ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Pear (ukb-b-10793) (👉 📊) Heel bone mineral density (BMD) (left) MR Egger 10 -2.848993915 1.034594193 0.02491489
Pear (ukb-b-10793) (👉 📊) Heel bone mineral density (BMD) (left) Inverse variance weighted 10 -1.122209515 0.500137593 0.024845172
Snackpot (ukb-b-12912) (👉 📊) Heel bone mineral density (BMD) (left) Weighted median 26 5.899232285 2.637089552 0.02528478
Snackpot (ukb-b-12912) (👉 📊) Heel bone mineral density (BMD) (left) Inverse variance weighted 26 3.920111251 1.810690608 0.03038912
Snackpot (ukb-b-12912) (👉 📊) Heel bone mineral density (BMD) (left) Weighted mode 26 6.309664794 2.710132507 0.028288055
Other drink (ukb-b-1310) (👉 📊) Heel bone mineral density (BMD) (left) MR Egger 11 6.517954895 2.789616064 0.044272899
Other drink (ukb-b-1310) (👉 📊) Heel bone mineral density (BMD) (left) Inverse variance weighted 11 2.921177287 1.194007531 0.014423811
Cheese (ukb-b-1489) (👉 📊) Heel bone mineral density (BMD) (left) Inverse variance weighted 177 0.66730836 0.287912793 0.020463198
Water (ukb-b-14898) (👉 📊) Heel bone mineral density (BMD) (left) MR Egger 141 3.319237512 1.263272495 0.009567791
Water (ukb-b-14898) (👉 📊) Heel bone mineral density (BMD) (left) Weighted median 141 1.641616573 0.607382317 0.006876367
Water (ukb-b-14898) (👉 📊) Heel bone mineral density (BMD) (left) Inverse variance weighted 141 0.936150951 0.371982772 0.0118476
Water (ukb-b-14898) (👉 📊) Heel bone mineral density (BMD) (left) Weighted mode 141 2.714226415 1.02318805 0.008906987
Unsalted peanuts (ukb-b-15555) (👉 📊) Heel bone mineral density (BMD) (left) Weighted median 15 -2.869020326 1.351503696 0.03376762
Unsalted peanuts (ukb-b-15555) (👉 📊) Heel bone mineral density (BMD) (left) Inverse variance weighted 15 -2.341820745 0.963960358 0.015124899
Dried fruit (ukb-b-16576) (👉 📊) Heel bone mineral density (BMD) (left) MR Egger 142 -3.852091855 1.864228339 0.040641337
Ice-cream (ukb-b-17189) (👉 📊) Heel bone mineral density (BMD) (left) Inverse variance weighted 11 -1.534269095 0.673670944 0.022757844
Parsnip (ukb-b-2468) (👉 📊) Heel bone mineral density (BMD) (left) Weighted median 5 3.07272088 1.53911252 0.045887811
Parsnip (ukb-b-2468) (👉 📊) Heel bone mineral density (BMD) (left) Inverse variance weighted 5 3.224054514 1.172071313 0.00594622
Wholemeal pasta (ukb-b-4150) (👉 📊) Heel bone mineral density (BMD) (left) Inverse variance weighted 7 -5.885965888 2.347874282 0.012178345
Danish pastry (ukb-b-447) (👉 📊) Heel bone mineral density (BMD) (left) Weighted median 7 -4.846078842 2.231326994 0.029867949
Beer/cider (ukb-b-4961) (👉 📊) Heel bone mineral density (BMD) (left) Weighted median 8 0.850962921 0.411467819 0.038629176
Sushi (ukb-b-5213) (👉 📊) Heel bone mineral density (BMD) (left) Weighted median 22 2.794222531 1.145001644 0.014672408
Sushi (ukb-b-5213) (👉 📊) Heel bone mineral density (BMD) (left) Inverse variance weighted 22 2.470047766 1.073447906 0.021389307
Sushi (ukb-b-5213) (👉 📊) Heel bone mineral density (BMD) (left) Weighted mode 22 2.525161956 1.073270095 0.028460784
Coffee (ukb-b-5237) (👉 📊) Heel bone mineral density (BMD) (left) MR Egger 107 -2.768168693 0.960171834 0.004778774
Coffee (ukb-b-5237) (👉 📊) Heel bone mineral density (BMD) (left) Weighted mode 107 -2.160724876 0.867453169 0.014293998
Sausage (ukb-b-5847) (👉 📊) Heel bone mineral density (BMD) (left) Simple mode 6 2.253786484 0.793738746 0.036269594
Blue cheese (ukb-b-7429) (👉 📊) Heel bone mineral density (BMD) (left) Inverse variance weighted 6 6.735865866 2.678735244 0.011917782
Filtered coffee (ukb-b-748) (👉 📊) Heel bone mineral density (BMD) (left) Weighted median 17 -1.097417871 0.44945835 0.014620503
