 -3.069254714 1.517744571 0.04315082
Soya dessert (ukb-b-998) (👉 📊) Seropositive rheumatoid arthritis, strict definition Inverse variance weighted 28 -3.451045387 1.68381408 0.040409278

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Avocado (ukb-b-12236) Seropositive rheumatoid arthritis, strict definition rs2142667 -14.4050795872835 4.44338897464581 0.001187303455732
Avocado (ukb-b-12236) Seropositive rheumatoid arthritis, strict definition rs62196418 9.63722922424646 4.116804375823 0.0192347926832745
Scotch egg (ukb-b-13516) Seropositive rheumatoid arthritis, strict definition rs118035561 43.8359529883859 22.1795818182025 0.048108330862645
Scotch egg (ukb-b-13516) Seropositive rheumatoid arthritis, strict definition rs141315161 29.6288980519 13.9132367102047 0.0332089917331332
Scotch egg (ukb-b-13516) Seropositive rheumatoid arthritis, strict definition rs148303914 29.9026907227205 13.8172247809676 0.0304520412242582
Scotch egg (ukb-b-13516) Seropositive rheumatoid arthritis, strict definition rs4861592 48.5367742649296 22.3494592426631 0.0298767666220915
Scotch egg (ukb-b-13516) Seropositive rheumatoid arthritis, strict definition rs76118553 -73.1041381402556 35.0188171822602 0.036836882995149
Pea (ukb-b-15945) Seropositive rheumatoid arthritis, strict definition rs115234215 5.8639368735338 2.25719769673704 0.0093800285292368
Pea (ukb-b-15945) Seropositive rheumatoid arthritis, strict definition All - Inverse variance weighted 1.46763474681939 0.509234993300151 0.003951117228453
Rose wine (ukb-b-16124) Seropositive rheumatoid arthritis, strict definition rs41273040 -8.81282935459543 2.52574361212167 0.0004844651192133
Rose wine (ukb-b-16124) Seropositive rheumatoid arthritis, strict definition All - Inverse variance weighted -1.57696271630685 0.765811003757746 0.0394744958299896
Hot chocolate (ukb-b-16449) Seropositive rheumatoid arthritis, strict definition rs1042953 8.54759041157026 4.25110248787831 0.0443596741038242
Hot chocolate (ukb-b-16449) Seropositive rheumatoid arthritis, strict definition rs1512376 7.23293537664795 3.66418929293181 0.0483871516908965
Hot chocolate (ukb-b-16449) Seropositive rheumatoid arthritis, strict definition rs6796609 16.2497202183158 7.76157435305866 0.0362946149904648
Espresso (ukb-b-19142) Seropositive rheumatoid arthritis, strict definition rs115032220 -3.66393861050274 1.31407775783424 0.0052998449143142
Espresso (ukb-b-19142) Seropositive rheumatoid arthritis, strict definition rs11680934 7.28623546206706 3.63288425426096 0.0448953326504246
Espresso (ukb-b-19142) Seropositive rheumatoid arthritis, strict definition rs181774247 8.24185626107537 3.99435251902457 0.0390767962563501
Espresso (ukb-b-19142) Seropositive rheumatoid arthritis, strict definition rs58895686 9.522784742024 4.83536880615484 0.0489069523374126
Espresso (ukb-b-19142) Seropositive rheumatoid arthritis, strict definition rs76256974 -8.16717791411043 3.69056748466258 0.0268985410246517
Goat's cheese (ukb-b-20122) Seropositive rheumatoid arthritis, strict definition rs6899522 -21.0165146817073 7.81485299717524 0.0071601200939314
Goat's cheese (ukb-b-20122) Seropositive rheumatoid arthritis, strict definition All - Inverse variance weighted -1.96129261950528 0.967544156857969 0.0426538926379932
