ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint (ukb-b-19054)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Other fish (ukb-b-1252) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Wald ratio 1 -0.047655434 0.021718221 0.02821669
Red wine (ukb-b-13556) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Wald ratio 1 0.008775114 0.00416655 0.035196861
Shellfish (ukb-b-143) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Wald ratio 1 0.058920537 0.028940198 0.041756274
Cheese (ukb-b-1489) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Weighted median 133 -0.004725501 0.001361312 0.000517975
Cheese (ukb-b-1489) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Inverse variance weighted 133 -0.005423147 0.001001473 6.12e-08
Cereal (ukb-b-15926) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Inverse variance weighted 125 -0.00450183 0.001252226 0.000324314
Pea (ukb-b-15945) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Inverse variance weighted 2 -0.007443367 0.003694643 0.043942609
Dried fruit (ukb-b-16576) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint MR Egger 114 -0.017654387 0.008846761 0.048407505
Dried fruit (ukb-b-16576) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Weighted median 114 -0.007477111 0.002037206 0.000242287
Dried fruit (ukb-b-16576) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Inverse variance weighted 114 -0.006528431 0.001603431 4.67e-05
Dried fruit (ukb-b-16576) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Weighted mode 114 -0.010507184 0.004928656 0.035184759
Non-oily fish (ukb-b-17627) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint MR Egger 42 0.026116811 0.011777779 0.032336535
Cheesecake (ukb-b-1814) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Weighted median 6 -0.018380749 0.00898743 0.0408389
Oily fish (ukb-b-2209) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Weighted median 124 -0.004499298 0.001751147 0.010189156
Whole-wheat cereal (ukb-b-2375) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Inverse variance weighted 3 0.008644024 0.004223496 0.040692314
Milk (ukb-b-2966) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint MR Egger 8 0.13755615 0.046742702 0.025852223
Fresh fruit (ukb-b-3881) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Inverse variance weighted 107 -0.005241513 0.001801784 0.003625075
Poultry (ukb-b-8006) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Inverse variance weighted 50 0.005454231 0.002586142 0.034942657
Soft cheese (ukb-b-8007) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Weighted median 4 -0.021326348 0.008887502 0.016413509
Soft cheese (ukb-b-8007) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Inverse variance weighted 4 -0.016823236 0.007402468 0.023047145
Cappuccino (ukb-b-8374) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Weighted median 7 -0.008898506 0.004253504 0.036434819
Cappuccino (ukb-b-8374) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Inverse variance weighted 7 -0.006592691 0.003316773 0.046846844
Soya dessert (ukb-b-998) (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint Wald ratio 1 0.08556791 0.032795242 0.009076578

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Other fish (ukb-b-1252) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs61373860 -0.0476554340208182 0.0217182212114023 0.0282166904169215
Red wine (ukb-b-13556) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs3751395 0.0087751140537037 0.0041665501772756 0.035196860671338
Shellfish (ukb-b-143) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs12487739 0.0589205370639319 0.0289401977928609 0.0417562737886611
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs10269830 -0.0260632099030638 0.0120447893450767 0.0304752738977003
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs10499731 -0.0222203591305922 0.0111022679860504 0.0453465852221133
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs11649653 0.0198015669567101 0.0096822038487922 0.0408399932014094
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs13181793 -0.0236314966854104 0.0118517686793741 0.0461606311578026
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs13266268 -0.0230657597505981 0.0115505097235073 0.0458309030386102
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs17115145 -0.0220260702141205 0.0103957890160396 0.03411166348058
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs17207890 -0.0240695224719101 0.0118386886818306 0.0420399935579729
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs17481439 -0.0289823479451845 0.0123180277444087 0.0186306505430789
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs1931805 -0.0315392163845429 0.010357383094735 0.0023260675571501
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs2302351 -0.0331604533758336 0.0116811945188892 0.0045285007347889
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs2644109 -0.0313956575582897 0.0123408558369936 0.0109577857338307
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs26579 -0.0228994508112838 0.0104888013936738 0.0290189821912426
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs2870681 0.0302841287858314 0.0121957371673603 0.0130217723326471
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs531358 -0.0250033417890724 0.010392888065256 0.016136536792716
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs62034322 -0.0218644469161494 0.0096547666032794 0.0235355672296743
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs67238148 -0.0214248754775376 0.0096001378209778 0.0256330894742931
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint All - Inverse variance weighted -0.0054231466977263 0.0010014726259949 6.12297583129734e-08
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs10260232 -0.0371330406745565 0.0154543574510486 0.0162720678035656
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs12354267 -0.0265731113648657 0.0121796467850918 0.0291269761286424
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs1397440 -0.040516284701072 0.0150492617981765 0.0070973000576025
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs17115145 -0.0326517764557891 0.0154108733756631 0.03411166348058
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs1853931 -0.0257755274857103 0.0117203267235904 0.0278625827653618
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs2656195 -0.0408555104320607 0.0153854567881122 0.007919963364331
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs2968426 -0.0339707365792759 0.0150488888888889 0.0239856854455683
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs67723420 -0.0395502223235663 0.0128802303044123 0.0021361874067416
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs844137 0.0330814071048511 0.0154552754877436 0.0323175675951521
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint All - Inverse variance weighted -0.0045018299114737 0.0012522257749665 0.0003243137231733