Filtered coffee (ukb-b-748) (👉 📊) Heel bone mineral density (BMD) (left) Inverse variance weighted 17 -0.829133487 0.368905675 0.024604979
Filtered coffee (ukb-b-748) (👉 📊) Heel bone mineral density (BMD) (left) Weighted mode 17 -1.32306478 0.534639481 0.024909496
Spinach (ukb-b-812) (👉 📊) Heel bone mineral density (BMD) (left) Inverse variance weighted 7 -1.020586797 0.494591992 0.039065873
Squash (ukb-b-8793) (👉 📊) Heel bone mineral density (BMD) (left) MR Egger 13 -4.095897735 1.76951661 0.040958456

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Pear (ukb-b-10793) Heel bone mineral density (BMD) (left) rs1873849 -2.22083722862782 0.844707593227381 0.0085606265746259
Pear (ukb-b-10793) Heel bone mineral density (BMD) (left) rs59427628 -4.10727661755377 2.01242218216094 0.0412546331911227
Pear (ukb-b-10793) Heel bone mineral density (BMD) (left) All - Inverse variance weighted -1.12220951456014 0.500137593433398 0.0248451717171639
Pear (ukb-b-10793) Heel bone mineral density (BMD) (left) All - MR Egger -2.84899391543099 1.03459419327294 0.024914889578133
Snackpot (ukb-b-12912) Heel bone mineral density (BMD) (left) rs77707295 -15.4788593976753 7.06896829498319 0.0285466219742704
Snackpot (ukb-b-12912) Heel bone mineral density (BMD) (left) All - Inverse variance weighted 3.92011125087912 1.81069060765701 0.0303891196863195
Other drink (ukb-b-1310) Heel bone mineral density (BMD) (left) rs2184436 5.78776425554127 2.06329566654745 0.0050299944086701
Other drink (ukb-b-1310) Heel bone mineral density (BMD) (left) All - Inverse variance weighted 2.9211772869379 1.194007531346 0.0144238108935215
Other drink (ukb-b-1310) Heel bone mineral density (BMD) (left) All - MR Egger 6.51795489525917 2.78961606425383 0.0442728987216054
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (left) rs11104660 9.01224162821165 3.34621193788229 0.0070755616712982
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (left) rs11669334 20.4860510941335 7.50164206450721 0.00631663143399
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (left) rs11735256 -12.3905363092946 3.7163236943891 0.0008558073071568
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (left) rs1473781 11.1074340893856 4.43957946185373 0.0123524863134336
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (left) rs221418 -8.91574442412473 3.87907467807922 0.0215378727981324
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (left) rs2352974 9.04312556907541 3.39582815992054 0.0077445029834266
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (left) rs2900884 9.25951167207335 3.62384028932566 0.0106137320875829
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (left) rs683996 7.48870894077903 3.2680638823845 0.0219355627322553
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (left) rs7730004 -12.7290072964331 4.64993021571295 0.0061915271551063
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (left) rs9504123 -8.94810382058628 3.20028792005984 0.0051734458480978
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (left) All - Inverse variance weighted 0.667308359842505 0.287912793401567 0.0204631984510937
Water (ukb-b-14898) Heel bone mineral density (BMD) (left) rs10758255 17.9659037183302 6.93606251912006 0.0095915582926374
Water (ukb-b-14898) Heel bone mineral density (BMD) (left) rs10954732 7.99740105652702 3.61215476896711 0.0268270574255833
Water (ukb-b-14898) Heel bone mineral density (BMD) (left) rs11714200 -9.28201777584186 3.92541198676664 0.0180496953840775
Water (ukb-b-14898) Heel bone mineral density (BMD) (left) rs11770515 26.5418174079591 13.3900829963822 0.0474569033650083
