ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Pear (ukb-b-10793) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) MR Egger 10 -2.893105383 1.027517357 0.022645901
Pear (ukb-b-10793) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Inverse variance weighted 10 -1.074369152 0.520301852 0.038932853
Snackpot (ukb-b-12912) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Weighted median 26 5.788065768 2.648969178 0.028886961
Snackpot (ukb-b-12912) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Inverse variance weighted 26 3.766797119 1.798487007 0.03622209
Snackpot (ukb-b-12912) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Weighted mode 26 6.250123846 2.661395099 0.027064456
Other drink (ukb-b-1310) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) MR Egger 11 6.466166438 2.77116869 0.044500745
Other drink (ukb-b-1310) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Inverse variance weighted 11 2.671731725 1.185797349 0.024252222
Cheese (ukb-b-1489) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Inverse variance weighted 177 0.652149756 0.279946621 0.019829928
Water (ukb-b-14898) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) MR Egger 141 3.266179789 1.25398026 0.010197011
Water (ukb-b-14898) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Weighted median 141 1.543868633 0.567327912 0.0065026
Water (ukb-b-14898) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Inverse variance weighted 141 0.915177448 0.368354084 0.01297318
Water (ukb-b-14898) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Weighted mode 141 2.331626012 0.898192932 0.010440143
Unsalted peanuts (ukb-b-15555) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Weighted median 15 -2.896500293 1.308217007 0.026823109
Unsalted peanuts (ukb-b-15555) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Inverse variance weighted 15 -2.475258446 0.957528001 0.009736467
Unsalted peanuts (ukb-b-15555) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Weighted mode 15 -2.786021233 1.268797103 0.04545689
Dried fruit (ukb-b-16576) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) MR Egger 143 -4.064701562 1.816962062 0.026849972
Ice-cream (ukb-b-17189) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Inverse variance weighted 11 -1.416188027 0.692635378 0.040890644
Fruit smoothie (ukb-b-1780) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Inverse variance weighted 11 -1.298018647 0.653661126 0.047059209
Parsnip (ukb-b-2468) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Inverse variance weighted 5 3.136096159 1.163691503 0.007039815
Hard cheese (ukb-b-3542) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) MR Egger 7 6.157232249 2.393960147 0.049914874
Wholemeal pasta (ukb-b-4150) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Inverse variance weighted 7 -5.781286462 2.329469098 0.013071904
Danish pastry (ukb-b-447) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Weighted median 7 -4.581663516 2.271746893 0.043716188
Beer/cider (ukb-b-4961) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Weighted median 8 0.816734801 0.411339798 0.047083565
Sushi (ukb-b-5213) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Weighted median 22 3.143660206 1.128483517 0.00534059
Sushi (ukb-b-5213) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Inverse variance weighted 22 2.499610828 1.075394322 0.020105845
Sushi (ukb-b-5213) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Weighted mode 22 2.658464306 0.994226377 0.01420743
Coffee (ukb-b-5237) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) MR Egger 107 -2.683529462 0.940520593 0.005213716
Coffee (ukb-b-5237) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Weighted mode 107 -2.037701761 0.852302929 0.018574487
Blue cheese (ukb-b-7429) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Inverse variance weighted 6 6.496081164 2.809437995 0.020764731
Filtered coffee (ukb-b-748) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Weighted median 17 -1.049328825 0.446351699 0.018727997
Filtered coffee (ukb-b-748) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Inverse variance weighted 17 -0.862778205 0.353576996 0.014681475
Filtered coffee (ukb-b-748) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Weighted mode 17 -1.273839116 0.527325061 0.028030993
Spinach (ukb-b-812) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) Inverse variance weighted 7 -0.998965162 0.491200022 0.041979454
Squash (ukb-b-8793) (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) MR Egger 13 -4.007017361 1.742618461 0.042074598

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Pear (ukb-b-10793) Heel bone mineral density (BMD) T-score, automated (left) rs1873849 -2.19175236314532 0.839098369170043 0.0090005649647452
Pear (ukb-b-10793) Heel bone mineral density (BMD) T-score, automated (left) All - Inverse variance weighted -1.07436915178643 0.520301852373879 0.0389328529317544
Pear (ukb-b-10793) Heel bone mineral density (BMD) T-score, automated (left) All - MR Egger -2.89310538323103 1.02751735727495 0.0226459014896544
Snackpot (ukb-b-12912) Heel bone mineral density (BMD) T-score, automated (left) rs77707295 -15.1938203535228 7.02187488768842 0.0304809326089632
Snackpot (ukb-b-12912) Heel bone mineral density (BMD) T-score, automated (left) All - Inverse variance weighted 3.76679711865758 1.79848700676085 0.0362220896944197
