ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Bread (ukb-b-11348) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Weighted median 117 -0.013618266 0.004359664 0.001785948
Bread (ukb-b-11348) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Inverse variance weighted 117 -0.010765686 0.003255756 0.000944146
Vegetable pieces (ukb-b-12566) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified MR Egger 14 0.02293155 0.00776477 0.012070404
Other sweets (ukb-b-139) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Inverse variance weighted 26 -0.012730655 0.00509432 0.012454792
Cheese (ukb-b-1489) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Weighted median 203 -0.008910774 0.003111723 0.004188374
Cheese (ukb-b-1489) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Inverse variance weighted 203 -0.011358959 0.002210468 2.77e-07
Broad bean (ukb-b-15212) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Inverse variance weighted 21 0.017223592 0.007743339 0.026127547
Cereal (ukb-b-15926) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Weighted median 175 -0.013726318 0.004004339 0.000608356
Cereal (ukb-b-15926) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Inverse variance weighted 175 -0.01414073 0.002660856 1.07e-07
Dried fruit (ukb-b-16576) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Weighted median 157 -0.009501927 0.004301553 0.027177917
Dried fruit (ukb-b-16576) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Inverse variance weighted 157 -0.01086722 0.003001343 0.000293709
Porridge (ukb-b-29) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified MR Egger 14 0.032468794 0.011166945 0.013139987
Other vegetables (ukb-b-3055) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Inverse variance weighted 14 0.016142577 0.006502796 0.013049866
Standard tea (ukb-b-3291) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Inverse variance weighted 15 4.27e-05 1.77e-05 0.015720624
Pizza (ukb-b-3852) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Weighted median 17 0.017543197 0.007005615 0.012274168
Dairy smoothie (ukb-b-4955) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified MR Egger 21 0.023985695 0.010920588 0.040677299
Dairy smoothie (ukb-b-4955) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Inverse variance weighted 21 0.014557195 0.00683519 0.03319287
Yorkshire pudding (ukb-b-5605) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified MR Egger 17 -0.032664291 0.014138883 0.035513601
Pork (ukb-b-5640) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Inverse variance weighted 84 0.018139122 0.005085991 0.000361799
Liver (ukb-b-6373) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified MR Egger 26 -0.048587001 0.020946123 0.029189593
Liver (ukb-b-6373) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Inverse variance weighted 26 -0.023557417 0.010064334 0.019248496
Other meat (ukb-b-770) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Inverse variance weighted 25 -0.02268868 0.010748562 0.034784579
Cooked vegetable (ukb-b-8089) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Inverse variance weighted 94 0.009656512 0.004557427 0.034102988
Onion (ukb-b-8124) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified Inverse variance weighted 14 -0.006985262 0.003511315 0.04666174
Chocolate sweet (ukb-b-9835) (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified MR Egger 19 0.023921356 0.010091917 0.029861705

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Bread (ukb-b-11348) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs10966045 0.0679871599221176 0.0346162009507271 0.049526938682937
Bread (ukb-b-11348) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs11013753 -0.0716841921847301 0.0341009712268368 0.0355431285975688
Bread (ukb-b-11348) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs11691161 -0.0645574308440717 0.0326099346580823 0.0477388235604595
Bread (ukb-b-11348) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs1566029 -0.118299257876625 0.0355297450958441 0.0008697593814163
Bread (ukb-b-11348) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs1994315 -0.0564160509751009 0.0216509846111781 0.0091685734268911
Bread (ukb-b-11348) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs2089848 -0.0945373837186861 0.0365310533832555 0.0096573210273368
Bread (ukb-b-11348) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs319694 -0.0944000718745789 0.0329281703427519 0.0041458157724894
Bread (ukb-b-11348) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs73802707 -0.0667932653676175 0.0296618873041382 0.0243335761691469
Bread (ukb-b-11348) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs7802468 -0.03817896859892 0.0149448671888047 0.0106293319592308
Bread (ukb-b-11348) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs78844209 -0.0681046816070816 0.0340237820652682 0.0453192931200248
Bread (ukb-b-11348) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs9529024 0.0758183465072889 0.0272306822844491 0.0053643648689355
Bread (ukb-b-11348) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - Inverse variance weighted -0.0107656864364651 0.0032557562062878 0.0009441462475804
Vegetable pieces (ukb-b-12566) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - MR Egger 0.0229315496499198 0.0077647697850116 0.012070404385673
Other sweets (ukb-b-139) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs10978815 -0.0677459041859116 0.0269343634141795 0.0118957442254575
