ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Ankle spacing width (right) (ukb-e-4119_EAS)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Sweetened cereal (ukb-b-10640) (👉 📊) Ankle spacing width (right) Inverse variance weighted 7 -4.401318117 1.905728115 0.020914716
Pear (ukb-b-10793) (👉 📊) Ankle spacing width (right) Simple mode 10 2.236527319 0.898976622 0.034543125
Other alcohol (ukb-b-12901) (👉 📊) Ankle spacing width (right) Simple mode 17 -6.39592449 2.71941433 0.031812802
Other drink (ukb-b-1310) (👉 📊) Ankle spacing width (right) MR Egger 11 -8.971959141 2.537081904 0.006350555
Other drink (ukb-b-1310) (👉 📊) Ankle spacing width (right) Inverse variance weighted 11 -3.186101578 1.083238474 0.003268649
Naan bread (ukb-b-13281) (👉 📊) Ankle spacing width (right) Weighted median 9 2.795784258 1.337959045 0.036654752
Naan bread (ukb-b-13281) (👉 📊) Ankle spacing width (right) Inverse variance weighted 9 2.342823111 0.930550433 0.011813243
Herbal tea (ukb-b-13344) (👉 📊) Ankle spacing width (right) MR Egger 37 0.019695244 0.009564427 0.046974017
Red wine (ukb-b-13556) (👉 📊) Ankle spacing width (right) Weighted median 8 -0.81676982 0.342501777 0.017092263
Red wine (ukb-b-13556) (👉 📊) Ankle spacing width (right) Inverse variance weighted 8 -0.722631195 0.253461093 0.004357461
Lamb/mutton (ukb-b-14179) (👉 📊) Ankle spacing width (right) Inverse variance weighted 110 -1.127495427 0.474135381 0.017406677
Lobster/crab (ukb-b-14746) (👉 📊) Ankle spacing width (right) Weighted median 16 5.28481178 2.577545445 0.040332503
Lobster/crab (ukb-b-14746) (👉 📊) Ankle spacing width (right) Inverse variance weighted 16 5.023758618 2.243824251 0.025160669
Lobster/crab (ukb-b-14746) (👉 📊) Ankle spacing width (right) Weighted mode 16 4.593110206 1.884712518 0.027738489
Other savoury snack (ukb-b-18718) (👉 📊) Ankle spacing width (right) MR Egger 11 5.628246059 1.955386977 0.018227596
Cereal bar (ukb-b-18788) (👉 📊) Ankle spacing width (right) Weighted median 8 -1.397559276 0.671208627 0.037328467
Cereal bar (ukb-b-18788) (👉 📊) Ankle spacing width (right) Inverse variance weighted 8 -1.291971291 0.476737793 0.006727816
Mixed fruit (ukb-b-18956) (👉 📊) Ankle spacing width (right) MR Egger 7 -16.59995153 6.161151035 0.043076878
Powdered/instant soup (ukb-b-19931) (👉 📊) Ankle spacing width (right) Inverse variance weighted 6 1.894547601 0.811571293 0.019573783
Vegetarian sausages/burgers (ukb-b-3383) (👉 📊) Ankle spacing width (right) MR Egger 12 -5.279657435 2.249561546 0.040851061
Seeds (ukb-b-4548) (👉 📊) Ankle spacing width (right) Weighted median 8 -3.774360134 1.852664671 0.041623967
Seeds (ukb-b-4548) (👉 📊) Ankle spacing width (right) Inverse variance weighted 8 -3.027753101 1.45778039 0.037805154
Beer/cider (ukb-b-4961) (👉 📊) Ankle spacing width (right) Weighted median 8 -0.814910814 0.37635184 0.030365496
Beer/cider (ukb-b-4961) (👉 📊) Ankle spacing width (right) Weighted mode 8 -0.925080006 0.381870916 0.04592372
Sushi (ukb-b-5213) (👉 📊) Ankle spacing width (right) MR Egger 22 -5.635809904 2.408518228 0.029768993
Poultry (ukb-b-8006) (👉 📊) Ankle spacing width (right) Inverse variance weighted 70 -1.082247528 0.53771841 0.044149785
Other grain (ukb-b-8765) (👉 📊) Ankle spacing width (right) Inverse variance weighted 23 -2.808760889 1.232771375 0.022702052

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Sweetened cereal (ukb-b-10640) Ankle spacing width (right) rs55646860 -29.7117800730337 12.2078828043251 0.014940454002613
Sweetened cereal (ukb-b-10640) Ankle spacing width (right) All - Inverse variance weighted -4.40131811671623 1.90572811542838 0.0209147164215603
Pear (ukb-b-10793) Ankle spacing width (right) rs17484600 -7.83379797751191 2.65670167786271 0.003191206793725
Other alcohol (ukb-b-12901) Ankle spacing width (right) rs7695589 -10.4791327474794 4.34586952784491 0.0158963936519931
Other drink (ukb-b-1310) Ankle spacing width (right) rs2184436 -6.64807493402674 1.87939217600603 0.0004041579710982
Other drink (ukb-b-1310) Ankle spacing width (right) All - Inverse variance weighted -3.18610157801527 1.08323847368186 0.0032686485420205
Other drink (ukb-b-1310) Ankle spacing width (right) All - MR Egger -8.97195914117819 2.53708190359473 0.0063505547112399
