ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Crisp (ukb-b-12602) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Inverse variance weighted 6 -0.008896325 0.004384088 0.042434839
Herbal tea (ukb-b-13344) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Inverse variance weighted 7 -0.000350426 0.000153251 0.02221795
Cheese (ukb-b-1489) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Weighted median 183 -0.005300804 0.0021266 0.012680481
Cheese (ukb-b-1489) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Inverse variance weighted 183 -0.005622791 0.001526597 0.000230306
Dried fruit (ukb-b-16576) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Weighted median 147 -0.007971162 0.003185894 0.01234879
Dried fruit (ukb-b-16576) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Inverse variance weighted 147 -0.00604278 0.002404932 0.011982433
Dried fruit (ukb-b-16576) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Simple mode 147 -0.022822767 0.009469851 0.017195129
Standard tea (ukb-b-3291) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Weighted mode 8 7.13e-05 2.7e-05 0.033401948
Drinking water (ukb-b-3975) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Inverse variance weighted 14 -0.002383129 0.001148145 0.037927699
Whole egg (ukb-b-4075) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Weighted median 3 -0.022483779 0.009179615 0.014312782
Whole egg (ukb-b-4075) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Inverse variance weighted 3 -0.026315264 0.006540481 5.74e-05
Coffee (ukb-b-5237) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants MR Egger 107 0.018222675 0.005133857 0.000578895
Coffee (ukb-b-5237) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Weighted median 107 0.011348835 0.003402154 0.000850608
Coffee (ukb-b-5237) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Inverse variance weighted 107 0.008954607 0.002338342 0.000128421
Coffee (ukb-b-5237) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Weighted mode 107 0.012336976 0.004563037 0.007989799
Pork (ukb-b-5640) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Weighted median 70 0.010772215 0.005190748 0.037961309
Pork (ukb-b-5640) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Inverse variance weighted 70 0.01084402 0.003587615 0.002505916
Tea (ukb-b-6066) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants MR Egger 129 0.009607775 0.004611676 0.039223998
Watercress (ukb-b-6181) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Weighted median 4 -0.023193664 0.011506309 0.043827747
Watercress (ukb-b-6181) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Inverse variance weighted 4 -0.022706934 0.009552566 0.017451689
Bread roll (ukb-b-6246) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Inverse variance weighted 8 0.009598554 0.004738028 0.042779739
Oatcakes (ukb-b-6298) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Inverse variance weighted 3 -0.014912501 0.007265607 0.040123185
Processed meat (ukb-b-6324) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Inverse variance weighted 114 0.00521895 0.002115139 0.01360881
Filtered coffee (ukb-b-748) (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants Inverse variance weighted 16 0.004242564 0.001642727 0.009804912

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Crisp (ukb-b-12602) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs7377083 -0.0226413045059373 0.0113016936660864 0.0451391980011518
Crisp (ukb-b-12602) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants All - Inverse variance weighted -0.0088963248335012 0.0043840883186496 0.0424348392246224
Herbal tea (ukb-b-13344) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs855736 -0.0009769962214009 0.0004129900759872 0.0179977152141388
Herbal tea (ukb-b-13344) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants All - Inverse variance weighted -0.0003504262504389 0.0001532506870833 0.0222179501859207
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs11213287 -0.0457903266018449 0.0204467179541974 0.0251237136471923
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs113829457 -0.0426890454730536 0.021763090152451 0.049816740363336
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs114121746 0.0546060744960657 0.0208639731962588 0.0088643377124206
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs11620149 -0.0386600469603101 0.0185954906786613 0.0376172425176229
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs13107325 -0.0299935536742342 0.0149303762528331 0.0445483024729243
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs17207890 -0.0534481193477665 0.0207401856673061 0.0099652763609117
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs2644109 -0.0489105585303053 0.0216197289760426 0.0236781728588507
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs6126641 -0.0518657946469076 0.0185498261001058 0.0051735250514394
