ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Fractured bone site(s): Wrist (ukb-b-9571)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Avocado (ukb-b-12236) (👉 📊) Fractured bone site(s): Wrist Weighted median 9 -0.025307508 0.012586569 0.04435973
Double crust pastry (ukb-b-1255) (👉 📊) Fractured bone site(s): Wrist Weighted median 7 -0.036498364 0.012792692 0.004329995
Double crust pastry (ukb-b-1255) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 7 -0.032442989 0.009696132 0.000819946
Herbal tea (ukb-b-13344) (👉 📊) Fractured bone site(s): Wrist MR Egger 20 0.000759807 0.000341269 0.038996181
Rose wine (ukb-b-16124) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 7 -0.013105229 0.005373275 0.014729399
Grapefruit (ukb-b-18758) (👉 📊) Fractured bone site(s): Wrist Weighted median 6 0.049795477 0.021495639 0.02052888
Grapefruit (ukb-b-18758) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 6 0.044132129 0.017467111 0.011517773
Cereal bar (ukb-b-18788) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 7 -0.013018745 0.005730922 0.023106636
Powdered/instant soup (ukb-b-19931) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 4 -0.040542262 0.017935037 0.023789849
Salad / raw vegetable (ukb-b-1996) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 98 -0.010246701 0.004103363 0.0125197
Green bean (ukb-b-2299) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 9 0.008520847 0.004314407 0.048270961
Whole-wheat cereal (ukb-b-2375) (👉 📊) Fractured bone site(s): Wrist MR Egger 8 0.061965328 0.023645208 0.039552867
Coleslaw (ukb-b-2691) (👉 📊) Fractured bone site(s): Wrist Weighted median 7 0.019703473 0.009679282 0.041787152
Beef (ukb-b-2862) (👉 📊) Fractured bone site(s): Wrist MR Egger 90 0.031157605 0.015086158 0.041835468
Beef (ukb-b-2862) (👉 📊) Fractured bone site(s): Wrist Weighted median 90 0.010267678 0.004895014 0.035942378
Croissant (ukb-b-4007) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 11 0.028764198 0.011633576 0.013416589
Apple (ukb-b-4070) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 14 0.006480771 0.002997849 0.030633073
Whole egg (ukb-b-4075) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 4 0.015560987 0.006736011 0.020881577
Filtered coffee (ukb-b-748) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 17 -0.004683319 0.00203218 0.021190198
Other meat (ukb-b-770) (👉 📊) Fractured bone site(s): Wrist MR Egger 8 -0.177438131 0.05817498 0.022509717
Yogurt (ukb-b-7753) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 7 -0.010260823 0.004378637 0.019109743
Instant coffee (ukb-b-930) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 14 -0.00308373 0.001415121 0.029322148
Chocolate sweet (ukb-b-9835) (👉 📊) Fractured bone site(s): Wrist Weighted median 6 -0.02127458 0.009691487 0.028150538
Chocolate sweet (ukb-b-9835) (👉 📊) Fractured bone site(s): Wrist Inverse variance weighted 6 -0.017275634 0.007175916 0.016064513

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Double crust pastry (ukb-b-1255) Fractured bone site(s): Wrist rs10789657 -0.05412389990457 0.0265969497755629 0.041854251020582
Double crust pastry (ukb-b-1255) Fractured bone site(s): Wrist rs1728888 -0.0568352351677965 0.0264268811318371 0.0315030487641952
Double crust pastry (ukb-b-1255) Fractured bone site(s): Wrist All - Inverse variance weighted -0.0324429890513513 0.0096961322384556 0.0008199461189877
Herbal tea (ukb-b-13344) Fractured bone site(s): Wrist rs73293092 0.0010720717396117 0.0005390641375747 0.0467271783851301
Herbal tea (ukb-b-13344) Fractured bone site(s): Wrist All - MR Egger 0.0007598066323389 0.0003412689170761 0.0389961813989057
Rose wine (ukb-b-16124) Fractured bone site(s): Wrist rs71514907 -0.051026840588146 0.023065164823937 0.0269466123633917
Rose wine (ukb-b-16124) Fractured bone site(s): Wrist All - Inverse variance weighted -0.0131052292307382 0.005373275073602 0.014729399399101
Grapefruit (ukb-b-18758) Fractured bone site(s): Wrist All - Inverse variance weighted 0.0441321288522893 0.0174671108639153 0.0115177728187325
Cereal bar (ukb-b-18788) Fractured bone site(s): Wrist rs9839143 -0.037716373548168 0.0147302860172941 0.0104532360437472
Cereal bar (ukb-b-18788) Fractured bone site(s): Wrist All - Inverse variance weighted -0.0130187449638669 0.0057309215975568 0.0231066361625176
Powdered/instant soup (ukb-b-19931) Fractured bone site(s): Wrist rs6555009 -0.0822838244730737 0.034782269608569 0.0179968457886502
Powdered/instant soup (ukb-b-19931) Fractured bone site(s): Wrist All - Inverse variance weighted -0.0405422624808528 0.017935036626458 0.0237898486536757
Salad / raw vegetable (ukb-b-1996) Fractured bone site(s): Wrist rs17457620 -0.09404697010993 0.0413390342509312 0.0229049616703249
