ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Fractured bone site(s): Wrist (ukb-a-439)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Sweets (ukb-b-10217) (👉 📊) Fractured bone site(s): Wrist MR Egger 20 0.016906045 0.007855417 0.045204307
Double crust pastry (ukb-b-1255) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 11 -0.01940349 0.009054275 0.032111504
Homemade soup (ukb-b-12658) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 18 -0.012271919 0.005719302 0.031896739
Red wine (ukb-b-13556) (👉 📊) Fractured bone site(s): Wrist Weighted median 11 0.009674382 0.004400434 0.02791306
Red wine (ukb-b-13556) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 11 0.006616735 0.003243952 0.041378818
Water (ukb-b-14898) (👉 📊) Fractured bone site(s): Wrist MR Egger 159 0.01690788 0.008255242 0.042212211
Espresso (ukb-b-19142) (👉 📊) Fractured bone site(s): Wrist MR Egger 32 0.025171392 0.010776566 0.026379677
Espresso (ukb-b-19142) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 32 0.0167544 0.005788838 0.00380054
Cherry (ukb-b-2221) (👉 📊) Fractured bone site(s): Wrist MR Egger 17 0.041795691 0.016149427 0.020582196
Cabbage/kale (ukb-b-2975) (👉 📊) Fractured bone site(s): Wrist MR Egger 20 -0.016561511 0.007719878 0.045819713
Cabbage/kale (ukb-b-2975) (👉 📊) Fractured bone site(s): Wrist Weighted median 20 -0.010323295 0.005179854 0.046264731
Latte (ukb-b-3000) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 9 0.018711842 0.008283481 0.023887458
Croissant (ukb-b-4007) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 26 0.0255284 0.008716711 0.00340412
Apple (ukb-b-4070) (👉 📊) Fractured bone site(s): Wrist Weighted median 18 0.008128491 0.003863699 0.035394955
Apple (ukb-b-4070) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 18 0.008053479 0.002825903 0.004373598
Other cheese (ukb-b-4088) (👉 📊) Fractured bone site(s): Wrist Weighted median 16 -0.038629126 0.01703873 0.023381894
Other cheese (ukb-b-4088) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 16 -0.026154511 0.01287062 0.042142563
Tofu (ukb-b-5522) (👉 📊) Fractured bone site(s): Wrist MR Egger 49 0.043818752 0.021737955 0.049561022
Tofu (ukb-b-5522) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 49 0.029377178 0.012010324 0.014445346
Tea (ukb-b-6066) (👉 📊) Fractured bone site(s): Wrist MR Egger 141 -0.013268925 0.006049667 0.029945921
Instant coffee (ukb-b-930) (👉 📊) Fractured bone site(s): Wrist Weighted median 20 -0.004955757 0.001981646 0.012390308

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Sweets (ukb-b-10217) Fractured bone site(s): Wrist rs11038176 -0.041229334152706 0.0176858837071721 0.0197428100291765
Sweets (ukb-b-10217) Fractured bone site(s): Wrist All - MR Egger 0.0169060453381568 0.007855417004384 0.0452043070864775
Double crust pastry (ukb-b-1255) Fractured bone site(s): Wrist rs10789657 -0.0653892305517266 0.0311894284805429 0.0360361730102451
Double crust pastry (ukb-b-1255) Fractured bone site(s): Wrist rs4530350 -0.060023940106207 0.030303560546705 0.0476187146674836
Double crust pastry (ukb-b-1255) Fractured bone site(s): Wrist All - Inverse variance weighted -0.0194034904272742 0.0090542747003917 0.0321115043458515
Homemade soup (ukb-b-12658) Fractured bone site(s): Wrist rs2319386 -0.0578385718959668 0.0250596313211217 0.0209970440388487
