ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Salted peanuts (ukb-b-1099) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement MR Egger 6 -0.237471249 0.08237471 0.044885736
Flavoured milk (ukb-b-12763) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 4 0.045602896 0.017454721 0.0089846
Naan bread (ukb-b-13281) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Weighted median 5 0.049725409 0.020923977 0.017478715
Herbal tea (ukb-b-13344) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 6 -0.000426069 0.000181799 0.019097277
Sweetcorn (ukb-b-13567) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Weighted median 14 -0.012168231 0.005405553 0.02438165
Sweetcorn (ukb-b-13567) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 14 -0.007853878 0.003947633 0.046644291
Other sweets (ukb-b-139) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement MR Egger 12 0.064897103 0.027953814 0.042657575
Cheese (ukb-b-1489) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement MR Egger 183 -0.014284516 0.006652285 0.033098977
Cheese (ukb-b-1489) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Weighted median 183 -0.006292576 0.002009311 0.001737922
Cheese (ukb-b-1489) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 183 -0.006959887 0.001453765 1.69e-06
Water (ukb-b-14898) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement MR Egger 146 -0.019759603 0.007644274 0.010734681
Savoury biscuits (ukb-b-1503) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 3 -0.055291091 0.024364733 0.023249584
Cereal (ukb-b-15926) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Weighted median 159 -0.005560088 0.002802077 0.047225315
Cereal (ukb-b-15926) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 159 -0.006898656 0.002252039 0.002189149
Rose wine (ukb-b-16124) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Weighted median 6 -0.011151523 0.005417463 0.03954793
Rose wine (ukb-b-16124) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 6 -0.010457316 0.00416964 0.012142829
Dried fruit (ukb-b-16576) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Weighted median 147 -0.007353412 0.00294064 0.012397734
Dried fruit (ukb-b-16576) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 147 -0.007255778 0.002277448 0.001442922
Goat's cheese (ukb-b-20122) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 9 -0.020523052 0.008837342 0.020216221
Butternut squash (ukb-b-20341) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Weighted median 4 0.034440359 0.015501343 0.026299116
Butternut squash (ukb-b-20341) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 4 0.032571471 0.012691153 0.010273935
Whole-wheat cereal (ukb-b-2375) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 7 -0.011350718 0.004945357 0.021720119
Fizzy drink (ukb-b-2832) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 9 -0.009262719 0.004138272 0.025201106
Standard tea (ukb-b-3291) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement MR Egger 8 0.000217695 4.96e-05 0.004622942
Standard tea (ukb-b-3291) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 8 5.05e-05 2.26e-05 0.025421966
Sushi (ukb-b-5213) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 2 -0.09145462 0.044310311 0.039021703
Coffee (ukb-b-5237) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement MR Egger 106 0.029438178 0.004753529 1.2e-08
Coffee (ukb-b-5237) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Weighted median 106 0.01020853 0.003869088 0.008327733
Coffee (ukb-b-5237) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 106 0.009783323 0.002334592 2.78e-05
Coffee (ukb-b-5237) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Weighted mode 106 0.016375185 0.004584192 0.000536158
Baguette (ukb-b-5277) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 4 0.013100273 0.006323733 0.038302353
Tea (ukb-b-6066) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement MR Egger 127 0.020488624 0.004580514 1.71e-05
Tea (ukb-b-6066) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Weighted median 127 0.009378017 0.002778301 0.00073695
Tea (ukb-b-6066) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 127 0.00533899 0.00177194 0.002586147
Tea (ukb-b-6066) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Weighted mode 127 0.011095595 0.004690118 0.019519377
Cheese spread (ukb-b-6185) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 5 -0.033661631 0.014849394 0.023398228
Doughnut (ukb-b-6214) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 5 0.055976356 0.021066664 0.007881471
Processed meat (ukb-b-6324) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 113 0.006487871 0.002071828 0.001739324
Filtered coffee (ukb-b-748) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Weighted median 16 0.005433445 0.00246698 0.027632267
Filtered coffee (ukb-b-748) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 16 0.00592303 0.002456189 0.015888305
Poultry (ukb-b-8006) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Weighted median 68 0.010065813 0.004498877 0.025259818
Poultry (ukb-b-8006) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 68 0.009601913 0.003618895 0.007971561
Soft cheese (ukb-b-8007) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Weighted median 5 -0.031532054 0.014900475 0.034329693
Soft cheese (ukb-b-8007) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement Inverse variance weighted 5 -0.031126016 0.011216969 0.005521793
