ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Osteoarthrosis (ukb-e-740_AFR)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Tinned tomato (ukb-b-10565) (👉 📊) Osteoarthrosis Inverse variance weighted 7 1.2636823 0.614641536 0.039785762
Bread (ukb-b-11348) (👉 📊) Osteoarthrosis MR Egger 101 -5.023881185 2.497149278 0.046953401
Bread (ukb-b-11348) (👉 📊) Osteoarthrosis Weighted median 101 -3.152675886 1.069694119 0.003205946
Bread (ukb-b-11348) (👉 📊) Osteoarthrosis Inverse variance weighted 101 -1.779149476 0.718956996 0.013337587
Bread (ukb-b-11348) (👉 📊) Osteoarthrosis Simple mode 101 -4.361330845 2.132543456 0.043468433
Bread (ukb-b-11348) (👉 📊) Osteoarthrosis Weighted mode 101 -3.764219101 1.60344731 0.020865554
Lamb/mutton (ukb-b-14179) (👉 📊) Osteoarthrosis MR Egger 111 7.771163343 3.330549791 0.021467167
Grapefruit juice (ukb-b-14351) (👉 📊) Osteoarthrosis Inverse variance weighted 9 6.293298108 2.655701207 0.01780102
Cereal (ukb-b-15926) (👉 📊) Osteoarthrosis MR Egger 159 4.826010729 2.216154549 0.030924717
Rose wine (ukb-b-16124) (👉 📊) Osteoarthrosis Inverse variance weighted 8 2.882778172 1.42363427 0.042873223
Hot chocolate (ukb-b-16449) (👉 📊) Osteoarthrosis Weighted median 10 -5.216599762 2.423952553 0.031389106
Low fat hard cheese (ukb-b-18079) (👉 📊) Osteoarthrosis Inverse variance weighted 7 -3.084007697 1.485635544 0.037904641
Hard cheese (ukb-b-3542) (👉 📊) Osteoarthrosis Inverse variance weighted 7 -2.387592064 1.198527641 0.046359616
Oat crunch (ukb-b-5186) (👉 📊) Osteoarthrosis Weighted median 6 -10.60212042 4.366693115 0.015184361
Oat crunch (ukb-b-5186) (👉 📊) Osteoarthrosis Inverse variance weighted 6 -8.805156319 3.383607839 0.009260132
Filtered coffee (ukb-b-748) (👉 📊) Osteoarthrosis Inverse variance weighted 16 1.567874695 0.67846876 0.020838278

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Tinned tomato (ukb-b-10565) Osteoarthrosis All - Inverse variance weighted 1.26368229976211 0.614641536158298 0.0397857623088241
Bread (ukb-b-11348) Osteoarthrosis rs1451488 -42.5031497585362 18.4098871610955 0.0209595005912276
Bread (ukb-b-11348) Osteoarthrosis rs2068650 -16.8675563208495 6.03314679294016 0.005176918364987
Bread (ukb-b-11348) Osteoarthrosis rs34855425 18.5074012452617 8.14565787893861 0.0230830511921743
Bread (ukb-b-11348) Osteoarthrosis rs78844209 -19.9248823364399 7.6941059127887 0.0096079324932092
Bread (ukb-b-11348) Osteoarthrosis All - Inverse variance weighted -1.77914947564614 0.718956995632442 0.0133375867649794
Bread (ukb-b-11348) Osteoarthrosis All - MR Egger -5.02388118472916 2.49714927811968 0.0469534012320915
Lamb/mutton (ukb-b-14179) Osteoarthrosis rs10510562 -67.1215152354782 24.3015218955187 0.0057443325158751
Lamb/mutton (ukb-b-14179) Osteoarthrosis rs10905778 -28.0239806931005 10.0076063174021 0.0051060180435451
Lamb/mutton (ukb-b-14179) Osteoarthrosis rs12634740 25.1511846931694 8.91741845940319 0.0047955478128272
