ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Pear (ukb-b-10793) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Weighted median 16 0.838412032 0.384870408 0.029374273
Pear (ukb-b-10793) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Inverse variance weighted 16 0.647716137 0.295804958 0.028547959
Bread (ukb-b-11348) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Inverse variance weighted 113 -0.391233356 0.19812865 0.048308674
Fried potatoes (ukb-b-12836) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Weighted median 16 0.556218705 0.246975371 0.024314554
Fried potatoes (ukb-b-12836) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Inverse variance weighted 16 0.463679098 0.188047397 0.013672423
Cheese (ukb-b-1489) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Inverse variance weighted 198 -0.317842068 0.129496097 0.014109915
Cereal (ukb-b-15926) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level MR Egger 175 -1.156946645 0.57170303 0.044541376
Dried fruit (ukb-b-16576) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Inverse variance weighted 155 -0.544435777 0.197647697 0.005876808
Low fat hard cheese (ukb-b-18079) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level MR Egger 16 2.634251203 0.945685678 0.014589379
Cereal bar (ukb-b-18788) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Weighted median 12 -1.1737946 0.465870575 0.01174975
Cereal bar (ukb-b-18788) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Simple mode 12 -1.488810421 0.670637832 0.048366087
Cereal bar (ukb-b-18788) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Weighted mode 12 -1.470564532 0.617948952 0.036517182
Single crust pastry (ukb-b-2024) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Inverse variance weighted 15 0.994293845 0.425869118 0.019556985
Oily fish (ukb-b-2209) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level MR Egger 168 -1.408685362 0.621554797 0.02471879
Milk (ukb-b-2966) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level MR Egger 20 -1.939538367 0.866560909 0.038086335
Milk (ukb-b-2966) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Weighted median 20 -1.206234652 0.542766151 0.026257385
Latte (ukb-b-3000) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Weighted median 9 1.682770358 0.703293384 0.016724892
White wine (ukb-b-311) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Inverse variance weighted 13 0.509215747 0.231785587 0.028025743
Vegetarian sausages/burgers (ukb-b-3383) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level MR Egger 34 1.861301199 0.867958687 0.039691952
Cake (ukb-b-3433) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Inverse variance weighted 10 -0.79753042 0.40400965 0.048377417
Baked bean (ukb-b-4058) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Weighted median 13 -0.995925248 0.502562501 0.047513465
Baked bean (ukb-b-4058) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Inverse variance weighted 13 -0.984667238 0.39032971 0.011647257
Bread roll (ukb-b-6246) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Inverse variance weighted 18 -0.461370255 0.216149344 0.03280207
Courgette (ukb-b-7420) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Weighted median 19 -1.399975646 0.480454533 0.003569938
Courgette (ukb-b-7420) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Inverse variance weighted 19 -1.052240945 0.339889418 0.001962607
Couscous (ukb-b-758) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Weighted median 17 2.317008109 1.110729261 0.036976432
Couscous (ukb-b-758) (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level Inverse variance weighted 17 1.772902928 0.832277701 0.033156595

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Pear (ukb-b-10793) Dislocation, sprain and strain of joints and ligaments at wrist and hand level All - Inverse variance weighted 0.647716136775958 0.295804958440683 0.0285479591017018
Bread (ukb-b-11348) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs10761661 -5.18928708250618 1.95033608470031 0.0077975092625963
Bread (ukb-b-11348) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs13016665 3.36170904950388 1.49108062679607 0.0241618744897474
Bread (ukb-b-11348) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs146642700 -7.62690201107158 3.68773284051813 0.0386229292977173
Bread (ukb-b-11348) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs17332107 -3.87517664939428 1.97314040404938 0.0495342710908615
Bread (ukb-b-11348) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs319694 -4.8155967836126 2.29100220115898 0.0355567111743239
Bread (ukb-b-11348) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs55745436 -5.43036984617677 2.2198219672986 0.0144327356244258
Bread (ukb-b-11348) Dislocation, sprain and strain of joints and ligaments at wrist and hand level All - Inverse variance weighted -0.391233356477982 0.198128650455277 0.0483086735063693
