ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Pineapple (ukb-b-1164) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level Weighted median 16 -1.379913934 0.64241994 0.031714262
Pineapple (ukb-b-1164) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level Inverse variance weighted 16 -1.247566271 0.464346616 0.007215884
Avocado (ukb-b-12236) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level Inverse variance weighted 24 -1.074987448 0.383862161 0.005103114
Sweetcorn (ukb-b-13567) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level Inverse variance weighted 20 -0.764866293 0.327870835 0.01965717
Water (ukb-b-14898) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level Weighted median 153 0.62080939 0.263423515 0.018438288
Water (ukb-b-14898) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level Weighted mode 153 0.803760271 0.392825493 0.04246996
Broad bean (ukb-b-15212) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level Weighted median 21 -1.040779783 0.517580186 0.044340555
Rose wine (ukb-b-16124) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level MR Egger 14 1.908082269 0.766932777 0.028539725
Espresso (ukb-b-19142) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level Inverse variance weighted 33 0.718921044 0.252585911 0.004423833
Bran cereal (ukb-b-19498) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level Inverse variance weighted 4 0.880387493 0.433473853 0.042254504
Goat's cheese (ukb-b-20122) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level MR Egger 35 1.740375672 0.785288282 0.033682619
Scotch pancake (ukb-b-2035) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level Inverse variance weighted 53 -1.328397581 0.464711414 0.004255914
Cherry (ukb-b-2221) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level MR Egger 17 -3.067397638 1.260731366 0.027957237
Other vegetables (ukb-b-3055) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level Inverse variance weighted 14 0.9618082 0.34949352 0.005923147
Green tea (ukb-b-4078) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level MR Egger 126 0.008301502 0.004192497 0.049908298
Bacon (ukb-b-4414) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level Weighted median 12 -0.972550439 0.377978835 0.010081281
Bacon (ukb-b-4414) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level Inverse variance weighted 12 -0.716500028 0.291653787 0.014022753
Ham (ukb-b-4442) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level Weighted median 9 -0.60338564 0.303100671 0.046512741
Ham (ukb-b-4442) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level Weighted mode 9 -0.899564484 0.380023719 0.045449765
Seeds (ukb-b-4548) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level Inverse variance weighted 15 1.259656589 0.639990278 0.049040048
Other egg (ukb-b-8266) (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level Simple mode 21 -3.839763923 1.555781576 0.022728763

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Pineapple (ukb-b-1164) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs3096085 -5.63686238444828 2.7272583125882 0.0387473039736894
Pineapple (ukb-b-1164) Dislocation, sprain and strain of joints and ligaments at ankle and foot level All - Inverse variance weighted -1.24756627131207 0.464346616081435 0.0072158840021015
Avocado (ukb-b-12236) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs183191848 -3.28173956946349 1.25560774879925 0.0089576497105422
Avocado (ukb-b-12236) Dislocation, sprain and strain of joints and ligaments at ankle and foot level All - Inverse variance weighted -1.07498744765835 0.383862160831865 0.0051031140825502
Sweetcorn (ukb-b-13567) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs10445348 -2.72439697491032 1.3092241018319 0.0374407846866585
Sweetcorn (ukb-b-13567) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs10497125 -2.49268778080429 1.23629272999568 0.0437727782854923
Sweetcorn (ukb-b-13567) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs1841715 2.44579709078872 1.1953143676787 0.040741236636499
Sweetcorn (ukb-b-13567) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs866596 -3.33877520959407 1.26431561245658 0.00827162176144
Sweetcorn (ukb-b-13567) Dislocation, sprain and strain of joints and ligaments at ankle and foot level All - Inverse variance weighted -0.764866293170642 0.327870835151644 0.0196571699043955
Water (ukb-b-14898) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs11140831 3.69885803815154 1.55061297669235 0.017059786954651
Water (ukb-b-14898) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs113707721 5.62239332691691 2.35803657362849 0.0171091474359592
Water (ukb-b-14898) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs11858506 6.29033095949569 2.22476696413043 0.0046926032915175
Water (ukb-b-14898) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs12297697 9.37778655511469 2.99825849656188 0.0017615323148683
Water (ukb-b-14898) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs12981418 4.27325284341625 2.17791388879427 0.0497525531472781
Water (ukb-b-14898) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs2716991 -4.50640631596909 2.11101072568455 0.0327842948714621
Water (ukb-b-14898) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs393521 -5.15622122644405 2.05196559011549 0.0119770253522359
Water (ukb-b-14898) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs4796172 5.53433052274176 2.35310038649421 0.0186762224153562
Water (ukb-b-14898) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs6933066 -4.94560916861592 2.08693837444892 0.0177981108913978
Water (ukb-b-14898) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs7626335 -3.87226179089786 1.9222018962011 0.0439578249087614
Water (ukb-b-14898) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs782221 4.50025176233635 2.13211228600201 0.034798010789326