Pea (ukb-b-15945) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint All - Inverse variance weighted -0.0074433671934791 0.0036946427950269 0.0439426092341385
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs10026792 -0.0286778223390034 0.0132951643387268 0.0310047686131372
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs10740991 -0.0174462034769102 0.0086858235258976 0.0445813023357858
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs10896126 -0.0290616296888534 0.0094879072556466 0.0021911695790338
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs11073575 0.0312312578858727 0.0149786358156534 0.0370644393295038
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs2579020 -0.0376285839693624 0.0158293757033764 0.0174476385415437
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs322672 -0.0580244716676885 0.016734535180917 0.0005256192161315
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs3796183 -0.0462418244736397 0.0166792663362753 0.0055642291942881
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs4149513 0.026191389599318 0.0111543904518329 0.018870520153214
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs62057232 0.0409672182649499 0.0167632307863686 0.0145305137478773
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs6765212 -0.0373168268180826 0.0134308801048264 0.0054621447158126
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs7742849 -0.0322031782119823 0.0163942847358307 0.0494961267842479
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs898751 -0.038927812037838 0.0145989898708039 0.0076651767576654
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint All - Inverse variance weighted -0.0065284313470665 0.0016034312994548 4.67037561704766e-05
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint All - MR Egger -0.0176543872724673 0.008846760851495 0.0484075051883974
Non-oily fish (ukb-b-17627) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs1445978 -0.030291828900316 0.0150580207768596 0.0442543130200795
Non-oily fish (ukb-b-17627) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs2447091 -0.039968323473238 0.0160378541661441 0.0126981648361126
Non-oily fish (ukb-b-17627) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint All - MR Egger 0.0261168109305275 0.0117777790197898 0.0323365352574151
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs10061973 0.0254430018153168 0.0120722256521779 0.0350686225399439
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs10828250 -0.0141040990360465 0.0070362152664026 0.0450164427411993
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs11767283 0.0226423741760263 0.0089733216397431 0.0116259478199331
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs1201289 0.0247385447256794 0.0124945695240759 0.0477098506499148
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs13058717 -0.0282517837939241 0.0144057037778694 0.0498612212805938
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs17050031 0.0252581084221359 0.010904375394217 0.0205403747909094
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs275160 -0.0254159652770901 0.0118592599927386 0.0321024620708808
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs55701338 -0.0304342410259743 0.0147009380212734 0.0384313325892818
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs55871839 0.0257094465227253 0.013095231081917 0.0496150559705985
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs6965147 0.0264341975254317 0.013158294764044 0.044543716109986
Oily fish (ukb-b-2209) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs9841174 -0.0181516568435726 0.0091650482809021 0.0476439595976513
Whole-wheat cereal (ukb-b-2375) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint All - Inverse variance weighted 0.0086440237121995 0.004223495636439 0.0406923136676064
Milk (ukb-b-2966) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs56674454 0.0223948643958484 0.0105352358029534 0.0335273481557915
Milk (ukb-b-2966) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint All - MR Egger 0.13755614989036 0.0467427019358117 0.0258522226909396
Fresh fruit (ukb-b-3881) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs11129657 -0.0568724746145996 0.0197115278719337 0.003911162603292
Fresh fruit (ukb-b-3881) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs11649274 0.0476962098372607 0.0202502980642908 0.0185060774884253
Fresh fruit (ukb-b-3881) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs12885598 -0.0431632534937842 0.0177559946191133 0.0150608881787024
Fresh fruit (ukb-b-3881) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs60452247 -0.0417573330957666 0.0170418171848591 0.0142742621162183
Fresh fruit (ukb-b-3881) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs62334820 -0.0661283028342923 0.0233291628088126 0.0045886432197393
Fresh fruit (ukb-b-3881) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs7014421 -0.0514315793019809 0.0228181848807438 0.0241978482029849
Fresh fruit (ukb-b-3881) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs898751 -0.0599903331286434 0.022498009002919 0.0076651767576654
Fresh fruit (ukb-b-3881) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint All - Inverse variance weighted -0.0052415125883407 0.0018017838772387 0.0036250750774643
Poultry (ukb-b-8006) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs17767108 0.0398950988470972 0.015587125220648 0.0104825722375969
Poultry (ukb-b-8006) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs1959437 0.0321298338190124 0.0136366858312987 0.0184663473011435
Poultry (ukb-b-8006) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs2696187 0.0396611481958395 0.0146879654633081 0.006928782212427
Poultry (ukb-b-8006) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs4428348 0.0426978343306392 0.0141683147120107 0.0025815586551271
Poultry (ukb-b-8006) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs4547132 -0.05428783900077 0.0155229093789467 0.0004700420089122
Poultry (ukb-b-8006) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs9537989 0.0297634950376991 0.0143754314556979 0.0384109852989393
Poultry (ukb-b-8006) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs9997448 0.0291054603138199 0.0129526212182023 0.024635485988309
Poultry (ukb-b-8006) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint All - Inverse variance weighted 0.0054542310144042 0.0025861419318176 0.034942656506877
Soft cheese (ukb-b-8007) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint All - Inverse variance weighted -0.016823235936215 0.0074024682156242 0.023047145178719
Cappuccino (ukb-b-8374) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint All - Inverse variance weighted -0.0065926909703075 0.0033167730807767 0.0468468435556594
Soya dessert (ukb-b-998) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint rs13250489 0.0855679102202201 0.0327952415142961 0.0090765780528081