ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Crisp (ukb-b-12602) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee MR Egger 9 -1.857480977 0.645724808 0.023767332
Flavoured milk (ukb-b-12763) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee Inverse variance weighted 20 0.879590188 0.350527776 0.012096011
Cottage cheese (ukb-b-14171) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee Inverse variance weighted 24 1.049670914 0.479997348 0.028755193
Cheese (ukb-b-1489) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee Inverse variance weighted 198 -0.208609795 0.084716852 0.013799694
Broad bean (ukb-b-15212) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee Inverse variance weighted 21 0.474840465 0.237422213 0.045502065
Dried fruit (ukb-b-16576) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee Inverse variance weighted 155 -0.324308971 0.122265529 0.00798988
Other fruit (ukb-b-18659) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee MR Egger 20 1.026500723 0.453489372 0.036194683
Salad / raw vegetable (ukb-b-1996) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee Inverse variance weighted 109 0.364693471 0.183716147 0.047134226
Plain cereal (ukb-b-20023) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee MR Egger 13 -0.819915927 0.35706051 0.042306827
Beef (ukb-b-2862) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee MR Egger 98 1.215291185 0.519273575 0.02133493
Sweet biscuits (ukb-b-3646) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee Inverse variance weighted 11 -0.204602875 0.093470336 0.02859971
Croissant (ukb-b-4007) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee Simple mode 27 -1.333820717 0.498020228 0.012656667
Sliced bread (ukb-b-4566) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee Inverse variance weighted 15 0.145995605 0.06889117 0.034071807
Coffee (ukb-b-5237) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee Inverse variance weighted 117 0.269018985 0.132035196 0.04160203
Banana (ukb-b-5362) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee MR Egger 16 0.69097402 0.289315706 0.031567802
Watercress (ukb-b-6181) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee MR Egger 12 1.251755411 0.527075496 0.038949603
Processed meat (ukb-b-6324) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee Inverse variance weighted 125 -0.263624998 0.11793909 0.025400024
Filtered coffee (ukb-b-748) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee MR Egger 21 -0.614485257 0.255498343 0.026525112
Other cereal (ukb-b-8917) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee Inverse variance weighted 14 -1.103996543 0.516079273 0.032419511
Sweet potato (ukb-b-9686) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee Inverse variance weighted 24 0.745099691 0.351915288 0.034236937
Other milk-based pudding (ukb-b-9857) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee Weighted median 22 -1.210389586 0.486983567 0.012937561
Other milk-based pudding (ukb-b-9857) (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee Inverse variance weighted 22 -1.067040798 0.365140597 0.003474859

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Crisp (ukb-b-12602) Dislocation, sprain and strain of joints and ligaments of knee rs114906375 -2.17710893400218 0.857376920400857 0.011108500577018
Crisp (ukb-b-12602) Dislocation, sprain and strain of joints and ligaments of knee All - MR Egger -1.8574809770667 0.645724807976638 0.0237673322562041
Flavoured milk (ukb-b-12763) Dislocation, sprain and strain of joints and ligaments of knee rs148140816 5.21818044316721 2.61506067975656 0.0459955886808101
Flavoured milk (ukb-b-12763) Dislocation, sprain and strain of joints and ligaments of knee All - Inverse variance weighted 0.879590188453205 0.350527775934451 0.0120960105888167
Cottage cheese (ukb-b-14171) Dislocation, sprain and strain of joints and ligaments of knee rs114902125 7.47560975609756 2.80487804878049 0.0076938568790868
Cottage cheese (ukb-b-14171) Dislocation, sprain and strain of joints and ligaments of knee rs73271717 7.46770125704227 2.38118687828894 0.0017119583702781
Cottage cheese (ukb-b-14171) Dislocation, sprain and strain of joints and ligaments of knee All - Inverse variance weighted 1.04967091382683 0.47999734776739 0.0287551930957819
