ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Knee and hip osteoarthritis (ieu-a-1170)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Pear (ukb-b-10793) (👉 📊) Knee and hip osteoarthritis Weighted median 5 2.222520564 0.728032079 0.002267333
Pear (ukb-b-10793) (👉 📊) Knee and hip osteoarthritis Inverse variance weighted 5 1.68108494 0.526360708 0.001404188
Flavoured milk (ukb-b-12763) (👉 📊) Knee and hip osteoarthritis Wald ratio 1 7.085122785 3.206665272 0.027139972
Red wine (ukb-b-13556) (👉 📊) Knee and hip osteoarthritis Inverse variance weighted 5 -0.591279953 0.298350188 0.047498045
Grapefruit juice (ukb-b-14351) (👉 📊) Knee and hip osteoarthritis Weighted median 3 -5.359244503 2.082758685 0.010077836
Grapefruit juice (ukb-b-14351) (👉 📊) Knee and hip osteoarthritis Inverse variance weighted 3 -4.046549493 1.926179378 0.035657074
Non-oily fish (ukb-b-17627) (👉 📊) Knee and hip osteoarthritis MR Egger 28 5.005021759 2.183537834 0.030239739
Cheesy biscuits (ukb-b-19847) (👉 📊) Knee and hip osteoarthritis Inverse variance weighted 4 -4.91597208 1.711370783 0.004071933
Fizzy drink (ukb-b-2832) (👉 📊) Knee and hip osteoarthritis Inverse variance weighted 6 -1.073161479 0.513424652 0.036599615
Prune (ukb-b-3022) (👉 📊) Knee and hip osteoarthritis Inverse variance weighted 4 -2.961317156 1.07288081 0.005777397
Sweet biscuits (ukb-b-3646) (👉 📊) Knee and hip osteoarthritis Inverse variance weighted 2 -0.736938386 0.324953434 0.023339713
Drinking water (ukb-b-3975) (👉 📊) Knee and hip osteoarthritis MR Egger 11 -0.9863447 0.389682063 0.032174476
Dairy smoothie (ukb-b-4955) (👉 📊) Knee and hip osteoarthritis Inverse variance weighted 4 -2.777167408 1.004661378 0.005704821
Coffee (ukb-b-5237) (👉 📊) Knee and hip osteoarthritis Weighted median 65 1.009620191 0.379950753 0.007878343
Coffee (ukb-b-5237) (👉 📊) Knee and hip osteoarthritis Inverse variance weighted 65 0.70826354 0.263070802 0.007096268
Garlic bread (ukb-b-602) (👉 📊) Knee and hip osteoarthritis Inverse variance weighted 3 -2.544726075 1.170498182 0.029701092
Tea (ukb-b-6066) (👉 📊) Knee and hip osteoarthritis MR Egger 78 1.054871585 0.486313664 0.033200896
Tea (ukb-b-6066) (👉 📊) Knee and hip osteoarthritis Weighted median 78 0.642784896 0.276774053 0.020210468
Filtered coffee (ukb-b-748) (👉 📊) Knee and hip osteoarthritis Weighted median 9 0.709445533 0.274144547 0.009657644
Cappuccino (ukb-b-8374) (👉 📊) Knee and hip osteoarthritis Inverse variance weighted 7 1.317301086 0.538224279 0.014385323

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Pear (ukb-b-10793) Knee and hip osteoarthritis rs1609494 2.49829772104056 1.1718108449051 0.0330070570432204
Pear (ukb-b-10793) Knee and hip osteoarthritis rs4953674 2.31816562059021 1.15522000864735 0.044782941419622
Pear (ukb-b-10793) Knee and hip osteoarthritis rs9512379 2.61587209676382 1.04258079735787 0.0121061361742675
Pear (ukb-b-10793) Knee and hip osteoarthritis All - Inverse variance weighted 1.68108494021743 0.52636070826161 0.0014041880119164
Flavoured milk (ukb-b-12763) Knee and hip osteoarthritis rs9872037 7.08512278517337 3.20666527239389 0.0271399719848267
Red wine (ukb-b-13556) Knee and hip osteoarthritis rs566577 -1.32663931600359 0.608906777908019 0.029352238148413
Red wine (ukb-b-13556) Knee and hip osteoarthritis All - Inverse variance weighted -0.591279953035294 0.298350187656229 0.0474980451944576
Grapefruit juice (ukb-b-14351) Knee and hip osteoarthritis rs2745952 -5.35290167991995 2.667531202275 0.044782941419622
Grapefruit juice (ukb-b-14351) Knee and hip osteoarthritis rs4715882 -6.22642160615454 2.33069991591471 0.007551724483974
Grapefruit juice (ukb-b-14351) Knee and hip osteoarthritis All - Inverse variance weighted -4.04654949332769 1.92617937792573 0.0356570740799018
Non-oily fish (ukb-b-17627) Knee and hip osteoarthritis rs56094641 6.84629195630586 1.66666137040715 3.99466116098239e-05