Instant coffee (ukb-b-930) (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement MR Egger 13 0.026657529 0.011980861 0.047943317

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Salted peanuts (ukb-b-1099) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs6975809 -0.0616826044987048 0.0211385653867789 0.0035226988234233
Salted peanuts (ukb-b-1099) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - MR Egger -0.237471248701039 0.082374710466106 0.0448857362617603
Flavoured milk (ukb-b-12763) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs34654942 0.0942366317032332 0.0330553307785089 0.0043599040953577
Flavoured milk (ukb-b-12763) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted 0.0456028957205759 0.017454721479531 0.0089846003335518
Herbal tea (ukb-b-13344) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs10239996 -0.0007454416063695 0.0003764349289411 0.0476735530313888
Herbal tea (ukb-b-13344) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs62478619 -0.0009778499845745 0.0003972383388234 0.0138310979959992
Herbal tea (ukb-b-13344) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted -0.000426069219989 0.0001817991021814 0.0190972774807737
Sweetcorn (ukb-b-13567) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted -0.0078538775703798 0.0039476325129797 0.0466442908644148
Other sweets (ukb-b-139) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - MR Egger 0.0648971025577799 0.027953814379553 0.0426575753576563
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs114121746 0.0401031332874963 0.0199476694059741 0.0443870748180258
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs141547796 -0.0375876550583261 0.0190420867520821 0.0483902479220801
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs1514755 -0.0317427892689421 0.0156718514311538 0.0428196211374121
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs17115145 -0.0350321413598745 0.0174126205300995 0.0442323558233761
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs2245959 0.0747062433551443 0.0197112999282572 0.0001506344664648
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs2802530 -0.0423964115834344 0.0178766924720561 0.0177111252893022
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs281219 0.0437962969850704 0.0199800641221147 0.028379519536737
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs34198643 -0.0513351616109601 0.015720572913548 0.0010928006798208
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs4675530 -0.0484484609878311 0.0200122584108805 0.0154804659728913
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs4692708 -0.0344308137245584 0.0172225013238469 0.0455892991713884
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs6126641 -0.0467420988961137 0.0177355209435959 0.0084011563129089
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs6685323 0.041699649697466 0.0179603597045934 0.0202458473433768
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs6873324 -0.0394652389272719 0.0178413189490727 0.0269657300106964
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs72810360 -0.0523594147317521 0.0172315882874889 0.0023770261420622
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs7299943 -0.0559475643085713 0.0188638704626921 0.003018396528398
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs73096946 -0.0321948968987053 0.0145993473003293 0.0274380635129869
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs75499503 -0.0431707075635124 0.0189615283994089 0.0228010083008037
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs919109 -0.0363476642826333 0.0159338355518552 0.022538847201635
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs9649582 -0.0327069222664642 0.0161688080675396 0.0430895788622351
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted -0.006959887046157 0.0014537647695537 1.6887855894506e-06
Cheese (ukb-b-1489) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - MR Egger -0.0142845158557629 0.0066522848818482 0.0330989773849071
Water (ukb-b-14898) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs10954732 -0.047083721762385 0.0219494900985904 0.0319453238814988
Water (ukb-b-14898) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs1421085 0.0698579517069109 0.0185811823480433 0.0001701801703184
Water (ukb-b-14898) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs1515099 0.05367466801044 0.0231936019051238 0.0206566724669901
Water (ukb-b-14898) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs17348586 0.0536895305020878 0.0240499287096446 0.0255872483400393
Water (ukb-b-14898) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs2274156 -0.0487793643883326 0.0217824989116239 0.0251309867484242
Water (ukb-b-14898) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs2435200 0.0395941643852718 0.0198113947868271 0.0456565109743503
Water (ukb-b-14898) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs2472297 -0.0361513164784986 0.0074313483169602 1.14627710302124e-06
Water (ukb-b-14898) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs2508822 -0.0644139238803209 0.0230311012630552 0.0051607726801254
Water (ukb-b-14898) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs3195047 0.0515950806296476 0.025448587405722 0.0426190544740295