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments of knee rs10938397 -2.35301524344658 1.07026780303925 0.0279114009897496
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments of knee rs13107325 -5.22906744296888 1.95104221314708 0.0073591243164103
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments of knee rs1434511 -2.4605464109961 1.04901038211746 0.0189970815157517
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments of knee rs2029401 3.28268939914753 1.18589302901141 0.0056381393988418
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments of knee rs34453616 -2.54796506083839 1.2892398062326 0.0481172599267945
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments of knee rs35270670 -2.28946115242317 0.995152447586603 0.0214134874543579
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments of knee rs3733421 -2.56403161690785 1.26356953782869 0.0424382208502791
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments of knee rs614132 2.59681757356546 1.11954635186878 0.02036649907133
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments of knee rs6539284 2.53842899450007 1.13648618381212 0.0255109422267575
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments of knee rs66905828 -3.14747410806914 1.32756589474425 0.0177467072998718
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments of knee rs6857 3.12969454181272 1.13327886566692 0.0057513983636123
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments of knee rs7185391 2.48913354088646 1.12048609544436 0.0263187039803534
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments of knee rs7299943 -2.61629104692843 1.24290991993188 0.0352937127529999
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments of knee rs75499503 -3.21716196819606 1.15252176003507 0.0052478780800139
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments of knee rs78370515 3.4001870814231 1.07056099530162 0.0014927991468026
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments of knee rs829120 -2.59438683588902 1.20911238339272 0.0318972912866516
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments of knee All - Inverse variance weighted -0.208609795389258 0.0847168524922533 0.0137996944196988
Broad bean (ukb-b-15212) Dislocation, sprain and strain of joints and ligaments of knee rs138763370 2.60950391507699 0.94099795049661 0.005552097566101
Broad bean (ukb-b-15212) Dislocation, sprain and strain of joints and ligaments of knee rs72662025 4.22840351619892 1.69833403889733 0.0127837988761003
Broad bean (ukb-b-15212) Dislocation, sprain and strain of joints and ligaments of knee rs976088 -3.83209442165296 1.80609530126823 0.0338581923864045
Broad bean (ukb-b-15212) Dislocation, sprain and strain of joints and ligaments of knee All - Inverse variance weighted 0.474840465130376 0.237422212513642 0.0455020649260511
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments of knee rs10740991 -2.16261425413705 0.91403309636179 0.0179808095349131
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments of knee rs11134477 -3.66191669770878 1.72993995719346 0.0342778169792106
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments of knee rs11772627 -1.87086146898079 0.82906980549586 0.0240343970856188
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments of knee rs1419750 3.82955280878444 1.50828755876706 0.011116756967975
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments of knee rs3764002 -2.26346073238578 1.08981442670426 0.0378086594703814
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments of knee rs429358 -1.79999498608639 0.882448795407255 0.0413729673838021
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments of knee rs4740634 -3.56635693397052 1.48057848470897 0.0160068586850699
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments of knee rs62007687 -3.84183829702608 1.66103008724363 0.0207267536881628
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments of knee rs6765212 -3.33952100167431 1.36492683992138 0.014418411743333
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments of knee rs742877 4.31212942637742 1.86702705236269 0.0209090112358326
