ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Satsuma (ukb-b-11563) (👉 📊) Fracture of shoulder and upper arm Weighted median 18 -0.640049088 0.297262069 0.031307086
Grape (ukb-b-12051) (👉 📊) Fracture of shoulder and upper arm Inverse variance weighted 8 -0.790772482 0.278124727 0.004465887
Other alcohol (ukb-b-12901) (👉 📊) Fracture of shoulder and upper arm Weighted median 43 -1.252435582 0.598458642 0.036369797
Orange (ukb-b-13520) (👉 📊) Fracture of shoulder and upper arm Inverse variance weighted 7 -1.096268801 0.535992422 0.040824647
Dried fruit (ukb-b-16576) (👉 📊) Fracture of shoulder and upper arm MR Egger 155 -1.337140797 0.666828536 0.046702477
Fruit smoothie (ukb-b-1780) (👉 📊) Fracture of shoulder and upper arm MR Egger 24 -1.182318517 0.543078597 0.040484791
Espresso (ukb-b-19142) (👉 📊) Fracture of shoulder and upper arm Inverse variance weighted 33 -0.596577822 0.251812009 0.017829519
Bran cereal (ukb-b-19498) (👉 📊) Fracture of shoulder and upper arm Inverse variance weighted 4 1.027316241 0.43255802 0.017549946
Cheesy biscuits (ukb-b-19847) (👉 📊) Fracture of shoulder and upper arm Weighted mode 24 -2.163894848 0.950945444 0.032510039
Salad / raw vegetable (ukb-b-1996) (👉 📊) Fracture of shoulder and upper arm MR Egger 109 -1.759564249 0.802542251 0.030510175
Butternut squash (ukb-b-20341) (👉 📊) Fracture of shoulder and upper arm MR Egger 16 3.048879135 0.984997592 0.007905593
Butternut squash (ukb-b-20341) (👉 📊) Fracture of shoulder and upper arm Weighted median 16 1.724175159 0.820060219 0.035509654
Crumbed or deep-fried poultry (ukb-b-39) (👉 📊) Fracture of shoulder and upper arm Weighted median 12 1.279022566 0.649810935 0.049033582
Crumbed or deep-fried poultry (ukb-b-39) (👉 📊) Fracture of shoulder and upper arm Inverse variance weighted 12 1.120126063 0.45850197 0.014565231
Beer/cider (ukb-b-4961) (👉 📊) Fracture of shoulder and upper arm MR Egger 14 1.134322624 0.462771383 0.03052884
Beer/cider (ukb-b-4961) (👉 📊) Fracture of shoulder and upper arm Inverse variance weighted 14 0.511488512 0.181317401 0.004788069
Coffee (ukb-b-5237) (👉 📊) Fracture of shoulder and upper arm Weighted median 117 0.572662116 0.271185719 0.034712432
Eggs in sandwiches (ukb-b-5382) (👉 📊) Fracture of shoulder and upper arm MR Egger 15 -3.555653587 1.463028671 0.030311693
Onion (ukb-b-8124) (👉 📊) Fracture of shoulder and upper arm Inverse variance weighted 13 -0.483428692 0.228398939 0.034293997
Other grain (ukb-b-8765) (👉 📊) Fracture of shoulder and upper arm Inverse variance weighted 70 1.212000509 0.560620744 0.030626638
Soya dessert (ukb-b-998) (👉 📊) Fracture of shoulder and upper arm Weighted median 28 2.391261337 1.164410229 0.040012052

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Satsuma (ukb-b-11563) Fracture of shoulder and upper arm rs76469063 7.33970375843885 2.75585261814396 0.0077374932956607
Grape (ukb-b-12051) Fracture of shoulder and upper arm rs139190506 -1.26552160968175 0.455279115678192 0.0054415668853465
Grape (ukb-b-12051) Fracture of shoulder and upper arm rs62355507 -2.12377743075532 1.03558806608038 0.0402870461398839
Grape (ukb-b-12051) Fracture of shoulder and upper arm All - Inverse variance weighted -0.790772481851648 0.278124726747771 0.0044658872796799
Other alcohol (ukb-b-12901) Fracture of shoulder and upper arm rs12280926 6.43849542527957 3.11032579755047 0.0384487008169289
Other alcohol (ukb-b-12901) Fracture of shoulder and upper arm rs180874328 -4.72243816952815 1.92376108468502 0.014096513848601
Other alcohol (ukb-b-12901) Fracture of shoulder and upper arm rs80024463 9.02104600733464 4.16952126455845 0.0304974602639106
Orange (ukb-b-13520) Fracture of shoulder and upper arm rs2760994 -4.03691209679668 1.27686860520226 0.0015691999136724
Orange (ukb-b-13520) Fracture of shoulder and upper arm rs72758819 -2.27052698300574 1.00596959385949 0.0240047450037588
Orange (ukb-b-13520) Fracture of shoulder and upper arm All - Inverse variance weighted -1.09626880050913 0.53599242208648 0.0408246474153477
Dried fruit (ukb-b-16576) Fracture of shoulder and upper arm rs13361944 6.51541933881641 2.47615152002104 0.0085066815726691
Dried fruit (ukb-b-16576) Fracture of shoulder and upper arm rs17592481 -6.53557410159674 2.59136465835906 0.0116670196441027
Dried fruit (ukb-b-16576) Fracture of shoulder and upper arm rs2165150 -4.78697941598851 2.19403223232807 0.029122954152385
Dried fruit (ukb-b-16576) Fracture of shoulder and upper arm rs2328887 -5.25643596753254 2.20073674544284 0.0169178051615266
