ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Operative procedures - secondary OPCS: Z84.6 Knee joint (ukb-b-10001)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Other fish (ukb-b-1252) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint Weighted median 3 0.077960876 0.033793308 0.021055292
Other fish (ukb-b-1252) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint Inverse variance weighted 3 0.077164341 0.024769595 0.001837674
Homemade soup (ukb-b-12658) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint Inverse variance weighted 10 0.012953 0.006366041 0.041880805
Fried potatoes (ukb-b-12836) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint MR Egger 11 -0.046923066 0.014418133 0.009926483
Cheese (ukb-b-1489) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint Inverse variance weighted 187 -0.00460536 0.001502192 0.002171172
Broad bean (ukb-b-15212) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint Inverse variance weighted 6 -0.018743907 0.009094922 0.039310667
Cereal (ukb-b-15926) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint Inverse variance weighted 161 -0.006881492 0.002327852 0.003115002
Pea (ukb-b-15945) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint Inverse variance weighted 6 -0.008957552 0.004149759 0.0308834
Dried fruit (ukb-b-16576) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint Weighted median 149 -0.007917339 0.003406047 0.020098988
Dried fruit (ukb-b-16576) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint Inverse variance weighted 149 -0.007383855 0.002611744 0.004696077
Oily fish (ukb-b-2209) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint MR Egger 160 -0.016955508 0.008094741 0.0377993
Parsnip (ukb-b-2468) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint Inverse variance weighted 6 0.017034479 0.008293939 0.039990535
Fizzy drink (ukb-b-2832) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint Inverse variance weighted 9 -0.013171463 0.005695543 0.020745134
Other vegetables (ukb-b-3055) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint MR Egger 7 0.096618122 0.036671935 0.046272688
Pizza (ukb-b-3852) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint Inverse variance weighted 5 0.015990438 0.006747273 0.017792358
Whole egg (ukb-b-4075) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint Weighted median 3 -0.018614322 0.009458465 0.049067258
Seeds (ukb-b-4548) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint Inverse variance weighted 6 -0.029754894 0.013508565 0.027618101
Olives (ukb-b-5232) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint MR Egger 8 -0.230010486 0.079272566 0.027280538
Coffee (ukb-b-5237) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint Weighted median 108 0.007805111 0.00378457 0.039174338
Fresh tomato (ukb-b-730) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint Weighted median 9 0.007168562 0.003171953 0.023822276
Fresh tomato (ukb-b-730) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint Inverse variance weighted 9 0.004705791 0.002313014 0.041902755
Cooked vegetable (ukb-b-8089) (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint Weighted median 80 0.010668242 0.005005972 0.033080644

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Other fish (ukb-b-1252) Operative procedures - secondary OPCS: Z84.6 Knee joint rs61373860 0.10700233706664 0.0431618302749667 0.0131715710499895
Other fish (ukb-b-1252) Operative procedures - secondary OPCS: Z84.6 Knee joint All - Inverse variance weighted 0.0771643405884033 0.0247695945388102 0.0018376740476386
Homemade soup (ukb-b-12658) Operative procedures - secondary OPCS: Z84.6 Knee joint rs1896796 0.0413295516636471 0.0180773876283323 0.0222392354652172
Homemade soup (ukb-b-12658) Operative procedures - secondary OPCS: Z84.6 Knee joint rs71371995 0.0347532782157277 0.0177167083253221 0.0498078676912186
Homemade soup (ukb-b-12658) Operative procedures - secondary OPCS: Z84.6 Knee joint All - Inverse variance weighted 0.0129529997564093 0.0063660407453655 0.0418808048532424
Fried potatoes (ukb-b-12836) Operative procedures - secondary OPCS: Z84.6 Knee joint rs2906294 -0.0206357485938552 0.0069648720493776 0.0030482248848991