Other sweets (ukb-b-139) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs76589137 -0.0514448926769592 0.0238025620026894 0.0306708256651598
Other sweets (ukb-b-139) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - Inverse variance weighted -0.0127306545106828 0.0050943204853405 0.0124547924790872
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs10499731 -0.0783838336127971 0.0287364302639555 0.0063781128926079
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs113829457 -0.0815761323404578 0.032037143113479 0.0108872018204445
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs11756671 -0.0766439339554917 0.033566642737497 0.0224105661247801
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs13107325 -0.087064144370266 0.0220541834253992 7.8892978292393e-05
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs136309 0.0863349739639061 0.0299083386832156 0.0038936428080752
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs1473677 -0.0727431220259257 0.0330297954383854 0.0276406973340056
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs1536456 -0.0670565104444682 0.031470232376072 0.0331063051345492
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs2352974 -0.0534766023783903 0.0233975526308529 0.0222797822846626
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs2824098 0.0656128416923105 0.0315442063020749 0.037522937549667
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs2960578 -0.0490817584947323 0.0198676900670652 0.0134950330235448
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs35392738 -0.0640088725477504 0.0322187410994019 0.0469559973458939
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs61757207 -0.0900709996343632 0.0286902974052185 0.0016928049172906
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs6694085 -0.0682244819840966 0.0326231935346415 0.0365022855627583
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs7236339 -0.0681872826069534 0.0324223796624297 0.0354576329461669
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs73096946 -0.0456440067212526 0.0226828676049224 0.0441917026169601
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs75499503 -0.112751274491087 0.0292884769036053 0.0001182720641389
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs9377684 -0.106090501247814 0.0310294279085766 0.0006284512218579
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs975303 -0.046043824851003 0.0206000300814078 0.02540856171317
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs9996848 0.0785348673116711 0.0315181123455757 0.0127119892619438
Cheese (ukb-b-1489) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - Inverse variance weighted -0.0113589593682954 0.0022104680010302 2.7662736983612e-07
Broad bean (ukb-b-15212) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs184217006 0.0756350786101747 0.0310396773542353 0.0148210503834976
Broad bean (ukb-b-15212) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs72796907 0.0930644677061025 0.0294293777395273 0.0015652919371882
Broad bean (ukb-b-15212) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - Inverse variance weighted 0.0172235917374608 0.007743338973032 0.0261275472465124
Cereal (ukb-b-15926) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs10931025 0.0869215004857583 0.0411194433837781 0.0345256601551707
Cereal (ukb-b-15926) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs11038810 -0.0750656978885067 0.0316942241541902 0.017863537109596
Cereal (ukb-b-15926) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs11109785 -0.0799104483037891 0.0403167431780956 0.0474718475651145
Cereal (ukb-b-15926) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs12354267 -0.0747657396993295 0.0314915044688469 0.0175891243345731
Cereal (ukb-b-15926) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs141612194 -0.0844492984693878 0.0389575892857143 0.0301796977845186
Cereal (ukb-b-15926) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs491711 -0.0646106857167301 0.0313902553792189 0.0395609680752934
Cereal (ukb-b-15926) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs62442924 -0.0925480523765013 0.0338287159588089 0.0062231902032512
Cereal (ukb-b-15926) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs9439799 -0.0937059091520308 0.035880994097471 0.0090126202224132
Cereal (ukb-b-15926) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - Inverse variance weighted -0.0141407300365325 0.002660855875206 1.07036365964253e-07
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs10156491 0.088727461465321 0.0381765921997261 0.0201183897314156
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs11082011 -0.0781783886156652 0.0392951120847279 0.0466439004250477
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs11586016 -0.0973283540085319 0.035473842347477 0.0060757430948909
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs11772627 -0.0542136381983004 0.0240875323173592 0.024404994159645
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs2508819 -0.0878163712154239 0.0415708225774059 0.0346476907988046
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs4800488 -0.0649188057011249 0.028219566741213 0.0214205261034054
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs4866437 -0.104140465140999 0.0410944607780373 0.0112713131407838
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs4963390 -0.0885119862223794 0.0377486045546107 0.0190385621366684