Oily fish (ukb-b-2209) Seropositive rheumatoid arthritis, strict definition rs1053924 -11.6819253987926 3.80602086914804 0.0021454109647989
Oily fish (ukb-b-2209) Seropositive rheumatoid arthritis, strict definition rs11576565 8.40624251286754 4.1824670979255 0.0444442569561548
Oily fish (ukb-b-2209) Seropositive rheumatoid arthritis, strict definition rs11740769 10.2239391210898 3.95015829678469 0.0096469059906341
Oily fish (ukb-b-2209) Seropositive rheumatoid arthritis, strict definition rs13023088 -7.94688367583765 3.62089986338998 0.0281832465669793
Oily fish (ukb-b-2209) Seropositive rheumatoid arthritis, strict definition rs13070166 -7.31853207135569 3.42000633334506 0.03236141877933
Oily fish (ukb-b-2209) Seropositive rheumatoid arthritis, strict definition rs13113700 -12.179587848331 4.93814235111414 0.0136466981717034
Oily fish (ukb-b-2209) Seropositive rheumatoid arthritis, strict definition rs16891727 -9.14522310718336 3.23814262163062 0.0047396024770647
Oily fish (ukb-b-2209) Seropositive rheumatoid arthritis, strict definition rs170795 -9.3427008038911 4.31669256231845 0.0304398564360914
Oily fish (ukb-b-2209) Seropositive rheumatoid arthritis, strict definition rs17756423 -11.6842486112983 4.34878227002178 0.007214309292046
Oily fish (ukb-b-2209) Seropositive rheumatoid arthritis, strict definition rs2271308 8.75939252609848 3.82805513068044 0.022125317517118
Oily fish (ukb-b-2209) Seropositive rheumatoid arthritis, strict definition rs2591847 9.47649777327914 4.10818984549723 0.0210697000572567
Oily fish (ukb-b-2209) Seropositive rheumatoid arthritis, strict definition rs275160 -7.3192065220979 3.55645773508928 0.0395896879563969
Oily fish (ukb-b-2209) Seropositive rheumatoid arthritis, strict definition rs303817 -7.56264773672855 3.32844866309767 0.0230790283265287
Oily fish (ukb-b-2209) Seropositive rheumatoid arthritis, strict definition rs4851487 9.67216342710499 4.63052119328964 0.0367270770582451
Oily fish (ukb-b-2209) Seropositive rheumatoid arthritis, strict definition rs6842641 -9.62694576470873 3.99441588728485 0.0159481044192632
Oily fish (ukb-b-2209) Seropositive rheumatoid arthritis, strict definition rs72484727 13.3680897108007 4.06256147944128 0.0009998927723778
Oily fish (ukb-b-2209) Seropositive rheumatoid arthritis, strict definition rs7919624 -10.5522230415114 4.00565973813747 0.0084303915744649
Oily fish (ukb-b-2209) Seropositive rheumatoid arthritis, strict definition All - MR Egger -2.79847723642146 1.34451681643425 0.0389321564216941
Beef (ukb-b-2862) Seropositive rheumatoid arthritis, strict definition rs10247400 -15.2828878604204 5.10253248694715 0.0027430326731203
Beef (ukb-b-2862) Seropositive rheumatoid arthritis, strict definition rs117340623 10.8739975533506 5.45086867151373 0.046052593966954
Beef (ukb-b-2862) Seropositive rheumatoid arthritis, strict definition rs4676964 6.17824807350992 3.0179805740903 0.0406437121317468
Beef (ukb-b-2862) Seropositive rheumatoid arthritis, strict definition rs4714375 -10.3005187695191 4.78724550741966 0.0314242398635857
Beef (ukb-b-2862) Seropositive rheumatoid arthritis, strict definition rs62169335 -8.26942851125509 4.18117171917392 0.0479537814825985
Beef (ukb-b-2862) Seropositive rheumatoid arthritis, strict definition rs67616875 -11.1247795915617 4.90858267692775 0.0234273047275417