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments of knee rs7835197 -4.54915077404606 1.71072617641192 0.0078328119414685
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments of knee All - Inverse variance weighted -0.324308970604178 0.122265529384175 0.0079898797836027
Other fruit (ukb-b-18659) Dislocation, sprain and strain of joints and ligaments of knee rs150927868 -4.34579495226573 1.88062240216571 0.0208423558574396
Other fruit (ukb-b-18659) Dislocation, sprain and strain of joints and ligaments of knee rs2980435 -2.3184275406573 1.06308384791115 0.0291944342408815
Other fruit (ukb-b-18659) Dislocation, sprain and strain of joints and ligaments of knee All - MR Egger 1.02650072274258 0.453489371616906 0.0361946826405128
Salad / raw vegetable (ukb-b-1996) Dislocation, sprain and strain of joints and ligaments of knee rs1004549 2.89907295181315 1.47410489075245 0.0492216521753002
Salad / raw vegetable (ukb-b-1996) Dislocation, sprain and strain of joints and ligaments of knee rs1019957 4.07090493102263 2.01320708337458 0.043166079096483
Salad / raw vegetable (ukb-b-1996) Dislocation, sprain and strain of joints and ligaments of knee rs62109696 4.86615593502542 2.30919416061288 0.0350919179773239
Salad / raw vegetable (ukb-b-1996) Dislocation, sprain and strain of joints and ligaments of knee rs62461186 5.06884818138543 1.93057000299723 0.0086503822814778
Salad / raw vegetable (ukb-b-1996) Dislocation, sprain and strain of joints and ligaments of knee rs6482190 -3.05183686867343 1.47268872151101 0.0382384830475093
Salad / raw vegetable (ukb-b-1996) Dislocation, sprain and strain of joints and ligaments of knee rs6502052 3.8729621332605 1.91882318456371 0.043549108660613
Salad / raw vegetable (ukb-b-1996) Dislocation, sprain and strain of joints and ligaments of knee rs76566997 3.71770391782463 1.87061684472821 0.0468757199550604
Salad / raw vegetable (ukb-b-1996) Dislocation, sprain and strain of joints and ligaments of knee All - Inverse variance weighted 0.364693471457896 0.18371614677241 0.0471342256634902
Plain cereal (ukb-b-20023) Dislocation, sprain and strain of joints and ligaments of knee rs4920261 2.18723195686803 0.937385124372013 0.0196306572572906
Plain cereal (ukb-b-20023) Dislocation, sprain and strain of joints and ligaments of knee All - MR Egger -0.819915926511484 0.357060510227695 0.0423068273493043
Beef (ukb-b-2862) Dislocation, sprain and strain of joints and ligaments of knee rs11121250 -3.89343062210297 1.74607891409075 0.0257598158528189
Beef (ukb-b-2862) Dislocation, sprain and strain of joints and ligaments of knee rs17413652 4.20088621435207 1.93191440386054 0.0296699997021953
Beef (ukb-b-2862) Dislocation, sprain and strain of joints and ligaments of knee rs34962644 3.59482088033987 1.68003792743157 0.032376914361447
Beef (ukb-b-2862) Dislocation, sprain and strain of joints and ligaments of knee rs429358 2.41728052574168 1.18507346108784 0.0413729673838021
Beef (ukb-b-2862) Dislocation, sprain and strain of joints and ligaments of knee rs62169335 3.14878364036555 1.41437166796748 0.025995608166468
Beef (ukb-b-2862) Dislocation, sprain and strain of joints and ligaments of knee rs74818437 -3.15196006161574 1.58106383735886 0.0461991615545033
Beef (ukb-b-2862) Dislocation, sprain and strain of joints and ligaments of knee rs803370 5.41020102731633 1.64793479567681 0.0010270179153738
Beef (ukb-b-2862) Dislocation, sprain and strain of joints and ligaments of knee All - MR Egger 1.21529118475876 0.519273575203043 0.0213349299331373
Sweet biscuits (ukb-b-3646) Dislocation, sprain and strain of joints and ligaments of knee rs117635565 -0.612168520102652 0.292718135158255 0.0364990118262732
Sweet biscuits (ukb-b-3646) Dislocation, sprain and strain of joints and ligaments of knee All - Inverse variance weighted -0.204602875250405 0.0934703363808133 0.0285997103386671
Croissant (ukb-b-4007) Dislocation, sprain and strain of joints and ligaments of knee rs3776992 3.73909985622271 1.65811273386067 0.0241312225404774
Sliced bread (ukb-b-4566) Dislocation, sprain and strain of joints and ligaments of knee rs117466345 0.481355425066387 0.209821595541759 0.0217837419717068
Sliced bread (ukb-b-4566) Dislocation, sprain and strain of joints and ligaments of knee All - Inverse variance weighted 0.145995604537227 0.0688911703098572 0.0340718069869474
