ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement (ukb-b-8136)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Chocolate-covered raisin (ukb-b-1160) (👉 📊) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement Inverse variance weighted 2 -0.038290976 0.015428838 0.013072807
Double crust pastry (ukb-b-1255) (👉 📊) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement Weighted median 5 0.020622245 0.008411185 0.014215765
Double crust pastry (ukb-b-1255) (👉 📊) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement Inverse variance weighted 5 0.012825664 0.00614958 0.037013394
Lobster/crab (ukb-b-14746) (👉 📊) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement Weighted median 5 -0.078057594 0.032267672 0.015560463
Lobster/crab (ukb-b-14746) (👉 📊) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement Inverse variance weighted 5 -0.071265963 0.024694781 0.003903315
Cheese (ukb-b-1489) (👉 📊) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement Inverse variance weighted 159 -0.002485596 0.001050625 0.017989885
Dark chocolate (ukb-b-16139) (👉 📊) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement Inverse variance weighted 5 -0.014742876 0.00650033 0.023328009
Non-oily fish (ukb-b-17627) (👉 📊) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement MR Egger 46 0.033096081 0.013935623 0.021976896
Other fruit (ukb-b-18659) (👉 📊) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement Inverse variance weighted 2 -0.027595715 0.009838498 0.005033674
Oily fish (ukb-b-2209) (👉 📊) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement MR Egger 148 0.015065375 0.005416169 0.006124343
Watercress (ukb-b-6181) (👉 📊) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement Inverse variance weighted 3 -0.018350009 0.007517082 0.014642283
Crumble (ukb-b-7641) (👉 📊) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement Weighted median 5 0.037635505 0.012567555 0.002747543
Crumble (ukb-b-7641) (👉 📊) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement Inverse variance weighted 5 0.035778475 0.009282366 0.000115987
Yogurt (ukb-b-7753) (👉 📊) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement Inverse variance weighted 5 -0.005737002 0.002772147 0.038497685
Cooked vegetable (ukb-b-8089) (👉 📊) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement Inverse variance weighted 73 0.0053935 0.002421687 0.025936138

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Chocolate-covered raisin (ukb-b-1160) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement All - Inverse variance weighted -0.0382909763292378 0.0154288376915439 0.0130728065149562
Double crust pastry (ukb-b-1255) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement All - Inverse variance weighted 0.0128256641819667 0.0061495799653249 0.0370133941193486
Lobster/crab (ukb-b-14746) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs457294 -0.139989544818976 0.0531805828002122 0.0084798158335153
Lobster/crab (ukb-b-14746) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement All - Inverse variance weighted -0.0712659626210237 0.0246947806854596 0.0039033154821281
Cheese (ukb-b-1489) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs10146812 0.0307507852400964 0.0149621953659958 0.0398565853582601
Cheese (ukb-b-1489) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs13181793 -0.0373618022744013 0.0141655138961249 0.0083515116776021
Cheese (ukb-b-1489) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs1873036 -0.0320713292547275 0.0142674499443826 0.0245846748978958
Cheese (ukb-b-1489) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs2960578 -0.0329565074405985 0.0091787153075486 0.0003299986877286
Cheese (ukb-b-1489) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs35760956 0.0310598577727468 0.0145917128433583 0.0332877214144351
Cheese (ukb-b-1489) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs62048491 -0.0293590219210381 0.0137650763815036 0.0329359674431339
Cheese (ukb-b-1489) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs7607369 -0.0308958722609139 0.0133812638015967 0.0209496608154298
Cheese (ukb-b-1489) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs78876700 0.0274302765728179 0.0126763186251485 0.0304720812654129
Cheese (ukb-b-1489) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement All - Inverse variance weighted -0.0024855963745728 0.0010506250709518 0.0179898848868609
Dark chocolate (ukb-b-16139) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement All - Inverse variance weighted -0.0147428760235553 0.0065003299351848 0.0233280090466705