Beef (ukb-b-2862) Seropositive rheumatoid arthritis, strict definition rs7220792 -8.70100943083266 4.32207004407374 0.0440980211996215
Beef (ukb-b-2862) Seropositive rheumatoid arthritis, strict definition All - MR Egger 3.36042459963608 1.53233002256111 0.0307215722108168
Cabbage/kale (ukb-b-2975) Seropositive rheumatoid arthritis, strict definition rs116816200 5.04518244557136 2.28466847142258 0.0272249206097905
Cabbage/kale (ukb-b-2975) Seropositive rheumatoid arthritis, strict definition All - Inverse variance weighted -0.920948355241006 0.415390635968957 0.0266185982909208
Prune (ukb-b-3022) Seropositive rheumatoid arthritis, strict definition rs118054480 7.26533453500245 3.36759319658585 0.0309724544901188
Prune (ukb-b-3022) Seropositive rheumatoid arthritis, strict definition All - Inverse variance weighted 1.94776131361627 0.906980795322912 0.0317517387062275
Prune (ukb-b-3022) Seropositive rheumatoid arthritis, strict definition All - MR Egger 4.80843560439825 1.63513338425452 0.011475086870204
Ham (ukb-b-4442) Seropositive rheumatoid arthritis, strict definition All - Inverse variance weighted 0.926102954431821 0.46553872389061 0.0466664952973524
Watercress (ukb-b-6181) Seropositive rheumatoid arthritis, strict definition rs191852210 -3.79360452367238 1.63731678863702 0.0205056773393939
Watercress (ukb-b-6181) Seropositive rheumatoid arthritis, strict definition rs7704452 7.25368949332539 3.57604860175145 0.042518513040939
Watercress (ukb-b-6181) Seropositive rheumatoid arthritis, strict definition All - MR Egger -3.96471181193103 1.7558600058644 0.0475305869073153
Bread roll (ukb-b-6246) Seropositive rheumatoid arthritis, strict definition rs9849625 4.9241806619925 1.87743122685239 0.008720308330466
Bread roll (ukb-b-6246) Seropositive rheumatoid arthritis, strict definition All - Inverse variance weighted 1.07379018826097 0.396498580148611 0.0067652977684395
Filtered coffee (ukb-b-748) Seropositive rheumatoid arthritis, strict definition rs1215980 -3.94914418609284 1.17777124843752 0.0007992177915188
Filtered coffee (ukb-b-748) Seropositive rheumatoid arthritis, strict definition All - Inverse variance weighted -0.566676310867925 0.284218570914516 0.0461734062330132
Crispbread (ukb-b-8759) Seropositive rheumatoid arthritis, strict definition rs13021209 2.68018532754358 1.20504456587231 0.0261391655470776
Crispbread (ukb-b-8759) Seropositive rheumatoid arthritis, strict definition rs79252206 5.26054097056484 1.91179395385839 0.0059300295122588
Crispbread (ukb-b-8759) Seropositive rheumatoid arthritis, strict definition rs79463892 2.71142672692059 1.37508069722402 0.0486289038215588
Crispbread (ukb-b-8759) Seropositive rheumatoid arthritis, strict definition All - Inverse variance weighted 0.651267218151682 0.320527123041029 0.0421675220097398
Fortified wine (ukb-b-9524) Seropositive rheumatoid arthritis, strict definition rs12686701 -8.91401239265137 4.44147655801096 0.044750407590066
Soya dessert (ukb-b-998) Seropositive rheumatoid arthritis, strict definition rs116362645 -28.2096516248166 11.0189658109794 0.0104642122984548
Soya dessert (ukb-b-998) Seropositive rheumatoid arthritis, strict definition rs34374711 -44.6591323368575 17.8885095946707 0.0125416414349386
Soya dessert (ukb-b-998) Seropositive rheumatoid arthritis, strict definition All - Inverse variance weighted -3.45104538704757 1.6838140802454 0.0404092781618576