ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Osteoarthrosis (ukb-e-740_CSA)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Muesli (ukb-b-11004) (👉 📊) Osteoarthrosis Weighted median 9 3.449819801 1.630554625 0.03436744
Muesli (ukb-b-11004) (👉 📊) Osteoarthrosis Inverse variance weighted 9 2.863778592 1.278367691 0.025078993
Chocolate-covered raisin (ukb-b-1160) (👉 📊) Osteoarthrosis Inverse variance weighted 31 2.541853481 1.253832443 0.042635086
Unsalted nuts (ukb-b-12217) (👉 📊) Osteoarthrosis Inverse variance weighted 14 -2.977774728 1.238005762 0.016159213
Grapefruit juice (ukb-b-14351) (👉 📊) Osteoarthrosis Weighted median 14 -6.142930967 2.933285324 0.036240807
Grapefruit juice (ukb-b-14351) (👉 📊) Osteoarthrosis Inverse variance weighted 14 -4.538691664 2.052474479 0.02701322
Ice-cream (ukb-b-17189) (👉 📊) Osteoarthrosis Inverse variance weighted 14 2.323631682 1.159636724 0.04509596
Grapefruit (ukb-b-18758) (👉 📊) Osteoarthrosis MR Egger 11 -12.89909889 5.2983673 0.037700633
Grapefruit (ukb-b-18758) (👉 📊) Osteoarthrosis Weighted median 11 -6.328702395 3.111344543 0.041944221
Cereal bar (ukb-b-18788) (👉 📊) Osteoarthrosis MR Egger 11 -4.946507659 1.674321832 0.016107072
Cereal bar (ukb-b-18788) (👉 📊) Osteoarthrosis Weighted median 11 -4.046152788 1.391521175 0.003640751
Cereal bar (ukb-b-18788) (👉 📊) Osteoarthrosis Inverse variance weighted 11 -2.737729712 0.974003552 0.004941841
Cereal bar (ukb-b-18788) (👉 📊) Osteoarthrosis Weighted mode 11 -4.549616289 1.768784416 0.027786987
Cheesy biscuits (ukb-b-19847) (👉 📊) Osteoarthrosis MR Egger 9 19.79414244 7.52843823 0.033949621
Cheesy biscuits (ukb-b-19847) (👉 📊) Osteoarthrosis Weighted median 9 9.256774632 4.599868616 0.044177811
Butternut squash (ukb-b-20341) (👉 📊) Osteoarthrosis Weighted median 10 -5.698183005 2.515611162 0.023504784
Butternut squash (ukb-b-20341) (👉 📊) Osteoarthrosis Inverse variance weighted 10 -4.118859636 1.792089997 0.021541572
Parsnip (ukb-b-2468) (👉 📊) Osteoarthrosis Inverse variance weighted 11 2.767311175 1.320294101 0.036083888
Latte (ukb-b-3000) (👉 📊) Osteoarthrosis Inverse variance weighted 3 -4.922117858 2.494376622 0.048463015
Green tea (ukb-b-4078) (👉 📊) Osteoarthrosis Weighted median 61 -0.031958939 0.0153985 0.037944114
Green tea (ukb-b-4078) (👉 📊) Osteoarthrosis Weighted mode 61 -0.030361817 0.013702397 0.030509978
Wholemeal pasta (ukb-b-4150) (👉 📊) Osteoarthrosis MR Egger 13 -15.75728279 4.87761327 0.008007655
Danish pastry (ukb-b-447) (👉 📊) Osteoarthrosis Inverse variance weighted 11 6.412047653 3.065863495 0.036489279
Milk chocolate (ukb-b-4569) (👉 📊) Osteoarthrosis Weighted median 12 -2.847284299 1.43042646 0.046534312
Pork (ukb-b-5185) (👉 📊) Osteoarthrosis MR Egger 12 4.952376474 1.872628431 0.024538931
Cucumber (ukb-b-588) (👉 📊) Osteoarthrosis Inverse variance weighted 10 2.520967762 0.853838462 0.003152005
Filtered coffee (ukb-b-748) (👉 📊) Osteoarthrosis Inverse variance weighted 18 -0.994703753 0.478950212 0.037816176
Yogurt (ukb-b-7753) (👉 📊) Osteoarthrosis Inverse variance weighted 8 -1.969384675 0.996826149 0.048193852
