ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) (ukb-b-15026)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Tinned tomato (ukb-b-10565) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Inverse variance weighted 2 -0.019145499 0.00585884 0.001083881
Salted peanuts (ukb-b-1099) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Weighted median 6 0.019901703 0.008876149 0.024951354
Sponge pudding (ukb-b-12067) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Inverse variance weighted 6 0.017683733 0.008916467 0.047337624
Unsalted nuts (ukb-b-12217) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Wald ratio 1 -0.029802391 0.013672073 0.029272249
Vegetable pieces (ukb-b-12566) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Inverse variance weighted 5 0.006447827 0.002881805 0.025258448
Crisp (ukb-b-12602) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Weighted median 5 -0.009915512 0.004522125 0.028331424
Crisp (ukb-b-12602) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Inverse variance weighted 5 -0.009748251 0.003745922 0.009258365
Homemade soup (ukb-b-12658) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Inverse variance weighted 6 -0.010155705 0.004705283 0.030899668
Mixed vegetable (ukb-b-13155) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Weighted median 4 0.010198279 0.003922265 0.009319675
Mixed vegetable (ukb-b-13155) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Inverse variance weighted 4 0.007939444 0.00320135 0.013137137
Battered fish (ukb-b-14166) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Inverse variance weighted 4 -0.020454038 0.010282777 0.046684098
Cheese (ukb-b-1489) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Weighted median 162 -0.004569739 0.001564816 0.003496894
Cheese (ukb-b-1489) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Inverse variance weighted 162 -0.005501715 0.001049075 1.57e-07
Cereal (ukb-b-15926) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) MR Egger 140 -0.015983539 0.006383483 0.013448518
Cereal (ukb-b-15926) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Weighted median 140 -0.007308483 0.002136048 0.000622774
Cereal (ukb-b-15926) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Inverse variance weighted 140 -0.005326905 0.001436859 0.000209458
Dried fruit (ukb-b-16576) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Inverse variance weighted 127 -0.003598614 0.001732586 0.03779974
Oily fish (ukb-b-2209) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Weighted median 148 -0.005070014 0.001848486 0.006091913
Oily fish (ukb-b-2209) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Inverse variance weighted 148 -0.004934891 0.001221776 5.37e-05
Fizzy drink (ukb-b-2832) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Inverse variance weighted 5 -0.007924201 0.004007939 0.048027396
Fresh fruit (ukb-b-3881) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Inverse variance weighted 119 -0.004933371 0.002094962 0.018529016
Baked bean (ukb-b-4058) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Weighted median 4 -0.011918752 0.005474818 0.029479575
Filtered coffee (ukb-b-748) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) MR Egger 14 0.017528922 0.007739971 0.042843892
Poultry (ukb-b-8006) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Inverse variance weighted 62 0.005331371 0.002574504 0.038374266
Cauliflower (ukb-b-905) (👉 📊) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) Inverse variance weighted 6 0.008029889 0.003362469 0.016936061

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Tinned tomato (ukb-b-10565) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs10900329 -0.0168997373513298 0.0080610093967723 0.0360397161376417
Tinned tomato (ukb-b-10565) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs58393161 -0.0216602884313515 0.0085301843528574 0.0111089745949112
Tinned tomato (ukb-b-10565) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) All - Inverse variance weighted -0.0191454989617188 0.0058588398827387 0.0010838810537613
Salted peanuts (ukb-b-1099) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs28639739 0.0340013957672936 0.0137887514609311 0.0136677410289292
Salted peanuts (ukb-b-1099) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs6975809 0.0336907018896227 0.0155189344222449 0.0299355795767617
Sponge pudding (ukb-b-12067) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) All - Inverse variance weighted 0.0176837332804475 0.0089164666663388 0.0473376236630615
Unsalted nuts (ukb-b-12217) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs2664108 -0.0298023912839884 0.0136720725501826 0.0292722490558248
Vegetable pieces (ukb-b-12566) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs72883121 0.0160384793073129 0.0064039582122472 0.0122637273976219