Fried potatoes (ukb-b-12836) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs117525941 1.74467814010211 0.888265970130237 0.0495139346183294
Fried potatoes (ukb-b-12836) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs4669886 1.93414897445124 0.764663548038863 0.0114253897844285
Fried potatoes (ukb-b-12836) Dislocation, sprain and strain of joints and ligaments at wrist and hand level All - Inverse variance weighted 0.463679097573799 0.18804739699692 0.0136724231968154
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs2968940 -5.1564027370479 2.0039100684262 0.0100771482958953
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs59784053 -5.25702824237327 2.07046035391932 0.0111149964990578
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs62034322 -4.16203221987012 1.57870187650246 0.0083799874410136
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs62098037 -4.28910385106771 2.0259171381639 0.0342499093081692
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs7259537 -4.48660898606307 2.12861612426714 0.0350518737947459
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs78548855 -3.64596886795884 1.71245813291697 0.0332472312617939
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs9996848 -4.35916141454489 1.69223961634596 0.0099958818138157
Cheese (ukb-b-1489) Dislocation, sprain and strain of joints and ligaments at wrist and hand level All - Inverse variance weighted -0.317842068448218 0.129496096756184 0.0141099152678299
Cereal (ukb-b-15926) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs11109785 -5.61465303261952 2.57506568942082 0.0292284050255199
Cereal (ukb-b-15926) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs11876432 5.12057350423247 2.61029235274351 0.0497990733018326
Cereal (ukb-b-15926) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs11940694 4.53228264388418 1.81607144267136 0.0125725815508006
Cereal (ukb-b-15926) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs1397440 -5.94085146474755 2.48162149793252 0.0166685028013914
Cereal (ukb-b-15926) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs143747365 -3.85707386480534 1.31889836253029 0.0034504739638783
Cereal (ukb-b-15926) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs17811999 5.47188547312673 2.5652695601804 0.0329194341242092
Cereal (ukb-b-15926) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs2569098 5.09604303839984 2.43799331723447 0.036594335208517
Cereal (ukb-b-15926) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs4797242 5.04758905451746 2.02953320736231 0.0128800427653748
Cereal (ukb-b-15926) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs4941367 5.51056157449213 2.54410963201918 0.0303105828684824
Cereal (ukb-b-15926) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs529565 -4.84859301564638 2.18137109088385 0.026234195721413
Cereal (ukb-b-15926) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs9319377 -6.8470615435233 2.42759454724917 0.0047946957544164
Cereal (ukb-b-15926) Dislocation, sprain and strain of joints and ligaments at wrist and hand level All - MR Egger -1.15694664459688 0.571703030056329 0.0445413763794278
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs1000214 -5.20493919107628 2.59823793765922 0.0451496750595879
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs10040819 4.99436262419844 2.46635191318441 0.042867364228306
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs12708665 -7.61056459114356 2.8891958170082 0.0084349124430455
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs1735720 -6.65455053823571 2.38594529102008 0.0052860862733435
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs2521754 -6.49496921459679 2.88143865445262 0.024191660127278
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs3757323 -5.06935233684779 2.56277679113369 0.0479207905828903
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs4808846 -5.85644405994215 2.5397252457967 0.0211142046198774
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs597941 -4.96562012789182 2.41775827187746 0.0399939240548094
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs7203102 -5.37623513339858 2.64639512109642 0.0422011042803875
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs862227 -6.677869192327 2.41145276389586 0.005618882148839
Dried fruit (ukb-b-16576) Dislocation, sprain and strain of joints and ligaments at wrist and hand level All - Inverse variance weighted -0.544435777227066 0.197647696914251 0.0058768080432714
Low fat hard cheese (ukb-b-18079) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs10473702 3.03908781511749 1.45203692759176 0.0363507206838644
Low fat hard cheese (ukb-b-18079) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs142165664 2.96099824734343 1.03625586167294 0.0042712622637759
Low fat hard cheese (ukb-b-18079) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs9895448 -4.81184982233829 1.95213836208742 0.013704679800123
