ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Pineapple (ukb-b-1164) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Weighted median 3 -0.02197135 0.010510367 0.036577796
Herbal tea (ukb-b-13344) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Weighted median 3 -0.000342982 0.000172897 0.047285173
Herbal tea (ukb-b-13344) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Inverse variance weighted 3 -0.000318217 0.000139089 0.022145128
Vegetarian alternatives (ukb-b-14425) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Inverse variance weighted 6 0.02959473 0.014044862 0.035103964
Cheese (ukb-b-1489) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Weighted median 140 -0.003116106 0.00137539 0.023474863
Cheese (ukb-b-1489) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Inverse variance weighted 140 -0.003027605 0.000994978 0.002343218
Water (ukb-b-14898) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint MR Egger 115 -0.009047355 0.004202922 0.033474155
Cereal (ukb-b-15926) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Weighted median 126 -0.004251142 0.00191995 0.026815413
Cereal (ukb-b-15926) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Inverse variance weighted 126 -0.003807662 0.001262165 0.002554829
Rose wine (ukb-b-16124) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Inverse variance weighted 3 -0.006615817 0.003325634 0.046663724
Lettuce (ukb-b-2867) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Inverse variance weighted 4 -0.004920893 0.002257934 0.029303548
Standard tea (ukb-b-3291) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Inverse variance weighted 8 2.85e-05 9.02e-06 0.00156141
Coffee (ukb-b-5237) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint MR Egger 86 0.007572044 0.003016678 0.013989452
Coffee (ukb-b-5237) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Weighted median 86 0.004579097 0.002143815 0.032682935
Coffee (ukb-b-5237) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Inverse variance weighted 86 0.003939562 0.00142947 0.005852005
Coffee (ukb-b-5237) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Weighted mode 86 0.005514595 0.002235812 0.015653014
Banana (ukb-b-5362) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Inverse variance weighted 7 -0.003706598 0.001741027 0.033256601
Pork (ukb-b-5640) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Inverse variance weighted 58 0.005087416 0.002524077 0.043846481
Tea (ukb-b-6066) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint MR Egger 105 0.007584637 0.002773515 0.007353108
Tea (ukb-b-6066) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Weighted median 105 0.003929404 0.001959775 0.044960091
Tea (ukb-b-6066) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Inverse variance weighted 105 0.002698932 0.001078161 0.012305082
Tea (ukb-b-6066) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Weighted mode 105 0.004466036 0.00213677 0.039048555
Bread roll (ukb-b-6246) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Inverse variance weighted 7 0.005481136 0.002249414 0.014822158
Filtered coffee (ukb-b-748) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Weighted median 13 0.003028851 0.001486418 0.041581473
Filtered coffee (ukb-b-748) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Inverse variance weighted 13 0.002442776 0.001052274 0.020263859
Instant coffee (ukb-b-930) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint MR Egger 9 0.020016475 0.006641467 0.019555085
Instant coffee (ukb-b-930) (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint Weighted median 9 0.002628713 0.00110626 0.017491247

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Pineapple (ukb-b-1164) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs62007226 -0.0330256485917735 0.0136817338230612 0.015784973828575
Herbal tea (ukb-b-13344) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint All - Inverse variance weighted -0.0003182166099257 0.0001390886253152 0.0221451277123766
Vegetarian alternatives (ukb-b-14425) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs10767356 0.0680091434567138 0.0278837956587317 0.0147271412167691
Vegetarian alternatives (ukb-b-14425) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs4440163 0.0637931093401862 0.0282893297975587 0.024131840790789
Vegetarian alternatives (ukb-b-14425) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint All - Inverse variance weighted 0.0295947301282273 0.01404486168532 0.0351039635006717
Cheese (ukb-b-1489) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs11756671 -0.0376276989342316 0.0132284131279106 0.0044486698015421
Cheese (ukb-b-1489) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs13181793 -0.0361679212403212 0.0122866176814042 0.0032433085064458
Cheese (ukb-b-1489) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs1931805 0.0215090651535655 0.010737241122797 0.0451535900253293
Cheese (ukb-b-1489) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs2339928 -0.023497354924686 0.0099849237437574 0.0186084474779071
Cheese (ukb-b-1489) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs281219 0.029564088640269 0.0123659721344035 0.0168134763471485
Cheese (ukb-b-1489) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs35392738 -0.0281416845757489 0.0128906553429481 0.0290279045825951
Cheese (ukb-b-1489) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs6694085 -0.0267606040690158 0.0128110442651721 0.0367194408387059
Cheese (ukb-b-1489) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs72845670 -0.0268277568069572 0.0118764176702702 0.0238889934287851
Cheese (ukb-b-1489) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint All - Inverse variance weighted -0.0030276047852205 0.0009949783722585 0.0023432184564891
Water (ukb-b-14898) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs2229357 -0.0287586026086387 0.0129605263157895 0.0264909519306698
Water (ukb-b-14898) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs2289292 0.0253510846581565 0.0112885112381549 0.0247205334435326
Water (ukb-b-14898) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs34940743 -0.0301223994919266 0.0136617848001386 0.0274635262880684
Water (ukb-b-14898) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs4603502 0.0272155839784584 0.0114009669226768 0.0169805106955114
Water (ukb-b-14898) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs6541139 -0.0289769740404209 0.0140777310717555 0.0395560279015723
