ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC (ukb-b-10298)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Homemade soup (ukb-b-12658) (👉 📊) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC Weighted median 3 0.012984931 0.005910873 0.028035635
Homemade soup (ukb-b-12658) (👉 📊) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC Inverse variance weighted 3 0.011065421 0.004655404 0.017458913
Water (ukb-b-14898) (👉 📊) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC MR Egger 96 -0.008308585 0.003841978 0.033111245
Cereal (ukb-b-15926) (👉 📊) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC Inverse variance weighted 102 -0.003060584 0.001347883 0.023167561
Carrot (ukb-b-16710) (👉 📊) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC Wald ratio 1 0.006923714 0.003198575 0.030416468
Other savoury snack (ukb-b-18718) (👉 📊) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC Inverse variance weighted 2 -0.02812508 0.011057523 0.010974037
Cabbage/kale (ukb-b-2975) (👉 📊) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC Wald ratio 1 0.014225899 0.005687073 0.012368779
Standard tea (ukb-b-3291) (👉 📊) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC Weighted median 7 2.12e-05 1.01e-05 0.036773878
Standard tea (ukb-b-3291) (👉 📊) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC Weighted mode 7 2.68e-05 1.08e-05 0.047665683
Coffee (ukb-b-5237) (👉 📊) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC Inverse variance weighted 71 0.003102091 0.001342938 0.020892087
Coffee (ukb-b-5237) (👉 📊) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC Weighted mode 71 0.004260871 0.002006504 0.037245688
Tea (ukb-b-6066) (👉 📊) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC MR Egger 85 0.005001868 0.002398187 0.040078158
Instant coffee (ukb-b-930) (👉 📊) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC Weighted median 4 0.002350397 0.001182842 0.046913982
Instant coffee (ukb-b-930) (👉 📊) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC Inverse variance weighted 4 0.002373345 0.000951256 0.012597168

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Homemade soup (ukb-b-12658) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC All - Inverse variance weighted 0.0110654208754654 0.0046554041025464 0.0174589134116787
Water (ukb-b-14898) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs11140831 -0.0183833244496132 0.0092830837815574 0.0476694218953973
Water (ukb-b-14898) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs13409451 0.0339669854389393 0.0129612680011433 0.0087761548335477
Water (ukb-b-14898) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs1963510 0.0211706045029609 0.0085631406498932 0.0134248917554735
Water (ukb-b-14898) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs2472297 -0.0084696292794154 0.0038497308393205 0.0278028143545181
Water (ukb-b-14898) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs2478807 0.0323346140514688 0.0132156337183767 0.014417311410173
Water (ukb-b-14898) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs4974310 0.0324345256942657 0.0130431514229286 0.0128930711157935
Water (ukb-b-14898) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs6541139 -0.0286594934092005 0.0117833059331962 0.0150069371993749
Water (ukb-b-14898) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs7624543 0.0242144830307814 0.0115690607734807 0.0363457686327677
Water (ukb-b-14898) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC All - MR Egger -0.0083085854968379 0.0038419783406538 0.0331112452821843
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs10260232 -0.032003835271336 0.0134100544270123 0.0170070534933063
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs10812904 0.0296884417190927 0.0127642932243646 0.0200240026435885
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs2339515 -0.0328433283854006 0.0133409490454138 0.0138224974885694
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs2472297 -0.0178556378455444 0.0081159868279943 0.0278028143545181
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs4797242 -0.0228731016866121 0.0108560781020365 0.0351228088121683
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs56393452 0.0452149305180863 0.0122798277046209 0.0002313666902551
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs62097852 -0.0252300747797762 0.0128186240170925 0.0490409121647198
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs67723420 -0.0304722000532056 0.0111764146999582 0.0064015065837739
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs9354833 -0.0382097669720713 0.0136283386823971 0.0050519959400428
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC All - Inverse variance weighted -0.0030605837817269 0.0013478828271186 0.0231675609841139
Carrot (ukb-b-16710) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs28656094 0.0069237137425645 0.0031985752539809 0.0304164679899843
Other savoury snack (ukb-b-18718) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs10493299 -0.0377707734451622 0.0160641212080219 0.0187104315762253
Other savoury snack (ukb-b-18718) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC All - Inverse variance weighted -0.0281250801752403 0.0110575228748849 0.0109740365400556
Cabbage/kale (ukb-b-2975) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs72652073 0.0142258990537784 0.0056870734002359 0.0123687791988029
Standard tea (ukb-b-3291) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs2472297 2.77290227773696e-05 1.26037717364683e-05 0.0278028143545181
Standard tea (ukb-b-3291) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs4791937 -7.07532101718386e-05 2.54095329514698e-05 0.005360794213561
Coffee (ukb-b-5237) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs11032480 0.0346263634086179 0.0147861182841286 0.0191901903555175
Coffee (ukb-b-5237) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs2189234 -0.0277853265631243 0.0116868214228854 0.0174308124856679
Coffee (ukb-b-5237) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs2472297 0.0060907924976544 0.0027684696626698 0.0278028143545181
Coffee (ukb-b-5237) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs4840338 0.045682495030937 0.0151019896062389 0.0024868884810295
Coffee (ukb-b-5237) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs6063085 0.033605940099514 0.0112723570207289 0.002870555594917
Coffee (ukb-b-5237) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC All - Inverse variance weighted 0.0031020913679733 0.0013429379865076 0.0208920865590422
Tea (ukb-b-6066) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs1428831 0.0201147483640893 0.00996911605368 0.0436218573062466
Tea (ukb-b-6066) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs1950709 0.0244751667049896 0.0109322066375412 0.0251680838824839
Tea (ukb-b-6066) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs2318540 -0.0263794289307682 0.0112920785269322 0.0194860105469376
Tea (ukb-b-6066) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs2472297 0.005305884492167 0.0024117026242236 0.0278028143545181
Tea (ukb-b-6066) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs901746 -0.0225723778262293 0.0098611943040148 0.0220787392458702
Tea (ukb-b-6066) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC All - MR Egger 0.005001867667045 0.0023981868077688 0.0400781582176771
Instant coffee (ukb-b-930) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC rs2472297 0.0038710312711557 0.001759513666172 0.0278028143545181
Instant coffee (ukb-b-930) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC All - Inverse variance weighted 0.0023733448329229 0.000951256037306 0.0125971676766826