ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Heel bone mineral density (BMD) (right) (ukb-e-4124_EAS)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Other drink (ukb-b-1310) (👉 📊) Heel bone mineral density (BMD) (right) Inverse variance weighted 11 2.34470974 1.166354394 0.04440058
Red wine (ukb-b-13556) (👉 📊) Heel bone mineral density (BMD) (right) Weighted median 8 0.850001492 0.373896221 0.023004369
Red wine (ukb-b-13556) (👉 📊) Heel bone mineral density (BMD) (right) Inverse variance weighted 8 0.698510302 0.326940565 0.032638237
Red wine (ukb-b-13556) (👉 📊) Heel bone mineral density (BMD) (right) Weighted mode 8 0.920948526 0.360811601 0.037968371
Cheese (ukb-b-1489) (👉 📊) Heel bone mineral density (BMD) (right) Inverse variance weighted 177 0.816159219 0.275993632 0.003104801
Water (ukb-b-14898) (👉 📊) Heel bone mineral density (BMD) (right) MR Egger 141 2.839222597 1.233748779 0.022861918
Water (ukb-b-14898) (👉 📊) Heel bone mineral density (BMD) (right) Inverse variance weighted 141 0.752142275 0.359645818 0.03649745
Ice-cream (ukb-b-17189) (👉 📊) Heel bone mineral density (BMD) (right) Inverse variance weighted 11 -1.484700539 0.650600444 0.022486589
Parsnip (ukb-b-2468) (👉 📊) Heel bone mineral density (BMD) (right) Inverse variance weighted 5 2.722146055 1.146424201 0.017574323
Porridge (ukb-b-29) (👉 📊) Heel bone mineral density (BMD) (right) MR Egger 10 2.521318065 0.999090447 0.035607822
Beer/cider (ukb-b-4961) (👉 📊) Heel bone mineral density (BMD) (right) Weighted median 8 0.981499925 0.396769514 0.013371139
Beer/cider (ukb-b-4961) (👉 📊) Heel bone mineral density (BMD) (right) Inverse variance weighted 8 0.793624069 0.350958077 0.023740233
Sushi (ukb-b-5213) (👉 📊) Heel bone mineral density (BMD) (right) Weighted median 22 2.760612861 1.220694219 0.02372766
Sushi (ukb-b-5213) (👉 📊) Heel bone mineral density (BMD) (right) Inverse variance weighted 22 2.404274013 0.908327005 0.008122722
Sushi (ukb-b-5213) (👉 📊) Heel bone mineral density (BMD) (right) Weighted mode 22 2.418512376 1.068824554 0.034372015
Coffee (ukb-b-5237) (👉 📊) Heel bone mineral density (BMD) (right) MR Egger 107 -2.598297785 0.990987863 0.01004241
Blue cheese (ukb-b-7429) (👉 📊) Heel bone mineral density (BMD) (right) Weighted median 6 9.290422382 3.599721205 0.00985509
Blue cheese (ukb-b-7429) (👉 📊) Heel bone mineral density (BMD) (right) Inverse variance weighted 6 7.295946958 3.086447774 0.018085384

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Other drink (ukb-b-1310) Heel bone mineral density (BMD) (right) rs2184436 5.51227151018357 2.02269673565263 0.0064260779518749
Other drink (ukb-b-1310) Heel bone mineral density (BMD) (right) All - Inverse variance weighted 2.34470973961346 1.1663543941373 0.0444005804114438
Red wine (ukb-b-13556) Heel bone mineral density (BMD) (right) rs1229984 0.922597651569614 0.371777754955325 0.013079995305863
Red wine (ukb-b-13556) Heel bone mineral density (BMD) (right) rs402236 1.96696360206921 0.92162025883803 0.0328227155174898
Red wine (ukb-b-13556) Heel bone mineral density (BMD) (right) All - Inverse variance weighted 0.6985103015508 0.32694056530325 0.0326382367396732
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (right) rs10269830 8.76900906706766 3.67784610151894 0.017112650305139
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (right) rs11104660 10.105393159041 3.26443418977444 0.001964129625073
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (right) rs11669334 21.1359629411968 7.14903031769627 0.0031117272386494
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (right) rs11735256 -10.9170671265677 3.62758066406577 0.0026171058537452
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (right) rs12672200 6.80718427132831 3.03921996018426 0.0251052048712397
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (right) rs1473781 10.1400945277431 4.33690570136361 0.0193823565147689
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (right) rs2086504 6.28900413114178 3.18112566288711 0.0480445192642832
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (right) rs2352974 8.18089010291643 3.30960461330464 0.0134410910887368
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (right) rs2900884 9.42307517560359 3.54205853756054 0.0078062122591179
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (right) rs4074103 6.28098824820136 3.12467033778509 0.0444176124146059
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (right) rs66510028 24.0241554349729 11.1712635342952 0.0315131878390979