Dried fruit (ukb-b-16576) Fracture of shoulder and upper arm rs34419562 -6.25318948601657 2.74565331454981 0.0227571653728707
Dried fruit (ukb-b-16576) Fracture of shoulder and upper arm rs3764002 -3.81053995351141 1.53183706131159 0.0128621963654395
Dried fruit (ukb-b-16576) Fracture of shoulder and upper arm rs429358 -3.44957256386472 1.24846448895686 0.0057263606067782
Dried fruit (ukb-b-16576) Fracture of shoulder and upper arm rs62007687 5.85315364076326 2.35030107582772 0.0127604921992326
Dried fruit (ukb-b-16576) Fracture of shoulder and upper arm rs75265668 -15.5495996035162 5.31470902783212 0.0034360832231959
Dried fruit (ukb-b-16576) Fracture of shoulder and upper arm All - MR Egger -1.33714079669125 0.666828535878906 0.0467024773886669
Fruit smoothie (ukb-b-1780) Fracture of shoulder and upper arm rs6429985 9.37026255336167 3.58999637280159 0.0090514799006815
Fruit smoothie (ukb-b-1780) Fracture of shoulder and upper arm All - MR Egger -1.18231851739285 0.543078596791995 0.0404847913320426
Espresso (ukb-b-19142) Fracture of shoulder and upper arm rs181774247 -4.74701018211597 1.84341662405005 0.0100206702971758
Espresso (ukb-b-19142) Fracture of shoulder and upper arm All - Inverse variance weighted -0.596577821740864 0.25181200890954 0.0178295185541702
Bran cereal (ukb-b-19498) Fracture of shoulder and upper arm All - Inverse variance weighted 1.02731624109756 0.432558019880865 0.0175499456025749
Cheesy biscuits (ukb-b-19847) Fracture of shoulder and upper arm rs78427380 11.6919665101656 3.25985500838649 0.0003349504498927
Cheesy biscuits (ukb-b-19847) Fracture of shoulder and upper arm rs9560935 7.07187653694941 3.28391675041927 0.0312803169734008
Salad / raw vegetable (ukb-b-1996) Fracture of shoulder and upper arm rs115312977 -7.09902995092871 3.13995555521847 0.0237673352613926
Salad / raw vegetable (ukb-b-1996) Fracture of shoulder and upper arm rs140806757 -4.20277296360485 1.93890814558059 0.0301893039316661
Salad / raw vegetable (ukb-b-1996) Fracture of shoulder and upper arm rs17460017 4.43871706758305 2.22830756013746 0.0463745831386537
Salad / raw vegetable (ukb-b-1996) Fracture of shoulder and upper arm rs6460754 5.94395861845005 2.81250724873002 0.0345663696438829
Salad / raw vegetable (ukb-b-1996) Fracture of shoulder and upper arm All - MR Egger -1.75956424864974 0.80254225061858 0.0305101753467052
Butternut squash (ukb-b-20341) Fracture of shoulder and upper arm rs149640202 2.51617689486049 1.21584305320859 0.0384999857600955
Butternut squash (ukb-b-20341) Fracture of shoulder and upper arm rs78400819 3.12334919445711 1.15895336668923 0.0070394122976308
Butternut squash (ukb-b-20341) Fracture of shoulder and upper arm All - MR Egger 3.04887913526755 0.984997591785572 0.0079055934625032
Crumbed or deep-fried poultry (ukb-b-39) Fracture of shoulder and upper arm rs117845922 5.27875830231018 2.65223848928496 0.046557564410882
Crumbed or deep-fried poultry (ukb-b-39) Fracture of shoulder and upper arm All - Inverse variance weighted 1.12012606320751 0.45850196973789 0.0145652310408244
Beer/cider (ukb-b-4961) Fracture of shoulder and upper arm rs75510754 0.964199757466676 0.417819894902226 0.0210162562275187
Beer/cider (ukb-b-4961) Fracture of shoulder and upper arm All - Inverse variance weighted 0.511488511572402 0.18131740132497 0.0047880687019545
Beer/cider (ukb-b-4961) Fracture of shoulder and upper arm All - MR Egger 1.13432262384858 0.462771382833356 0.0305288400620445
Coffee (ukb-b-5237) Fracture of shoulder and upper arm rs2189234 4.52593349881695 1.97258606032509 0.0217666009976658
Coffee (ukb-b-5237) Fracture of shoulder and upper arm rs34276507 5.16573615557263 2.58286807778632 0.0455002638963584
Eggs in sandwiches (ukb-b-5382) Fracture of shoulder and upper arm rs920644 5.80206567518918 2.77870012757554 0.0367932962736832
Eggs in sandwiches (ukb-b-5382) Fracture of shoulder and upper arm rs9879100 -8.3051618043583 3.44360367497783 0.0158755231158103
Eggs in sandwiches (ukb-b-5382) Fracture of shoulder and upper arm All - MR Egger -3.55565358711831 1.46302867089426 0.030311693442698
Onion (ukb-b-8124) Fracture of shoulder and upper arm rs113181638 -1.53320374111236 0.643993186290206 0.0172761977418935
Onion (ukb-b-8124) Fracture of shoulder and upper arm rs4378921 -1.71598718654305 0.677363363109098 0.0112983455111213
Onion (ukb-b-8124) Fracture of shoulder and upper arm All - Inverse variance weighted -0.48342869211438 0.228398938573321 0.0342939965509246
Other grain (ukb-b-8765) Fracture of shoulder and upper arm All - Inverse variance weighted 1.21200050879126 0.560620743994388 0.0306266383047887