ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Flavoured milk (ukb-b-12763) (👉 📊) Injuries to the knee and lower leg Weighted median 20 0.714470718 0.339487515 0.035329916
Flavoured milk (ukb-b-12763) (👉 📊) Injuries to the knee and lower leg Inverse variance weighted 20 0.59273841 0.243429546 0.014893909
Other alcohol (ukb-b-12901) (👉 📊) Injuries to the knee and lower leg MR Egger 43 0.687119557 0.33772179 0.048395807
Snackpot (ukb-b-12912) (👉 📊) Injuries to the knee and lower leg MR Egger 116 2.71351953 1.03289435 0.009795913
Cheese (ukb-b-1489) (👉 📊) Injuries to the knee and lower leg Inverse variance weighted 198 -0.138131496 0.060146989 0.021643573
Broad bean (ukb-b-15212) (👉 📊) Injuries to the knee and lower leg Inverse variance weighted 21 0.470364245 0.163971114 0.00412319
Dried fruit (ukb-b-16576) (👉 📊) Injuries to the knee and lower leg Inverse variance weighted 155 -0.227169558 0.09044885 0.012019191
Low fat hard cheese (ukb-b-18079) (👉 📊) Injuries to the knee and lower leg MR Egger 16 0.897993717 0.41866037 0.049987435
Cheesy biscuits (ukb-b-19847) (👉 📊) Injuries to the knee and lower leg MR Egger 24 -1.128010485 0.524908823 0.042898979
Seeds (ukb-b-4548) (👉 📊) Injuries to the knee and lower leg Inverse variance weighted 15 0.724217904 0.315322453 0.021632844
Feta (ukb-b-4740) (👉 📊) Injuries to the knee and lower leg Weighted median 28 1.145199811 0.516421381 0.026584265
Banana (ukb-b-5362) (👉 📊) Injuries to the knee and lower leg MR Egger 16 0.510139598 0.201570874 0.02399285
Pork (ukb-b-5640) (👉 📊) Injuries to the knee and lower leg Inverse variance weighted 82 0.297521307 0.139420182 0.03284358
Cheese spread (ukb-b-6185) (👉 📊) Injuries to the knee and lower leg Inverse variance weighted 24 0.746651928 0.323693931 0.021073767
Doughnut (ukb-b-6214) (👉 📊) Injuries to the knee and lower leg MR Egger 31 1.102010916 0.507332155 0.038160603
Doughnut (ukb-b-6214) (👉 📊) Injuries to the knee and lower leg Inverse variance weighted 31 0.692251589 0.292438672 0.017924774
Processed meat (ukb-b-6324) (👉 📊) Injuries to the knee and lower leg Inverse variance weighted 125 -0.197805399 0.082468124 0.016459322
Cappuccino (ukb-b-8374) (👉 📊) Injuries to the knee and lower leg Weighted median 21 -0.381945513 0.182458362 0.03631973
Other grain (ukb-b-8765) (👉 📊) Injuries to the knee and lower leg MR Egger 70 1.0844148 0.490863466 0.03053286
Other milk-based pudding (ukb-b-9857) (👉 📊) Injuries to the knee and lower leg Inverse variance weighted 22 -0.600723394 0.275878919 0.029444079

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Flavoured milk (ukb-b-12763) Injuries to the knee and lower leg rs9872037 3.8909938084561 1.53207881207959 0.0110953128987481
Flavoured milk (ukb-b-12763) Injuries to the knee and lower leg All - Inverse variance weighted 0.592738409815264 0.243429545839901 0.0148939089375782
Other alcohol (ukb-b-12901) Injuries to the knee and lower leg rs117693960 1.95344876341168 0.955597232018358 0.040932046636374
Other alcohol (ukb-b-12901) Injuries to the knee and lower leg All - MR Egger 0.687119556877486 0.337721789867406 0.0483958072864911
Snackpot (ukb-b-12912) Injuries to the knee and lower leg rs111393448 17.9794236900251 6.19277102292854 0.0036926195451134
Snackpot (ukb-b-12912) Injuries to the knee and lower leg rs144939326 -8.97714035331459 4.45294660382668 0.0437999757901902
Snackpot (ukb-b-12912) Injuries to the knee and lower leg rs1468798 6.64518233047772 3.34889135915895 0.0472231645041677
