ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Flavoured milk (ukb-b-12763) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle Weighted median 21 -0.023699784 0.011865585 0.045786644
Snackpot (ukb-b-12912) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle MR Egger 121 -0.068433664 0.030738332 0.027874569
Plum (ukb-b-14182) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle Inverse variance weighted 12 0.008820116 0.004347517 0.042481629
Cereal (ukb-b-15926) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle Inverse variance weighted 175 -0.00501302 0.002077315 0.015812221
Rose wine (ukb-b-16124) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle MR Egger 15 0.017380312 0.00787548 0.045912695
Hot chocolate (ukb-b-16449) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle Inverse variance weighted 18 0.012143188 0.005732718 0.034156002
Dried fruit (ukb-b-16576) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle MR Egger 157 -0.020306927 0.009256334 0.029735805
Low calorie hot chocolate (ukb-b-1795) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle Weighted median 24 0.029582951 0.012207555 0.015378893
Low calorie hot chocolate (ukb-b-1795) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle Inverse variance weighted 24 0.026774797 0.009169578 0.003500768
Milk-based pudding (ukb-b-20554) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle Weighted median 17 0.021368104 0.010500357 0.041852048
Cherry (ukb-b-2221) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle Inverse variance weighted 17 0.014678585 0.006703139 0.028538197
Beef (ukb-b-2862) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle MR Egger 102 0.020749833 0.009703394 0.03491946
Other cheese (ukb-b-4088) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle Inverse variance weighted 16 0.024311641 0.009970899 0.014758166
Lamb (ukb-b-530) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle MR Egger 14 -0.033725529 0.010751112 0.008580635
Eggs in sandwiches (ukb-b-5382) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle MR Egger 15 -0.042570819 0.018326435 0.037047639
Sausage (ukb-b-5847) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle Inverse variance weighted 14 -0.010668639 0.00339586 0.001679925
Peach/nectarine (ukb-b-6154) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle Weighted median 16 -0.013697221 0.00628792 0.029380803
Doughnut (ukb-b-6214) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle Weighted median 33 0.023367119 0.011075644 0.034877731
Processed meat (ukb-b-6324) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle MR Egger 129 0.016943646 0.008316067 0.043681522
Poultry (ukb-b-8006) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle MR Egger 80 -0.025899695 0.01094348 0.02042932
Soft cheese (ukb-b-8007) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle MR Egger 17 0.033415222 0.015635746 0.049468171
Spinach (ukb-b-812) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle MR Egger 15 0.022115402 0.009389374 0.034875494
Spinach (ukb-b-812) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle Weighted median 15 0.014386042 0.006839349 0.035428824
Instant coffee (ukb-b-930) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle MR Egger 20 -0.007312512 0.002666015 0.013374413
Other milk-based pudding (ukb-b-9857) (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle MR Egger 23 0.064065663 0.017519798 0.001471668

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Flavoured milk (ukb-b-12763) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs114155753 -0.096787419525557 0.0398389638788245 0.0151210712605657
Snackpot (ukb-b-12912) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs11024072 -0.311352201489514 0.144480069834769 0.0311631065093046
Snackpot (ukb-b-12912) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs116412151 -0.301584645762728 0.128831676776882 0.0192362897084317
Snackpot (ukb-b-12912) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs117541068 -0.416442069299924 0.14629058815668 0.0044178146253973
Snackpot (ukb-b-12912) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs144027086 0.272171165357485 0.1365458362076 0.0462331348190169
Snackpot (ukb-b-12912) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs145419059 -0.244979252382459 0.120608713999367 0.0422356919651259
Snackpot (ukb-b-12912) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs1729766 0.298355097873375 0.148644685762719 0.0447316049273366
Snackpot (ukb-b-12912) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs187707703 -0.292978479338299 0.144313023814882 0.0423403128433092
Snackpot (ukb-b-12912) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs35346248 0.444376040652006 0.150829402647755 0.0032168738954979
Snackpot (ukb-b-12912) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - MR Egger -0.0684336635440162 0.0307383320544964 0.0278745688680075
Plum (ukb-b-14182) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - Inverse variance weighted 0.0088201156414138 0.0043475167966305 0.0424816287512647
Cereal (ukb-b-15926) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs117477397 0.0569123471442478 0.028465463823583 0.0455707938792545