Soft cheese (ukb-b-8007) (👉 📊) Osteoarthrosis Inverse variance weighted 13 3.849559172 1.626110929 0.017916414
Stewed fruit (ukb-b-8676) (👉 📊) Osteoarthrosis MR Egger 5 -27.21826159 8.03727375 0.042885171
Sweet potato (ukb-b-9686) (👉 📊) Osteoarthrosis MR Egger 14 5.088420627 2.236594331 0.042050774

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Muesli (ukb-b-11004) Osteoarthrosis All - Inverse variance weighted 2.86377859167008 1.27836769070262 0.0250789929082015
Chocolate-covered raisin (ukb-b-1160) Osteoarthrosis All - Inverse variance weighted 2.54185348095341 1.25383244295867 0.0426350862452401
Unsalted nuts (ukb-b-12217) Osteoarthrosis rs145713169 -16.9833013035466 7.41381545207085 0.0219770686594197
Unsalted nuts (ukb-b-12217) Osteoarthrosis All - Inverse variance weighted -2.9777747277767 1.23800576174798 0.0161592132635539
Grapefruit juice (ukb-b-14351) Osteoarthrosis rs1610378 -14.700164072799 7.38801794368414 0.0466206394090152
Grapefruit juice (ukb-b-14351) Osteoarthrosis rs4715882 -8.01634015637354 3.63951255631832 0.0276239269640892
Grapefruit juice (ukb-b-14351) Osteoarthrosis All - Inverse variance weighted -4.53869166429757 2.05247447938102 0.0270132201158013
Ice-cream (ukb-b-17189) Osteoarthrosis rs113438694 9.14362754841888 4.03685106603635 0.0235102491689634
Ice-cream (ukb-b-17189) Osteoarthrosis All - Inverse variance weighted 2.32363168242252 1.15963672433016 0.0450959604328864
Grapefruit (ukb-b-18758) Osteoarthrosis rs13027142 25.7046476092894 11.4555814258752 0.0248418224772044
Grapefruit (ukb-b-18758) Osteoarthrosis All - MR Egger -12.8990988908855 5.2983672996619 0.0377006334033512
Cereal bar (ukb-b-18788) Osteoarthrosis rs138513641 -5.19682444886065 1.79886116745781 0.003865274689716
Cereal bar (ukb-b-18788) Osteoarthrosis rs76116349 -5.88194250627965 2.86596427574658 0.0401363131791995
Cereal bar (ukb-b-18788) Osteoarthrosis All - Inverse variance weighted -2.7377297122021 0.974003551792406 0.0049418410781084
Cereal bar (ukb-b-18788) Osteoarthrosis All - MR Egger -4.94650765921485 1.67432183174681 0.0161070717193146
Cheesy biscuits (ukb-b-19847) Osteoarthrosis rs145326237 18.4273051915717 7.75392320059186 0.0174771094616319
Cheesy biscuits (ukb-b-19847) Osteoarthrosis rs9560935 -34.1680082357577 12.2940678716859 0.0054488393846938
Cheesy biscuits (ukb-b-19847) Osteoarthrosis All - MR Egger 19.7941424381887 7.52843822976929 0.0339496213966999
Butternut squash (ukb-b-20341) Osteoarthrosis rs75010843 -6.25177240970378 3.00826265178272 0.0376909125207217
Butternut squash (ukb-b-20341) Osteoarthrosis All - Inverse variance weighted -4.11885963557777 1.79208999684651 0.0215415724616796
Parsnip (ukb-b-2468) Osteoarthrosis rs4001121 10.5121300275535 4.41288456595425 0.017212127887722
Parsnip (ukb-b-2468) Osteoarthrosis All - Inverse variance weighted 2.76731117502556 1.32029410099389 0.0360838882032912
Latte (ukb-b-3000) Osteoarthrosis rs17623187 -10.3047686049553 5.19973663085929 0.0475031249732938