Non-oily fish (ukb-b-17627) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs56094641 0.0309315590863952 0.0126469910625621 0.0144545466167114
Non-oily fish (ukb-b-17627) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs56399747 -0.0411318414462022 0.0205523768337713 0.0453581324940873
Non-oily fish (ukb-b-17627) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs838133 0.022988321799308 0.0099856648541769 0.021327711255593
Non-oily fish (ukb-b-17627) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement All - MR Egger 0.0330960814968474 0.0139356228640877 0.0219768962016223
Other fruit (ukb-b-18659) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs926923 -0.0306565762588519 0.0134548800626977 0.0226984320922946
Other fruit (ukb-b-18659) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement All - Inverse variance weighted -0.0275957153726204 0.0098384976058846 0.0050336740878601
Oily fish (ukb-b-2209) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs12855717 -0.0301501251042535 0.0128460808843971 0.0189237789387984
Oily fish (ukb-b-2209) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs1339229 -0.0336899884338672 0.0155628197839682 0.0304049929217866
Oily fish (ukb-b-2209) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs1421085 0.0211304338415921 0.0086162303721579 0.0141907252506483
Oily fish (ukb-b-2209) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs7338243 0.0391022936276101 0.0164630891846082 0.0175418564081312
Oily fish (ukb-b-2209) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs7919624 0.0387791705693617 0.0160505390701289 0.0156891934884907
Oily fish (ukb-b-2209) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs903676 -0.0334176823130411 0.0150109953076363 0.0259998756079506
Oily fish (ukb-b-2209) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs9301837 0.0292111949589654 0.014172955255736 0.0392980983855578
Oily fish (ukb-b-2209) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement All - MR Egger 0.0150653745693377 0.0054161689160738 0.0061243433555698
Watercress (ukb-b-6181) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement All - Inverse variance weighted -0.0183500085095506 0.0075170824125853 0.014642283237406
Crumble (ukb-b-7641) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs12452190 0.0527122035469059 0.0209136863389359 0.0117200066596943
Crumble (ukb-b-7641) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs76702874 0.0447153605384197 0.0212862412014518 0.0356699766043802
Crumble (ukb-b-7641) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement All - Inverse variance weighted 0.0357784753390941 0.0092823663217358 0.0001159870980499
Yogurt (ukb-b-7753) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs11521361 -0.0121231924871132 0.0059431513474465 0.0413643424987065
Yogurt (ukb-b-7753) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement All - Inverse variance weighted -0.0057370018402323 0.0027721465586529 0.0384976852967557
Cooked vegetable (ukb-b-8089) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs10248006 0.0423690342072921 0.0215729977468251 0.0495318839924092
Cooked vegetable (ukb-b-8089) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs12550717 0.0364134676191337 0.0176438959136293 0.0390367087106993
Cooked vegetable (ukb-b-8089) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs12642480 0.0419012184384674 0.0212168118172265 0.0482787656704524
Cooked vegetable (ukb-b-8089) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs13115533 0.0459390204657999 0.0215673795995216 0.0331696920897967
Cooked vegetable (ukb-b-8089) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs1352243 -0.0413814006760343 0.0201069922060508 0.0395843536283286
Cooked vegetable (ukb-b-8089) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs1421085 0.0377985984745828 0.0154129079716598 0.0141907252506483
Cooked vegetable (ukb-b-8089) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs1444405 0.0453765418876863 0.020561064422241 0.0273199289505269
Cooked vegetable (ukb-b-8089) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs4851029 -0.0339509946532474 0.0153958955810662 0.0274402193822387
Cooked vegetable (ukb-b-8089) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement rs838133 0.0318320114308204 0.0138271858449481 0.021327711255593
Cooked vegetable (ukb-b-8089) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement All - Inverse variance weighted 0.0053935002202313 0.0024216868675454 0.0259361383288276