ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Fractured bone site(s): Leg (ukb-b-3798)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Avocado (ukb-b-12236) (👉 📊) Fractured bone site(s): Leg Inverse variance weighted 5 -0.016501036 0.007099076 0.020104489
Other drink (ukb-b-1310) (👉 📊) Fractured bone site(s): Leg Inverse variance weighted 7 0.015292611 0.006172122 0.013223565
Cereal (ukb-b-15926) (👉 📊) Fractured bone site(s): Leg Inverse variance weighted 142 -0.003940185 0.001442232 0.006295029
Low calorie hot chocolate (ukb-b-1795) (👉 📊) Fractured bone site(s): Leg Wald ratio 1 0.066886556 0.026494957 0.011586255
Other fruit (ukb-b-18659) (👉 📊) Fractured bone site(s): Leg Weighted median 3 0.023917073 0.011010796 0.029844543
Other fruit (ukb-b-18659) (👉 📊) Fractured bone site(s): Leg Inverse variance weighted 3 0.024167819 0.008674267 0.0053338
Espresso (ukb-b-19142) (👉 📊) Fractured bone site(s): Leg Weighted median 9 0.016433652 0.007133924 0.021245548
Espresso (ukb-b-19142) (👉 📊) Fractured bone site(s): Leg Inverse variance weighted 9 0.013199115 0.005310694 0.012941163
Butternut squash (ukb-b-20341) (👉 📊) Fractured bone site(s): Leg Weighted median 4 -0.032305566 0.011777401 0.006087825
Butternut squash (ukb-b-20341) (👉 📊) Fractured bone site(s): Leg Inverse variance weighted 4 -0.028899666 0.009608517 0.002632211
Orange juice (ukb-b-2763) (👉 📊) Fractured bone site(s): Leg Inverse variance weighted 5 -0.006822212 0.003153783 0.030527046
Oatcakes (ukb-b-6298) (👉 📊) Fractured bone site(s): Leg Weighted median 3 0.014311287 0.007012139 0.041257766
Other egg (ukb-b-8266) (👉 📊) Fractured bone site(s): Leg Wald ratio 1 0.06323516 0.030770225 0.039871636
Soya dessert (ukb-b-998) (👉 📊) Fractured bone site(s): Leg Wald ratio 1 -0.088665647 0.042004111 0.03478261

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Avocado (ukb-b-12236) Fractured bone site(s): Leg All - Inverse variance weighted -0.0165010358372282 0.0070990758646211 0.0201044887399123
Other drink (ukb-b-1310) Fractured bone site(s): Leg rs6496597 0.0417053862190187 0.016766633510921 0.0128679286446952
Other drink (ukb-b-1310) Fractured bone site(s): Leg All - Inverse variance weighted 0.0152926109057551 0.0061721221945128 0.0132235653455693
Cereal (ukb-b-15926) Fractured bone site(s): Leg rs10812904 -0.0454943824464326 0.0188391239125136 0.0157400300347377
Cereal (ukb-b-15926) Fractured bone site(s): Leg rs12887676 0.0515197885090225 0.0203753916387401 0.0114541305263829
Cereal (ukb-b-15926) Fractured bone site(s): Leg rs12892571 -0.0380796283291016 0.0185895953757225 0.0405171289296845
Cereal (ukb-b-15926) Fractured bone site(s): Leg rs1455349 -0.0504937012164921 0.0200115372294336 0.0116282481562054
Cereal (ukb-b-15926) Fractured bone site(s): Leg rs1966434 -0.0348807542983916 0.017764014707997 0.0495808421605394
Cereal (ukb-b-15926) Fractured bone site(s): Leg rs616243 -0.0418102755556378 0.0197155301090175 0.0339489749301304
Cereal (ukb-b-15926) Fractured bone site(s): Leg All - Inverse variance weighted -0.0039401851857601 0.0014422323438356 0.0062950290132517
Low calorie hot chocolate (ukb-b-1795) Fractured bone site(s): Leg rs4969076 0.0668865560876598 0.0264949573435667 0.0115862553636735
Other fruit (ukb-b-18659) Fractured bone site(s): Leg All - Inverse variance weighted 0.0241678189752289 0.008674267060793 0.0053337997613869
Espresso (ukb-b-19142) Fractured bone site(s): Leg All - Inverse variance weighted 0.0131991145673346 0.005310693506446 0.0129411625767015
Butternut squash (ukb-b-20341) Fractured bone site(s): Leg All - Inverse variance weighted -0.0288996664751736 0.0096085167788933 0.0026322108358394
Orange juice (ukb-b-2763) Fractured bone site(s): Leg All - Inverse variance weighted -0.006822211949706 0.0031537828504587 0.0305270462677851
Other egg (ukb-b-8266) Fractured bone site(s): Leg rs10865141 0.0632351600627489 0.0307702250225512 0.0398716360460759
Soya dessert (ukb-b-998) Fractured bone site(s): Leg rs13250489 -0.0886656470379951 0.0420041113001741 0.0347826100025787