ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Ankle spacing width (ukb-e-3143_CSA)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Pineapple (ukb-b-1164) (👉 📊) Ankle spacing width Inverse variance weighted 16 -1.088711592 0.552091941 0.048612443
Cheese (ukb-b-1489) (👉 📊) Ankle spacing width Inverse variance weighted 192 0.366058031 0.156602556 0.019413348
Water (ukb-b-14898) (👉 📊) Ankle spacing width Inverse variance weighted 154 -0.46011322 0.214453989 0.031912078
Cheesy biscuits (ukb-b-19847) (👉 📊) Ankle spacing width MR Egger 9 6.430480384 2.448363497 0.034088524
Melon (ukb-b-19862) (👉 📊) Ankle spacing width Weighted median 12 -2.143770392 0.890412945 0.016057162
Melon (ukb-b-19862) (👉 📊) Ankle spacing width Inverse variance weighted 12 -1.413743255 0.650052448 0.029644047
Milk (ukb-b-2966) (👉 📊) Ankle spacing width MR Egger 18 2.522691253 1.158842701 0.044805547
Standard tea (ukb-b-3291) (👉 📊) Ankle spacing width Inverse variance weighted 12 0.003943798 0.001558132 0.011370352
Pizza (ukb-b-3852) (👉 📊) Ankle spacing width Inverse variance weighted 10 -0.801055128 0.408299562 0.049770643
Crumbed or deep-fried poultry (ukb-b-39) (👉 📊) Ankle spacing width Inverse variance weighted 6 -2.098524503 1.059634784 0.047656081
Baked bean (ukb-b-4058) (👉 📊) Ankle spacing width MR Egger 9 -3.493455535 1.308717863 0.032028812
Wholemeal pasta (ukb-b-4150) (👉 📊) Ankle spacing width Weighted median 12 2.434783128 1.219866927 0.045940281
Milk chocolate (ukb-b-4569) (👉 📊) Ankle spacing width MR Egger 12 2.036999365 0.806141362 0.030032566
Milk chocolate (ukb-b-4569) (👉 📊) Ankle spacing width Weighted median 12 1.290926799 0.519018089 0.012873556
Milk chocolate (ukb-b-4569) (👉 📊) Ankle spacing width Inverse variance weighted 12 0.886115514 0.388810442 0.02266454
Beer/cider (ukb-b-4961) (👉 📊) Ankle spacing width Weighted median 12 0.918014874 0.369516704 0.012978221
Beer/cider (ukb-b-4961) (👉 📊) Ankle spacing width Inverse variance weighted 12 0.541489287 0.266727979 0.04234454
Soya dessert (ukb-b-998) (👉 📊) Ankle spacing width Inverse variance weighted 17 -2.464278228 1.1722127 0.035531824

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Pineapple (ukb-b-1164) Ankle spacing width All - Inverse variance weighted -1.08871159168385 0.552091940699704 0.0486124425320199
Cheese (ukb-b-1489) Ankle spacing width rs13181793 5.09135332267395 2.32380575966082 0.0284550654044386
Cheese (ukb-b-1489) Ankle spacing width rs2824098 5.37349961309363 2.38352318738865 0.0241687755388621
Cheese (ukb-b-1489) Ankle spacing width rs3204347 6.74952243945004 3.21203688418272 0.0356127461341198
Cheese (ukb-b-1489) Ankle spacing width rs34205186 -6.96229426151333 2.82627786853511 0.0137620662689517
Cheese (ukb-b-1489) Ankle spacing width rs3733421 -5.41582505556939 2.47548951790672 0.0286856726747049
Cheese (ukb-b-1489) Ankle spacing width rs614132 -4.67625899280576 2.245717238364 0.0373149951368489
Cheese (ukb-b-1489) Ankle spacing width rs6694085 4.26618325737933 2.17534179299586 0.0498609002965618
Cheese (ukb-b-1489) Ankle spacing width All - Inverse variance weighted 0.366058030955237 0.156602555747611 0.019413347890261