Water (ukb-b-14898) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs3746410 -0.0649607164278376 0.0161549013902168 5.79233149304799e-05
Water (ukb-b-14898) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs4603502 0.0487184449680242 0.0184209479514091 0.008175597550748
Water (ukb-b-14898) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs58959216 -0.0467632578755739 0.0231431850561976 0.043320570511527
Water (ukb-b-14898) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs6491286 -0.0566592159654729 0.024450552179744 0.0204875035156329
Water (ukb-b-14898) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs6747465 -0.0479301539129027 0.0243007738040834 0.048567211744608
Water (ukb-b-14898) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs780093 -0.0465882919839197 0.0236537022989509 0.0488844259302577
Water (ukb-b-14898) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs7937776 0.0606656579599349 0.0248619664472287 0.0146832398445023
Water (ukb-b-14898) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - MR Egger -0.0197596032738051 0.007644274196975 0.0107346809094546
Savoury biscuits (ukb-b-1503) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs12830907 -0.0968078173729743 0.0412020197318403 0.0187941442925281
Savoury biscuits (ukb-b-1503) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted -0.0552910907355477 0.0243647329801259 0.023249584264026
Cereal (ukb-b-15926) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs10260232 -0.0740643300965398 0.0258857314746054 0.0042203685089094
Cereal (ukb-b-15926) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs11678980 -0.0792595161612556 0.0254808868655986 0.0018674067948154
Cereal (ukb-b-15926) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs12414768 0.0553381407976845 0.0245559795414767 0.0242244582586869
Cereal (ukb-b-15926) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs13066686 -0.0808080265559158 0.0261313761227943 0.0019856152371398
Cereal (ukb-b-15926) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs17115145 -0.051932171164919 0.0258127295305636 0.0442323558233761
Cereal (ukb-b-15926) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs2339515 -0.0522191592162657 0.0257519375602816 0.0425831217181652
Cereal (ukb-b-15926) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs2472297 -0.0762140577095346 0.0156667381622276 1.14627710302124e-06
Cereal (ukb-b-15926) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs3115230 -0.0580147065229702 0.0221761820542085 0.0088945243293785
Cereal (ukb-b-15926) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs34234069 -0.0726458677326845 0.0233218041192318 0.0018398641613972
Cereal (ukb-b-15926) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs3766823 -0.050250909373677 0.0250951710313723 0.0452402772398867
Cereal (ukb-b-15926) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs489693 0.067588568791481 0.0236734669092867 0.0043032131037542
Cereal (ukb-b-15926) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs491711 -0.0703250203191171 0.0203336612910125 0.0005430878819925
Cereal (ukb-b-15926) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs62009152 -0.097245569013676 0.0263418012303566 0.0002227753783818
Cereal (ukb-b-15926) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs62097852 0.0518677431218367 0.0247445316194112 0.0360707032068517
Cereal (ukb-b-15926) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs62442924 -0.0579819180105099 0.0217889544337007 0.0077892920476137
Cereal (ukb-b-15926) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs6486751 0.051639654055613 0.026103753080275 0.0479009230646268
Cereal (ukb-b-15926) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs7796203 0.0559583732167706 0.0266838696214986 0.035985950443705
Cereal (ukb-b-15926) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted -0.0068986563312001 0.0022520386503937 0.0021891491947178
Rose wine (ukb-b-16124) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs13224220 -0.0116101080952028 0.0049875892217639 0.0199227484038699
Rose wine (ukb-b-16124) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted -0.0104573158790194 0.0041696399159463 0.0121428289712975
Dried fruit (ukb-b-16576) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs11085749 -0.0548489395736765 0.0241937810425785 0.0233860902827382
Dried fruit (ukb-b-16576) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs11772627 -0.0437792492554735 0.0155190413334933 0.0047873879253582
Dried fruit (ukb-b-16576) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs13071694 -0.0793853721664672 0.0286253365487561 0.0055498526843595
Dried fruit (ukb-b-16576) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs17175518 0.0614890137610689 0.0225081331222491 0.0062978361107692
Dried fruit (ukb-b-16576) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs1735720 -0.0545478354070553 0.0259614147909968 0.0356311518016042
Dried fruit (ukb-b-16576) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs1797235 0.0479904396942299 0.0227902520807137 0.0352265836923635
Dried fruit (ukb-b-16576) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs2328887 -0.0679420736534341 0.0192101624428706 0.0004050404724715
Dried fruit (ukb-b-16576) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs2508819 -0.0536176653555457 0.0269360669308502 0.0465300659677794
Dried fruit (ukb-b-16576) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs2521754 -0.0598520798918757 0.0269199579516444 0.0261932311857186