Snackpot (ukb-b-12912) Injuries to the knee and lower leg rs7093445 7.59060285818694 2.44027458607302 0.0018673753039492
Snackpot (ukb-b-12912) Injuries to the knee and lower leg rs72919932 10.6078679224008 5.19266261935706 0.0410665819027064
Snackpot (ukb-b-12912) Injuries to the knee and lower leg rs76717272 16.2274338748883 6.06246937540232 0.0074350366843835
Snackpot (ukb-b-12912) Injuries to the knee and lower leg All - MR Egger 2.71351952963188 1.03289435015275 0.0097959134210509
Cheese (ukb-b-1489) Injuries to the knee and lower leg rs11620149 -1.85012305864381 0.888285382896263 0.0372692252644252
Cheese (ukb-b-1489) Injuries to the knee and lower leg rs12666766 -1.97545053741234 0.897932062460154 0.0278068950269972
Cheese (ukb-b-1489) Injuries to the knee and lower leg rs1434511 -3.27044413248384 0.725051293522361 6.46328468616992e-06
Cheese (ukb-b-1489) Injuries to the knee and lower leg rs1873036 -1.78670745272525 0.896829810901001 0.0463438472367039
Cheese (ukb-b-1489) Injuries to the knee and lower leg rs2029401 1.72727897703836 0.824969063660113 0.0362822563270125
Cheese (ukb-b-1489) Injuries to the knee and lower leg rs242643 1.87487158413807 0.821861516334498 0.0225336575784201
Cheese (ukb-b-1489) Injuries to the knee and lower leg rs4074103 -1.75819847950996 0.858000858000858 0.0404444849579225
Cheese (ukb-b-1489) Injuries to the knee and lower leg rs531358 -1.655704585846 0.759497516443121 0.0292574615519785
Cheese (ukb-b-1489) Injuries to the knee and lower leg rs61734410 -1.38104959769425 0.606460910291822 0.0227726304595378
Cheese (ukb-b-1489) Injuries to the knee and lower leg rs6539284 1.80842327059155 0.796369880627473 0.023157069243638
Cheese (ukb-b-1489) Injuries to the knee and lower leg rs6857 2.28632422317687 0.790659673721108 0.0038320427944837
Cheese (ukb-b-1489) Injuries to the knee and lower leg rs7185391 1.88001022725564 0.782084254538345 0.0162235992846681
Cheese (ukb-b-1489) Injuries to the knee and lower leg rs75499503 -2.12120569331608 0.798987477815724 0.007933962279205
Cheese (ukb-b-1489) Injuries to the knee and lower leg All - Inverse variance weighted -0.1381314959072 0.0601469894170127 0.0216435732978772
Broad bean (ukb-b-15212) Injuries to the knee and lower leg rs72662025 2.45038224967005 1.18534751101925 0.0387127794642274
Broad bean (ukb-b-15212) Injuries to the knee and lower leg rs7844716 1.65268768334504 0.818080403255795 0.0433624368300393
Broad bean (ukb-b-15212) Injuries to the knee and lower leg All - Inverse variance weighted 0.470364244779185 0.163971114137304 0.0041231902156845
Dried fruit (ukb-b-16576) Injuries to the knee and lower leg rs10192800 3.41210088093175 1.17254325805215 0.0036142875616128
Dried fruit (ukb-b-16576) Injuries to the knee and lower leg rs10740991 -1.82209212019834 0.633251687675488 0.0040101972835999
Dried fruit (ukb-b-16576) Injuries to the knee and lower leg rs11073575 -2.42685449321998 1.06736655951804 0.022984980188233
Dried fruit (ukb-b-16576) Injuries to the knee and lower leg rs11085749 -2.40051842586273 1.0441716919672 0.021506695595673
Dried fruit (ukb-b-16576) Injuries to the knee and lower leg rs11772627 -1.24360470824379 0.57816710120106 0.0314806677008146
Dried fruit (ukb-b-16576) Injuries to the knee and lower leg rs12137234 -2.06759365415332 1.03869633810546 0.0465286171341322
Dried fruit (ukb-b-16576) Injuries to the knee and lower leg rs12600070 -2.14255737415236 1.02342087631333 0.0363022987303798
Dried fruit (ukb-b-16576) Injuries to the knee and lower leg rs1648404 2.02847296342908 1.00892634306682 0.0443755138655369