Other drink (ukb-b-1310) Heel bone mineral density (BMD) T-score, automated (left) rs2184436 5.68385032527477 2.04976268958251 0.0055553913643676
Other drink (ukb-b-1310) Heel bone mineral density (BMD) T-score, automated (left) All - Inverse variance weighted 2.67173172547251 1.18579734885647 0.0242522215096962
Other drink (ukb-b-1310) Heel bone mineral density (BMD) T-score, automated (left) All - MR Egger 6.46616643768319 2.77116869045164 0.0445007454465672
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (left) rs11104660 9.04562030090873 3.32451580062919 0.0065107695742025
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (left) rs11620149 -20.5663526549549 10.2067951002857 0.0439081340744542
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (left) rs11669334 19.6978601306738 7.45324437376845 0.0082209713206885
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (left) rs11735256 -11.6789176699094 3.68785894881369 0.0015409668515576
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (left) rs1473781 10.4964827872956 4.40903189674923 0.0172808360348292
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (left) rs2086504 6.39887492309045 3.23606105886145 0.048000350664061
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (left) rs221418 -9.07222714503874 3.84985200128203 0.0184474108928519
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (left) rs2352974 8.98794249924123 3.37168556686808 0.0076825487845505
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (left) rs2900884 8.90603276722187 3.59930576379613 0.0133469459158012
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (left) rs683996 7.14508376769778 3.24631545370847 0.027737256974912
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (left) rs7730004 -12.1194989664859 4.61724643570129 0.0086691577191026
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (left) rs9504123 -8.22124680676894 3.17417752247611 0.0095964775513622
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (left) All - Inverse variance weighted 0.652149755523462 0.279946621423959 0.019829927850454
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (left) rs10758255 18.2532840151663 6.88878382512445 0.008056072831519
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (left) rs10822004 -11.4346098937905 5.66481072981797 0.0435357350440152
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (left) rs10954732 7.56330216484458 3.58484702957711 0.0348757811386457
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (left) rs11714200 -8.85577092602387 3.89948456281178 0.0231463339526929
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (left) rs11770515 34.0668227282401 12.7856990849117 0.0077114924452997
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (left) rs11858506 -16.3751883146656 5.90523170326804 0.0055542675630026
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (left) rs2043294 -24.5191978646225 9.21394839504483 0.0077886831074872
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (left) rs4410790 3.33642141269913 1.25002429433067 0.0076058141681182
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (left) rs959424 -12.4016108365367 4.74212886692294 0.0089175473272657
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (left) All - Inverse variance weighted 0.915177448177679 0.36835408425499 0.0129731800981346
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (left) All - MR Egger 3.26617978935965 1.25398025988102 0.0101970112653857
Unsalted peanuts (ukb-b-15555) Heel bone mineral density (BMD) T-score, automated (left) All - Inverse variance weighted -2.47525844643389 0.957528000914458 0.0097364673929484
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (left) rs11085749 10.1812122295111 4.22297479132713 0.0159127738402645
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (left) rs117451379 11.5661384476384 4.54571668407461 0.0109464483975999
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (left) rs12727104 -12.7178125667552 4.78882480393054 0.0079137590727091
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (left) rs1419750 -11.7881765231298 4.24780843678296 0.0055181408003086
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (left) rs17175518 -11.1254153546389 4.27010664393452 0.009176206961229
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (left) rs1735720 12.2186495176849 6.01425975115336 0.0421928290050072
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (left) rs4073960 -33.2536930471241 11.0070932535071 0.002518458012871
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (left) rs4269101 -7.0746348633951 2.7748209617738 0.0107852001120625
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (left) rs57499472 -10.1086426877287 3.93450164492434 0.0101924557535402
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (left) rs7599488 10.5324807496592 4.34452829464063 0.0153375324006097
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (left) rs7730004 -16.7377696555948 6.37669985348352 0.0086691577191026
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (left) rs898751 9.74970003069453 4.3374166364372 0.0245881382052759
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (left) rs9300104 18.6705567808973 6.54589720738259 0.0043410496371196