Dried fruit (ukb-b-16576) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs3764002 -0.0379765270738864 0.0189828906756087 0.045439172713217
Dried fruit (ukb-b-16576) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs536421612 -0.0569384498913247 0.0243106241299871 0.019174441175126
Dried fruit (ukb-b-16576) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs62007687 -0.0848250777124791 0.026018284890389 0.00111329673872
Dried fruit (ukb-b-16576) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs75641275 -0.0438043117510398 0.0221073630245811 0.0475424668877624
Dried fruit (ukb-b-16576) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs7582086 -0.0512468049616699 0.0228008113657679 0.0246025435963564
Dried fruit (ukb-b-16576) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs7810473 -0.0558845373638061 0.0280561372839781 0.0463839182857107
Dried fruit (ukb-b-16576) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted -0.0072557779578284 0.0022774480931232 0.0014429218586898
Goat's cheese (ukb-b-20122) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs10947005 -0.0902130601664346 0.0426915721540782 0.0345892050461485
Goat's cheese (ukb-b-20122) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted -0.0205230517529687 0.008837341724958 0.020216220913923
Butternut squash (ukb-b-20341) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs4817646 0.0516281920766242 0.0253362344608061 0.0415777833486326
Butternut squash (ukb-b-20341) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted 0.0325714708404979 0.0126911531197929 0.0102739346516319
Whole-wheat cereal (ukb-b-2375) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs1712999 -0.0402596190770136 0.012519532441618 0.0013010655744857
Whole-wheat cereal (ukb-b-2375) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted -0.0113507176223611 0.0049453573232197 0.0217201189769003
Fizzy drink (ukb-b-2832) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted -0.0092627193302794 0.0041382721068593 0.0252011064266619
Standard tea (ukb-b-3291) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs2472297 0.0001183570903747 2.4329757531227e-05 1.14627710302124e-06
Standard tea (ukb-b-3291) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted 5.0450914783162e-05 2.25738265829325e-05 0.0254219663721955
Standard tea (ukb-b-3291) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - MR Egger 0.0002176954020795 4.96001485496545e-05 0.0046229423193972
Sushi (ukb-b-5213) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted -0.091454619542029 0.0443103113034855 0.0390217029289814
Coffee (ukb-b-5237) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs13163336 0.0519001552130165 0.0200644267822736 0.0096906890350129
Coffee (ukb-b-5237) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs13387939 0.0438895734425398 0.0175139226132232 0.0122111863218692
Coffee (ukb-b-5237) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs1421085 0.0452468370131481 0.0120349896993949 0.0001701801703184
Coffee (ukb-b-5237) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs2472297 0.0259976157070677 0.0053441300773819 1.14627710302124e-06
Coffee (ukb-b-5237) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs476828 0.038723055903056 0.0148333631190873 0.0090399966931805
Coffee (ukb-b-5237) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs6030315 0.0649578977782823 0.0289287667557555 0.024739705429119
Coffee (ukb-b-5237) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs780093 0.0333103396396735 0.0169122503479144 0.0488844259302577
Coffee (ukb-b-5237) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs9398171 0.0554865210864179 0.0222432927783969 0.0126124704324466
Coffee (ukb-b-5237) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted 0.0097833228150044 0.002334591806938 2.78227011744759e-05
Coffee (ukb-b-5237) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - MR Egger 0.029438177763215 0.0047535292120298 1.19532478861743e-08
Baguette (ukb-b-5277) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted 0.0131002733652908 0.0063237332501045 0.0383023530985665
Tea (ukb-b-6066) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs1156954 -0.0654480590616814 0.022402286258633 0.0034836126994137
Tea (ukb-b-6066) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs12997185 -0.0401203193325914 0.0202255658864459 0.0472955574752897
Tea (ukb-b-6066) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs1712999 0.0676441324915429 0.0210352936919988 0.0013010655744857
Tea (ukb-b-6066) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs17685 0.0219731200277471 0.010591836292298 0.0380297837476584
Tea (ukb-b-6066) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs2472297 0.0226473559994976 0.0046554429349914 1.14627710302124e-06
Tea (ukb-b-6066) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs4135060 0.050313287247633 0.0209716202824839 0.016434841207729
Tea (ukb-b-6066) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs58864227 0.0439704307211463 0.0219501852469667 0.0451567073116406
Tea (ukb-b-6066) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs6129076 0.0474102755409195 0.0200553140034475 0.0180799970288883
Tea (ukb-b-6066) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs6265 0.0499430306556086 0.0198623654693408 0.0119216405240609
