ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Chocolate-covered raisin (ukb-b-1160) (👉 📊) Fracture at wrist and hand level Inverse variance weighted 51 0.75841154 0.319132357 0.017478727
Pineapple (ukb-b-1164) (👉 📊) Fracture at wrist and hand level MR Egger 16 3.329779905 1.0865658 0.008404438
Pineapple (ukb-b-1164) (👉 📊) Fracture at wrist and hand level Weighted median 16 1.3862385 0.695096999 0.046118249
Pineapple (ukb-b-1164) (👉 📊) Fracture at wrist and hand level Inverse variance weighted 16 1.566733458 0.474987875 0.000972131
Pineapple (ukb-b-1164) (👉 📊) Fracture at wrist and hand level Simple mode 16 2.867881598 1.250651662 0.036709728
Unsalted nuts (ukb-b-12217) (👉 📊) Fracture at wrist and hand level MR Egger 15 -2.501346006 1.112346601 0.042508473
Red wine (ukb-b-13556) (👉 📊) Fracture at wrist and hand level Inverse variance weighted 10 0.464633064 0.230644211 0.043956928
Other sweets (ukb-b-139) (👉 📊) Fracture at wrist and hand level Inverse variance weighted 26 -0.546436485 0.254403876 0.031720951
Lamb/mutton (ukb-b-14179) (👉 📊) Fracture at wrist and hand level Weighted median 128 -0.650078341 0.322750818 0.043990606
Lamb/mutton (ukb-b-14179) (👉 📊) Fracture at wrist and hand level Inverse variance weighted 128 -0.516960533 0.224005913 0.021010341
Shellfish (ukb-b-143) (👉 📊) Fracture at wrist and hand level Inverse variance weighted 40 1.612752581 0.584006525 0.005753092
Cheese (ukb-b-1489) (👉 📊) Fracture at wrist and hand level Inverse variance weighted 198 -0.256408498 0.114802205 0.025517268
Savoury biscuits (ukb-b-1503) (👉 📊) Fracture at wrist and hand level Weighted median 32 2.34094274 0.965301295 0.015304582
Savoury biscuits (ukb-b-1503) (👉 📊) Fracture at wrist and hand level Inverse variance weighted 32 1.777852648 0.666296512 0.007624512
Mashed potato (ukb-b-15710) (👉 📊) Fracture at wrist and hand level Inverse variance weighted 11 -0.625935862 0.299123382 0.036387782
Non-oily fish (ukb-b-17627) (👉 📊) Fracture at wrist and hand level MR Egger 67 -1.590945237 0.718529204 0.030330434
Boiled/baked potatoes (ukb-b-18007) (👉 📊) Fracture at wrist and hand level Inverse variance weighted 9 0.338305758 0.168614911 0.04481561
Milk (ukb-b-2966) (👉 📊) Fracture at wrist and hand level MR Egger 20 -1.956179999 0.768460517 0.020286204
Cake (ukb-b-3433) (👉 📊) Fracture at wrist and hand level Weighted median 10 -1.131215382 0.459933285 0.013912272
Pizza (ukb-b-3852) (👉 📊) Fracture at wrist and hand level Inverse variance weighted 16 0.780203685 0.277537939 0.004936316
Croissant (ukb-b-4007) (👉 📊) Fracture at wrist and hand level MR Egger 27 -1.410998176 0.528354928 0.013121158
Croissant (ukb-b-4007) (👉 📊) Fracture at wrist and hand level Inverse variance weighted 27 -0.814632232 0.33564613 0.015221871
Other bread (ukb-b-4964) (👉 📊) Fracture at wrist and hand level MR Egger 17 -0.997752025 0.44337461 0.039860512
Other bread (ukb-b-4964) (👉 📊) Fracture at wrist and hand level Inverse variance weighted 17 -0.64593257 0.262691818 0.013936393
Olives (ukb-b-5232) (👉 📊) Fracture at wrist and hand level MR Egger 23 1.64590736 0.775688172 0.045912115
Baguette (ukb-b-5277) (👉 📊) Fracture at wrist and hand level Inverse variance weighted 13 0.603533978 0.285431183 0.034475651
Pork (ukb-b-5640) (👉 📊) Fracture at wrist and hand level Inverse variance weighted 82 -0.743720705 0.284914489 0.009045504
Processed meat (ukb-b-6324) (👉 📊) Fracture at wrist and hand level Inverse variance weighted 125 -0.338717462 0.166165322 0.041506297