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (left) rs979678 -8.59487949051114 3.77266987537288 0.0227149329504994
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (left) All - MR Egger -4.06470156231088 1.81696206238038 0.0268499717169788
Ice-cream (ukb-b-17189) Heel bone mineral density (BMD) T-score, automated (left) rs28607628 -3.96648967251848 1.91274357866924 0.0381055627377425
Ice-cream (ukb-b-17189) Heel bone mineral density (BMD) T-score, automated (left) All - Inverse variance weighted -1.41618802683093 0.692635378141775 0.0408906439206467
Fruit smoothie (ukb-b-1780) Heel bone mineral density (BMD) T-score, automated (left) rs117735178 -7.52827493619114 2.95355027045591 0.0108066360718503
Fruit smoothie (ukb-b-1780) Heel bone mineral density (BMD) T-score, automated (left) All - Inverse variance weighted -1.29801864676446 0.653661125989443 0.0470592094699711
Parsnip (ukb-b-2468) Heel bone mineral density (BMD) T-score, automated (left) All - Inverse variance weighted 3.13609615861928 1.16369150334186 0.0070398151757439
Hard cheese (ukb-b-3542) Heel bone mineral density (BMD) T-score, automated (left) rs10866415 -4.89379425239484 2.3171768707483 0.0346895327710832
Hard cheese (ukb-b-3542) Heel bone mineral density (BMD) T-score, automated (left) All - MR Egger 6.1572322486362 2.39396014727589 0.0499148742348156
Wholemeal pasta (ukb-b-4150) Heel bone mineral density (BMD) T-score, automated (left) All - Inverse variance weighted -5.7812864617006 2.32946909837126 0.0130719038926848
Beer/cider (ukb-b-4961) Heel bone mineral density (BMD) T-score, automated (left) rs1229984 0.918940278071328 0.405712132768491 0.0235123320336516
Beer/cider (ukb-b-4961) Heel bone mineral density (BMD) T-score, automated (left) rs3212737 7.30366042275305 3.44753814913145 0.0341314970086013
Sushi (ukb-b-5213) Heel bone mineral density (BMD) T-score, automated (left) rs6906404 25.2745230353966 12.7982945831544 0.0482868495389117
Sushi (ukb-b-5213) Heel bone mineral density (BMD) T-score, automated (left) rs72806087 7.01507466517956 3.40751166228501 0.0395221309036489
Sushi (ukb-b-5213) Heel bone mineral density (BMD) T-score, automated (left) rs7583354 19.0138327035118 6.17599012851163 0.0020792718041884
Sushi (ukb-b-5213) Heel bone mineral density (BMD) T-score, automated (left) rs78849633 8.38549711405577 4.11348670839769 0.041496203513475
Sushi (ukb-b-5213) Heel bone mineral density (BMD) T-score, automated (left) rs78998021 -12.0064430615241 4.38532360930321 0.0061838638875253
Sushi (ukb-b-5213) Heel bone mineral density (BMD) T-score, automated (left) All - Inverse variance weighted 2.49961082779965 1.07539432163455 0.0201058448856955
Coffee (ukb-b-5237) Heel bone mineral density (BMD) T-score, automated (left) rs1057868 -4.5471632858668 1.9994085479853 0.0229507072197086
Coffee (ukb-b-5237) Heel bone mineral density (BMD) T-score, automated (left) rs11236225 10.4308612322925 4.54487525121318 0.0217284273088281
Coffee (ukb-b-5237) Heel bone mineral density (BMD) T-score, automated (left) rs4410790 -2.63615888615889 0.9876638001638 0.0076058141681182
Coffee (ukb-b-5237) Heel bone mineral density (BMD) T-score, automated (left) rs476828 -7.49448002721073 2.81677149330397 0.00779869416855
Coffee (ukb-b-5237) Heel bone mineral density (BMD) T-score, automated (left) rs630194 -21.8702932187117 10.5167660503994 0.0375654969629512
Coffee (ukb-b-5237) Heel bone mineral density (BMD) T-score, automated (left) rs9953004 13.4620127170893 6.51490228282176 0.038796248917621
Coffee (ukb-b-5237) Heel bone mineral density (BMD) T-score, automated (left) All - MR Egger -2.68352946239709 0.940520593009071 0.0052137162000199
Blue cheese (ukb-b-7429) Heel bone mineral density (BMD) T-score, automated (left) rs10509498 12.9177576689656 6.5147904331624 0.0473858085564699
Blue cheese (ukb-b-7429) Heel bone mineral density (BMD) T-score, automated (left) rs59939687 9.21057696008622 3.96636003233132 0.0202235844111283
Blue cheese (ukb-b-7429) Heel bone mineral density (BMD) T-score, automated (left) All - Inverse variance weighted 6.49608116363398 2.80943799509599 0.0207647305873105
Filtered coffee (ukb-b-748) Heel bone mineral density (BMD) T-score, automated (left) rs6968865 -1.79704814052963 0.806671219160693 0.0258983212887301
Filtered coffee (ukb-b-748) Heel bone mineral density (BMD) T-score, automated (left) rs78169764 5.06729937294289 2.02299506738857 0.0122503303633545
Filtered coffee (ukb-b-748) Heel bone mineral density (BMD) T-score, automated (left) All - Inverse variance weighted -0.86277820453973 0.353576996055265 0.0146814751478055
Spinach (ukb-b-812) Heel bone mineral density (BMD) T-score, automated (left) rs111686396 -1.46658942992469 0.635158619279654 0.0209428667750231
Spinach (ukb-b-812) Heel bone mineral density (BMD) T-score, automated (left) All - Inverse variance weighted -0.998965162330185 0.491200022460225 0.0419794539856117
Squash (ukb-b-8793) Heel bone mineral density (BMD) T-score, automated (left) rs116156344 -5.69530367878293 2.33585069960305 0.0147600366834712
Squash (ukb-b-8793) Heel bone mineral density (BMD) T-score, automated (left) rs16850360 -2.64683498970364 1.15125197719879 0.0214996772773896
Squash (ukb-b-8793) Heel bone mineral density (BMD) T-score, automated (left) All - MR Egger -4.00701736148917 1.74261846096654 0.0420745975320014