Low fat hard cheese (ukb-b-18079) Dislocation, sprain and strain of joints and ligaments at wrist and hand level All - MR Egger 2.63425120252789 0.945685678309677 0.0145893794802204
Cereal bar (ukb-b-18788) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs11077661 3.51377784051381 1.1847027152378 0.0030174223615523
Single crust pastry (ukb-b-2024) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs142897541 3.03301154525129 1.01760632252921 0.0028774509125813
Single crust pastry (ukb-b-2024) Dislocation, sprain and strain of joints and ligaments at wrist and hand level All - Inverse variance weighted 0.994293845309214 0.42586911814212 0.0195569851560287
Oily fish (ukb-b-2209) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs10828250 -2.82435397246131 1.181364227497 0.016813708983157
Oily fish (ukb-b-2209) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs117551050 -8.88028690157682 3.91155494474217 0.0231911897169438
Oily fish (ukb-b-2209) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs1263459 5.2514937031618 2.45510082978004 0.0324345788609328
Oily fish (ukb-b-2209) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs17050031 3.87577598512764 1.83414666533878 0.034590312419129
Oily fish (ukb-b-2209) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs703987 4.47769245985362 2.11296732543293 0.0340778821700977
Oily fish (ukb-b-2209) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs733069 6.08612853510813 2.50316576847189 0.0150417392795186
Oily fish (ukb-b-2209) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs7683782 4.93869797962355 2.16888274909342 0.0227820420323133
Oily fish (ukb-b-2209) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs9958909 3.88282989779021 1.84624754943946 0.0354576596724376
Oily fish (ukb-b-2209) Dislocation, sprain and strain of joints and ligaments at wrist and hand level All - MR Egger -1.40868536234745 0.621554796822576 0.0247187903394762
Milk (ukb-b-2966) Dislocation, sprain and strain of joints and ligaments at wrist and hand level All - MR Egger -1.93953836724728 0.866560908686429 0.0380863353670624
Latte (ukb-b-3000) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs72773940 -5.58891824805829 2.51688152240638 0.0263799206024216
White wine (ukb-b-311) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs116453290 1.41383696717792 0.673834428483076 0.0358878001461724
White wine (ukb-b-311) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs339866 1.50517762048566 0.701781126850908 0.0319691307708373
White wine (ukb-b-311) Dislocation, sprain and strain of joints and ligaments at wrist and hand level All - Inverse variance weighted 0.509215746661884 0.231785587490809 0.0280257429981427
Vegetarian sausages/burgers (ukb-b-3383) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs16871519 -6.02074498992422 3.06600566222013 0.0495637696932464
Vegetarian sausages/burgers (ukb-b-3383) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs72737216 5.14873455679501 1.79920834832674 0.0042141986579207
Vegetarian sausages/burgers (ukb-b-3383) Dislocation, sprain and strain of joints and ligaments at wrist and hand level All - MR Egger 1.86130119945873 0.867958686674395 0.0396919524336061
Cake (ukb-b-3433) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs71489608 -2.09846034643673 0.971455069469309 0.0307633156573441
Cake (ukb-b-3433) Dislocation, sprain and strain of joints and ligaments at wrist and hand level All - Inverse variance weighted -0.797530419796122 0.404009649573334 0.0483774168413027
Baked bean (ukb-b-4058) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs114412661 -2.86774278073309 0.908777081349066 0.0016016483245253
Baked bean (ukb-b-4058) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs148676637 -2.18486491467891 1.0789930422228 0.0428765005938361
Baked bean (ukb-b-4058) Dislocation, sprain and strain of joints and ligaments at wrist and hand level All - Inverse variance weighted -0.984667237777317 0.390329710176471 0.011647257132115
Bread roll (ukb-b-6246) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs9849625 -2.66939973445762 1.02490042160676 0.0091996217280855
Bread roll (ukb-b-6246) Dislocation, sprain and strain of joints and ligaments at wrist and hand level All - Inverse variance weighted -0.46137025509377 0.216149344162011 0.0328020703799703
Courgette (ukb-b-7420) Dislocation, sprain and strain of joints and ligaments at wrist and hand level rs77959176 -3.34740882917466 1.53166986564299 0.0288548677059896
Courgette (ukb-b-7420) Dislocation, sprain and strain of joints and ligaments at wrist and hand level All - Inverse variance weighted -1.05224094530399 0.339889417658671 0.0019626072645267
Couscous (ukb-b-758) Dislocation, sprain and strain of joints and ligaments at wrist and hand level All - Inverse variance weighted 1.77290292817356 0.832277700608304 0.0331565953556757