Fried potatoes (ukb-b-12836) Operative procedures - secondary OPCS: Z84.6 Knee joint rs4669886 0.0181404143715227 0.0087087912087912 0.0372511996579162
Fried potatoes (ukb-b-12836) Operative procedures - secondary OPCS: Z84.6 Knee joint All - MR Egger -0.046923066114091 0.0144181332157971 0.0099264829057559
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z84.6 Knee joint rs11669334 0.0484888858160196 0.022530507830055 0.0313860545404698
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z84.6 Knee joint rs11756671 -0.0706596167651444 0.0241616507445653 0.0034506196547482
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z84.6 Knee joint rs17481439 -0.0604590146373562 0.0233242790356025 0.0095390244638059
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z84.6 Knee joint rs2900884 -0.059497678306936 0.0227293296622414 0.0088534728972915
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z84.6 Knee joint rs35392738 -0.0561400964932722 0.0235443584233103 0.017105163734152
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z84.6 Knee joint rs59784053 0.0556005952573518 0.0232709229724046 0.0168817382548746
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z84.6 Knee joint rs71386942 -0.0396065138287422 0.0193336746129474 0.040503532585206
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z84.6 Knee joint rs79398870 -0.0477509737605591 0.0230187913080182 0.0380389803452971
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z84.6 Knee joint All - Inverse variance weighted -0.0046053599515904 0.0015021917419134 0.0021711722697346
Broad bean (ukb-b-15212) Operative procedures - secondary OPCS: Z84.6 Knee joint rs7844716 -0.0585328265091104 0.0236347560219807 0.0132656346028008
Broad bean (ukb-b-15212) Operative procedures - secondary OPCS: Z84.6 Knee joint All - Inverse variance weighted -0.0187439071295328 0.0090949219689986 0.0393106671835862
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z84.6 Knee joint rs11643192 0.0603733309908644 0.0278732211876318 0.0303113681590785
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z84.6 Knee joint rs11678980 -0.0769681623600664 0.0288055104729965 0.0075401909202146
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z84.6 Knee joint rs12414768 0.0797832930306197 0.0277592103554266 0.0040515539180793
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z84.6 Knee joint rs1376619 -0.0554077568956723 0.0270693883156119 0.0406699867525263
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z84.6 Knee joint rs149604870 0.0640270346381301 0.0302366217692028 0.0342146650361783
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z84.6 Knee joint rs2799849 -0.0476671073656206 0.0214862639813771 0.0265212961729739
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z84.6 Knee joint rs3115230 -0.0739068122217479 0.0250702654666794 0.0031985069903977
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z84.6 Knee joint rs529565 -0.0580246693239733 0.0263254803974062 0.0275155014266712
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z84.6 Knee joint rs6087577 -0.0559711619646866 0.0270005868839083 0.0381759148456786
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z84.6 Knee joint rs62442924 -0.0812220659969052 0.0246313300709298 0.0009754607728021
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z84.6 Knee joint rs72702504 0.0574339822255195 0.0276746774012998 0.0379563157083712
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z84.6 Knee joint rs7306606 -0.0682973589671792 0.0296620216739847 0.021305939263976
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z84.6 Knee joint rs7330712 -0.0759473738261237 0.0300470121067586 0.0114839169598115
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z84.6 Knee joint rs7999064 -0.0798228908163513 0.0279567371816117 0.0043005787845321
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z84.6 Knee joint rs9374896 -0.0405080306963741 0.0142043762302799 0.0043472534033504
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z84.6 Knee joint All - Inverse variance weighted -0.0068814920003543 0.0023278519754905 0.0031150018201601
Pea (ukb-b-15945) Operative procedures - secondary OPCS: Z84.6 Knee joint rs61995486 -0.0210309654916716 0.0104158026996965 0.0434726541579506