Water (ukb-b-14898) Heel bone mineral density (BMD) (left) rs11858506 -17.2560605136614 5.94701666655373 0.0037122301996815
Water (ukb-b-14898) Heel bone mineral density (BMD) (left) rs2043294 -25.4859352542605 9.27383478201355 0.0059931673035073
Water (ukb-b-14898) Heel bone mineral density (BMD) (left) rs4410790 3.4497949558491 1.25941810219167 0.0061589357170047
Water (ukb-b-14898) Heel bone mineral density (BMD) (left) rs959424 -11.8181402159985 4.77759472817133 0.0133737277456358
Water (ukb-b-14898) Heel bone mineral density (BMD) (left) All - Inverse variance weighted 0.936150951232213 0.37198277215402 0.0118475997786878
Water (ukb-b-14898) Heel bone mineral density (BMD) (left) All - MR Egger 3.31923751170375 1.26327249453459 0.00956779134672
Unsalted peanuts (ukb-b-15555) Heel bone mineral density (BMD) (left) All - Inverse variance weighted -2.34182074489241 0.963960358009788 0.0151248988666787
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) (left) rs11085749 10.2576412915004 4.2509628985345 0.0158211270537881
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) (left) rs117451379 12.0275024189569 4.57519271557552 0.0085673753787415
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) (left) rs12727104 -11.7260215447527 4.83078519332296 0.0152094437706492
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) (left) rs1419750 -11.852358972439 4.27562083148363 0.0055699506815276
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) (left) rs17175518 -10.716584610567 4.30316104451906 0.0127600036538276
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) (left) rs1735720 12.246609814064 6.05433617596347 0.0430954992166436
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) (left) rs4073960 -35.6893842907211 11.0721689737559 0.0012670429623323
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) (left) rs4140799 16.2954973246198 8.3042531142271 0.0497267063719373
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) (left) rs4269101 -7.45841751207467 2.79364803510525 0.0075901618417042
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) (left) rs57499472 -10.1590850165098 3.95972280931488 0.0102996014637398
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) (left) rs7599488 11.3197764848206 4.37525203064693 0.0096751425347521
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) (left) rs7730004 -17.5795379546006 6.42183815357514 0.0061915271551063
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) (left) rs898751 9.64366436922734 4.36532075787594 0.0271639542017511
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) (left) rs9300104 19.2929086735939 6.59070654365674 0.0034193000140399
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) (left) rs979678 -9.19605438940029 3.79737569313544 0.0154486610969107
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) (left) All - MR Egger -3.85209185493418 1.86422833943485 0.0406413369523445
Ice-cream (ukb-b-17189) Heel bone mineral density (BMD) (left) rs28607628 -4.23960265237164 1.92735194735906 0.0278279446572673
Ice-cream (ukb-b-17189) Heel bone mineral density (BMD) (left) All - Inverse variance weighted -1.53426909520036 0.673670943948753 0.0227578438053393
Parsnip (ukb-b-2468) Heel bone mineral density (BMD) (left) rs4001121 2.92110377365289 1.48481434415695 0.049146422447701
Parsnip (ukb-b-2468) Heel bone mineral density (BMD) (left) All - Inverse variance weighted 3.22405451436575 1.17207131275266 0.0059462199471789
Wholemeal pasta (ukb-b-4150) Heel bone mineral density (BMD) (left) All - Inverse variance weighted -5.88596588792894 2.34787428167559 0.0121783445540692