Dried fruit (ukb-b-16576) Injuries to the knee and lower leg rs1801140 2.67590936195587 1.09570661896243 0.0145989922072135
Dried fruit (ukb-b-16576) Injuries to the knee and lower leg rs4073960 -2.3334293974918 1.18995602740617 0.0498863141538686
Dried fruit (ukb-b-16576) Injuries to the knee and lower leg rs4149513 -1.58567774936061 0.801364023870418 0.0478471564083117
Dried fruit (ukb-b-16576) Injuries to the knee and lower leg rs429358 -1.27854797061847 0.616711374063025 0.0381563932109387
Dried fruit (ukb-b-16576) Injuries to the knee and lower leg rs6765212 -2.93914246196404 0.946349275678824 0.0018978476381414
Dried fruit (ukb-b-16576) Injuries to the knee and lower leg rs72784460 2.05354821939173 1.02244172948618 0.0445928850493556
Dried fruit (ukb-b-16576) Injuries to the knee and lower leg rs7835197 -3.5365236202955 1.18906976387376 0.0029375971870864
Dried fruit (ukb-b-16576) Injuries to the knee and lower leg All - Inverse variance weighted -0.227169557640751 0.0904488503340246 0.012019191151995
Low fat hard cheese (ukb-b-18079) Injuries to the knee and lower leg rs118109475 1.82884469360389 0.756094802656025 0.0155716529016384
Low fat hard cheese (ukb-b-18079) Injuries to the knee and lower leg rs27779 1.74574423617543 0.868774126922982 0.0444911315083297
Low fat hard cheese (ukb-b-18079) Injuries to the knee and lower leg rs7915755 -2.37342979684662 0.786055527572996 0.002532612791795
Low fat hard cheese (ukb-b-18079) Injuries to the knee and lower leg All - MR Egger 0.897993717025858 0.418660369523923 0.0499874353759044
Cheesy biscuits (ukb-b-19847) Injuries to the knee and lower leg rs11722366 3.60822193504933 1.63038176324451 0.0268897351665657
Cheesy biscuits (ukb-b-19847) Injuries to the knee and lower leg rs4527950 3.05007866787059 1.41934353851404 0.0316394600986086
Cheesy biscuits (ukb-b-19847) Injuries to the knee and lower leg rs62139637 -3.46055490154669 1.44276911303155 0.016460096529306
Cheesy biscuits (ukb-b-19847) Injuries to the knee and lower leg rs72759617 -3.85316168344335 1.41382159960971 0.0064232944654203
Cheesy biscuits (ukb-b-19847) Injuries to the knee and lower leg All - MR Egger -1.12801048534745 0.524908822502123 0.0428989794825938
Seeds (ukb-b-4548) Injuries to the knee and lower leg rs183161766 3.13967096678729 1.24564495083334 0.0117182125360903
Seeds (ukb-b-4548) Injuries to the knee and lower leg All - Inverse variance weighted 0.724217903751003 0.315322453303876 0.0216328436312132
Feta (ukb-b-4740) Injuries to the knee and lower leg rs117582379 -7.92050600790166 3.41065405415591 0.0202176695105015
Feta (ukb-b-4740) Injuries to the knee and lower leg rs117998163 2.96064532895776 1.2790395483105 0.0206271085672928
Feta (ukb-b-4740) Injuries to the knee and lower leg rs2710434 2.19108574064464 1.05562430419722 0.0379281612629803
Banana (ukb-b-5362) Injuries to the knee and lower leg rs111386164 0.546920108530887 0.266604509729541 0.0402252290221024
Banana (ukb-b-5362) Injuries to the knee and lower leg All - MR Egger 0.510139597794723 0.201570873693298 0.0239928497865811
Pork (ukb-b-5640) Injuries to the knee and lower leg rs10137783 6.80401630002195 2.51217080645972 0.0067604194047993
Pork (ukb-b-5640) Injuries to the knee and lower leg rs10931858 2.98928466549641 1.36954011106444 0.0290584767909603
Pork (ukb-b-5640) Injuries to the knee and lower leg rs12932179 -3.68077861564124 1.33721170680599 0.0059128182093367
Pork (ukb-b-5640) Injuries to the knee and lower leg rs1451077 3.18116550418978 1.18514008979619 0.0072701310393299