Pea (ukb-b-15945) Operative procedures - secondary OPCS: Z84.6 Knee joint All - Inverse variance weighted -0.0089575519361705 0.0041497585597576 0.0308834000319061
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z84.6 Knee joint rs10740991 -0.0360628472429655 0.0164464424398112 0.0283257880877183
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z84.6 Knee joint rs11632215 -0.0722549033471443 0.0271009799623853 0.0076728603966015
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z84.6 Knee joint rs11772627 -0.0613969826222605 0.0175434988927555 0.0004657820877585
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z84.6 Knee joint rs12644768 -0.0630911290941884 0.0284337634466627 0.026494841499735
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z84.6 Knee joint rs17175518 0.0633778117986813 0.0254445816878621 0.0127449531616548
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z84.6 Knee joint rs17184650 0.0651843977498345 0.0316668596955659 0.0395477121649245
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z84.6 Knee joint rs17592481 0.0696422582980832 0.031837582409207 0.028711662617829
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z84.6 Knee joint rs2508819 -0.0743285607222105 0.0304507447918453 0.0146489289096315
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z84.6 Knee joint rs2521754 0.0619988924763478 0.0304316526505481 0.0416183867080619
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z84.6 Knee joint rs3757323 -0.0702711148079042 0.0289126183036216 0.0150794509464674
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z84.6 Knee joint rs3819391 -0.0818453162682968 0.031290271094293 0.008905013759348
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z84.6 Knee joint rs4740634 0.0609703300717378 0.0285023246162924 0.0324247084117398
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z84.6 Knee joint rs6712271 -0.063344547358395 0.0309468015606015 0.0406693662784328
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z84.6 Knee joint rs7045666 -0.092711953158471 0.0303074799242743 0.0022204359280256
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z84.6 Knee joint rs7941325 -0.0646397963647573 0.0308938961559995 0.0364102482948085
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z84.6 Knee joint rs9385269 -0.0437195561558924 0.020663860184134 0.0343661004504921
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z84.6 Knee joint rs954212 -0.0661773524606352 0.0295639801066485 0.0251920304224245
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z84.6 Knee joint All - Inverse variance weighted -0.0073838550445947 0.0026117438915776 0.0046960768600052
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z84.6 Knee joint rs10819087 -0.05404953145917 0.026729005574537 0.0431628948314797
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z84.6 Knee joint rs10828250 -0.035023031638721 0.013322909531326 0.008569114416235
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z84.6 Knee joint rs12576625 -0.0606682905414017 0.0238954583433645 0.0111200121918029
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z84.6 Knee joint rs13070166 0.044129129868759 0.0207606347419162 0.0335352764133519
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z84.6 Knee joint rs13160801 0.0575715430362347 0.0256789130503047 0.02496283217778
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z84.6 Knee joint rs16891727 -0.0336869711139126 0.015508552828526 0.0298440195938296
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z84.6 Knee joint rs1821849 -0.0661462688613197 0.0276862142234669 0.0168878207662805
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z84.6 Knee joint rs6059844 -0.0473857510386269 0.0225264315778947 0.0354166500385311
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z84.6 Knee joint rs7147583 -0.0720989681967744 0.027885278229343 0.0097221878379388
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z84.6 Knee joint rs7919624 0.0798978656410052 0.0254276689451763 0.001677049807731
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z84.6 Knee joint rs7965154 0.0507395811458353 0.0255479085928104 0.0470270887978824