Vegetable pieces (ukb-b-12566) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) All - Inverse variance weighted 0.0064478272730174 0.0028818045821245 0.0252584479520515
Crisp (ukb-b-12602) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs7377083 -0.0198086685835366 0.0079331746177978 0.0125269814161198
Crisp (ukb-b-12602) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) All - Inverse variance weighted -0.0097482514348886 0.0037459222352717 0.0092583653060832
Homemade soup (ukb-b-12658) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) All - Inverse variance weighted -0.0101557048960691 0.0047052825585159 0.0308996676662599
Mixed vegetable (ukb-b-13155) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) All - Inverse variance weighted 0.0079394438991886 0.0032013500978471 0.0131371373326918
Battered fish (ukb-b-14166) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) All - Inverse variance weighted -0.0204540377155262 0.0102827772692641 0.046684098251202
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs17481439 -0.0446374327622749 0.0151475595479482 0.0032103937997132
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs2352974 -0.0277087989404851 0.0111326325083464 0.0128113432406231
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs34198643 -0.0342839778211561 0.0115413218686754 0.0029727504899902
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs531358 -0.0346727325201647 0.0127802166086917 0.0066677030043326
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs62048491 -0.0282559625388503 0.0141621942472733 0.0460245154820166
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs6539284 0.0266001642512879 0.0134837034517657 0.0485224607566306
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs660240 -0.0354241665240592 0.0152296239829493 0.0200183365180728
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs7236339 -0.0404801481077789 0.0154550627534583 0.0088132115497024
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs72845670 -0.0316382062672795 0.0140874269231098 0.0247138061289691
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs7386207 -0.0306693392225583 0.0130659177108839 0.0189111465746502
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) All - Inverse variance weighted -0.005501714879745 0.0010490749044224 1.56835124714888e-07
Cereal (ukb-b-15926) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs10931025 -0.04513540815784 0.0195636150087243 0.0210486990596715
Cereal (ukb-b-15926) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs11038810 -0.0326535121202051 0.0150958749090648 0.0305353988411489
Cereal (ukb-b-15926) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs3766823 -0.0470131934784299 0.0184244723040635 0.010720767038263
Cereal (ukb-b-15926) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs7306606 -0.0436676576249173 0.019263513473259 0.0233988762674891
Cereal (ukb-b-15926) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs7796203 0.0500682416226584 0.0195900164629123 0.0105942787278092
Cereal (ukb-b-15926) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs834233 -0.0486779692571697 0.0169051165200217 0.0039832974306632
Cereal (ukb-b-15926) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs9846396 -0.0273631699450173 0.0135767167471631 0.0438577036778672
Cereal (ukb-b-15926) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) All - Inverse variance weighted -0.0053269049937707 0.0014368587111156 0.0002094584682115
Cereal (ukb-b-15926) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) All - MR Egger -0.015983538990428 0.0063834825079818 0.0134485184667131
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs11152349 0.0347688442971505 0.0176377476127783 0.0486924722602037
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs11253371 0.0534570076354552 0.020562567921679 0.009329868197728
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs17175518 0.0425624989126842 0.0165243297785355 0.0100023698231367
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs4073960 -0.0382344957096507 0.0178244257067688 0.0319479015892619
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs4740634 -0.0388642125808104 0.0185104732015294 0.0357658357193651
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs4866437 -0.0455883596375311 0.0195638729378 0.0197939009834013
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs4963390 -0.0545404640720865 0.0179119831470177 0.0023274616919104
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs62007687 -0.0430430523179279 0.0191017330080577 0.0242365543577695
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs7334175 -0.0524612990794243 0.020400662934302 0.010124476273282