Cooked vegetable (ukb-b-8089) (👉 📊) Fracture at wrist and hand level MR Egger 94 -1.663089555 0.753960623 0.029888613

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Chocolate-covered raisin (ukb-b-1160) Fracture at wrist and hand level rs114187371 4.71226760332733 2.30600329524529 0.0410051172246419
Chocolate-covered raisin (ukb-b-1160) Fracture at wrist and hand level rs73229996 5.38591528931221 2.58451639722029 0.0371678010617633
Chocolate-covered raisin (ukb-b-1160) Fracture at wrist and hand level rs76994094 3.84680079276275 1.74788096857471 0.0277475779486634
Chocolate-covered raisin (ukb-b-1160) Fracture at wrist and hand level All - Inverse variance weighted 0.758411540326318 0.319132357274035 0.0174787273336404
Pineapple (ukb-b-1164) Fracture at wrist and hand level rs111799849 3.88895784204212 1.53627625391309 0.0113602275305362
Pineapple (ukb-b-1164) Fracture at wrist and hand level rs114311510 3.54842949139177 1.4767830339418 0.016269624647684
Pineapple (ukb-b-1164) Fracture at wrist and hand level All - Inverse variance weighted 1.5667334584221 0.474987875201994 0.0009721312024863
Pineapple (ukb-b-1164) Fracture at wrist and hand level All - MR Egger 3.3297799050178 1.08656580000561 0.0084044380462227
Unsalted nuts (ukb-b-12217) Fracture at wrist and hand level rs117713405 -4.14195511783665 1.68937133819776 0.0142154288467821
Unsalted nuts (ukb-b-12217) Fracture at wrist and hand level rs77536627 -4.01921820175746 1.96613535201115 0.0409315675078425
Unsalted nuts (ukb-b-12217) Fracture at wrist and hand level All - MR Egger -2.50134600643245 1.11234660085599 0.0425084733515143
Red wine (ukb-b-13556) Fracture at wrist and hand level All - Inverse variance weighted 0.464633063645207 0.230644211195837 0.0439569283609281
Other sweets (ukb-b-139) Fracture at wrist and hand level rs76694902 -1.89794742746263 0.876815329108935 0.0304189458948785
Other sweets (ukb-b-139) Fracture at wrist and hand level rs78668444 -2.75407302600837 1.33135283721732 0.0385810599040076
Other sweets (ukb-b-139) Fracture at wrist and hand level All - Inverse variance weighted -0.546436484743883 0.254403875747136 0.0317209508013968
Lamb/mutton (ukb-b-14179) Fracture at wrist and hand level rs2726033 -5.81685750595912 2.05486814069208 0.0046436211420232
Lamb/mutton (ukb-b-14179) Fracture at wrist and hand level rs416769 -5.39287412901834 2.54699597418698 0.0342304139472675
Lamb/mutton (ukb-b-14179) Fracture at wrist and hand level rs7183481 -4.87928135156093 2.35251065164545 0.0380724319553097
Lamb/mutton (ukb-b-14179) Fracture at wrist and hand level All - Inverse variance weighted -0.516960533290233 0.224005913069442 0.0210103406618186
Shellfish (ukb-b-143) Fracture at wrist and hand level rs145725821 5.09945649302826 2.35240010068397 0.0301763805220616
Shellfish (ukb-b-143) Fracture at wrist and hand level All - Inverse variance weighted 1.61275258115001 0.584006525162921 0.0057530916615915
Cheese (ukb-b-1489) Fracture at wrist and hand level rs11213287 -4.04245467820636 1.75410478327457 0.0211907502811687
Cheese (ukb-b-1489) Fracture at wrist and hand level rs11620149 -4.54326855073694 1.83314945260121 0.0131974926436636
Cheese (ukb-b-1489) Fracture at wrist and hand level rs1647396 -3.25706039991754 1.63265306122449 0.0460483885158576
Cheese (ukb-b-1489) Fracture at wrist and hand level rs6126641 -3.90896718584606 1.5197338575533 0.0101072214151077
Cheese (ukb-b-1489) Fracture at wrist and hand level rs61757207 -5.46389388684265 2.71025662742441 0.0437993381854059