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs62084586 0.0856583996535917 0.0339695847580368 0.0116815674346077
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs75641275 -0.0720336409792886 0.0340021749415661 0.0341326618975732
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs7835197 0.0823488347116314 0.0404128757076883 0.0415811380078789
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - Inverse variance weighted -0.010867219802014 0.0030013426756586 0.0002937092813813
Porridge (ukb-b-29) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs6026835 0.0470861155796621 0.0168034335150498 0.0050759759291937
Porridge (ukb-b-29) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs911784 -0.0411794404987457 0.0185155646347788 0.0261454474559983
Porridge (ukb-b-29) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - MR Egger 0.0324687936866241 0.011166944631572 0.0131399866183396
Other vegetables (ukb-b-3055) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs10047705 0.049768804607922 0.023104902161587 0.0312373027571967
Other vegetables (ukb-b-3055) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs116555090 0.0677008076636141 0.0206992831579972 0.0010728784211582
Other vegetables (ukb-b-3055) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - Inverse variance weighted 0.0161425774412621 0.0065027962435445 0.0130498660823912
Standard tea (ukb-b-3291) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs10801677 0.0001556105964321 7.59654697190108e-05 0.0405170477443582
Standard tea (ukb-b-3291) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - Inverse variance weighted 4.27249376789204e-05 1.76890115943218e-05 0.0157206241546099
Pizza (ukb-b-3852) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs111868420 -0.0409746148771063 0.0202755029375111 0.0432908788529288
Dairy smoothie (ukb-b-4955) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - Inverse variance weighted 0.01455719492712 0.0068351898374986 0.0331928704865985
Dairy smoothie (ukb-b-4955) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - MR Egger 0.023985695238742 0.0109205877702536 0.0406772988699172
Yorkshire pudding (ukb-b-5605) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - MR Egger -0.0326642908217059 0.0141388827487616 0.0355136011221621
Pork (ukb-b-5640) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs10137783 0.114592803556176 0.0457458370685347 0.0122455315965862
Pork (ukb-b-5640) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs2314715 0.118105732160836 0.0498907263356352 0.0179189687810782
Pork (ukb-b-5640) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs2863724 0.132274626466557 0.0454692649664071 0.0036247121020935
Pork (ukb-b-5640) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs61791721 0.105849301458879 0.0478754985335152 0.0270407926346588
Pork (ukb-b-5640) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs6909236 0.135399286677671 0.0489978341493866 0.0057207368949122
Pork (ukb-b-5640) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs7969045 0.086795708221475 0.0436143231521474 0.0465828407667834
Pork (ukb-b-5640) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs9379832 0.0826663470339537 0.0342514928300571 0.0157996606812548
Pork (ukb-b-5640) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - Inverse variance weighted 0.0181391215211301 0.005085991453373 0.0003617989874919
Liver (ukb-b-6373) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs58346866 -0.10511616485803 0.052325666553223 0.0445494968685097
Liver (ukb-b-6373) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - Inverse variance weighted -0.0235574167930214 0.010064333963729 0.0192484955600793
Liver (ukb-b-6373) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - MR Egger -0.0485870011982663 0.0209461225316724 0.0291895934061253
Other meat (ukb-b-770) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs75788396 -0.12020814654642 0.0511284566566461 0.0187179710585882
Other meat (ukb-b-770) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - Inverse variance weighted -0.0226886802938641 0.0107485618720644 0.0347845792234296
Cooked vegetable (ukb-b-8089) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs10129582 0.0979125097900272 0.0399672034087942 0.0142927093401149
Cooked vegetable (ukb-b-8089) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs111608385 0.0984100341496347 0.0471298878784663 0.0367924217924358
Cooked vegetable (ukb-b-8089) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs12079852 0.11189773389716 0.0438954946285312 0.0107975023451013
Cooked vegetable (ukb-b-8089) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs335352 0.12174361256448 0.0470615031769312 0.0096842439201224
Cooked vegetable (ukb-b-8089) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs60123882 0.090615834572084 0.0431605040747791 0.0357721209402664
Cooked vegetable (ukb-b-8089) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - Inverse variance weighted 0.0096565119944314 0.0045574266765121 0.0341029883208517
Onion (ukb-b-8124) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - Inverse variance weighted -0.006985261865097 0.0035113152438592 0.0466617398784038
Chocolate sweet (ukb-b-9835) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified rs185905470 0.0518471612553985 0.0218541259479486 0.017671998890853
Chocolate sweet (ukb-b-9835) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified All - MR Egger 0.0239213557284706 0.0100919171454984 0.0298617053389582