Homemade soup (ukb-b-12658) Fractured bone site(s): Wrist All - Inverse variance weighted -0.0122719186573274 0.0057193016892476 0.0318967394137061
Red wine (ukb-b-13556) Fractured bone site(s): Wrist All - Inverse variance weighted 0.0066167345349367 0.0032439520800132 0.0413788177885285
Water (ukb-b-14898) Fractured bone site(s): Wrist rs11012726 -0.0667930169674294 0.030411155860176 0.0280681367065701
Water (ukb-b-14898) Fractured bone site(s): Wrist rs11140831 0.0668792298622216 0.0278497359112274 0.0163310715059148
Water (ukb-b-14898) Fractured bone site(s): Wrist rs12620738 -0.0858637247117551 0.0367192460882393 0.0193672986396334
Water (ukb-b-14898) Fractured bone site(s): Wrist rs1721282 0.0891827036183127 0.0383993942305272 0.020205873626542
Water (ukb-b-14898) Fractured bone site(s): Wrist rs1873276 -0.0770658459453354 0.0390330923876214 0.0483394557549191
Water (ukb-b-14898) Fractured bone site(s): Wrist rs1977819 0.121759464382415 0.0377133855166642 0.0012442050359127
Water (ukb-b-14898) Fractured bone site(s): Wrist rs34940743 0.0694775889609515 0.0343205481033852 0.0429317935531172
Water (ukb-b-14898) Fractured bone site(s): Wrist rs6503416 -0.0903249847397236 0.0405036127817236 0.0257442825501678
Water (ukb-b-14898) Fractured bone site(s): Wrist rs9516045 -0.10605414483171 0.041015061724053 0.0097171165978471
Water (ukb-b-14898) Fractured bone site(s): Wrist rs953855 0.116369101406816 0.0390568909265583 0.0028874106980686
Water (ukb-b-14898) Fractured bone site(s): Wrist All - MR Egger 0.016907879937587 0.0082552420351029 0.0422122105855335
Espresso (ukb-b-19142) Fractured bone site(s): Wrist rs139165502 0.0616936421580182 0.0276099203153847 0.0254519179214327
Espresso (ukb-b-19142) Fractured bone site(s): Wrist rs73051368 0.0642913831666055 0.0309591163895189 0.0378334744010136
Espresso (ukb-b-19142) Fractured bone site(s): Wrist rs73269888 0.0785155539000097 0.0301335912598469 0.0091718219457156
Espresso (ukb-b-19142) Fractured bone site(s): Wrist rs76762868 0.0621830317878296 0.0313687924982529 0.0474432692353334
Espresso (ukb-b-19142) Fractured bone site(s): Wrist All - Inverse variance weighted 0.0167543995838085 0.0057888381929555 0.0038005399992488
Espresso (ukb-b-19142) Fractured bone site(s): Wrist All - MR Egger 0.0251713921658736 0.010776566481128 0.0263796774150264
Cherry (ukb-b-2221) Fractured bone site(s): Wrist rs118161273 0.067185322336307 0.033507658643326 0.044955177432658
Cherry (ukb-b-2221) Fractured bone site(s): Wrist rs4488206 -0.0833509081341522 0.0383238573296169 0.0296369247872312
Cherry (ukb-b-2221) Fractured bone site(s): Wrist All - MR Egger 0.0417956908043332 0.0161494269302546 0.020582196072798
Cabbage/kale (ukb-b-2975) Fractured bone site(s): Wrist rs10962528 0.0342666607256903 0.0162291880170506 0.0347360763615174
Cabbage/kale (ukb-b-2975) Fractured bone site(s): Wrist rs138929729 -0.0394243761823259 0.016983244752725 0.0202669425631625
Cabbage/kale (ukb-b-2975) Fractured bone site(s): Wrist rs2314759 0.034684317440653 0.0158889987064804 0.0290421451512578
Cabbage/kale (ukb-b-2975) Fractured bone site(s): Wrist All - MR Egger -0.0165615105995857 0.0077198776089755 0.0458197130911906
Latte (ukb-b-3000) Fractured bone site(s): Wrist All - Inverse variance weighted 0.0187118415578719 0.0082834811602732 0.0238874581682432