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (right) rs6706648 23.2362075343467 10.5298474720624 0.027335070942457
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (right) rs683996 12.0268810578436 3.19484417250854 0.0001669056268245
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (right) rs7730004 -9.99063653869936 4.52184513188347 0.0271457259956635
Cheese (ukb-b-1489) Heel bone mineral density (BMD) (right) All - Inverse variance weighted 0.816159218602061 0.275993631806366 0.0031048006163511
Water (ukb-b-14898) Heel bone mineral density (BMD) (right) rs10758255 20.8026253580666 6.77012357352764 0.002121246316379
Water (ukb-b-14898) Heel bone mineral density (BMD) (right) rs11858506 -14.8957747496855 5.81149786670823 0.0103725476559737
Water (ukb-b-14898) Heel bone mineral density (BMD) (right) rs2043294 -26.1703511053316 8.83751967695572 0.0030636543600862
Water (ukb-b-14898) Heel bone mineral density (BMD) (right) rs4410790 3.20361240500917 1.22799743451868 0.0090857583972662
Water (ukb-b-14898) Heel bone mineral density (BMD) (right) rs654975 33.8287141494194 13.9258458975752 0.0151320345759228
Water (ukb-b-14898) Heel bone mineral density (BMD) (right) All - Inverse variance weighted 0.752142275220201 0.359645818058281 0.0364974495749331
Water (ukb-b-14898) Heel bone mineral density (BMD) (right) All - MR Egger 2.83922259702241 1.23374877887542 0.0228619184150913
Ice-cream (ukb-b-17189) Heel bone mineral density (BMD) (right) All - Inverse variance weighted -1.48470053949949 0.650600444496141 0.0224865885231121
Parsnip (ukb-b-2468) Heel bone mineral density (BMD) (right) rs9398444 4.98213476926174 2.5149715666046 0.0475923394977764
Parsnip (ukb-b-2468) Heel bone mineral density (BMD) (right) All - Inverse variance weighted 2.72214605504175 1.14642420120764 0.0175743228087416
Porridge (ukb-b-29) Heel bone mineral density (BMD) (right) All - MR Egger 2.52131806489585 0.999090446763247 0.0356078220372305
Beer/cider (ukb-b-4961) Heel bone mineral density (BMD) (right) rs1229984 0.990617619760892 0.399187656794185 0.013079995305863
Beer/cider (ukb-b-4961) Heel bone mineral density (BMD) (right) rs3212737 7.38607867962445 3.38791643139469 0.029248254622252
Beer/cider (ukb-b-4961) Heel bone mineral density (BMD) (right) All - Inverse variance weighted 0.793624068718747 0.350958077234995 0.0237402333338089
Sushi (ukb-b-5213) Heel bone mineral density (BMD) (right) rs72806087 8.3162935620646 3.34820440644059 0.0129986234178639
Sushi (ukb-b-5213) Heel bone mineral density (BMD) (right) rs7583354 13.6363955045466 6.05189542392013 0.024243784632483
Sushi (ukb-b-5213) Heel bone mineral density (BMD) (right) rs77376288 3.75212902411843 1.70742477448115 0.0279821208600013
Sushi (ukb-b-5213) Heel bone mineral density (BMD) (right) All - Inverse variance weighted 2.40427401336141 0.908327005072206 0.0081227218816085
Coffee (ukb-b-5237) Heel bone mineral density (BMD) (right) rs2372891 16.3849640324824 7.50682438580528 0.0290596922067893
Coffee (ukb-b-5237) Heel bone mineral density (BMD) (right) rs2597805 9.69150747537803 4.64534825905985 0.0369530663301623
Coffee (ukb-b-5237) Heel bone mineral density (BMD) (right) rs4410790 -2.53122440622441 0.970260032760033 0.0090857583972662
Coffee (ukb-b-5237) Heel bone mineral density (BMD) (right) rs476828 -6.7623269783986 2.7625806377226 0.0143719561065058
Coffee (ukb-b-5237) Heel bone mineral density (BMD) (right) rs4938000 -10.0496036599554 4.81956176473045 0.0370539086388016
Coffee (ukb-b-5237) Heel bone mineral density (BMD) (right) rs4970968 -12.4095463444636 4.65718111524331 0.0077078885245035
Coffee (ukb-b-5237) Heel bone mineral density (BMD) (right) rs630194 -20.3905472417711 10.3229897915144 0.0482391068487674
Coffee (ukb-b-5237) Heel bone mineral density (BMD) (right) rs7743687 -15.8485743988032 7.9871125130244 0.0472259348666907
Coffee (ukb-b-5237) Heel bone mineral density (BMD) (right) rs9953004 16.1442456569437 6.39032463916975 0.0115252078444855
Coffee (ukb-b-5237) Heel bone mineral density (BMD) (right) All - MR Egger -2.59829778527731 0.990987863333641 0.0100424102498958
Blue cheese (ukb-b-7429) Heel bone mineral density (BMD) (right) rs10509498 16.1199674115253 6.41022848238494 0.0119124968156512
Blue cheese (ukb-b-7429) Heel bone mineral density (BMD) (right) rs59939687 10.7482390978022 3.89804087602479 0.0058273035178996
Blue cheese (ukb-b-7429) Heel bone mineral density (BMD) (right) All - Inverse variance weighted 7.2959469581763 3.08644777388147 0.0180853842841802