Cereal (ukb-b-15926) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs11940694 -0.0693800879610255 0.0215116031173261 0.0012586699999991
Cereal (ukb-b-15926) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs12523398 -0.0605664766502056 0.0278588214745066 0.0297013646876061
Cereal (ukb-b-15926) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs1397440 -0.0707363110642718 0.0303344387829097 0.0197069355888196
Cereal (ukb-b-15926) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs4739095 -0.0492214121377938 0.024214883099117 0.0420835958511084
Cereal (ukb-b-15926) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs6510177 -0.0525714592570999 0.0259616122251715 0.0428705502415557
Cereal (ukb-b-15926) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs79642906 -0.0580137789746725 0.0265022772206343 0.0285960333506405
Cereal (ukb-b-15926) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - Inverse variance weighted -0.0050130198259112 0.0020773147007702 0.0158122209653731
Rose wine (ukb-b-16124) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs12456862 -0.0514826354931884 0.0204263609967629 0.0117220966132975
Rose wine (ukb-b-16124) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs145013270 -0.0461871956289345 0.020277942748545 0.0227440889564251
Rose wine (ukb-b-16124) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - MR Egger 0.0173803123719536 0.0078754799593134 0.0459126952872264
Hot chocolate (ukb-b-16449) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs116341761 0.0642561471280111 0.0249421714293867 0.0099891398663911
Hot chocolate (ukb-b-16449) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - Inverse variance weighted 0.0121431881427674 0.0057327182680779 0.0341560022817666
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs10740991 -0.0472047912061652 0.0175588744847362 0.0071801300087093
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs2533273 -0.0681599620921796 0.0268060130065134 0.0109995954953994
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs67518212 -0.0580580556823368 0.0294844363304427 0.0489406271880143
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs746868 -0.0432350548215877 0.0210266940451745 0.0397633956783119
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs893856 -0.0554468976872989 0.0278033829803158 0.0461247358068383
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs9860336 0.0842620135579554 0.0333841543205821 0.0116023894436748
Dried fruit (ukb-b-16576) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - MR Egger -0.0203069267058032 0.0092563339321768 0.029735804577168
Low calorie hot chocolate (ukb-b-1795) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs192654283 0.10483325037332 0.0399246723079476 0.0086451663410909
Low calorie hot chocolate (ukb-b-1795) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs62342194 -0.108691803762369 0.0437343940379078 0.0129452990321989
Low calorie hot chocolate (ukb-b-1795) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - Inverse variance weighted 0.0267747971848637 0.0091695779238875 0.0035007675354633
Milk-based pudding (ukb-b-20554) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs118108800 0.0523888927561178 0.0260375388392829 0.0442144126172313
Milk-based pudding (ukb-b-20554) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs139719165 -0.0649267923877732 0.0305875465348277 0.0337828168957406
Milk-based pudding (ukb-b-20554) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs7463703 0.0637327427790605 0.0277533284120477 0.0216530221863644
Cherry (ukb-b-2221) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - Inverse variance weighted 0.0146785848652539 0.0067031392365154 0.0285381974278312
Beef (ukb-b-2862) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs11600756 -0.0899166969774931 0.0323940525722802 0.0055080262126057
Beef (ukb-b-2862) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs4863708 0.0844690238407828 0.0335753553254653 0.0118761100896128
Beef (ukb-b-2862) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs6669189 -0.08088419267148 0.0335685310876383 0.0159733306079115
Beef (ukb-b-2862) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs7791463 -0.0765808308355484 0.0276519983327154 0.0056150996735207
Beef (ukb-b-2862) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - MR Egger 0.0207498327260767 0.0097033936539213 0.0349194595585705
Other cheese (ukb-b-4088) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs113253175 0.0737444480807892 0.0366557576324279 0.0442398879396256
Other cheese (ukb-b-4088) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs17704421 0.0820707300432113 0.0386614168751421 0.0337700200687205
Other cheese (ukb-b-4088) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - Inverse variance weighted 0.0243116412210723 0.0099708988606961 0.014758165728208
Lamb (ukb-b-530) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs78938647 -0.0449008504459656 0.0220161792159303 0.0414053460641913
Lamb (ukb-b-530) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - MR Egger -0.0337255288804838 0.0107511118789195 0.0085806353655914
Eggs in sandwiches (ukb-b-5382) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs112216864 -0.0980729785166793 0.0330362396091979 0.0029911267145526