Lamb/mutton (ukb-b-14179) Osteoarthrosis rs3737627 -67.9237896385228 29.0225760146157 0.0192642467769096
Lamb/mutton (ukb-b-14179) Osteoarthrosis rs4272399 44.4044832947607 15.9267542421754 0.0053027426549177
Lamb/mutton (ukb-b-14179) Osteoarthrosis rs4759074 -41.5833781121261 13.7116245746015 0.0024236856139794
Lamb/mutton (ukb-b-14179) Osteoarthrosis rs74032724 10.9649822109449 3.96825758369511 0.0057242417571548
Lamb/mutton (ukb-b-14179) Osteoarthrosis rs74697766 -51.3289396099389 21.301845811657 0.0159699943108072
Lamb/mutton (ukb-b-14179) Osteoarthrosis rs9321151 17.0996170061377 7.81950149243454 0.0287577706101068
Lamb/mutton (ukb-b-14179) Osteoarthrosis All - MR Egger 7.77116334347076 3.33054979119876 0.0214671668100902
Grapefruit juice (ukb-b-14351) Osteoarthrosis rs12141930 21.6492322366481 10.1678181548161 0.0332384178519603
Grapefruit juice (ukb-b-14351) Osteoarthrosis All - Inverse variance weighted 6.29329810839159 2.65570120672612 0.0178010198276607
Cereal (ukb-b-15926) Osteoarthrosis rs11119497 -18.7526123744648 8.03918125231712 0.0196664164002475
Cereal (ukb-b-15926) Osteoarthrosis rs2873054 -23.5242796831302 8.59321381628908 0.0061900304195906
Cereal (ukb-b-15926) Osteoarthrosis rs6502045 -18.8189881527478 8.57054771049015 0.0281081040915078
Cereal (ukb-b-15926) Osteoarthrosis rs67723420 -31.3628244593927 15.5816516550754 0.044135160546226
Cereal (ukb-b-15926) Osteoarthrosis rs7040561 39.7455204843716 18.8155023511694 0.0346537340830968
Cereal (ukb-b-15926) Osteoarthrosis rs9973711 16.8470997728869 8.55708039983487 0.0489771379060168
Cereal (ukb-b-15926) Osteoarthrosis All - MR Egger 4.82601072898243 2.21615454894009 0.030924717382666
Rose wine (ukb-b-16124) Osteoarthrosis rs71514907 12.7499760047805 3.48317702898932 0.000251778142275
Rose wine (ukb-b-16124) Osteoarthrosis All - Inverse variance weighted 2.88277817249887 1.42363427017687 0.0428732231128764
Hot chocolate (ukb-b-16449) Osteoarthrosis rs1789571 25.831771321462 9.94108983799705 0.0093636177247744
Hot chocolate (ukb-b-16449) Osteoarthrosis rs6796609 -5.48888621063687 2.57915669496049 0.0333229170608632
Low fat hard cheese (ukb-b-18079) Osteoarthrosis rs10473702 -5.37253663208951 2.63659336852188 0.0415818295787725
Low fat hard cheese (ukb-b-18079) Osteoarthrosis All - Inverse variance weighted -3.08400769653918 1.48563554380272 0.0379046409264839
Hard cheese (ukb-b-3542) Osteoarthrosis All - Inverse variance weighted -2.38759206416267 1.19852764134674 0.0463596156249662
Oat crunch (ukb-b-5186) Osteoarthrosis rs10434441 -12.496743339854 5.93043332347136 0.0350982857051751
Oat crunch (ukb-b-5186) Osteoarthrosis All - Inverse variance weighted -8.80515631859283 3.38360783889024 0.0092601316545393
Filtered coffee (ukb-b-748) Osteoarthrosis rs12535729 6.17083468658655 2.93142645955359 0.0352859043337594
Filtered coffee (ukb-b-748) Osteoarthrosis All - Inverse variance weighted 1.56787469479427 0.678468759998983 0.0208382783139355