Beer/cider (ukb-b-4961) Heel bone mineral density (BMD) (left) rs1229984 0.999807022541605 0.408560847630512 0.0143993496255473
Beer/cider (ukb-b-4961) Heel bone mineral density (BMD) (left) rs3212737 7.42991817796031 3.4703346882661 0.0322756273057071
Sushi (ukb-b-5213) Heel bone mineral density (BMD) (left) rs6906404 26.0490153978284 12.8826452364886 0.0431738921878218
Sushi (ukb-b-5213) Heel bone mineral density (BMD) (left) rs72806087 7.31161094440166 3.43008382682281 0.0330386821216455
Sushi (ukb-b-5213) Heel bone mineral density (BMD) (left) rs7583354 19.3223167149257 6.2166539300162 0.0018826005037937
Sushi (ukb-b-5213) Heel bone mineral density (BMD) (left) rs78849633 8.79196813267214 4.14193967970084 0.0337815746909311
Sushi (ukb-b-5213) Heel bone mineral density (BMD) (left) rs78998021 -11.8816236039538 4.41444814940295 0.0071124909025907
Sushi (ukb-b-5213) Heel bone mineral density (BMD) (left) All - Inverse variance weighted 2.470047766172 1.07344790648908 0.0213893072870449
Coffee (ukb-b-5237) Heel bone mineral density (BMD) (left) rs1057868 -4.82634868602419 2.0149466941341 0.0166079658242848
Coffee (ukb-b-5237) Heel bone mineral density (BMD) (left) rs11236225 10.3818440272536 4.57624626243812 0.0232903772494867
Coffee (ukb-b-5237) Heel bone mineral density (BMD) (left) rs2126069 11.6011118958367 5.72359247387769 0.0426733141090936
Coffee (ukb-b-5237) Heel bone mineral density (BMD) (left) rs4410790 -2.7257371007371 0.995085995085995 0.0061589357170047
Coffee (ukb-b-5237) Heel bone mineral density (BMD) (left) rs476828 -7.1947008261223 2.83810193645834 0.0112434611935884
Coffee (ukb-b-5237) Heel bone mineral density (BMD) (left) rs9953004 14.072188930895 6.55939429841176 0.031924966493277
Coffee (ukb-b-5237) Heel bone mineral density (BMD) (left) All - MR Egger -2.76816869281737 0.960171833538224 0.004778774013726
Sausage (ukb-b-5847) Heel bone mineral density (BMD) (left) rs17059045 -2.29072279379736 0.978863881094682 0.0192741781086306
Sausage (ukb-b-5847) Heel bone mineral density (BMD) (left) rs76866342 2.81554256086963 1.20560899088244 0.0195241222283768
Blue cheese (ukb-b-7429) Heel bone mineral density (BMD) (left) rs10509498 13.7164947929601 6.55981016196937 0.0365289967269794
Blue cheese (ukb-b-7429) Heel bone mineral density (BMD) (left) rs59939687 9.43574150340634 3.99330279819868 0.0181329742924145
Blue cheese (ukb-b-7429) Heel bone mineral density (BMD) (left) All - Inverse variance weighted 6.73586586599503 2.67873524437775 0.0119177820017528
Filtered coffee (ukb-b-748) Heel bone mineral density (BMD) (left) rs6968865 -1.85716619815079 0.812745866098024 0.0223098054560935
Filtered coffee (ukb-b-748) Heel bone mineral density (BMD) (left) rs78169764 5.27245319370981 2.03637466439511 0.0096216778426262
Filtered coffee (ukb-b-748) Heel bone mineral density (BMD) (left) All - Inverse variance weighted -0.829133487238527 0.368905675287449 0.0246049790551709
Spinach (ukb-b-812) Heel bone mineral density (BMD) (left) rs111686396 -1.45432241796436 0.639520223532218 0.0229609637688951
Spinach (ukb-b-812) Heel bone mineral density (BMD) (left) All - Inverse variance weighted -1.02058679683205 0.494591991724031 0.0390658728205915
Squash (ukb-b-8793) Heel bone mineral density (BMD) (left) rs116156344 -5.78868919481068 2.35040428651647 0.0137838222692449
Squash (ukb-b-8793) Heel bone mineral density (BMD) (left) rs16850360 -2.74569492941773 1.15889963291253 0.0178253662895017
Squash (ukb-b-8793) Heel bone mineral density (BMD) (left) All - MR Egger -4.09589773510412 1.76951661009664 0.0409584561321542