ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement (ukb-b-898)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Pear (ukb-b-10793) (👉 📊) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement MR Egger 6 -0.207341377 0.056725184 0.021671988
Naan bread (ukb-b-13281) (👉 📊) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement Weighted median 4 0.039009234 0.018229167 0.032360011
Celery (ukb-b-14145) (👉 📊) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement Weighted median 5 0.012547796 0.005850485 0.031973288
Celery (ukb-b-14145) (👉 📊) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement Inverse variance weighted 5 0.0099161 0.004542422 0.029035938
Cottage cheese (ukb-b-14171) (👉 📊) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement Weighted median 4 0.038444096 0.019440934 0.047987179
Cottage cheese (ukb-b-14171) (👉 📊) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement Inverse variance weighted 4 0.03225507 0.015742659 0.04047229
Cereal (ukb-b-15926) (👉 📊) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement MR Egger 147 -0.021425817 0.007732964 0.006326449
Garlic (ukb-b-17223) (👉 📊) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement Inverse variance weighted 2 -0.016336259 0.007300702 0.0252453
Non-oily fish (ukb-b-17627) (👉 📊) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement Inverse variance weighted 49 0.007888348 0.003032693 0.009292444
Porridge (ukb-b-29) (👉 📊) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement Weighted median 4 0.013242657 0.006484458 0.041130205
Spirits (ukb-b-3751) (👉 📊) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement Weighted median 7 0.010553114 0.00443562 0.017351453
Spirits (ukb-b-3751) (👉 📊) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement Inverse variance weighted 7 0.009164546 0.003367385 0.006497424
Baked bean (ukb-b-4058) (👉 📊) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement Weighted median 4 -0.012110913 0.005632767 0.031548692
Baked bean (ukb-b-4058) (👉 📊) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement Inverse variance weighted 4 -0.013348896 0.00467642 0.004310305
Bacon (ukb-b-4414) (👉 📊) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement Inverse variance weighted 5 0.009736686 0.004903399 0.04706651
Pork (ukb-b-5640) (👉 📊) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement Inverse variance weighted 64 0.007856854 0.003324055 0.018096628

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Pear (ukb-b-10793) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs34798770 0.0218308140357497 0.0108929160967788 0.0450561945672525
Pear (ukb-b-10793) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs4744 -0.0232498967970666 0.0105507879847502 0.0275512838279519
Pear (ukb-b-10793) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs4953674 -0.0219203778228623 0.0100541172334168 0.0292397551063121
Pear (ukb-b-10793) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement All - MR Egger -0.207341376564407 0.0567251840695126 0.0216719875965327
Naan bread (ukb-b-13281) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs166722 0.0528280558066124 0.026720228430659 0.0480324756650949
Celery (ukb-b-14145) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement All - Inverse variance weighted 0.0099160997384716 0.0045424221773065 0.0290359376780788
Cottage cheese (ukb-b-14171) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement All - Inverse variance weighted 0.032255070188815 0.0157426589427123 0.0404722902177654
Cereal (ukb-b-15926) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs10260232 0.0499400738853743 0.0214529615250844 0.0199180957156671
Cereal (ukb-b-15926) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs10931025 0.0697609392294568 0.0220841207774067 0.001583803348281
Cereal (ukb-b-15926) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs12354267 -0.0433392288341504 0.0169070084912383 0.0103656029476055
Cereal (ukb-b-15926) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs2205137 0.0439732951791068 0.0219699394270277 0.0453362727649256
Cereal (ukb-b-15926) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs2212484 -0.046182740009813 0.0206206727361936 0.0251147557685597
Cereal (ukb-b-15926) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs2582404 -0.0471991346301811 0.0189221800802006 0.0126176873753486
Cereal (ukb-b-15926) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs2656195 -0.04923781374728 0.0213576224443488 0.0211443099731441
Cereal (ukb-b-15926) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs2873054 0.0457460451232227 0.0216848180465484 0.0348938064181053
Cereal (ukb-b-15926) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs3021529 -0.0694631571926431 0.0211380500575278 0.001015608694388