Coffee (ukb-b-5237) Dislocation, sprain and strain of joints and ligaments of knee rs10938398 3.72304284291552 1.80833509513039 0.039511146777562
Coffee (ukb-b-5237) Dislocation, sprain and strain of joints and ligaments of knee rs11678584 -3.77758473664496 1.60985678650271 0.018948904060518
Coffee (ukb-b-5237) Dislocation, sprain and strain of joints and ligaments of knee rs2126069 3.68971949077344 1.55058763876062 0.017333224823245
Coffee (ukb-b-5237) Dislocation, sprain and strain of joints and ligaments of knee rs4615895 2.74533906986273 1.32759680393362 0.0386493113132997
Coffee (ukb-b-5237) Dislocation, sprain and strain of joints and ligaments of knee rs4937720 4.27844414753877 1.93906094405997 0.0273523946261215
Coffee (ukb-b-5237) Dislocation, sprain and strain of joints and ligaments of knee rs4938000 -3.81841981855346 1.68249123255012 0.0232377218253262
Coffee (ukb-b-5237) Dislocation, sprain and strain of joints and ligaments of knee rs55895231 5.9362694256828 2.20923663285354 0.0072092009863737
Coffee (ukb-b-5237) Dislocation, sprain and strain of joints and ligaments of knee rs75347775 3.61708642731379 1.49276582714537 0.0153896675618411
Coffee (ukb-b-5237) Dislocation, sprain and strain of joints and ligaments of knee All - Inverse variance weighted 0.269018984521738 0.132035196365712 0.0416020304118757
Banana (ukb-b-5362) Dislocation, sprain and strain of joints and ligaments of knee All - MR Egger 0.690974019568881 0.289315706373931 0.0315678016910684
Watercress (ukb-b-6181) Dislocation, sprain and strain of joints and ligaments of knee rs116023894 2.13340614217532 0.808392289757777 0.0083133114754033
Watercress (ukb-b-6181) Dislocation, sprain and strain of joints and ligaments of knee All - MR Egger 1.251755411248 0.527075495715082 0.0389496027064675
Processed meat (ukb-b-6324) Dislocation, sprain and strain of joints and ligaments of knee rs12245149 -2.77442119000435 1.31470829909614 0.0348330299597458
Processed meat (ukb-b-6324) Dislocation, sprain and strain of joints and ligaments of knee rs1820555 2.59955185190609 1.23021045385979 0.0345926171832206
Processed meat (ukb-b-6324) Dislocation, sprain and strain of joints and ligaments of knee rs2029401 2.6108589862759 0.94318989556564 0.0056381393988418
Processed meat (ukb-b-6324) Dislocation, sprain and strain of joints and ligaments of knee rs34241936 -2.37843632277299 1.07501667341724 0.0269345803243023
Processed meat (ukb-b-6324) Dislocation, sprain and strain of joints and ligaments of knee rs3733421 -2.43688639551192 1.20091164095372 0.0424382208502792
Processed meat (ukb-b-6324) Dislocation, sprain and strain of joints and ligaments of knee rs4077924 -3.56037027850897 1.20012481298055 0.0030104714641323
Processed meat (ukb-b-6324) Dislocation, sprain and strain of joints and ligaments of knee rs4813338 -2.74762224997598 1.31616870016332 0.0368347227996679
Processed meat (ukb-b-6324) Dislocation, sprain and strain of joints and ligaments of knee rs76587391 -2.73166150304377 1.31715334528316 0.0380873874443604
Processed meat (ukb-b-6324) Dislocation, sprain and strain of joints and ligaments of knee All - Inverse variance weighted -0.263624997890445 0.117939089801988 0.0254000240963195
Filtered coffee (ukb-b-748) Dislocation, sprain and strain of joints and ligaments of knee rs76653299 -1.37122243705898 0.461045250340423 0.0029379164157966
Filtered coffee (ukb-b-748) Dislocation, sprain and strain of joints and ligaments of knee All - MR Egger -0.614485256948046 0.255498343346981 0.0265251116560173
Other cereal (ukb-b-8917) Dislocation, sprain and strain of joints and ligaments of knee All - Inverse variance weighted -1.10399654304063 0.516079272667328 0.0324195113816848
Sweet potato (ukb-b-9686) Dislocation, sprain and strain of joints and ligaments of knee rs145152193 4.23825387819627 1.32627280971016 0.0013953440642276
Sweet potato (ukb-b-9686) Dislocation, sprain and strain of joints and ligaments of knee All - Inverse variance weighted 0.745099691238971 0.351915288200097 0.0342369373027266
Other milk-based pudding (ukb-b-9857) Dislocation, sprain and strain of joints and ligaments of knee All - Inverse variance weighted -1.06704079789235 0.365140597440255 0.003474859330344