Non-oily fish (ukb-b-17627) Knee and hip osteoarthritis All - MR Egger 5.00502175863942 2.18353783400621 0.0302397394955476
Cheesy biscuits (ukb-b-19847) Knee and hip osteoarthritis rs61948341 -8.99301427395583 3.45798363665783 0.0093046615028432
Cheesy biscuits (ukb-b-19847) Knee and hip osteoarthritis All - Inverse variance weighted -4.91597207989781 1.71137078278105 0.0040719326641347
Fizzy drink (ukb-b-2832) Knee and hip osteoarthritis rs949734 -2.742625744984 1.13553890167534 0.0157238268329055
Fizzy drink (ukb-b-2832) Knee and hip osteoarthritis All - Inverse variance weighted -1.07316147916748 0.513424652231985 0.036599615253686
Prune (ukb-b-3022) Knee and hip osteoarthritis rs973572 -4.93053099046447 2.06619117194709 0.0170193320005322
Prune (ukb-b-3022) Knee and hip osteoarthritis All - Inverse variance weighted -2.96131715622398 1.07288081041471 0.0057773972565422
Sweet biscuits (ukb-b-3646) Knee and hip osteoarthritis All - Inverse variance weighted -0.736938386046737 0.324953433846516 0.0233397127276488
Drinking water (ukb-b-3975) Knee and hip osteoarthritis rs10153636 -0.957731307466105 0.423730007590185 0.0238063895426317
Drinking water (ukb-b-3975) Knee and hip osteoarthritis rs2472297 -0.496050119258947 0.247198482269763 0.0447829414196219
Drinking water (ukb-b-3975) Knee and hip osteoarthritis All - MR Egger -0.986344699614101 0.389682062759954 0.0321744761444235
Dairy smoothie (ukb-b-4955) Knee and hip osteoarthritis rs6449463 -4.73680020210217 2.07952414125717 0.0227367733165293
Dairy smoothie (ukb-b-4955) Knee and hip osteoarthritis All - Inverse variance weighted -2.77716740800804 1.00466137813389 0.0057048205004805
Coffee (ukb-b-5237) Knee and hip osteoarthritis rs1338549 5.16232313111231 2.32606195397203 0.0264635790458348
Coffee (ukb-b-5237) Knee and hip osteoarthritis rs13387939 4.38340037932326 1.65843994249749 0.0082154021310112
Coffee (ukb-b-5237) Knee and hip osteoarthritis rs1421085 4.15049669409899 1.27476729261269 0.00113039217719
Coffee (ukb-b-5237) Knee and hip osteoarthritis rs2231142 7.50367582706109 2.68038604140477 0.0051185654935016
Coffee (ukb-b-5237) Knee and hip osteoarthritis rs2472297 1.04991091179838 0.523205970200642 0.0447829414196219
Coffee (ukb-b-5237) Knee and hip osteoarthritis rs34060476 -3.93781064831897 1.78858550561066 0.0276911727374648
Coffee (ukb-b-5237) Knee and hip osteoarthritis All - Inverse variance weighted 0.708263540253727 0.263070802277154 0.0070962684434449
Garlic bread (ukb-b-602) Knee and hip osteoarthritis All - Inverse variance weighted -2.54472607490947 1.17049818173508 0.0297010915059839
Tea (ukb-b-6066) Knee and hip osteoarthritis rs1275193 -5.86002329788141 2.05740181268882 0.0043958457402611
Tea (ukb-b-6066) Knee and hip osteoarthritis rs1481012 3.59367843466001 1.28369691542668 0.0051185654935016
Tea (ukb-b-6066) Knee and hip osteoarthritis rs2472297 0.914611034149213 0.455781484029521 0.044782941419622
Tea (ukb-b-6066) Knee and hip osteoarthritis rs7172571 -5.048291934883 2.08659452622094 0.0155464390030309
Tea (ukb-b-6066) Knee and hip osteoarthritis rs7825157 4.49938998023227 1.85971861872992 0.0155464390030309
Tea (ukb-b-6066) Knee and hip osteoarthritis rs984616 4.0743382045929 2.03037995824635 0.044782941419622
Tea (ukb-b-6066) Knee and hip osteoarthritis rs9937354 -5.46120931288718 1.50243040525677 0.0002780705100839
Tea (ukb-b-6066) Knee and hip osteoarthritis All - MR Egger 1.05487158490407 0.486313663731565 0.0332008959961745
Filtered coffee (ukb-b-748) Knee and hip osteoarthritis rs10468280 2.76624669493567 0.603371963766917 4.547568315537e-06
Filtered coffee (ukb-b-748) Knee and hip osteoarthritis rs3004179 0.989899270334596 0.495518779230154 0.0457488866260935
Cappuccino (ukb-b-8374) Knee and hip osteoarthritis All - Inverse variance weighted 1.31730108644416 0.538224278642 0.0143853228228379