Water (ukb-b-14898) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs7624543 0.0294746448303078 0.0138218232044199 0.032968100421566
Water (ukb-b-14898) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint All - MR Egger -0.0090473547495607 0.0042029215539816 0.0334741552584261
Cereal (ukb-b-15926) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs112780312 0.0258786002979841 0.0126445675526617 0.0406956003340041
Cereal (ukb-b-15926) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs12887676 -0.0327211289857496 0.0164922011490493 0.0472517714975192
Cereal (ukb-b-15926) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs1297594 0.0326805634001694 0.0142792466817283 0.0220982080085656
Cereal (ukb-b-15926) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs17662627 -0.034711705515221 0.0162212202267227 0.0323632659505261
Cereal (ukb-b-15926) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs2725370 -0.036672494778327 0.0139801907210162 0.0087114367843114
Cereal (ukb-b-15926) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs4007 -0.0330934134409702 0.0161506482394301 0.040457663866891
Cereal (ukb-b-15926) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs489693 0.0320963827621035 0.0146517262387891 0.0284792125119581
Cereal (ukb-b-15926) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs62442924 -0.0360175635658123 0.0134856922919825 0.0075671109923535
Cereal (ukb-b-15926) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs9973711 -0.0331848919126132 0.0161570808449366 0.0399861888039914
Cereal (ukb-b-15926) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint All - Inverse variance weighted -0.0038076615011813 0.0012621646726659 0.0025548292425387
Rose wine (ukb-b-16124) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs12456862 -0.0228208510541518 0.0105041430704966 0.0298136644662684
Rose wine (ukb-b-16124) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint All - Inverse variance weighted -0.0066158165606515 0.0033256344682953 0.0466637243109486
Lettuce (ukb-b-2867) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint All - Inverse variance weighted -0.0049208925705405 0.0022579336979213 0.029303548331344
Standard tea (ukb-b-3291) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs2389763 5.94328154018458e-05 2.44596807349334e-05 0.0151059925819723
Standard tea (ukb-b-3291) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint All - Inverse variance weighted 2.85329400915759e-05 9.02078719546378e-06 0.0015614102300789
Coffee (ukb-b-5237) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs2126069 -0.0311637556364427 0.0154525678636751 0.0437230322051225
Coffee (ukb-b-5237) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs2350804 0.0437035868236937 0.0172264224421556 0.011180411595575
Coffee (ukb-b-5237) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs476828 0.0282388548434518 0.009180565083794 0.0020984102630523
Coffee (ukb-b-5237) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs9296406 0.0356375352624766 0.0175333800921079 0.0420976408354039
Coffee (ukb-b-5237) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint All - Inverse variance weighted 0.0039395618096749 0.001429469572488 0.0058520047079277
Coffee (ukb-b-5237) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint All - MR Egger 0.0075720437033654 0.0030166779517703 0.0139894515518837
Banana (ukb-b-5362) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs6566594 -0.010308764940239 0.0047337479350889 0.0294270874790957
Banana (ukb-b-5362) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint All - Inverse variance weighted -0.0037065981222102 0.0017410274168038 0.0332566007860042
Pork (ukb-b-5640) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs10896701 0.0400108056673306 0.0191299287417311 0.0364806465022588
Pork (ukb-b-5640) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs11209948 -0.0456170995519111 0.0173284832142105 0.0084760931052717
Pork (ukb-b-5640) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs11211124 0.0334998538089549 0.0162069100638719 0.0387331614653795
Pork (ukb-b-5640) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs17446175 0.0416047942608848 0.0198858301011927 0.0364221550034094
Pork (ukb-b-5640) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs35934080 -0.038991942668224 0.017686769043729 0.0274834003131115
Pork (ukb-b-5640) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs4146837 -0.0344212978233128 0.0156228318998756 0.027575809863985
Pork (ukb-b-5640) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs72932757 0.0380436941410129 0.0181359208941664 0.0359317870637438
Pork (ukb-b-5640) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint All - Inverse variance weighted 0.0050874164867172 0.0025240766599404 0.0438464814835811
Tea (ukb-b-6066) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs10752269 0.0262526121171161 0.0105382709144158 0.0127323598983959
Tea (ukb-b-6066) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs1421488 0.0281995850157021 0.0130684537161657 0.0309405543557466
Tea (ukb-b-6066) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs2478875 0.0164211689800542 0.0076349552166545 0.0314929478686801
Tea (ukb-b-6066) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs34940743 0.0263189843618631 0.0119367748444594 0.0274635262880684
Tea (ukb-b-6066) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs4451355 -0.0358383094991517 0.0139846117789401 0.0103862927676877
Tea (ukb-b-6066) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs6265 0.0242172213432846 0.0122935304676027 0.0488480079166085
Tea (ukb-b-6066) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint rs9624470 0.0141391115995097 0.005469451067358 0.0097349020980524
Tea (ukb-b-6066) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint All - Inverse variance weighted 0.0026989317409895 0.0010781614539476 0.0123050818547446
Tea (ukb-b-6066) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint All - MR Egger 0.0075846366060941 0.0027735145589643 0.0073531081440191
Bread roll (ukb-b-6246) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint All - Inverse variance weighted 0.0054811359535474 0.002249413652041 0.0148221579553864
Filtered coffee (ukb-b-748) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint All - Inverse variance weighted 0.0024427761873002 0.0010522739477041 0.0202638592414792
Instant coffee (ukb-b-930) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint All - MR Egger 0.0200164753023205 0.0066414672316274 0.0195550846449142