Salad / raw vegetable (ukb-b-1996) Fractured bone site(s): Wrist rs2776307 -0.0843424482351379 0.0426785651891348 0.0481292976510754
Salad / raw vegetable (ukb-b-1996) Fractured bone site(s): Wrist rs3095337 -0.0618346036223043 0.0285125734839722 0.0301071047014073
Salad / raw vegetable (ukb-b-1996) Fractured bone site(s): Wrist rs324499 0.0765520377033792 0.0386443992490613 0.0475985788632626
Salad / raw vegetable (ukb-b-1996) Fractured bone site(s): Wrist rs62258905 -0.107817784622723 0.0431692068800158 0.0125050481565105
Salad / raw vegetable (ukb-b-1996) Fractured bone site(s): Wrist rs6460754 -0.0856444700888404 0.0422195031430493 0.0425039114849565
Salad / raw vegetable (ukb-b-1996) Fractured bone site(s): Wrist rs7619139 -0.0710728970464473 0.0237017593074981 0.0027119303166335
Salad / raw vegetable (ukb-b-1996) Fractured bone site(s): Wrist rs76566997 -0.0936035492307529 0.0437651399374343 0.0324543356272788
Salad / raw vegetable (ukb-b-1996) Fractured bone site(s): Wrist rs817555 -0.093225863830597 0.0403755227659126 0.0209452556149538
Salad / raw vegetable (ukb-b-1996) Fractured bone site(s): Wrist All - Inverse variance weighted -0.0102467014493261 0.0041033631347783 0.0125197001651134
Green bean (ukb-b-2299) Fractured bone site(s): Wrist All - Inverse variance weighted 0.008520847352313 0.0043144072457478 0.048270961419482
Whole-wheat cereal (ukb-b-2375) Fractured bone site(s): Wrist All - MR Egger 0.0619653283795745 0.0236452083321355 0.0395528666249928
Beef (ukb-b-2862) Fractured bone site(s): Wrist rs10959890 0.0676449967629364 0.0280836583555717 0.0160096253437447
Beef (ukb-b-2862) Fractured bone site(s): Wrist rs4759074 -0.0839768858831625 0.0335528384518281 0.0123206416831528
Beef (ukb-b-2862) Fractured bone site(s): Wrist rs6669189 0.0787835791013075 0.0369329698835784 0.0329123912842767
Beef (ukb-b-2862) Fractured bone site(s): Wrist rs7597864 -0.0984112614439381 0.0364026657812897 0.0068632424279703
Beef (ukb-b-2862) Fractured bone site(s): Wrist rs897509 0.0745929709705847 0.0328888708350682 0.0233273314509903
Beef (ukb-b-2862) Fractured bone site(s): Wrist All - MR Egger 0.0311576051052408 0.0150861582866565 0.0418354684785518
Croissant (ukb-b-4007) Fractured bone site(s): Wrist rs10147965 0.0790227426590387 0.0362878207369604 0.0294309340740942
Croissant (ukb-b-4007) Fractured bone site(s): Wrist rs1689216 0.0877279090556427 0.0373761574659718 0.0189170108304329
Croissant (ukb-b-4007) Fractured bone site(s): Wrist rs6446355 0.0739441567676136 0.0333954236315746 0.0268150037752633
Croissant (ukb-b-4007) Fractured bone site(s): Wrist All - Inverse variance weighted 0.0287641980131016 0.0116335764063241 0.0134165894563078
Apple (ukb-b-4070) Fractured bone site(s): Wrist rs1347300 0.0225728885757125 0.0103319787864178 0.0289064866472383
Apple (ukb-b-4070) Fractured bone site(s): Wrist rs2963826 -0.0234272071406277 0.0106262399414514 0.0274782198014897
Apple (ukb-b-4070) Fractured bone site(s): Wrist rs7195117 0.0222912796845083 0.0105633626725345 0.0348372874579814
Apple (ukb-b-4070) Fractured bone site(s): Wrist All - Inverse variance weighted 0.0064807706717229 0.0029978491879188 0.0306330733962687
Whole egg (ukb-b-4075) Fractured bone site(s): Wrist All - Inverse variance weighted 0.0155609868790495 0.0067360114668046 0.0208815766323435
Filtered coffee (ukb-b-748) Fractured bone site(s): Wrist rs6968865 -0.0145978583727487 0.0062234548402367 0.018995477286324
Filtered coffee (ukb-b-748) Fractured bone site(s): Wrist All - Inverse variance weighted -0.0046833190464798 0.002032180416434 0.0211901981184223
Other meat (ukb-b-770) Fractured bone site(s): Wrist rs113735393 -0.107240195113415 0.0410852636874686 0.0090492908458559
Other meat (ukb-b-770) Fractured bone site(s): Wrist rs2826909 0.120038970469946 0.045703400444131 0.0086273598802676
Other meat (ukb-b-770) Fractured bone site(s): Wrist All - MR Egger -0.177438130979232 0.0581749795177805 0.0225097171079423
Yogurt (ukb-b-7753) Fractured bone site(s): Wrist All - Inverse variance weighted -0.0102608234272351 0.0043786365200783 0.0191097426332267
Instant coffee (ukb-b-930) Fractured bone site(s): Wrist rs6968554 -0.0101697151350955 0.0040927149258557 0.012961204165929
Instant coffee (ukb-b-930) Fractured bone site(s): Wrist All - Inverse variance weighted -0.0030837298599082 0.0014151209205435 0.0293221482148911
Chocolate sweet (ukb-b-9835) Fractured bone site(s): Wrist rs72704169 -0.0371352008317348 0.0173632689519849 0.0324582106381375
Chocolate sweet (ukb-b-9835) Fractured bone site(s): Wrist All - Inverse variance weighted -0.0172756336915397 0.0071759157266786 0.0160645127486698