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z84.6 Knee joint All - MR Egger -0.0169555082134524 0.0080947407658054 0.0377993003776934
Parsnip (ukb-b-2468) Operative procedures - secondary OPCS: Z84.6 Knee joint All - Inverse variance weighted 0.0170344787573037 0.0082939389222765 0.0399905352243542
Fizzy drink (ukb-b-2832) Operative procedures - secondary OPCS: Z84.6 Knee joint rs6819167 -0.0401910067022654 0.0132107466816188 0.0023478060687955
Fizzy drink (ukb-b-2832) Operative procedures - secondary OPCS: Z84.6 Knee joint rs7829588 -0.0283830620855937 0.0137215989469929 0.0385934778966192
Fizzy drink (ukb-b-2832) Operative procedures - secondary OPCS: Z84.6 Knee joint All - Inverse variance weighted -0.01317146286692 0.0056955434824209 0.020745134221715
Other vegetables (ukb-b-3055) Operative procedures - secondary OPCS: Z84.6 Knee joint rs116068692 0.0350164873735936 0.0174062648225093 0.0442497258915709
Other vegetables (ukb-b-3055) Operative procedures - secondary OPCS: Z84.6 Knee joint All - MR Egger 0.0966181216780658 0.0366719353308799 0.0462726881355706
Pizza (ukb-b-3852) Operative procedures - secondary OPCS: Z84.6 Knee joint All - Inverse variance weighted 0.0159904377439032 0.0067472729684893 0.0177923582197124
Whole egg (ukb-b-4075) Operative procedures - secondary OPCS: Z84.6 Knee joint rs2184358 -0.0287136354900145 0.0114499065224608 0.0121498621393392
Seeds (ukb-b-4548) Operative procedures - secondary OPCS: Z84.6 Knee joint All - Inverse variance weighted -0.0297548935010901 0.0135085645192557 0.0276181013593829
Olives (ukb-b-5232) Operative procedures - secondary OPCS: Z84.6 Knee joint rs2308655 0.0556889276722238 0.0279244363299262 0.0461223132637685
Olives (ukb-b-5232) Operative procedures - secondary OPCS: Z84.6 Knee joint rs62171682 -0.071572708319992 0.0293499405867327 0.0147443575610133
Olives (ukb-b-5232) Operative procedures - secondary OPCS: Z84.6 Knee joint All - MR Egger -0.230010486156316 0.0792725657044875 0.0272805376494523
Coffee (ukb-b-5237) Operative procedures - secondary OPCS: Z84.6 Knee joint rs12930957 -0.0718654701234011 0.0312915222217776 0.0216391168022065
Coffee (ukb-b-5237) Operative procedures - secondary OPCS: Z84.6 Knee joint rs1338549 -0.07545658174985 0.0263269994000768 0.0041552462183738
Coffee (ukb-b-5237) Operative procedures - secondary OPCS: Z84.6 Knee joint rs2577374 -0.0693545631122131 0.0292411609425073 0.0177010510953606
Coffee (ukb-b-5237) Operative procedures - secondary OPCS: Z84.6 Knee joint rs2595223 -0.0641513992835958 0.0309652127164767 0.0382911126816425
Coffee (ukb-b-5237) Operative procedures - secondary OPCS: Z84.6 Knee joint rs476828 0.0404997088682759 0.0167685531618058 0.0157258010622464
Coffee (ukb-b-5237) Operative procedures - secondary OPCS: Z84.6 Knee joint rs75347775 0.0559786228278343 0.0275787529663936 0.0423795645112283
Coffee (ukb-b-5237) Operative procedures - secondary OPCS: Z84.6 Knee joint rs8068193 0.0679882611923841 0.0330215946562067 0.0395035290682727
Fresh tomato (ukb-b-730) Operative procedures - secondary OPCS: Z84.6 Knee joint rs9953073 0.0144353579341432 0.0060516158606463 0.0170618364134469
Fresh tomato (ukb-b-730) Operative procedures - secondary OPCS: Z84.6 Knee joint All - Inverse variance weighted 0.0047057907489844 0.0023130136438316 0.0419027549169987
Cooked vegetable (ukb-b-8089) Operative procedures - secondary OPCS: Z84.6 Knee joint rs13115533 0.067290623003732 0.0341673430963348 0.0489022812555653
Cooked vegetable (ukb-b-8089) Operative procedures - secondary OPCS: Z84.6 Knee joint rs1534749 0.110330073183154 0.0337896726504177 0.0010938642117164
Cooked vegetable (ukb-b-8089) Operative procedures - secondary OPCS: Z84.6 Knee joint rs2844793 -0.0700803619006354 0.0336389556546461 0.0372230050731766
Cooked vegetable (ukb-b-8089) Operative procedures - secondary OPCS: Z84.6 Knee joint rs28711392 0.0584319892798318 0.0240918100520189 0.0152920294435606
Cooked vegetable (ukb-b-8089) Operative procedures - secondary OPCS: Z84.6 Knee joint rs34903 0.075567318601656 0.032437848705509 0.0198271288687367
Cooked vegetable (ukb-b-8089) Operative procedures - secondary OPCS: Z84.6 Knee joint rs60123882 0.0676258209398342 0.0316553783694103 0.0326538466415299