Tea (ukb-b-6066) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs7172571 -0.0504891572736803 0.0218367223170425 0.0207709833155761
Tea (ukb-b-6066) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs9937354 -0.0570209972822038 0.0157217061799706 0.000286848476031
Tea (ukb-b-6066) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted 0.0053389901144999 0.0017719404669123 0.0025861471043248
Tea (ukb-b-6066) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - MR Egger 0.0204886241285429 0.0045805142371658 1.71159905943887e-05
Cheese spread (ukb-b-6185) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted -0.0336616305473798 0.0148493937138827 0.0233982283611242
Doughnut (ukb-b-6214) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs4467081 0.120541149518319 0.0380737217190303 0.0015455433051998
Doughnut (ukb-b-6214) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs76789854 0.081940392591765 0.0387154351103552 0.034304117479838
Doughnut (ukb-b-6214) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted 0.0559763558767058 0.0210666644402841 0.007881470844583
Processed meat (ukb-b-6324) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs10084188 0.0644292830188679 0.0223449962264151 0.0039342313524014
Processed meat (ukb-b-6324) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs10128495 -0.0404444018772148 0.0202590312665976 0.0458943100319657
Processed meat (ukb-b-6324) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs10203260 -0.042075510432608 0.0206885707886977 0.0419761762270135
Processed meat (ukb-b-6324) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs1422192 0.0435998137681885 0.017702276624961 0.0137799314258353
Processed meat (ukb-b-6324) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs4077924 0.0704750894092986 0.0191251090113372 0.0002287466514151
Processed meat (ukb-b-6324) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs62396185 0.0565243917319472 0.0203259552106466 0.0054208901562569
Processed meat (ukb-b-6324) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs6878756 0.046122528363047 0.0218961796712202 0.0351679743818835
Processed meat (ukb-b-6324) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs7412 0.0445905107283167 0.0203248211947215 0.0282430044590727
Processed meat (ukb-b-6324) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs7521527 0.0464742768654291 0.0210947865486455 0.0275865233063831
Processed meat (ukb-b-6324) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted 0.0064878706443877 0.0020718278350791 0.0017393243080499
Filtered coffee (ukb-b-748) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs10468280 0.0228435307809965 0.0065056726658482 0.0004458789981872
Filtered coffee (ukb-b-748) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs2470893 0.0225082014224612 0.0047283310588326 1.9332017888121e-06
Filtered coffee (ukb-b-748) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs2830854 0.0167115900013414 0.0061430812315728 0.0065204536782156
Filtered coffee (ukb-b-748) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted 0.0059230297594718 0.0024561892666382 0.0158883051812904
Poultry (ukb-b-8006) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs11678980 0.0740167095183043 0.0237953938245427 0.0018674067948154
Poultry (ukb-b-8006) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs2195042 0.0509290544345484 0.0248208115401423 0.040182392639571
Poultry (ukb-b-8006) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs28790681 -0.0517688923669127 0.0261301579915822 0.0475696070616306
Poultry (ukb-b-8006) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs4927088 -0.0540974110803461 0.0253319749242057 0.0327170380756885
Poultry (ukb-b-8006) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs780108 -0.0496100309454797 0.0237225699504635 0.0365048793112253
Poultry (ukb-b-8006) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs78693894 0.0796310658536104 0.0255037199297456 0.0017942483488665
Poultry (ukb-b-8006) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs7869395 0.0550353198333082 0.0251303946047289 0.0285249420008744
Poultry (ukb-b-8006) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs78974715 0.0582324764265197 0.0263775736853425 0.0272686123575639
Poultry (ukb-b-8006) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs811041 0.0801517914814393 0.0230316501386831 0.0005012798021511
Poultry (ukb-b-8006) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted 0.0096019134613786 0.0036188952702275 0.0079715606835376
Soft cheese (ukb-b-8007) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs12468108 -0.0676034682916836 0.0254587432363492 0.007921145024762
Soft cheese (ukb-b-8007) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - Inverse variance weighted -0.0311260158274361 0.0112169686046 0.005521793219559
Instant coffee (ukb-b-930) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs12510185 -0.0095961061340117 0.0043522342815384 0.0274632934769489
Instant coffee (ukb-b-930) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs167978 -0.0116944059177069 0.0043733626136538 0.0074950699203326
Instant coffee (ukb-b-930) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement rs2472297 0.016522904600067 0.0033964865252979 1.14627710302124e-06
Instant coffee (ukb-b-930) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement All - MR Egger 0.0266575292076536 0.0119808608292405 0.0479433169869106