Water (ukb-b-14898) Ankle spacing width rs12620738 -8.25275942577728 2.73874284289888 0.0025839047449108
Water (ukb-b-14898) Ankle spacing width rs1313237 -7.96708287913322 2.61784428368513 0.0023394030207832
Water (ukb-b-14898) Ankle spacing width rs1977819 -6.79761728942057 3.19893664155959 0.0335898233224717
Water (ukb-b-14898) Ankle spacing width rs959424 -7.04626578802856 3.07637744828849 0.0219956756867471
Water (ukb-b-14898) Ankle spacing width All - Inverse variance weighted -0.460113219522181 0.214453989471318 0.0319120776391184
Cheesy biscuits (ukb-b-19847) Ankle spacing width All - MR Egger 6.43048038376562 2.44836349704005 0.0340885244926429
Melon (ukb-b-19862) Ankle spacing width All - Inverse variance weighted -1.41374325458962 0.650052448289238 0.029644047237594
Milk (ukb-b-2966) Ankle spacing width rs191749866 3.87943619274803 1.39507507283649 0.005422376380807
Milk (ukb-b-2966) Ankle spacing width All - MR Egger 2.52269125286661 1.15884270116568 0.0448055469792837
Standard tea (ukb-b-3291) Ankle spacing width All - Inverse variance weighted 0.0039437976685941 0.0015581322447055 0.0113703523464333
Pizza (ukb-b-3852) Ankle spacing width rs1480734 -3.51143199645299 1.40293066358675 0.0123171204510485
Pizza (ukb-b-3852) Ankle spacing width All - Inverse variance weighted -0.801055128042539 0.408299561640965 0.0497706433394347
Crumbed or deep-fried poultry (ukb-b-39) Ankle spacing width rs117845922 -5.32055115123225 2.31114454539025 0.0213279406361169
Crumbed or deep-fried poultry (ukb-b-39) Ankle spacing width All - Inverse variance weighted -2.09852450308795 1.05963478380533 0.0476560806200369
Baked bean (ukb-b-4058) Ankle spacing width rs4609980 -2.64482942994633 1.32098507744346 0.0452670421241535
Baked bean (ukb-b-4058) Ankle spacing width All - MR Egger -3.49345553487343 1.30871786313055 0.0320288116634599
Milk chocolate (ukb-b-4569) Ankle spacing width rs112748887 3.95934766580377 1.70521536057997 0.0202380643554937
Milk chocolate (ukb-b-4569) Ankle spacing width rs899452 1.43929483838692 0.690513305932564 0.037125258391952
Milk chocolate (ukb-b-4569) Ankle spacing width All - Inverse variance weighted 0.886115513715644 0.388810442074496 0.0226645402870448
Milk chocolate (ukb-b-4569) Ankle spacing width All - MR Egger 2.03699936544372 0.806141361617862 0.0300325660704081
Beer/cider (ukb-b-4961) Ankle spacing width rs1229984 1.10824197535402 0.55255878920429 0.0448931318792507
Beer/cider (ukb-b-4961) Ankle spacing width rs281392 1.9955260567012 0.938322539163748 0.0334454151328138
Beer/cider (ukb-b-4961) Ankle spacing width All - Inverse variance weighted 0.541489287321134 0.266727978723912 0.0423445399526245
Soya dessert (ukb-b-998) Ankle spacing width rs144278273 -6.52602397282225 2.76344465098391 0.0181985176993577
Soya dessert (ukb-b-998) Ankle spacing width rs72835369 -35.5386896632458 14.1257267725446 0.0118734262095109
Soya dessert (ukb-b-998) Ankle spacing width rs76224945 -15.2450249846585 5.97790830191987 0.0107652704829578
Soya dessert (ukb-b-998) Ankle spacing width All - Inverse variance weighted -2.46427822828921 1.17221270034334 0.0355318242162199