Cheese (ukb-b-1489) Fracture at wrist and hand level rs6498981 -4.4136083394872 1.85474591698295 0.0173300464519945
Cheese (ukb-b-1489) Fracture at wrist and hand level rs678349 -4.30117873466442 1.86673081549194 0.0212157000654865
Cheese (ukb-b-1489) Fracture at wrist and hand level rs71386942 3.53501113770632 1.59801873348368 0.0269582908252502
Cheese (ukb-b-1489) Fracture at wrist and hand level rs72845670 -3.3553312961679 1.70334420392197 0.048855650650513
Cheese (ukb-b-1489) Fracture at wrist and hand level rs7607369 3.99184644131136 1.67317818923051 0.0170426278375202
Cheese (ukb-b-1489) Fracture at wrist and hand level rs78898535 -2.8817733122426 1.12734408302889 0.0105807070681616
Cheese (ukb-b-1489) Fracture at wrist and hand level All - Inverse variance weighted -0.256408498013391 0.114802205325758 0.0255172684960063
Savoury biscuits (ukb-b-1503) Fracture at wrist and hand level All - Inverse variance weighted 1.77785264835753 0.666296512142061 0.0076245121890359
Mashed potato (ukb-b-15710) Fracture at wrist and hand level rs115597995 -3.26030580513359 1.54578583675143 0.0349309882156078
Mashed potato (ukb-b-15710) Fracture at wrist and hand level rs55768233 -1.88600824162627 0.741453959886296 0.0109697184903318
Mashed potato (ukb-b-15710) Fracture at wrist and hand level All - Inverse variance weighted -0.625935862450019 0.29912338220986 0.0363877819914597
Non-oily fish (ukb-b-17627) Fracture at wrist and hand level rs12638455 6.36216359739305 2.51408077638919 0.011386364665447
Non-oily fish (ukb-b-17627) Fracture at wrist and hand level rs1603515 -3.94962114149136 1.80247373982224 0.0284356900503909
Non-oily fish (ukb-b-17627) Fracture at wrist and hand level rs55774808 -6.49846734260788 2.67861353454374 0.0152639005586698
Non-oily fish (ukb-b-17627) Fracture at wrist and hand level rs6953095 -4.9217399015652 2.3167649536647 0.0336365501053794
Non-oily fish (ukb-b-17627) Fracture at wrist and hand level All - MR Egger -1.59094523713883 0.718529204431675 0.0303304343234245
Boiled/baked potatoes (ukb-b-18007) Fracture at wrist and hand level rs9962730 1.16091757485219 0.437968904207801 0.0080328737451792
Boiled/baked potatoes (ukb-b-18007) Fracture at wrist and hand level All - Inverse variance weighted 0.33830575831997 0.168614910591337 0.044815610476984
Milk (ukb-b-2966) Fracture at wrist and hand level rs56674454 2.93881024727229 1.46275623167399 0.0445274935839779
Milk (ukb-b-2966) Fracture at wrist and hand level All - MR Egger -1.95617999925329 0.768460517141619 0.0202862035913379
Pizza (ukb-b-3852) Fracture at wrist and hand level rs117222790 1.93375282288829 0.929492789209048 0.0374853075058427
Pizza (ukb-b-3852) Fracture at wrist and hand level rs79236871 1.33836330699047 0.681713145133721 0.0496188400852345
Pizza (ukb-b-3852) Fracture at wrist and hand level All - Inverse variance weighted 0.780203685240908 0.27753793864651 0.004936315784832
Croissant (ukb-b-4007) Fracture at wrist and hand level rs117892082 -3.75549362348478 1.78871571290978 0.0357686642010021
Croissant (ukb-b-4007) Fracture at wrist and hand level rs3791299 -8.92530586722354 4.09985960193018 0.0294821778060591
Croissant (ukb-b-4007) Fracture at wrist and hand level All - Inverse variance weighted -0.814632231897235 0.335646130159793 0.0152218713314395
Croissant (ukb-b-4007) Fracture at wrist and hand level All - MR Egger -1.41099817572624 0.528354928105087 0.0131211578393159
Other bread (ukb-b-4964) Fracture at wrist and hand level rs114013769 -1.78466825477409 0.682430585386808 0.0089184485459988