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs683996 -0.0430753003095526 0.0199190233505629 0.0305780633359073
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs6857 0.0499552618401286 0.0201101652478718 0.0129886578549312
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs7012814 -0.0336824169236502 0.0124771955217351 0.0069439948699498
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs72810360 -0.047934410414297 0.0180233797633439 0.0078240852514716
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs75499503 -0.056077961379915 0.0198325661639409 0.0046902817035363
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs7730004 0.0472398989452856 0.0216692578131901 0.0292543251381904
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs79147413 -0.0548701167353654 0.0205584148802755 0.0076080673858176
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs9649582 -0.0367666899278902 0.0169111147599305 0.0296965811525396
Cheese (ukb-b-1489) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants All - Inverse variance weighted -0.00562279111633 0.0015265965937671 0.0002303062256667
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs11632215 0.0623680303180282 0.0250746638007834 0.0128719416072241
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs12708665 -0.0737832492412925 0.0298658285649858 0.0134927858534915
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs1648404 0.0533081632761431 0.0243837318592388 0.0287996306501885
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs17175518 0.100903776900193 0.0235416920373689 1.81777027401252e-05
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs2389238 0.0625207686366001 0.0285425697936535 0.0284923872926772
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs429358 -0.0359557271428213 0.0159065907894407 0.0237946070374399
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs742877 -0.0608942981462531 0.0274820913827718 0.0267064987808988
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs7730004 0.0652411910167463 0.0299265709653374 0.0292543251381904
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs7808471 -0.0609587212426969 0.0212273538946967 0.0040826249066302
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs7923809 -0.0653775042269283 0.0260881755482843 0.0122098520730822
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs9527691 -0.0664315304149932 0.0269554566416414 0.0137207297420432
Dried fruit (ukb-b-16576) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants All - Inverse variance weighted -0.0060427802103081 0.0024049322950527 0.011982432757211
Standard tea (ukb-b-3291) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs10493552 0.0001411015133447 5.42696487605309e-05 0.0093221625213616
Standard tea (ukb-b-3291) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs2472297 7.50042615723732e-05 2.54467793289248e-05 0.0032035965885905
Drinking water (ukb-b-3975) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs2472297 -0.0077839186477072 0.0026408587457578 0.0032035965885905
Drinking water (ukb-b-3975) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs2950835 -0.0115124360377791 0.004215142180698 0.0063102359574595
Drinking water (ukb-b-3975) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants All - Inverse variance weighted -0.0023831293588912 0.0011481445831063 0.0379276994642941
Whole egg (ukb-b-4075) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs2184358 -0.0235243653137176 0.0105937570981776 0.026378908586049
Whole egg (ukb-b-4075) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs2420110 -0.0389173436529278 0.0109106472984573 0.0003612095717737
Whole egg (ukb-b-4075) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants All - Inverse variance weighted -0.026315263652602 0.0065404813870673 5.73531122014084e-05
Coffee (ukb-b-5237) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs12604773 0.0595714418302473 0.0280818135412316 0.0338921000563343
Coffee (ukb-b-5237) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs13387939 0.0411736068326508 0.0183187160994938 0.0246001031363604
Coffee (ukb-b-5237) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs1421085 0.0381512301403255 0.0125873933536829 0.0024381959568163
Coffee (ukb-b-5237) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs2472297 0.0164749907468776 0.005589488452964 0.0032035965885905
Coffee (ukb-b-5237) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs4615895 -0.0450420815406679 0.021520426142184 0.0363498612840984
Coffee (ukb-b-5237) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs476828 0.0660915133661169 0.015514496053868 2.04441042295789e-05
Coffee (ukb-b-5237) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs4840338 0.0832657804895765 0.0304899066938727 0.006315601257191
Coffee (ukb-b-5237) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs516636 0.0506746769207053 0.02412830679901 0.0357097682543808