Eggs in sandwiches (ukb-b-5382) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - MR Egger -0.0425708188336106 0.0183264354490762 0.037047639476318
Sausage (ukb-b-5847) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs144214838 -0.0307335555195663 0.0124045551019017 0.0132268447297062
Sausage (ukb-b-5847) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs17059045 -0.025605460587849 0.0116509566421011 0.0279695540732119
Sausage (ukb-b-5847) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - Inverse variance weighted -0.0106686390077526 0.0033958595365323 0.0016799249634671
Peach/nectarine (ukb-b-6154) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs149599449 0.0442454744750507 0.0178471992045078 0.013170438035832
Peach/nectarine (ukb-b-6154) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs28542413 -0.0405014151181406 0.0165558730843154 0.014431192072955
Doughnut (ukb-b-6214) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs34987892 0.123781303621507 0.0447495332330509 0.0056732613523969
Doughnut (ukb-b-6214) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs80025943 0.0917122758164454 0.0446178639148612 0.0398301808886736
Processed meat (ukb-b-6324) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs144497252 0.0657813062531812 0.025871404451838 0.0110022916831326
Processed meat (ukb-b-6324) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs4016219 0.0504932739358437 0.025106985635863 0.044312307931258
Processed meat (ukb-b-6324) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs62504693 0.0818940999330805 0.0274150262101271 0.0028154769826093
Processed meat (ukb-b-6324) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs6484504 0.0446891965255157 0.0190989349051238 0.0192899888769355
Processed meat (ukb-b-6324) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs7096909 0.07296573638251 0.0257993787540215 0.0046810929497877
Processed meat (ukb-b-6324) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs7176446 0.054043238954728 0.0264603890844779 0.0411098460244773
Processed meat (ukb-b-6324) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs73238074 -0.0606940921217365 0.0254426156437837 0.0170545874063986
Processed meat (ukb-b-6324) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs8096167 -0.046112911735886 0.0230724901841205 0.0456505575684915
Processed meat (ukb-b-6324) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - MR Egger 0.0169436463909963 0.008316066973669 0.0436815215491461
Poultry (ukb-b-8006) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs144438383 -0.0817492029597628 0.0302444256727466 0.0068726861103083
Poultry (ukb-b-8006) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs1959437 -0.0551175474521541 0.0275229384894069 0.0452198073013683
Poultry (ukb-b-8006) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs28418529 0.0760836555096414 0.0310822507868154 0.0143724714817962
Poultry (ukb-b-8006) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs7045589 -0.0782336154816062 0.0272856938802564 0.0041411766832063
Poultry (ukb-b-8006) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs9997448 0.0666982971159911 0.0261266555816754 0.0106835351167882
Poultry (ukb-b-8006) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - MR Egger -0.0258996947460364 0.0109434802735251 0.0204293202087646
Soft cheese (ukb-b-8007) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs143439425 0.0610248934269762 0.0298834642282082 0.0411420405932021
Soft cheese (ukb-b-8007) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs2284636 -0.0856307115906503 0.0305398039651407 0.0050487765701842
Soft cheese (ukb-b-8007) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs6029122 0.0630716048533421 0.0298857177253614 0.0348216526119019
Soft cheese (ukb-b-8007) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs79571040 0.0598948287086586 0.0299161733613091 0.0452752067393934
Soft cheese (ukb-b-8007) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - MR Egger 0.0334152219381694 0.0156357462695507 0.0494681709974768
Spinach (ukb-b-812) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs191235830 0.0416103167497038 0.0192193957238149 0.0303863902773664
Spinach (ukb-b-812) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - MR Egger 0.022115402222653 0.0093893742148274 0.0348754938296529
Instant coffee (ukb-b-930) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs117671135 -0.0100385710105605 0.0051124259455597 0.0495807785103468
Instant coffee (ukb-b-930) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs2960876 -0.0109251153455317 0.0049435264489986 0.0271062588481424
Instant coffee (ukb-b-930) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - MR Egger -0.0073125120217469 0.0026660151127871 0.0133744126095142
Other milk-based pudding (ukb-b-9857) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs73146365 0.0926672612170123 0.0366242866494159 0.0113993168095902
Other milk-based pudding (ukb-b-9857) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle rs78428634 0.0990571699976843 0.036770133792067 0.0070609211929694
Other milk-based pudding (ukb-b-9857) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle All - MR Egger 0.0640656629186443 0.0175197982834643 0.0014716675554819