Other bread (ukb-b-4964) Fracture at wrist and hand level rs73017061 -1.61328138083489 0.725697506949949 0.0262106134444644
Other bread (ukb-b-4964) Fracture at wrist and hand level All - Inverse variance weighted -0.645932569841251 0.262691817657303 0.0139363933746429
Other bread (ukb-b-4964) Fracture at wrist and hand level All - MR Egger -0.997752024785787 0.443374610451146 0.0398605116105675
Olives (ukb-b-5232) Fracture at wrist and hand level rs117784231 9.23530704483413 3.87363939409184 0.0171189872360085
Olives (ukb-b-5232) Fracture at wrist and hand level All - MR Egger 1.64590735964406 0.775688172292186 0.0459121153599755
Baguette (ukb-b-5277) Fracture at wrist and hand level All - Inverse variance weighted 0.603533977902481 0.285431183069111 0.0344756513728267
Pork (ukb-b-5640) Fracture at wrist and hand level rs1105714 8.12172710206501 2.91473174587491 0.005329037100796
Pork (ukb-b-5640) Fracture at wrist and hand level rs12097622 -6.39529926124604 2.75966852970132 0.0204810962694674
Pork (ukb-b-5640) Fracture at wrist and hand level rs4146837 -4.51533507880795 2.26335435940247 0.0460456202798669
Pork (ukb-b-5640) Fracture at wrist and hand level rs7641973 -5.61202441349017 2.32058393469214 0.0155903288799459
Pork (ukb-b-5640) Fracture at wrist and hand level All - Inverse variance weighted -0.743720704822975 0.284914488711808 0.009045504080962
Processed meat (ukb-b-6324) Fracture at wrist and hand level rs12153596 -5.09612939081943 2.03468382332162 0.0122579677653332
Processed meat (ukb-b-6324) Fracture at wrist and hand level rs2873054 -3.35815030223353 1.40042012603781 0.016486702249562
Processed meat (ukb-b-6324) Fracture at wrist and hand level rs41286971 5.8925891484288 2.04603789876 0.0039767517097886
Processed meat (ukb-b-6324) Fracture at wrist and hand level rs444558 3.95458481670355 1.86664100837102 0.0341279482542424
Processed meat (ukb-b-6324) Fracture at wrist and hand level rs4778053 -3.58298869840344 1.37246685735454 0.0090378397774736
Processed meat (ukb-b-6324) Fracture at wrist and hand level rs6135282 -4.23860346781704 2.0110162438548 0.0350576131176831
Processed meat (ukb-b-6324) Fracture at wrist and hand level rs6484504 2.74029264257277 1.31844268652086 0.0376696456709854
Processed meat (ukb-b-6324) Fracture at wrist and hand level All - Inverse variance weighted -0.338717461823272 0.166165322067144 0.0415062965744326
Cooked vegetable (ukb-b-8089) Fracture at wrist and hand level rs12629972 3.95779482181448 1.70346201110217 0.0201585820006787
Cooked vegetable (ukb-b-8089) Fracture at wrist and hand level rs1534749 -5.51529165679361 2.66912880180629 0.0387976579466702
Cooked vegetable (ukb-b-8089) Fracture at wrist and hand level rs2222134 -3.59663955766702 1.35544998255361 0.0079669950693457
Cooked vegetable (ukb-b-8089) Fracture at wrist and hand level rs28437380 5.77986272236253 2.39451455640733 0.0157874242343648
Cooked vegetable (ukb-b-8089) Fracture at wrist and hand level rs335352 6.51711961745166 2.71217503271726 0.0162650733518196
Cooked vegetable (ukb-b-8089) Fracture at wrist and hand level rs349062 4.51479437470098 2.2237046920169 0.0423257463933924
Cooked vegetable (ukb-b-8089) Fracture at wrist and hand level rs4730098 -5.62672153868904 2.59405647774751 0.0300764494662807
Cooked vegetable (ukb-b-8089) Fracture at wrist and hand level rs6532382 5.53062073971183 2.51602662582278 0.0279379424005528
Cooked vegetable (ukb-b-8089) Fracture at wrist and hand level All - MR Egger -1.66308955495605 0.753960623236289 0.0298886127493961