Croissant (ukb-b-4007) Fractured bone site(s): Wrist rs10147965 0.0875789520670748 0.0428120699018725 0.0407898035544377
Croissant (ukb-b-4007) Fractured bone site(s): Wrist rs117892082 0.105166501644377 0.0422873438246141 0.0128843575153162
Croissant (ukb-b-4007) Fractured bone site(s): Wrist rs139115181 0.108033035217264 0.0386550058090932 0.0051931728149942
Croissant (ukb-b-4007) Fractured bone site(s): Wrist rs1689216 0.088603282227732 0.0438349440874361 0.0432494042102934
Croissant (ukb-b-4007) Fractured bone site(s): Wrist rs6446355 0.0828332827947185 0.0392148306709873 0.0346611718488485
Croissant (ukb-b-4007) Fractured bone site(s): Wrist All - Inverse variance weighted 0.0255283997056357 0.0087167113069874 0.0034041200483273
Apple (ukb-b-4070) Fractured bone site(s): Wrist All - Inverse variance weighted 0.0080534787027348 0.0028259028416172 0.0043735983839868
Other cheese (ukb-b-4088) Fractured bone site(s): Wrist rs78178165 -0.104880237975146 0.049995432719994 0.035923136095018
Other cheese (ukb-b-4088) Fractured bone site(s): Wrist All - Inverse variance weighted -0.0261545105801273 0.0128706201171826 0.0421425626717632
Tofu (ukb-b-5522) Fractured bone site(s): Wrist rs139598224 0.175669145283848 0.0874355261231065 0.0445235832739653
Tofu (ukb-b-5522) Fractured bone site(s): Wrist rs146906987 0.147625740508802 0.0727569278600454 0.0424555830969867
Tofu (ukb-b-5522) Fractured bone site(s): Wrist rs72767206 0.194194111085952 0.0817322900680135 0.0175025132877715
Tofu (ukb-b-5522) Fractured bone site(s): Wrist rs9917110 0.180598284277474 0.0883649924989963 0.0409756438436046
Tofu (ukb-b-5522) Fractured bone site(s): Wrist All - Inverse variance weighted 0.0293771782399387 0.0120103237270208 0.0144453455612647
Tofu (ukb-b-5522) Fractured bone site(s): Wrist All - MR Egger 0.0438187522439083 0.0217379545746291 0.0495610215954304
Tea (ukb-b-6066) Fractured bone site(s): Wrist rs111285082 -0.079704013439745 0.0311180208414628 0.0104267502198569
Tea (ukb-b-6066) Fractured bone site(s): Wrist rs11657857 0.073979101784207 0.0350109875716739 0.0345986042793882
Tea (ukb-b-6066) Fractured bone site(s): Wrist rs2318540 -0.075218425138051 0.0338942165975593 0.0264723593672172
Tea (ukb-b-6066) Fractured bone site(s): Wrist rs2403304 -0.0661836495031617 0.0318324299909666 0.0376057228239157
Tea (ukb-b-6066) Fractured bone site(s): Wrist rs34940743 -0.0607049772994787 0.0299870522952749 0.0429317935531172
Tea (ukb-b-6066) Fractured bone site(s): Wrist rs35596618 -0.0810875723947445 0.0326318116563044 0.0129579090256556
Tea (ukb-b-6066) Fractured bone site(s): Wrist rs4808193 -0.0607244507075799 0.0238921858563404 0.011034543578718
Tea (ukb-b-6066) Fractured bone site(s): Wrist rs6829 0.0617088357963462 0.0292279482725343 0.0347469202058464
Tea (ukb-b-6066) Fractured bone site(s): Wrist rs7172571 -0.0837418885317484 0.0339206224062795 0.0135581974899674
Tea (ukb-b-6066) Fractured bone site(s): Wrist rs75396527 0.062691468457282 0.0313073983436004 0.045236463148558
Tea (ukb-b-6066) Fractured bone site(s): Wrist rs9478663 0.0776775829877233 0.0343360155978916 0.0236802862086873
Tea (ukb-b-6066) Fractured bone site(s): Wrist All - MR Egger -0.0132689248063085 0.0060496671506035 0.0299459205906049
Instant coffee (ukb-b-930) Fractured bone site(s): Wrist rs143523613 0.0185891613898849 0.0067887670912868 0.0061772085214162