ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint (ukb-b-7012)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Beetroot (ukb-b-11880) (👉 📊) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint Inverse variance weighted 2 -0.009967597 0.004622086 0.031043475
Double crust pastry (ukb-b-1255) (👉 📊) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint Inverse variance weighted 5 0.010312141 0.004142757 0.01280317
Lamb/mutton (ukb-b-14179) (👉 📊) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint Weighted median 59 -0.005077291 0.002444681 0.037813338
Cheese (ukb-b-1489) (👉 📊) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint Inverse variance weighted 89 -0.003247607 0.001070502 0.002415546
Cheese (ukb-b-1489) (👉 📊) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint Simple mode 89 -0.009329071 0.004006489 0.022178337
Cereal (ukb-b-15926) (👉 📊) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint Inverse variance weighted 82 -0.002931138 0.001245741 0.018626244
Non-oily fish (ukb-b-17627) (👉 📊) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint MR Egger 30 0.027111317 0.011775228 0.028957861
Butternut squash (ukb-b-20341) (👉 📊) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint Wald ratio 1 0.033146211 0.012456189 0.007790352
Standard tea (ukb-b-3291) (👉 📊) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint Inverse variance weighted 4 2.34e-05 1.1e-05 0.033743033
Fresh fruit (ukb-b-3881) (👉 📊) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint Inverse variance weighted 83 -0.003904874 0.001631604 0.016698806
Oat crunch (ukb-b-5186) (👉 📊) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint Wald ratio 1 0.029372626 0.013139781 0.025391304
Soft cheese (ukb-b-8007) (👉 📊) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint Inverse variance weighted 3 -0.016326149 0.006814994 0.016592196
Soya dessert (ukb-b-998) (👉 📊) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint Wald ratio 1 0.056491772 0.02640576 0.032405463

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Beetroot (ukb-b-11880) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs28449718 -0.0148031280796007 0.0067149442095559 0.0274888487590779
Beetroot (ukb-b-11880) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint All - Inverse variance weighted -0.0099675966500366 0.0046220855181279 0.0310434754881025
Double crust pastry (ukb-b-1255) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs10789657 0.0232874739334818 0.0096485879899621 0.0157974012681063
Double crust pastry (ukb-b-1255) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint All - Inverse variance weighted 0.0103121414535098 0.0041427568992684 0.0128031704117739
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs11735256 0.0227570617684979 0.009180466486948 0.0131804211277588
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs1235070 -0.0184663156592873 0.0093330270852841 0.0478612013030174
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs13266268 -0.0243280235398068 0.0093000575158168 0.0088992530248014
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs1473781 -0.0194173051956317 0.0094240935434327 0.0393613015217241
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs1931805 -0.0171433884918845 0.0083394664577447 0.0398120514914892
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs2644109 -0.0276869414919682 0.009936475975802 0.0053297972616369
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs2870681 0.0204661009314812 0.0098198295587625 0.0371455699433072
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs2968940 -0.0261821440208537 0.0092092701205604 0.0044688191728386
Cheese (ukb-b-1489) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint All - Inverse variance weighted -0.0032476074382872 0.0010705016101691 0.0024155455369241
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs1376619 -0.0229564091497626 0.0112391611409738 0.041098234308518
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs1853931 -0.0203610366240915 0.0094368781313951 0.0309587107886667
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs2456141 0.0273424164295875 0.012333414829303 0.0266273262273175
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs4730682 -0.0238950094086238 0.0113470683157223 0.0352190258957181
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs67723420 -0.0237911868658078 0.0103709193174476 0.021788848562967
Cereal (ukb-b-15926) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint All - Inverse variance weighted -0.0029311376261303 0.0012457405023122 0.0186262436085369
Non-oily fish (ukb-b-17627) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs4953152 -0.0255593505452851 0.0129319231883976 0.0481033874641722
Non-oily fish (ukb-b-17627) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs7326846 -0.0266433104464034 0.0125044943576859 0.0331139684721117
Non-oily fish (ukb-b-17627) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint All - MR Egger 0.0271113172722937 0.0117752283051328 0.0289578605572519
Butternut squash (ukb-b-20341) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs1427206 0.0331462113951292 0.0124561890083708 0.0077903524853562
Standard tea (ukb-b-3291) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint All - Inverse variance weighted 2.33874521495779e-05 1.10155580781378e-05 0.0337430332894097
Fresh fruit (ukb-b-3881) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs10059461 -0.0329947550024438 0.0167743629771744 0.0491860766121056
Fresh fruit (ukb-b-3881) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs11649274 0.0323730473941207 0.0163050659538437 0.0470933765636084
Fresh fruit (ukb-b-3881) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs11896330 -0.0311995377512974 0.0130086778195217 0.0164685143303074
Fresh fruit (ukb-b-3881) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs4953150 -0.0292062882663188 0.0132006431881657 0.0269328409447158
Fresh fruit (ukb-b-3881) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs898751 -0.0414825746903419 0.0181147192737118 0.0220217404972654
Fresh fruit (ukb-b-3881) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint All - Inverse variance weighted -0.003904873513999 0.0016316038143004 0.0166988064609285
Oat crunch (ukb-b-5186) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs13220965 0.0293726255163619 0.0131397809916312 0.0253913043474532
Soft cheese (ukb-b-8007) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs12468108 -0.0281706307920351 0.0122384420404835 0.0213456011646706
Soft cheese (ukb-b-8007) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint All - Inverse variance weighted -0.0163261489263258 0.0068149939933264 0.0165921955802838
Soya dessert (ukb-b-998) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint rs13250489 0.0564917724818286 0.0264057597545023 0.0324054625728179