Cereal (ukb-b-15926) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs3115230 -0.0502629400848587 0.0183790588870786 0.0062419324729296
Cereal (ukb-b-15926) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs529565 0.0383171713566145 0.0192998790330577 0.04710464309169
Cereal (ukb-b-15926) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs6087577 0.0440227292065286 0.0197948960735503 0.0261522500987299
Cereal (ukb-b-15926) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs62377431 -0.0465965196109362 0.0197336177281995 0.0182121664577484
Cereal (ukb-b-15926) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs75756987 0.0451199738670785 0.0221060016630041 0.041243523384609
Cereal (ukb-b-15926) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs7588480 0.0488398626337885 0.0221431772234762 0.0274092628010086
Cereal (ukb-b-15926) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs78959390 -0.0602749252361588 0.0191523600056963 0.0016488285881286
Cereal (ukb-b-15926) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs844137 0.0436718989213891 0.0214543626836441 0.0417933566557953
Cereal (ukb-b-15926) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement All - MR Egger -0.0214258168419898 0.0077329635938998 0.0063264489359475
Garlic (ukb-b-17223) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement All - Inverse variance weighted -0.0163362587620173 0.0073007023603336 0.0252452995500467
Non-oily fish (ukb-b-17627) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs11165780 0.0593223783121962 0.0244962658013769 0.0154484943903022
Non-oily fish (ukb-b-17627) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs55858845 0.06539055086411 0.0219269220815321 0.0028618140093938
Non-oily fish (ukb-b-17627) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs56094641 0.0337071698113208 0.0146882224428997 0.021742102470459
Non-oily fish (ukb-b-17627) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs79262908 0.0700096867311157 0.0223505821725401 0.0017341722449379
Non-oily fish (ukb-b-17627) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement All - Inverse variance weighted 0.0078883478905315 0.0030326929416661 0.0092924443911169
Porridge (ukb-b-29) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs4726021 0.0229511642725547 0.0096664057846546 0.0175811893885888
Spirits (ukb-b-3751) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs62001190 0.0187619006385972 0.0086524082692932 0.0301281027516211
Spirits (ukb-b-3751) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement All - Inverse variance weighted 0.0091645458200539 0.0033673848137289 0.0064974238280045
Baked bean (ukb-b-4058) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs12540361 -0.0203438696543665 0.0093700622478301 0.0299193596484116
Baked bean (ukb-b-4058) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs9956645 -0.0205964048077881 0.0091981752664791 0.0251439611581745
Baked bean (ukb-b-4058) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement All - Inverse variance weighted -0.0133488963958255 0.0046764203752614 0.0043103052125579
Bacon (ukb-b-4414) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs66626876 0.0213969112826065 0.0088195808726271 0.0152633702282294
Bacon (ukb-b-4414) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs8116059 0.0192980880052237 0.0088339154480238 0.0289222062437119
Bacon (ukb-b-4414) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement All - Inverse variance weighted 0.0097366857903164 0.0049033992174204 0.0470665098771509
Pork (ukb-b-5640) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs1105714 -0.0551806145637783 0.0262011658926983 0.0352011724758849
Pork (ukb-b-5640) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs13198572 0.0662332350838028 0.0261339100406369 0.0112646794944185
Pork (ukb-b-5640) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs2314715 0.059169029033235 0.0268101093828016 0.0273163587650293
Pork (ukb-b-5640) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs3964074 0.0401072069767208 0.0204009424740054 0.0493045331130018
Pork (ukb-b-5640) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs4605770 0.0617362753178667 0.0245701198502885 0.0119825889219707
Pork (ukb-b-5640) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs482202 0.0695149260233867 0.0265241157369488 0.008771863080431
Pork (ukb-b-5640) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs7641973 -0.0481437104479556 0.022463962870657 0.0321008111744089
Pork (ukb-b-5640) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement rs7644667 -0.0666545023922272 0.0262627165950032 0.0111491287782358
Pork (ukb-b-5640) Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement All - Inverse variance weighted 0.0078568541066889 0.0033240554704478 0.0180966282717062