Coffee (ukb-b-5237) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs780093 0.0392055515853613 0.0176893970737579 0.026668870535591
Coffee (ukb-b-5237) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants All - Inverse variance weighted 0.0089546066704846 0.0023383424648713 0.0001284207970131
Coffee (ukb-b-5237) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants All - MR Egger 0.0182226753337679 0.0051338571911797 0.000578895156516
Pork (ukb-b-5640) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs10931858 0.0613085165641926 0.0307555252383856 0.0462160539260758
Pork (ukb-b-5640) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs12721051 0.0516396386195071 0.023704554461852 0.0293711328229902
Pork (ukb-b-5640) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs12932179 -0.0658947600601056 0.0320022332814072 0.0394877679527701
Pork (ukb-b-5640) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs9379832 0.0843706577169507 0.0231111014252713 0.0002615724098074
Pork (ukb-b-5640) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants All - Inverse variance weighted 0.0108440198272569 0.0035876152700072 0.002505915899463
Tea (ukb-b-6066) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs12765951 0.0502502367731991 0.023005905402143 0.0289451982319999
Tea (ukb-b-6066) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs2472297 0.0143518922941665 0.0048691824771816 0.0032035965885905
Tea (ukb-b-6066) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs2478875 -0.0256658125630872 0.0129023079066241 0.0466745000120455
Tea (ukb-b-6066) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs4135060 0.0803491051494204 0.0219350024475566 0.0002492256759864
Tea (ukb-b-6066) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs457534 0.0579254333780141 0.0228155639562028 0.0111215561753646
Tea (ukb-b-6066) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs7012814 -0.0575121033557418 0.0213045803708929 0.0069439948699498
Tea (ukb-b-6066) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs713598 0.0358177638110309 0.0174182086900701 0.0397497300892153
Tea (ukb-b-6066) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs9302428 0.0387204488106029 0.0194382517945075 0.0463741554932247
Tea (ukb-b-6066) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs9937354 -0.0449831468248618 0.0164433059188351 0.0062257009207996
Tea (ukb-b-6066) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants All - MR Egger 0.0096077754090881 0.0046116761032203 0.0392239983448318
Watercress (ukb-b-6181) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants All - Inverse variance weighted -0.0227069335446999 0.0095525658931734 0.0174516887255363
Bread roll (ukb-b-6246) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs153408 0.0268741348608166 0.0085180674693506 0.0016052187340204
Bread roll (ukb-b-6246) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs6022239 0.0207159689101632 0.0099801240295275 0.0379196152998395
Bread roll (ukb-b-6246) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants All - Inverse variance weighted 0.0095985536807899 0.0047380281419544 0.0427797392842974
Oatcakes (ukb-b-6298) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants All - Inverse variance weighted -0.0149125012012009 0.007265606622225 0.04012318483441
Processed meat (ukb-b-6324) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs12593984 0.0585583126550868 0.0233256346631036 0.0120570469797521
Processed meat (ukb-b-6324) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs4240672 -0.0324675089514664 0.0133829825760364 0.015265034347223
Processed meat (ukb-b-6324) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs62396185 0.0775417103903816 0.0212596497222019 0.0002649430424591
Processed meat (ukb-b-6324) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs7412 0.0728326785534401 0.0212574292334038 0.000612039198294
Processed meat (ukb-b-6324) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs7560257 0.0615001440284403 0.0224113171225225 0.0060666752803378
Processed meat (ukb-b-6324) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs959346 0.0570518435443204 0.0236958274665182 0.0160544803495038
Processed meat (ukb-b-6324) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants All - Inverse variance weighted 0.0052189499750573 0.0021151388636154 0.0136088104268998
Filtered coffee (ukb-b-748) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs10468280 0.0175875860187435 0.0068042676325726 0.0097439026652956
Filtered coffee (ukb-b-748) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants rs2470893 0.0129426480069476 0.0049454221520776 0.0088681213813709
Filtered coffee (ukb-b-748) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants All - Inverse variance weighted 0.0042425641704216 0.0016427272466851 0.0098049116749898