ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_EAS)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Red wine (ukb-b-13556) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) Weighted median 8 0.821091503 0.365361642 0.024618364
Red wine (ukb-b-13556) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) Inverse variance weighted 8 0.688817796 0.312909496 0.027712504
Red wine (ukb-b-13556) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) Weighted mode 8 0.885470667 0.363722538 0.045123753
Cheese (ukb-b-1489) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) Inverse variance weighted 177 0.803072297 0.272869832 0.003249854
Water (ukb-b-14898) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) MR Egger 141 2.826041058 1.238511992 0.024020041
Water (ukb-b-14898) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) Inverse variance weighted 141 0.742492525 0.361042959 0.039732298
Dried fruit (ukb-b-16576) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) MR Egger 143 -3.566288784 1.776899509 0.046658165
Ice-cream (ukb-b-17189) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) Inverse variance weighted 11 -1.393299881 0.65271193 0.032791068
Parsnip (ukb-b-2468) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) Inverse variance weighted 5 2.722837502 1.150718313 0.017971403
Porridge (ukb-b-29) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) MR Egger 10 2.68561409 1.002008254 0.027915987
Beer/cider (ukb-b-4961) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) Weighted median 8 0.89197732 0.411588537 0.030222822
Beer/cider (ukb-b-4961) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) Inverse variance weighted 8 0.762117616 0.359073225 0.033799348
Beer/cider (ukb-b-4961) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) Weighted mode 8 0.962386899 0.40336226 0.048459102
Sushi (ukb-b-5213) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) Weighted median 22 2.794176291 1.163513894 0.016328098
Sushi (ukb-b-5213) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) Inverse variance weighted 22 2.471603628 0.926186898 0.007617269
Sushi (ukb-b-5213) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) Weighted mode 22 2.469657506 1.102414445 0.036020086
Coffee (ukb-b-5237) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) MR Egger 107 -2.501308454 0.983893388 0.012473369
Coffee (ukb-b-5237) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) Weighted mode 107 -1.491050275 0.741289594 0.046818112
Blue cheese (ukb-b-7429) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) Weighted median 6 10.05715905 3.850774501 0.009008703
Blue cheese (ukb-b-7429) (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) Inverse variance weighted 6 7.162653514 3.179142715 0.024258257

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Red wine (ukb-b-13556) Heel bone mineral density (BMD) T-score, automated (right) rs1229984 0.874670500838725 0.373147102119065 0.01907629435152
Red wine (ukb-b-13556) Heel bone mineral density (BMD) T-score, automated (right) rs402236 1.9429193045362 0.925588735129886 0.0358065638683047
Red wine (ukb-b-13556) Heel bone mineral density (BMD) T-score, automated (right) All - Inverse variance weighted 0.688817796295343 0.31290949623495 0.0277125044004951
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (right) rs10269830 8.415456083349 3.69037709334694 0.0225852576243885
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (right) rs11104660 10.197184508958 3.2786201256707 0.0018695680679039
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (right) rs11669334 20.1610951706019 7.17668614097556 0.0049657292238464
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (right) rs11735256 -10.4900959429366 3.64013864005492 0.0039542978876086
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (right) rs12672200 6.14673699812546 3.04575904209716 0.0435777478553285
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (right) rs1473781 9.81764800719565 4.35387657086611 0.02413828365573
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (right) rs2086504 6.56368111101345 3.19431015792095 0.0398979451210322
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (right) rs2352974 8.31194989377259 3.32202080401733 0.0123467273641732
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (right) rs2900884 9.15046933638652 3.5556888295214 0.0100683491155597
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (right) rs66510028 25.1119001775399 11.2025205671276 0.0249853300556406
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (right) rs6706648 21.8339484347175 10.5728615548731 0.0389141475205291
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (right) rs683996 11.8311451997593 3.20861817733669 0.000226644048589
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (right) rs7730004 -9.77863364132643 4.53951203999788 0.0312311084934278
Cheese (ukb-b-1489) Heel bone mineral density (BMD) T-score, automated (right) All - Inverse variance weighted 0.803072297104649 0.272869831882457 0.0032498538882304
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (right) rs10758255 21.4886299376107 6.79608050356444 0.001567352241821
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (right) rs11858506 -14.4440454168671 5.83408433334914 0.0132936784335333
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (right) rs17444495 -10.713203287315 5.12819386549417 0.0367005917577531
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (right) rs2043294 -24.9726233659572 8.87174046950927 0.0048799925265674