Pork (ukb-b-5640) Injuries to the knee and lower leg rs34323725 -3.20612876825595 1.19807969761143 0.0074494121715193
Pork (ukb-b-5640) Injuries to the knee and lower leg rs4605770 3.31040819359808 1.27011579672743 0.009150408524222
Pork (ukb-b-5640) Injuries to the knee and lower leg All - Inverse variance weighted 0.297521306649293 0.139420181675231 0.0328435799395811
Cheese spread (ukb-b-6185) Injuries to the knee and lower leg rs139087594 4.25203392221717 2.08878717100622 0.0417857865676267
Cheese spread (ukb-b-6185) Injuries to the knee and lower leg rs75089783 2.84659133731817 1.28705351707665 0.0269865907560836
Cheese spread (ukb-b-6185) Injuries to the knee and lower leg rs78039274 2.00615220008025 0.932775040037311 0.0314970989108344
Cheese spread (ukb-b-6185) Injuries to the knee and lower leg All - Inverse variance weighted 0.746651927859586 0.32369393106311 0.0210737672012983
Doughnut (ukb-b-6214) Injuries to the knee and lower leg rs2148761 5.45769022028577 2.14046958453587 0.0107796160861822
Doughnut (ukb-b-6214) Injuries to the knee and lower leg rs34987892 5.93379846250369 2.86485301565465 0.0383363633923402
Doughnut (ukb-b-6214) Injuries to the knee and lower leg rs80025943 2.9538575148366 1.00000384616864 0.0031384041887189
Doughnut (ukb-b-6214) Injuries to the knee and lower leg All - Inverse variance weighted 0.692251589197248 0.292438671530143 0.0179247735858658
Doughnut (ukb-b-6214) Injuries to the knee and lower leg All - MR Egger 1.10201091627066 0.507332154831929 0.0381606025393951
Processed meat (ukb-b-6324) Injuries to the knee and lower leg rs117665299 -3.60258970540113 1.11931055363057 0.0012882737248498
Processed meat (ukb-b-6324) Injuries to the knee and lower leg rs2029401 1.37377658701952 0.656132101263054 0.0362822563270125
Processed meat (ukb-b-6324) Injuries to the knee and lower leg rs4778053 -1.32388395974907 0.668014842075218 0.0474995937643863
Processed meat (ukb-b-6324) Injuries to the knee and lower leg rs715400 -1.86182531537504 0.935453695042095 0.0465588599999438
Processed meat (ukb-b-6324) Injuries to the knee and lower leg rs72681540 -2.04750204750205 0.971695886950124 0.0351051983770064
Processed meat (ukb-b-6324) Injuries to the knee and lower leg rs77165542 -2.6034133641886 1.07442456299847 0.0153896675618411
Processed meat (ukb-b-6324) Injuries to the knee and lower leg All - Inverse variance weighted -0.197805399487387 0.0824681238716069 0.0164593219837386
Cappuccino (ukb-b-8374) Injuries to the knee and lower leg rs6797227 -1.4336570027565 0.664884407075478 0.0310641492060577
Other grain (ukb-b-8765) Injuries to the knee and lower leg rs117238119 4.67860178835079 1.62984078692548 0.0040970883425799
Other grain (ukb-b-8765) Injuries to the knee and lower leg rs76629987 13.9374739605852 6.66609019660249 0.0365458269136055
Other grain (ukb-b-8765) Injuries to the knee and lower leg rs80299147 3.63508098098196 1.70486277814248 0.0329917308194629
Other grain (ukb-b-8765) Injuries to the knee and lower leg All - MR Egger 1.08441480041171 0.490863466066678 0.0305328598618874
Other milk-based pudding (ukb-b-9857) Injuries to the knee and lower leg rs117055820 -1.92751355016439 0.899790617443998 0.0321789926357655
Other milk-based pudding (ukb-b-9857) Injuries to the knee and lower leg rs144298547 -2.16233670753964 0.934129457657123 0.0206230688132937
Other milk-based pudding (ukb-b-9857) Injuries to the knee and lower leg All - Inverse variance weighted -0.600723393720717 0.27587891886235 0.0294440793510932