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs9310545 -0.0416969389511446 0.0183275657459665 0.0229002781470047
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs9527691 -0.0449293504089259 0.0189210652469448 0.0175695138707995
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) All - Inverse variance weighted -0.0035986143991322 0.0017325855829606 0.037799740422602
Oily fish (ukb-b-2209) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs10819087 -0.0377421127295251 0.0173588882894763 0.0296883116289867
Oily fish (ukb-b-2209) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs11859365 -0.0173324204919595 0.0081842432943824 0.0341937688410779
Oily fish (ukb-b-2209) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs13070166 -0.0341974596249252 0.0134828471904578 0.0112009020955528
Oily fish (ukb-b-2209) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs1821849 -0.035359111694263 0.0179805536244088 0.0492386168567986
Oily fish (ukb-b-2209) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs1876245 -0.021628583903362 0.0107456900543787 0.0441390141875027
Oily fish (ukb-b-2209) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs28623270 -0.0320001906599076 0.012904423309856 0.0131461758272226
Oily fish (ukb-b-2209) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs303817 -0.0328946457632236 0.0136799976435762 0.0161910715787194
Oily fish (ukb-b-2209) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs4419275 -0.0484325861492138 0.0162135673941708 0.0028157855152436
Oily fish (ukb-b-2209) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs733069 -0.0432524467218345 0.0181028948375887 0.0168825425371533
Oily fish (ukb-b-2209) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) All - Inverse variance weighted -0.0049348913802376 0.0012217757077798 5.36534824685026e-05
Fizzy drink (ukb-b-2832) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs2212808 -0.0250764421407006 0.0092563657252785 0.0067465523902341
Fizzy drink (ukb-b-2832) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) All - Inverse variance weighted -0.0079242005456538 0.0040079391953758 0.0480273964100167
Fresh fruit (ukb-b-3881) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs1375566 -0.051122185600384 0.0212679127169121 0.0162290347581065
Fresh fruit (ukb-b-3881) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs1478254 -0.0717030825828177 0.0283146870002305 0.0113296441230352
Fresh fruit (ukb-b-3881) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs1620977 0.0300906316892107 0.0137693370375431 0.0288641996353502
Fresh fruit (ukb-b-3881) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs2189620 0.0533395400213026 0.0272129078070141 0.0499861669808192
Fresh fruit (ukb-b-3881) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs28479795 -0.036148730458317 0.0172664791139917 0.0362975392213014
Fresh fruit (ukb-b-3881) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs7864529 -0.0610265780561015 0.0284093562666294 0.0317045825449565
Fresh fruit (ukb-b-3881) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs9517948 -0.0580365733516464 0.0233287071327384 0.0128545045503641
Fresh fruit (ukb-b-3881) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) All - Inverse variance weighted -0.0049333714433937 0.0020949624703062 0.0185290160800828
Baked bean (ukb-b-4058) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs12540361 -0.0179697800380689 0.0083004578559407 0.0303942476963217
Filtered coffee (ukb-b-748) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs10932789 0.010523732733646 0.004529226755446 0.0201514266315216
Filtered coffee (ukb-b-748) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) All - MR Egger 0.0175289216441259 0.0077399712491049 0.0428438918477714
Poultry (ukb-b-8006) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs2965200 0.041232665047938 0.016146530130426 0.0106598865486038
Poultry (ukb-b-8006) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs7045589 0.038513496155186 0.0166218456134798 0.0205015037793923
Poultry (ukb-b-8006) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs72904998 0.0453342225579134 0.0180079226696022 0.011820443611092
Poultry (ukb-b-8006) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs9997448 0.0385564665634616 0.0159282724614414 0.0154936051260538
Poultry (ukb-b-8006) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) All - Inverse variance weighted 0.0053313708800829 0.0025745036223936 0.0383742664516431
Cauliflower (ukb-b-905) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) rs12549871 0.0182940415382777 0.0085243882794922 0.0318663875866517
Cauliflower (ukb-b-905) Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) All - Inverse variance weighted 0.0080298888729039 0.0033624692386082 0.0169360606656161