ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Sweetened cereal (ukb-b-10640) (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) Wald ratio 1 -0.037574053 0.015258375 0.013796447
Vegetable pieces (ukb-b-12566) (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) Weighted median 3 -0.007385863 0.003586035 0.039435075
Vegetable pieces (ukb-b-12566) (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) Inverse variance weighted 3 -0.006041294 0.00283245 0.032934055
Homemade soup (ukb-b-12658) (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) Inverse variance weighted 4 -0.008700398 0.004336307 0.044812803
Naan bread (ukb-b-13281) (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) Inverse variance weighted 2 0.028658209 0.013380458 0.032209917
Cheese (ukb-b-1489) (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) Inverse variance weighted 122 -0.00308528 0.000960871 0.001323114
Cereal (ukb-b-15926) (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) Weighted median 116 -0.003863617 0.001775476 0.02954759
Cereal (ukb-b-15926) (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) Inverse variance weighted 116 -0.003493657 0.001181661 0.003110878
Dried fruit (ukb-b-16576) (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) Weighted median 109 -0.004432857 0.001879794 0.01836574
Dried fruit (ukb-b-16576) (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) Inverse variance weighted 109 -0.004242994 0.001291522 0.001018859
Beef (ukb-b-2862) (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) Weighted median 59 0.005189917 0.002637308 0.049081339
Porridge (ukb-b-29) (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) Inverse variance weighted 2 -0.013530428 0.004760735 0.004481909
Drinking water (ukb-b-3975) (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) MR Egger 11 -0.008954706 0.003703337 0.038736861
Lamb (ukb-b-530) (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) Weighted median 4 0.016059601 0.00672048 0.016864398
Processed meat (ukb-b-6324) (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) MR Egger 70 -0.029291371 0.009079893 0.001931708
Filtered coffee (ukb-b-748) (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) Weighted median 11 0.003170335 0.001517684 0.03671402
Soft cheese (ukb-b-8007) (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) Inverse variance weighted 4 -0.01507092 0.006959873 0.030356942
Instant coffee (ukb-b-930) (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) Weighted median 7 0.002142196 0.001087699 0.048898503

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Sweetened cereal (ukb-b-10640) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs7258015 -0.0375740531185516 0.0152583746588564 0.0137964469132167
Vegetable pieces (ukb-b-12566) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) All - Inverse variance weighted -0.0060412939276123 0.002832450063042 0.0329340546740282
Homemade soup (ukb-b-12658) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) All - Inverse variance weighted -0.0087003981277728 0.004336306906847 0.04481280285748
Naan bread (ukb-b-13281) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs166722 0.0381264313574935 0.0180978242033054 0.0351448138342985
Naan bread (ukb-b-13281) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) All - Inverse variance weighted 0.0286582090905643 0.0133804581288176 0.0322099171481878
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs2245959 0.0340268473779291 0.0110647327795593 0.0021032439515338
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs2352974 -0.021153740032558 0.0085117815854096 0.0129467539546559
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs3733421 -0.0256908589505917 0.0115915442295454 0.0266678960107474
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs683996 -0.0220287659216622 0.0106901501366526 0.0393354780669387
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs72845670 -0.0248556437185973 0.0107711270318157 0.0210204074563956
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs7439876 0.0262420170076159 0.0106426522318227 0.0136730409703625
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs75499503 -0.0210898047783694 0.0106438566347779 0.0475457258709719
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs9377684 -0.0231209244798337 0.0108350470948997 0.03285083537242
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) All - Inverse variance weighted -0.0030852798825084 0.000960871410803 0.0013231140919656
Cereal (ukb-b-15926) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs10260232 -0.0352620533741928 0.0145302027617714 0.0152321960512686
Cereal (ukb-b-15926) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs10829656 -0.0296295230017296 0.0140332364085722 0.0347394894494005
Cereal (ukb-b-15926) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs2903760 -0.0280285927687015 0.0133190965610831 0.0353443156467507
Cereal (ukb-b-15926) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs6545770 -0.0207441724941725 0.0103621794871795 0.0452941860976965
Cereal (ukb-b-15926) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) All - Inverse variance weighted -0.0034936569633975 0.0011816612406813 0.0031108776668935
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs11134477 -0.0380410008397154 0.0156495166901324 0.0150651145456593
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs11253371 0.033453690940483 0.0157219574616228 0.0333509795615667
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs11772627 -0.0227290578058013 0.0081247750057271 0.0051499772566301
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs1289870 -0.0288120804424617 0.0145994295659353 0.0484377966642165
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs2508819 -0.0420938423030012 0.0151200581922205 0.0053697410474851
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs4149513 -0.0246719522591645 0.0104874680306905 0.01864681143204
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs7582086 -0.0274513123415463 0.0127989522455368 0.0319680939916394
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs7941325 -0.040054422107933 0.0153401891740578 0.0090257448950029
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) All - Inverse variance weighted -0.0042429943435983 0.0012915220754689 0.0010188591487931
Beef (ukb-b-2862) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs10959890 0.0279311216030571 0.0118157558148715 0.0180842861782017
Beef (ukb-b-2862) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs4863708 0.0319844302264222 0.015620117847159 0.0405949597411375
Beef (ukb-b-2862) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs62396185 0.0243185783478278 0.0094485573975897 0.0100592051866508
Porridge (ukb-b-29) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs4906184 -0.0138705738705739 0.0067314776175535 0.0393455986074331
Porridge (ukb-b-29) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) All - Inverse variance weighted -0.013530427908349 0.00476073465453 0.0044819086736968
Drinking water (ukb-b-3975) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs13162251 0.0072148454894415 0.0023830531594482 0.0024653366300033
Drinking water (ukb-b-3975) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) All - MR Egger -0.008954705676805 0.0037033373220975 0.0387368608811718
Lamb (ukb-b-530) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs10001236 0.0210694081293083 0.010333729498455 0.0414603271723145
Processed meat (ukb-b-6324) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs3733421 -0.0244169004207574 0.0110167426367461 0.0266678960107474
Processed meat (ukb-b-6324) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs4240672 -0.0222220080490184 0.0071825515037879 0.0019755222083769
Processed meat (ukb-b-6324) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs62396185 0.0293662298362496 0.0114097339157739 0.0100592051866508
Processed meat (ukb-b-6324) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs6961970 -0.0226566625280073 0.0102286252515306 0.026758335994071
Processed meat (ukb-b-6324) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) All - MR Egger -0.0292913712788318 0.0090798930552284 0.0019317080921681
Filtered coffee (ukb-b-748) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs12535729 0.0101462633412102 0.0035060364426426 0.003804393864954
Soft cheese (ukb-b-8007) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs2284636 -0.0284632805960491 0.0142255955252562 0.0454085739889833
Soft cheese (ukb-b-8007) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) All - Inverse variance weighted -0.0150709198003831 0.0069598727875714 0.0303569422017346
Instant coffee (ukb-b-930) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) rs12510185 -0.0062806903582609 0.0024431212277045 0.0101474180558083