Knee osteoarthritis (ieu-a-1171)

Mendelian Randomization Results

Intake (exposure)	Outcome	Method	Number of SNPs	b	se	P-value
Pear (ukb-b-10793) (👉 📊)	Knee osteoarthritis	Weighted median	5	1.779841263	0.847839074	0.035793301
Pear (ukb-b-10793) (👉 📊)	Knee osteoarthritis	Inverse variance weighted	5	1.708535572	0.682897199	0.012353133
Pineapple (ukb-b-1164) (👉 📊)	Knee osteoarthritis	Inverse variance weighted	5	3.168222319	1.209478011	0.008805991
Flavoured milk (ukb-b-12763) (👉 📊)	Knee osteoarthritis	Wald ratio	1	11.58910619	4.217180683	0.005994728
Celery (ukb-b-14145) (👉 📊)	Knee osteoarthritis	Wald ratio	1	-3.412083246	1.497954142	0.022736773
Grapefruit juice (ukb-b-14351) (👉 📊)	Knee osteoarthritis	Weighted median	3	-6.118593572	2.733240304	0.025182864
Grapefruit juice (ukb-b-14351) (👉 📊)	Knee osteoarthritis	Inverse variance weighted	3	-6.723111061	2.40865788	0.005250862
Melon (ukb-b-19862) (👉 📊)	Knee osteoarthritis	Weighted median	4	-3.452502037	1.652152248	0.036644785
Goat's cheese (ukb-b-20122) (👉 📊)	Knee osteoarthritis	MR Egger	6	-14.12976631	4.770348161	0.041472069
Parsnip (ukb-b-2468) (👉 📊)	Knee osteoarthritis	Wald ratio	1	-4.565113734	2.259033265	0.043297754
Prune (ukb-b-3022) (👉 📊)	Knee osteoarthritis	Weighted median	4	-5.479129951	1.831238918	0.00277125
Prune (ukb-b-3022) (👉 📊)	Knee osteoarthritis	Inverse variance weighted	4	-5.224957755	1.473250348	0.000390309
Standard tea (ukb-b-3291) (👉 📊)	Knee osteoarthritis	Weighted median	6	0.005312547	0.00267997	0.047443928
Drinking water (ukb-b-3975) (👉 📊)	Knee osteoarthritis	MR Egger	11	-1.415168153	0.513524701	0.022264804
Dairy smoothie (ukb-b-4955) (👉 📊)	Knee osteoarthritis	Inverse variance weighted	4	-3.143773934	1.279052986	0.013975525
Coffee (ukb-b-5237) (👉 📊)	Knee osteoarthritis	Weighted median	65	1.009384019	0.448100694	0.024285452
Coffee (ukb-b-5237) (👉 📊)	Knee osteoarthritis	Inverse variance weighted	65	0.773700779	0.328725718	0.018590791
Cappuccino (ukb-b-8374) (👉 📊)	Knee osteoarthritis	Inverse variance weighted	7	1.533992209	0.696278912	0.027585663

Mendelian Randomization Results (Single SNP)

Intake (exposure)	Outcome	SNP	b	se	P-value
Pear (ukb-b-10793)	Knee osteoarthritis	All - Inverse variance weighted	1.70853557152	0.682897199251363	0.0123531330427117
Pineapple (ukb-b-1164)	Knee osteoarthritis	All - Inverse variance weighted	3.16822231941771	1.20947801144207	0.0088059910802096
Flavoured milk (ukb-b-12763)	Knee osteoarthritis	rs9872037	11.5891061900848	4.21718068316124	0.00599472754713
Celery (ukb-b-14145)	Knee osteoarthritis	rs3110454	-3.41208324602133	1.49795414189763	0.0227367733165292
Grapefruit juice (ukb-b-14351)	Knee osteoarthritis	rs2745952	-6.39283488686432	3.17183632629417	0.0438523266124737
Grapefruit juice (ukb-b-14351)	Knee osteoarthritis	rs4715882	-10.7456608225298	3.15275912701899	0.0006536048249818
Grapefruit juice (ukb-b-14351)	Knee osteoarthritis	All - Inverse variance weighted	-6.72311106120005	2.40865788047097	0.0052508622003668
Goat's cheese (ukb-b-20122)	Knee osteoarthritis	rs59138812	-15.9361464325631	5.71321956671559	0.0052814599255595
Goat's cheese (ukb-b-20122)	Knee osteoarthritis	All - MR Egger	-14.1297663070171	4.77034816137737	0.0414720687955895
Parsnip (ukb-b-2468)	Knee osteoarthritis	rs9398444	-4.5651137335816	2.25903326455639	0.043297753873017
Prune (ukb-b-3022)	Knee osteoarthritis	rs11247295	-7.62736578270932	2.53897309708285	0.0026635510339768
Prune (ukb-b-3022)	Knee osteoarthritis	rs973572	-6.97580552137804	2.6392648415872	0.0082154021310112
Prune (ukb-b-3022)	Knee osteoarthritis	All - Inverse variance weighted	-5.22495775452636	1.47325034751798	0.0003903089241449
Standard tea (ukb-b-3291)	Knee osteoarthritis	rs10969132	0.0140870328082466	0.0064975938898995	0.0301557679516915
Standard tea (ukb-b-3291)	Knee osteoarthritis	rs2472297	0.0066283223120254	0.0030259319128092	0.0284875529203928
Drinking water (ukb-b-3975)	Knee osteoarthritis	rs10153636	-1.36852845864713	0.592275282813913	0.0208533546766374
Drinking water (ukb-b-3975)	Knee osteoarthritis	rs2472297	-0.687885202333531	0.314030261068308	0.0284875529203928
Drinking water (ukb-b-3975)	Knee osteoarthritis	All - MR Egger	-1.4151681530475	0.513524701243973	0.0222648040715249
Dairy smoothie (ukb-b-4955)	Knee osteoarthritis	All - Inverse variance weighted	-3.14377393397493	1.27905298620036	0.0139755246598268
Coffee (ukb-b-5237)	Knee osteoarthritis	rs13378244	9.75377611724657	3.59601185240762	0.0066800535049508
Coffee (ukb-b-5237)	Knee osteoarthritis	rs1421085	3.14243417859416	1.42223852102726	0.0271399719848267
Coffee (ukb-b-5237)	Knee osteoarthritis	rs2472297	1.4559379223082	0.664658237000439	0.0284875529203928
Coffee (ukb-b-5237)	Knee osteoarthritis	rs329122	9.51555806113669	3.4661050411633	0.006045242102079
Coffee (ukb-b-5237)	Knee osteoarthritis	rs641727	6.59899386657481	3.17048277127155	0.0373987213909691
Coffee (ukb-b-5237)	Knee osteoarthritis	rs7585210	8.33813141147299	3.84232397872414	0.030001160722457
Coffee (ukb-b-5237)	Knee osteoarthritis	rs8056750	5.53187510087057	2.74466691350289	0.0438523266124737
Coffee (ukb-b-5237)	Knee osteoarthritis	rs9953004	-7.8656036041075	3.45311431397126	0.0227367733165292
Coffee (ukb-b-5237)	Knee osteoarthritis	All - Inverse variance weighted	0.773700778850085	0.328725717678428	0.0185907912905606
Cappuccino (ukb-b-8374)	Knee osteoarthritis	rs11653897	4.15823129329659	1.88870234868757	0.0276911727374648
Cappuccino (ukb-b-8374)	Knee osteoarthritis	All - Inverse variance weighted	1.53399220936178	0.696278912381025	0.0275856632616074