ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Chocolate-covered raisin (ukb-b-1160) (👉 📊) Fracture of lower leg, including ankle Inverse variance weighted 51 -0.580823161 0.257712926 0.024211251
Pineapple (ukb-b-1164) (👉 📊) Fracture of lower leg, including ankle Inverse variance weighted 16 0.740023628 0.352172769 0.035613895
Avocado (ukb-b-12236) (👉 📊) Fracture of lower leg, including ankle Weighted median 24 -1.101352413 0.426862036 0.009876791
Avocado (ukb-b-12236) (👉 📊) Fracture of lower leg, including ankle Inverse variance weighted 24 -0.812490468 0.29161181 0.005332903
Double crust pastry (ukb-b-1255) (👉 📊) Fracture of lower leg, including ankle Inverse variance weighted 10 0.809470337 0.370009377 0.0286913
Cheese (ukb-b-1489) (👉 📊) Fracture of lower leg, including ankle MR Egger 198 0.850547085 0.310609572 0.006744405
Savoury biscuits (ukb-b-1503) (👉 📊) Fracture of lower leg, including ankle Weighted median 32 -1.757894103 0.728638332 0.015840309
Savoury biscuits (ukb-b-1503) (👉 📊) Fracture of lower leg, including ankle Weighted mode 32 -2.035298942 0.969366371 0.04399865
Broad bean (ukb-b-15212) (👉 📊) Fracture of lower leg, including ankle Inverse variance weighted 21 0.600723325 0.252876059 0.017522141
Carrot (ukb-b-16710) (👉 📊) Fracture of lower leg, including ankle Inverse variance weighted 5 -0.405638901 0.198646068 0.041149719
Low calorie hot chocolate (ukb-b-1795) (👉 📊) Fracture of lower leg, including ankle MR Egger 24 1.690051289 0.803217002 0.047023238
Cabbage/kale (ukb-b-2975) (👉 📊) Fracture of lower leg, including ankle Inverse variance weighted 20 0.29845815 0.15092277 0.047978876
Standard tea (ukb-b-3291) (👉 📊) Fracture of lower leg, including ankle MR Egger 14 0.005127946 0.002111838 0.03183758
Seeds (ukb-b-4548) (👉 📊) Fracture of lower leg, including ankle Inverse variance weighted 15 1.317657955 0.595796697 0.026995014
Doughnut (ukb-b-6214) (👉 📊) Fracture of lower leg, including ankle MR Egger 31 1.524064146 0.688060999 0.0347711
Doughnut (ukb-b-6214) (👉 📊) Fracture of lower leg, including ankle Inverse variance weighted 31 1.123849777 0.39516883 0.004455472
Blue cheese (ukb-b-7429) (👉 📊) Fracture of lower leg, including ankle Weighted median 20 -1.521296926 0.653305503 0.019879476
Other meat (ukb-b-770) (👉 📊) Fracture of lower leg, including ankle Inverse variance weighted 25 1.008194394 0.474595277 0.033643015
Cappuccino (ukb-b-8374) (👉 📊) Fracture of lower leg, including ankle Weighted median 21 -0.545400776 0.271232377 0.044343971
Cappuccino (ukb-b-8374) (👉 📊) Fracture of lower leg, including ankle Inverse variance weighted 21 -0.443674178 0.199918556 0.026468047
Other grain (ukb-b-8765) (👉 📊) Fracture of lower leg, including ankle MR Egger 70 1.959158722 0.757117943 0.011804373
Chocolate sweet (ukb-b-9835) (👉 📊) Fracture of lower leg, including ankle Weighted median 20 0.554439625 0.231047656 0.016409568
Chocolate sweet (ukb-b-9835) (👉 📊) Fracture of lower leg, including ankle Weighted mode 20 0.659139824 0.281947136 0.030488632

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Chocolate-covered raisin (ukb-b-1160) Fracture of lower leg, including ankle rs114187371 -3.88010119678229 1.72448942079213 0.0244489453100894
Chocolate-covered raisin (ukb-b-1160) Fracture of lower leg, including ankle rs73598208 -4.49095073427045 1.54039610185476 0.003551738562528