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (right) rs4410790 3.11323749489819 1.23253237624468 0.0115406597980989
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (right) rs654975 30.9737103444593 13.9669250890135 0.0265789065866437
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (right) All - Inverse variance weighted 0.742492525278857 0.361042958763891 0.0397322979129467
Water (ukb-b-14898) Heel bone mineral density (BMD) T-score, automated (right) All - MR Egger 2.82604105843453 1.23851199167784 0.0240200413594972
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (right) rs11085749 11.4428299851663 4.16161624860329 0.0059665868027957
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (right) rs11632215 -12.2177128554662 4.75203982069375 0.0101391865660368
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (right) rs12727104 -9.58985626659343 4.73770942048888 0.0429542482884784
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (right) rs17175518 -11.0036359840643 4.20051843217759 0.0088035545073361
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (right) rs1735720 16.6736567407615 5.94156298056759 0.0050117976155144
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (right) rs36198109 -16.7814481631893 8.0680872072314 0.0375275022569004
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (right) rs4073960 -30.3624717617857 10.8676452815455 0.0052086099253756
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (right) rs57499472 -8.9615841312469 3.88708585587012 0.0211399152634832
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (right) rs58563230 6.49706270994858 3.12753729323548 0.0377671113827976
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (right) rs7599488 14.4497570904622 4.28788140637902 0.000751938415118
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (right) rs7730004 -13.5048914057897 6.26934389650886 0.0312311084934277
Dried fruit (ukb-b-16576) Heel bone mineral density (BMD) T-score, automated (right) All - MR Egger -3.5662887838625 1.7768995094292 0.0466581647624294
Ice-cream (ukb-b-17189) Heel bone mineral density (BMD) T-score, automated (right) All - Inverse variance weighted -1.3932998811333 0.652711929516443 0.0327910677152837
Parsnip (ukb-b-2468) Heel bone mineral density (BMD) T-score, automated (right) rs9398444 5.47091238488249 2.52126214080821 0.0300136510164283
Parsnip (ukb-b-2468) Heel bone mineral density (BMD) T-score, automated (right) All - Inverse variance weighted 2.72283750160285 1.15071831267423 0.0179714025750982
Porridge (ukb-b-29) Heel bone mineral density (BMD) T-score, automated (right) All - MR Egger 2.68561408966199 1.00200825437089 0.0279159869103605
Beer/cider (ukb-b-4961) Heel bone mineral density (BMD) T-score, automated (right) rs1229984 0.939156964188897 0.400657961239099 0.0190762943515201
Beer/cider (ukb-b-4961) Heel bone mineral density (BMD) T-score, automated (right) rs3212737 7.44570039736121 3.4036986507956 0.0287036952301549
Beer/cider (ukb-b-4961) Heel bone mineral density (BMD) T-score, automated (right) All - Inverse variance weighted 0.762117616309182 0.359073224502387 0.0337993478503069
Sushi (ukb-b-5213) Heel bone mineral density (BMD) T-score, automated (right) rs72806087 8.1481088066849 3.36236733320941 0.0153791611804889
Sushi (ukb-b-5213) Heel bone mineral density (BMD) T-score, automated (right) rs7583354 13.6153625037684 6.07853722490588 0.025096913851442
Sushi (ukb-b-5213) Heel bone mineral density (BMD) T-score, automated (right) rs77376288 3.72521395378178 1.71457409003932 0.0298047123061258
Sushi (ukb-b-5213) Heel bone mineral density (BMD) T-score, automated (right) All - Inverse variance weighted 2.47160362842758 0.926186898105906 0.0076172685808439
Coffee (ukb-b-5237) Heel bone mineral density (BMD) T-score, automated (right) rs2372891 16.9751231823098 7.53794186825073 0.0243249708288166
Coffee (ukb-b-5237) Heel bone mineral density (BMD) T-score, automated (right) rs2597805 9.32519670178244 4.66462777345962 0.045594304298813
Coffee (ukb-b-5237) Heel bone mineral density (BMD) T-score, automated (right) rs4410790 -2.45981777231777 0.973843161343161 0.0115406597980989
Coffee (ukb-b-5237) Heel bone mineral density (BMD) T-score, automated (right) rs476828 -7.12552101048651 2.77180461314071 0.0101488669811573
Coffee (ukb-b-5237) Heel bone mineral density (BMD) T-score, automated (right) rs4938000 -9.56872141405632 4.83865386382322 0.0479785270036807
Coffee (ukb-b-5237) Heel bone mineral density (BMD) T-score, automated (right) rs4970968 -12.239192220829 4.67597017299712 0.0088585353105226
Coffee (ukb-b-5237) Heel bone mineral density (BMD) T-score, automated (right) rs630194 -21.8086371363392 10.3582218385844 0.0352528356766658
Coffee (ukb-b-5237) Heel bone mineral density (BMD) T-score, automated (right) rs9953004 15.978989599038 6.41701984852376 0.0127708922863474
Coffee (ukb-b-5237) Heel bone mineral density (BMD) T-score, automated (right) All - MR Egger -2.50130845393945 0.983893388261081 0.0124733693177433
Blue cheese (ukb-b-7429) Heel bone mineral density (BMD) T-score, automated (right) rs10509498 15.4374102328391 6.43491672076295 0.0164396005904595
Blue cheese (ukb-b-7429) Heel bone mineral density (BMD) T-score, automated (right) rs59939687 10.690504599515 3.91439898387283 0.0063128720561093
Blue cheese (ukb-b-7429) Heel bone mineral density (BMD) T-score, automated (right) All - Inverse variance weighted 7.1626535138286 3.17914271481996 0.0242582569456192