Naan bread (ukb-b-13281) Ankle spacing width (right) rs418458 2.87354979184286 1.13657071035085 0.0114628414682345
Naan bread (ukb-b-13281) Ankle spacing width (right) All - Inverse variance weighted 2.3428231106638 0.930550432991024 0.0118132430999443
Herbal tea (ukb-b-13344) Ankle spacing width (right) rs140435987 -0.0871015926594114 0.04081068497934 0.0328195388315377
Herbal tea (ukb-b-13344) Ankle spacing width (right) rs182602 -0.0752407524075241 0.0267062670626706 0.0048422568636862
Herbal tea (ukb-b-13344) Ankle spacing width (right) rs855736 -0.161159324004484 0.0793422746335589 0.0422356104232225
Herbal tea (ukb-b-13344) Ankle spacing width (right) All - MR Egger 0.0196952442093587 0.0095644270966628 0.0469740174009488
Red wine (ukb-b-13556) Ankle spacing width (right) rs1229984 -0.884940604566773 0.345246653657869 0.0103708494992043
Red wine (ukb-b-13556) Ankle spacing width (right) All - Inverse variance weighted -0.722631195000491 0.253461092955169 0.0043574605304905
Lamb/mutton (ukb-b-14179) Ankle spacing width (right) rs1474864 -7.74682519019931 3.37065000433915 0.0215437032358259
Lamb/mutton (ukb-b-14179) Ankle spacing width (right) rs6500598 -13.2451592096698 4.58998913492331 0.003905908490604
Lamb/mutton (ukb-b-14179) Ankle spacing width (right) All - Inverse variance weighted -1.1274954272328 0.474135380611728 0.01740667735878
Lobster/crab (ukb-b-14746) Ankle spacing width (right) rs35976064 29.6020234577849 8.92201629510251 0.0009070912007057
Lobster/crab (ukb-b-14746) Ankle spacing width (right) rs6128982 5.76709772118942 2.48935647345594 0.0205199574097476
Lobster/crab (ukb-b-14746) Ankle spacing width (right) rs6554575 -21.8981082527287 9.5135353517988 0.021347327853052
Lobster/crab (ukb-b-14746) Ankle spacing width (right) All - Inverse variance weighted 5.02375861820423 2.24382425096059 0.0251606687054298
Other savoury snack (ukb-b-18718) Ankle spacing width (right) All - MR Egger 5.62824605871956 1.9553869769881 0.0182275961765669
Cereal bar (ukb-b-18788) Ankle spacing width (right) rs76116349 -1.54025955902875 0.595869383198437 0.0097408765919321
Cereal bar (ukb-b-18788) Ankle spacing width (right) All - Inverse variance weighted -1.29197129057716 0.476737793171433 0.0067278157043459
Mixed fruit (ukb-b-18956) Ankle spacing width (right) rs11068761 -5.01433126147306 2.42697497665132 0.0388206617808907
Mixed fruit (ukb-b-18956) Ankle spacing width (right) rs186577081 -12.0738624189891 4.43428195314094 0.0064722417169541
Mixed fruit (ukb-b-18956) Ankle spacing width (right) All - MR Egger -16.5999515273135 6.16115103488559 0.0430768784454729
Powdered/instant soup (ukb-b-19931) Ankle spacing width (right) All - Inverse variance weighted 1.89454760065378 0.811571293362753 0.0195737829633083
Vegetarian sausages/burgers (ukb-b-3383) Ankle spacing width (right) All - MR Egger -5.27965743516035 2.24956154577288 0.0408510605779579
Seeds (ukb-b-4548) Ankle spacing width (right) All - Inverse variance weighted -3.02775310141314 1.45778039032318 0.0378051535775007
Beer/cider (ukb-b-4961) Ankle spacing width (right) rs1229984 -0.950184247525753 0.370700508173974 0.0103708494992043
Sushi (ukb-b-5213) Ankle spacing width (right) rs17452433 28.7104322649733 13.8638557030861 0.0383696693550053
Sushi (ukb-b-5213) Ankle spacing width (right) All - MR Egger -5.63580990447109 2.40851822811481 0.0297689925631074
Poultry (ukb-b-8006) Ankle spacing width (right) rs113631743 34.9811899631104 15.2854377442565 0.0221066480089763
Poultry (ukb-b-8006) Ankle spacing width (right) rs34344257 -14.167862266858 6.48015303682449 0.0287902379817747
Poultry (ukb-b-8006) Ankle spacing width (right) All - Inverse variance weighted -1.08224752753618 0.537718409994065 0.0441497851586688
Other grain (ukb-b-8765) Ankle spacing width (right) rs138677842 -14.6765515488565 6.58226321298877 0.0257665659338293
Other grain (ukb-b-8765) Ankle spacing width (right) rs77084670 -11.5299754144865 4.17764609468575 0.0057815246101082
Other grain (ukb-b-8765) Ankle spacing width (right) All - Inverse variance weighted -2.8087608893123 1.23277137530258 0.0227020520254885