Chocolate-covered raisin (ukb-b-1160) Fracture of lower leg, including ankle rs78209434 -6.08948601568778 2.21847445924685 0.0060529715329983
Chocolate-covered raisin (ukb-b-1160) Fracture of lower leg, including ankle All - Inverse variance weighted -0.580823161488194 0.257712925831399 0.0242112514778732
Pineapple (ukb-b-1164) Fracture of lower leg, including ankle rs75055053 2.99041827517157 1.49520913758578 0.0455002638963584
Pineapple (ukb-b-1164) Fracture of lower leg, including ankle All - Inverse variance weighted 0.740023628296966 0.352172768835627 0.03561389516628
Avocado (ukb-b-12236) Fracture of lower leg, including ankle rs77419563 -2.48954222907176 0.877267261672905 0.0045420251844249
Avocado (ukb-b-12236) Fracture of lower leg, including ankle All - Inverse variance weighted -0.812490468456134 0.29161181034893 0.0053329029828633
Double crust pastry (ukb-b-1255) Fracture of lower leg, including ankle rs11784977 2.4904599317132 1.17292629041976 0.033729753177745
Double crust pastry (ukb-b-1255) Fracture of lower leg, including ankle All - Inverse variance weighted 0.809470337348204 0.370009376867821 0.0286912998351384
Cheese (ukb-b-1489) Fracture of lower leg, including ankle rs12666766 -3.14276221861054 1.38281537618864 0.0230426200877618
Cheese (ukb-b-1489) Fracture of lower leg, including ankle rs12672200 -3.00071203336385 1.1116439251929 0.0069475817687285
Cheese (ukb-b-1489) Fracture of lower leg, including ankle rs12951057 1.67803476131728 0.822473375969597 0.0413274345082965
Cheese (ukb-b-1489) Fracture of lower leg, including ankle rs1434511 -2.86163861592336 1.12614349844962 0.0110505607711972
Cheese (ukb-b-1489) Fracture of lower leg, including ankle rs150702313 3.13831752678901 1.08880403990639 0.0039471733562834
Cheese (ukb-b-1489) Fracture of lower leg, including ankle rs2824098 -2.64535982292285 1.32267991146143 0.0455002638963584
Cheese (ukb-b-1489) Fracture of lower leg, including ankle rs34205186 -4.4098622272165 1.41644397019802 0.0018498695832764
Cheese (ukb-b-1489) Fracture of lower leg, including ankle rs4503172 -2.35346769962036 1.14972684342109 0.0406600614744854
Cheese (ukb-b-1489) Fracture of lower leg, including ankle rs6544743 2.66527740025973 1.27601099332548 0.0367295672553537
Cheese (ukb-b-1489) Fracture of lower leg, including ankle rs66510028 -2.96316671251031 1.25028131329549 0.0177880852606736
Cheese (ukb-b-1489) Fracture of lower leg, including ankle rs7185391 2.85761554542857 1.20320654544361 0.0175489501914767
Cheese (ukb-b-1489) Fracture of lower leg, including ankle rs72752436 2.44887547298159 1.13940733812338 0.0316142920709394
Cheese (ukb-b-1489) Fracture of lower leg, including ankle rs9996848 2.45763421313848 1.12417331403901 0.0288031546657366
Cheese (ukb-b-1489) Fracture of lower leg, including ankle All - MR Egger 0.850547085046549 0.310609572343812 0.0067444045600281
Broad bean (ukb-b-15212) Fracture of lower leg, including ankle rs547613760 3.13241034249533 1.25980915439589 0.0129036825723931
Broad bean (ukb-b-15212) Fracture of lower leg, including ankle All - Inverse variance weighted 0.600723325303778 0.252876058602453 0.0175221414183572
Carrot (ukb-b-16710) Fracture of lower leg, including ankle All - Inverse variance weighted -0.405638900686451 0.198646068376792 0.0411497191828464
Low calorie hot chocolate (ukb-b-1795) Fracture of lower leg, including ankle rs150202527 1.29231817153308 0.65082449432803 0.0470707468371006
