ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis (ukb-b-14753)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Cheese (ukb-b-1489) (👉 📊) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis Inverse variance weighted 86 -0.002678107 0.00101709 0.008460763
Mashed potato (ukb-b-15710) (👉 📊) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis Inverse variance weighted 2 -0.007282604 0.00333533 0.02900096
Cereal (ukb-b-15926) (👉 📊) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis MR Egger 81 -0.019268402 0.005925887 0.001688518
Cereal (ukb-b-15926) (👉 📊) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis Weighted median 81 -0.003707731 0.001773541 0.036565627
Cereal (ukb-b-15926) (👉 📊) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis Inverse variance weighted 81 -0.002854196 0.001262065 0.023726587
Non-oily fish (ukb-b-17627) (👉 📊) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis MR Egger 30 0.02984963 0.011979055 0.018902387
Fizzy drink (ukb-b-2832) (👉 📊) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis Inverse variance weighted 3 -0.007577842 0.003411582 0.026336718
Other vegetables (ukb-b-3055) (👉 📊) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis Inverse variance weighted 2 0.010353565 0.004977407 0.03751525
Whole egg (ukb-b-4075) (👉 📊) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis Inverse variance weighted 2 -0.00807404 0.003475932 0.02018767
Beer/cider (ukb-b-4961) (👉 📊) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis Wald ratio 1 -0.012119296 0.003779109 0.001341648
Coffee (ukb-b-5237) (👉 📊) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis MR Egger 59 0.009956974 0.003295621 0.003764831
Coffee (ukb-b-5237) (👉 📊) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis Weighted median 59 0.005801656 0.002274573 0.010752021
Coffee (ukb-b-5237) (👉 📊) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis Weighted mode 59 0.005625557 0.002636758 0.037124012
Doughnut (ukb-b-6214) (👉 📊) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis Inverse variance weighted 2 -0.027045396 0.012619731 0.032104756

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Cheese (ukb-b-1489) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs1931805 0.0162677366001124 0.0082982360342821 0.0499508196790149
Cheese (ukb-b-1489) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs2870681 0.0241142821108769 0.0097713637100697 0.0135926403699645
Cheese (ukb-b-1489) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs531358 -0.0220063645891878 0.0083268269712758 0.008221698977954
Cheese (ukb-b-1489) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs62098037 -0.0194576565066618 0.0095683518890308 0.0419976780452581
Cheese (ukb-b-1489) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs67967503 -0.0318103520909202 0.0100796674748874 0.0016000754342014
Cheese (ukb-b-1489) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs7936836 -0.0228977733620912 0.0066994699080042 0.0006311822366327
Cheese (ukb-b-1489) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs8059277 -0.0184598654077429 0.0089601937855564 0.0393786339086564
Cheese (ukb-b-1489) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs9649582 -0.0271932597184024 0.0077340831657156 0.0004380533429563
Cheese (ukb-b-1489) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis All - Inverse variance weighted -0.0026781069409521 0.0010170899651692 0.0084607630752392
Mashed potato (ukb-b-15710) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis All - Inverse variance weighted -0.0072826040173549 0.0033353297314922 0.0290009598436288
Cereal (ukb-b-15926) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs10124390 0.0311742758589708 0.0127215949861042 0.0142657733820551
Cereal (ukb-b-15926) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs10931025 0.0300448782704103 0.0127464438139521 0.018417369601967
Cereal (ukb-b-15926) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs11643192 -0.024807405130007 0.0117939652143359 0.0354309762073191
Cereal (ukb-b-15926) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs4410790 -0.0208637292359565 0.0099474084458004 0.0359578720082992
Cereal (ukb-b-15926) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs491711 -0.027996235616204 0.0097263977413697 0.0039972763813976
Cereal (ukb-b-15926) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs838133 -0.0126299300292957 0.0052456722271989 0.016053995128787
Cereal (ukb-b-15926) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs9354833 0.0267551204585253 0.0125836276812556 0.0334878583299201
Cereal (ukb-b-15926) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis All - Inverse variance weighted -0.002854195576451 0.0012620651629056 0.0237265870820142
Cereal (ukb-b-15926) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis All - MR Egger -0.019268401785991 0.0059258867056395 0.001688518159188
Non-oily fish (ukb-b-17627) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs510161 0.0305089203477631 0.0120531973230971 0.0113676580241034
Non-oily fish (ukb-b-17627) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs56094641 0.0178194240317776 0.0084776961271102 0.0355604393991657
Non-oily fish (ukb-b-17627) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs7148387 0.0251387475594936 0.0114597693862442 0.0282604274648368
Non-oily fish (ukb-b-17627) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs838133 0.0161163494809689 0.0066937098368759 0.016053995128787
Non-oily fish (ukb-b-17627) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis All - MR Egger 0.0298496300222135 0.0119790554294954 0.0189023874385044
Fizzy drink (ukb-b-2832) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs2212808 -0.0120313677291795 0.0060308867929569 0.0460474269182132
Fizzy drink (ukb-b-2832) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis All - Inverse variance weighted -0.0075778415461926 0.0034115821538549 0.0263367183815261
Other vegetables (ukb-b-3055) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis All - Inverse variance weighted 0.0103535645427105 0.00497740694524 0.0375152496332157
Whole egg (ukb-b-4075) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis All - Inverse variance weighted -0.0080740397234611 0.0034759323144752 0.0201876704125985
Beer/cider (ukb-b-4961) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs281392 -0.012119296224608 0.0037791090959017 0.0013416483293674
Coffee (ukb-b-5237) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs12604773 0.0252973455844819 0.0128425913035408 0.0488612141483013
Coffee (ukb-b-5237) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs1421085 0.012317204706999 0.0057566900003235 0.0323844261364643
Coffee (ukb-b-5237) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs4410790 0.0058280354217854 0.0027786906224406 0.0359578720082992
Coffee (ukb-b-5237) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs4840338 0.0308540185027437 0.0139442804598612 0.02692076405927
Coffee (ukb-b-5237) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs9953004 -0.0286313747524337 0.0140249002743251 0.0412044048010028
Coffee (ukb-b-5237) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis All - MR Egger 0.0099569743123553 0.0032956211297182 0.0037648314621753
Doughnut (ukb-b-6214) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis rs10922656 -0.0371008583291441 0.0175032738150651 0.0340353604328625
Doughnut (ukb-b-6214) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis All - Inverse variance weighted -0.0270453956215876 0.0126197313993503 0.0321047561085349