Water (ukb-b-14898) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs959424 6.56690463115504 2.33388248215266 0.0048971027225046
Broad bean (ukb-b-15212) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs147717277 -1.21948413520167 0.543590805549803 0.0248719182169918
Broad bean (ukb-b-15212) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs185311646 10.7580356950634 5.0722297573683 0.0339245171487671
Broad bean (ukb-b-15212) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs547613760 4.60571884905922 1.68680785873188 0.0063250846435116
Rose wine (ukb-b-16124) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs13224220 0.961166407336972 0.417808952225707 0.0214203274371259
Rose wine (ukb-b-16124) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs41273040 3.33208429580371 1.15970763035446 0.0040632311237132
Rose wine (ukb-b-16124) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs71641030 -4.8836114985311 1.90342149552124 0.0102967378492668
Rose wine (ukb-b-16124) Dislocation, sprain and strain of joints and ligaments at ankle and foot level All - MR Egger 1.90808226865268 0.766932777270225 0.0285397250450433
Espresso (ukb-b-19142) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs145046724 1.29881397776241 0.615227673676932 0.0347627626222285
Espresso (ukb-b-19142) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs28692629 4.1265009301539 1.81802807373584 0.023221696982371
Espresso (ukb-b-19142) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs79755398 -8.6340752862809 4.24770693842472 0.0420885202843013
Espresso (ukb-b-19142) Dislocation, sprain and strain of joints and ligaments at ankle and foot level All - Inverse variance weighted 0.718921044170094 0.252585910625455 0.0044238331933907
Bran cereal (ukb-b-19498) Dislocation, sprain and strain of joints and ligaments at ankle and foot level All - Inverse variance weighted 0.880387492706476 0.433473852829457 0.0422545037214531
Goat's cheese (ukb-b-20122) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs11750339 -8.85004990106722 4.25984720188894 0.0377507314046867
Goat's cheese (ukb-b-20122) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs79888670 4.02848103338726 1.80462849544421 0.0255948182409091
Goat's cheese (ukb-b-20122) Dislocation, sprain and strain of joints and ligaments at ankle and foot level All - MR Egger 1.74037567161657 0.785288281500431 0.0336826189662882
Scotch pancake (ukb-b-2035) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs721970 -12.2007966347765 6.12366451997171 0.0463270540626658
Scotch pancake (ukb-b-2035) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs77000583 -4.58007964316038 2.02695430682946 0.0238468938957195
Scotch pancake (ukb-b-2035) Dislocation, sprain and strain of joints and ligaments at ankle and foot level All - Inverse variance weighted -1.32839758081697 0.464711414387955 0.0042559136491202
Cherry (ukb-b-2221) Dislocation, sprain and strain of joints and ligaments at ankle and foot level All - MR Egger -3.0673976378228 1.26073136609996 0.0279572371189751
Other vegetables (ukb-b-3055) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs117427411 2.30867352136898 0.825253994840634 0.0051494847039117
Other vegetables (ukb-b-3055) Dislocation, sprain and strain of joints and ligaments at ankle and foot level All - Inverse variance weighted 0.9618082003165 0.349493520142985 0.0059231468833757
Green tea (ukb-b-4078) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs117251267 -0.054166877925941 0.0243652363005403 0.0262076158556595
Green tea (ukb-b-4078) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs141152256 -0.0697279260930938 0.020865553641494 0.000832453639314
Green tea (ukb-b-4078) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs145505382 -0.0748902301934534 0.0381893171750089 0.0498760318701786
Green tea (ukb-b-4078) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs150897364 0.0224470285019109 0.0111886224968074 0.044830967344746
Green tea (ukb-b-4078) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs181810048 0.0853110809108688 0.0300391129967848 0.0045113533830846
Green tea (ukb-b-4078) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs6708088 -0.0688074505870439 0.0347267649676395 0.0475469549602141
Green tea (ukb-b-4078) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs73163945 -0.0615767580491959 0.0304608430775278 0.0432274763634889
Green tea (ukb-b-4078) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs75230394 -0.0603463298459394 0.0303345187460872 0.0466612936634961
Green tea (ukb-b-4078) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs75897995 0.0537565134030502 0.0269555671234854 0.0461232262888989
Green tea (ukb-b-4078) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs76407111 0.0680794274524512 0.0274323894090915 0.0130751067516466
Green tea (ukb-b-4078) Dislocation, sprain and strain of joints and ligaments at ankle and foot level All - MR Egger 0.0083015021829826 0.0041924971126756 0.0499082979245717
Bacon (ukb-b-4414) Dislocation, sprain and strain of joints and ligaments at ankle and foot level All - Inverse variance weighted -0.716500027954314 0.291653787009051 0.0140227529638722
Seeds (ukb-b-4548) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs1441393 6.20860698523523 2.48565226277211 0.0124974509449828
Seeds (ukb-b-4548) Dislocation, sprain and strain of joints and ligaments at ankle and foot level All - Inverse variance weighted 1.25965658894737 0.639990277980965 0.0490400481634434
Other egg (ukb-b-8266) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs185735656 -7.0569080026749 3.04456360562725 0.0204562916466696
Other egg (ukb-b-8266) Dislocation, sprain and strain of joints and ligaments at ankle and foot level rs41286043 -25.5650996418928 12.3746828834561 0.0388360739027811