Low calorie hot chocolate (ukb-b-1795) Fracture of lower leg, including ankle rs4969076 -4.67793599949256 2.29932447432685 0.0419029452259953
Low calorie hot chocolate (ukb-b-1795) Fracture of lower leg, including ankle All - MR Egger 1.69005128909789 0.803217001866898 0.0470232383025538
Cabbage/kale (ukb-b-2975) Fracture of lower leg, including ankle All - Inverse variance weighted 0.298458150322614 0.150922769603085 0.0479788756829293
Standard tea (ukb-b-3291) Fracture of lower leg, including ankle All - MR Egger 0.0051279462560341 0.0021118382028151 0.0318375798484006
Seeds (ukb-b-4548) Fracture of lower leg, including ankle rs143824001 4.94851024969002 1.98237394848798 0.0125512450881023
Seeds (ukb-b-4548) Fracture of lower leg, including ankle rs1441393 5.20329873673628 1.8890957197068 0.0058802377607469
Seeds (ukb-b-4548) Fracture of lower leg, including ankle rs183161766 5.80045467385894 1.93707206177108 0.0027494512125227
Seeds (ukb-b-4548) Fracture of lower leg, including ankle All - Inverse variance weighted 1.31765795470947 0.595796696922743 0.0269950142284954
Doughnut (ukb-b-6214) Fracture of lower leg, including ankle rs148780953 4.79188666839347 1.98001554125406 0.0155151391848583
Doughnut (ukb-b-6214) Fracture of lower leg, including ankle rs2148761 7.52207676271728 3.30707623013599 0.0229335463134186
Doughnut (ukb-b-6214) Fracture of lower leg, including ankle All - Inverse variance weighted 1.12384977712409 0.395168829597171 0.0044554718795597
Doughnut (ukb-b-6214) Fracture of lower leg, including ankle All - MR Egger 1.52406414600933 0.68806099932088 0.0347711001139408
Blue cheese (ukb-b-7429) Fracture of lower leg, including ankle rs138371361 2.84533006749602 1.09270496658962 0.0092160882870421
Blue cheese (ukb-b-7429) Fracture of lower leg, including ankle rs78387684 -5.24930654458537 2.42221046238648 0.0302230049200368
Other meat (ukb-b-770) Fracture of lower leg, including ankle rs76220040 3.03981454576805 1.33151540502655 0.0224319222461216
Other meat (ukb-b-770) Fracture of lower leg, including ankle All - Inverse variance weighted 1.00819439395836 0.474595276992289 0.0336430149911035
Cappuccino (ukb-b-8374) Fracture of lower leg, including ankle All - Inverse variance weighted -0.443674177771811 0.199918555723206 0.0264680468435588
Other grain (ukb-b-8765) Fracture of lower leg, including ankle rs116701056 -5.27729184828079 2.61524329953604 0.0436019800117875
Other grain (ukb-b-8765) Fracture of lower leg, including ankle rs148766918 16.7668627952588 7.69591540888548 0.0293561651534254
Other grain (ukb-b-8765) Fracture of lower leg, including ankle rs7173652 -9.34012949442072 4.46342471414795 0.0363855383762003
Other grain (ukb-b-8765) Fracture of lower leg, including ankle rs75664696 5.94583043966024 2.91148031411934 0.0411315145601689
Other grain (ukb-b-8765) Fracture of lower leg, including ankle rs78626557 6.52109207998485 3.16042968855697 0.0390788015226752
Other grain (ukb-b-8765) Fracture of lower leg, including ankle All - MR Egger 1.95915872227367 0.757117942824533 0.0118043734974741
Chocolate sweet (ukb-b-9835) Fracture of lower leg, including ankle rs138083296 0.773556958144838 0.386778479072419 0.0455002638963584
Chocolate sweet (ukb-b-9835) Fracture of lower leg, including ankle rs150503648 -3.11480789380109 1.56267970552826 0.0462343186725949