ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Orange (ukb-b-13520) (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint Inverse variance weighted 4 -0.009733812 0.004065426 0.016652534
Red wine (ukb-b-13556) (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint Wald ratio 1 0.008619156 0.004374643 0.048809297
Other sweets (ukb-b-139) (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint MR Egger 8 0.189253741 0.062935154 0.023788599
Pea (ukb-b-15945) (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint Inverse variance weighted 2 0.008833972 0.003879192 0.022770035
Sprouts (ukb-b-16077) (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint Inverse variance weighted 4 0.013598483 0.005964854 0.02262146
Dried fruit (ukb-b-16576) (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint MR Egger 116 -0.016294593 0.007937408 0.042372686
Ice-cream (ukb-b-17189) (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint Inverse variance weighted 7 -0.00646732 0.003226673 0.045034622
Grapefruit (ukb-b-18758) (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint Wald ratio 1 0.052576518 0.020473491 0.010227859
Plain cereal (ukb-b-20023) (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint Inverse variance weighted 5 0.009047789 0.00425656 0.033535715
Beef (ukb-b-2862) (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint MR Egger 63 -0.031159205 0.013433916 0.023735146
Cabbage/kale (ukb-b-2975) (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint Inverse variance weighted 2 -0.010703511 0.004734532 0.023775805
Other vegetables (ukb-b-3055) (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint Weighted median 3 -0.01578664 0.007417167 0.033304576
Other vegetables (ukb-b-3055) (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint Inverse variance weighted 3 -0.013109501 0.006276292 0.036731715
Spirits (ukb-b-3751) (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint Inverse variance weighted 3 0.007891087 0.003969291 0.046807878
Sushi (ukb-b-5213) (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint Wald ratio 1 -0.08955339 0.037168158 0.015978269
Processed meat (ukb-b-6324) (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint MR Egger 81 -0.020167923 0.009016702 0.028123484
Poultry (ukb-b-8006) (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint Inverse variance weighted 53 0.005355363 0.002083995 0.010176939

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Orange (ukb-b-13520) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs2225962 -0.0194823380763711 0.0074024023395825 0.0084910357700489
Orange (ukb-b-13520) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint All - Inverse variance weighted -0.0097338121112482 0.0040654257765362 0.0166525336189839
Red wine (ukb-b-13556) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs3751395 0.0086191559390527 0.0043746425893685 0.048809296877121
Other sweets (ukb-b-139) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs1817113 -0.0274427788214546 0.0110130736495035 0.0127084525346587
Other sweets (ukb-b-139) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint All - MR Egger 0.189253740988901 0.0629351536214138 0.0237885986730334
Pea (ukb-b-15945) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs1108523 0.0130722937168812 0.0057830767936748 0.0237940033838892
Pea (ukb-b-15945) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint All - Inverse variance weighted 0.0088339717826651 0.0038791917863192 0.022770034904621
Sprouts (ukb-b-16077) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs2148815 0.0257388523406315 0.0118944077198384 0.0304685176547841
Sprouts (ukb-b-16077) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint All - Inverse variance weighted 0.0135984832803498 0.0059648543803643 0.0226214604063744
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs10268994 0.0602087566857012 0.0175686056958858 0.0006101426170058
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs11772627 -0.024800314173821 0.0097279341980385 0.0107911038500759
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs11811826 -0.0251333050885927 0.012473936661169 0.0439187398614075
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs1622515 -0.0315340333300058 0.0138446475261642 0.022744114696974
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs3796183 0.0373599388578996 0.0175124000452136 0.0328966797054016
Dried fruit (ukb-b-16576) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint All - MR Egger -0.0162945930229927 0.0079374082001025 0.042372686345213
Ice-cream (ukb-b-17189) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint All - Inverse variance weighted -0.0064673201204478 0.0032266728032956 0.0450346220752795
Grapefruit (ukb-b-18758) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs13027142 0.0525765181608369 0.0204734905688029 0.0102278589791784
Plain cereal (ukb-b-20023) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint All - Inverse variance weighted 0.0090477889580225 0.0042565604137376 0.033535715399434
Beef (ukb-b-2862) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs11165829 -0.0304669562063117 0.0140077058068058 0.0296290674471742
Beef (ukb-b-2862) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs2567950 -0.0307394879357031 0.0149752720718856 0.0401033219162201
Beef (ukb-b-2862) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs62169335 0.0414616343942153 0.0143889088483917 0.003957877978345
Beef (ukb-b-2862) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs6851529 0.0574656481256843 0.0175341318915875 0.0010478298294227
Beef (ukb-b-2862) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs7597864 0.0361215432672479 0.0172187827061977 0.0359229145277337
Beef (ukb-b-2862) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint All - MR Egger -0.0311592051868509 0.0134339160335601 0.0237351458915391
Cabbage/kale (ukb-b-2975) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint All - Inverse variance weighted -0.0107035112001159 0.0047345316306621 0.0237758048089065
Other vegetables (ukb-b-3055) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs489526 -0.0209866570364175 0.0095008743252489 0.0271803103756642
Other vegetables (ukb-b-3055) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint All - Inverse variance weighted -0.013109500739845 0.0062762915412644 0.0367317145911295
Spirits (ukb-b-3751) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint All - Inverse variance weighted 0.0078910873230352 0.0039692910027921 0.0468078781625494
Sushi (ukb-b-5213) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs61905205 -0.0895533903208782 0.0371681584742655 0.0159782685917179
Processed meat (ukb-b-6324) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs4653392 0.0264777229573148 0.0131437355161845 0.0439597161484023
Processed meat (ukb-b-6324) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint All - MR Egger -0.0201679228866209 0.0090167022602977 0.0281234843842802
Poultry (ukb-b-8006) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs1062633 0.0309236830110048 0.0149137201276291 0.0381252454484143
Poultry (ukb-b-8006) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs1960425 0.0326559138376693 0.016370819011243 0.0460686692890937
Poultry (ukb-b-8006) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint rs7869395 0.0309686964093724 0.015752912220218 0.0493098236827502
Poultry (ukb-b-8006) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint All - Inverse variance weighted 0.0053553631934224 0.0020839946250925 0.0101769391820536