Latte (ukb-b-3000) Osteoarthrosis All - Inverse variance weighted -4.92211785829382 2.49437662193989 0.0484630148329035
Green tea (ukb-b-4078) Osteoarthrosis rs181810048 -0.388934005104578 0.177334349829295 0.0282912226554926
Green tea (ukb-b-4078) Osteoarthrosis rs191330751 -0.209225382932166 0.0857067833698031 0.0146394990829601
Green tea (ukb-b-4078) Osteoarthrosis rs72869596 0.204923781913401 0.0935775741139063 0.0285328447544761
Green tea (ukb-b-4078) Osteoarthrosis rs9327186 -0.0422064614538531 0.0167814135921927 0.0119008117049747
Wholemeal pasta (ukb-b-4150) Osteoarthrosis rs145584824 -15.7458259556036 7.08011964426838 0.0261518667067502
Wholemeal pasta (ukb-b-4150) Osteoarthrosis rs3821340 20.9820778085385 8.50542434397891 0.013628633245597
Wholemeal pasta (ukb-b-4150) Osteoarthrosis All - MR Egger -15.7572827945835 4.87761326981154 0.0080076548110934
Danish pastry (ukb-b-447) Osteoarthrosis rs2862126 24.3314982304365 9.16240660637043 0.0079172293037137
Danish pastry (ukb-b-447) Osteoarthrosis rs76394359 18.4536303984926 8.24752491611986 0.0252553147627107
Danish pastry (ukb-b-447) Osteoarthrosis All - Inverse variance weighted 6.41204765259077 3.06586349467777 0.03648927925093
Milk chocolate (ukb-b-4569) Osteoarthrosis rs4708314 -8.403485307423 3.33041579796231 0.0116274349881218
Milk chocolate (ukb-b-4569) Osteoarthrosis rs62108673 7.7549519256029 3.57957232175695 0.0302770839502837
Milk chocolate (ukb-b-4569) Osteoarthrosis rs899452 -4.41306368995732 1.73295741428361 0.0108793447308483
Pork (ukb-b-5185) Osteoarthrosis rs11015253 11.5288773933066 5.20034907316868 0.0266269879396096
Pork (ukb-b-5185) Osteoarthrosis rs79938133 3.18722579579617 1.49838266739524 0.0334108869255357
Pork (ukb-b-5185) Osteoarthrosis All - MR Egger 4.9523764742195 1.8726284306598 0.0245389307403245
Cucumber (ukb-b-588) Osteoarthrosis All - Inverse variance weighted 2.52096776211713 0.853838462064754 0.0031520046825147
Filtered coffee (ukb-b-748) Osteoarthrosis rs10875059 -3.15826043015507 1.5764578408674 0.0451354061307399
Filtered coffee (ukb-b-748) Osteoarthrosis rs74852036 -7.11478331437119 3.37738386016278 0.0351526141776272
Filtered coffee (ukb-b-748) Osteoarthrosis All - Inverse variance weighted -0.994703752987303 0.478950212086025 0.0378161758563396
Yogurt (ukb-b-7753) Osteoarthrosis All - Inverse variance weighted -1.96938467493688 0.996826148844262 0.0481938523391071
Soft cheese (ukb-b-8007) Osteoarthrosis All - Inverse variance weighted 3.84955917203159 1.62611092874078 0.0179164136161222
Stewed fruit (ukb-b-8676) Osteoarthrosis rs112872798 -16.2034791045811 5.93051691533915 0.0062909048194046
Stewed fruit (ukb-b-8676) Osteoarthrosis rs2519958 19.7450258190181 9.19290538285569 0.0317252932162979
Stewed fruit (ukb-b-8676) Osteoarthrosis All - MR Egger -27.2182615903179 8.03727374955237 0.0428851705084175
Sweet potato (ukb-b-9686) Osteoarthrosis rs28360770 -16.0432673889133 7.61718157540841 0.0351874442023648
Sweet potato (ukb-b-9686) Osteoarthrosis All - MR Egger 5.08842062711847 2.23659433084406 0.0420507736873153