ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Sweets (ukb-b-10217) (👉 📊) M17 Gonarthrosis [arthrosis of knee] Inverse variance weighted 16 1.524196129 0.759454856 0.044753836
Oily fish (ukb-b-10546) (👉 📊) M17 Gonarthrosis [arthrosis of knee] Inverse variance weighted 9 2.430733004 1.185842727 0.040384562
Bread (ukb-b-11348) (👉 📊) M17 Gonarthrosis [arthrosis of knee] MR Egger 113 -4.257776038 2.006948613 0.036103354
Fried potatoes (ukb-b-12836) (👉 📊) M17 Gonarthrosis [arthrosis of knee] MR Egger 13 3.491622125 1.38343667 0.028279876
Vegetarian alternatives (ukb-b-14425) (👉 📊) M17 Gonarthrosis [arthrosis of knee] MR Egger 6 -296.9600926 98.62178006 0.039507539
Lobster/crab (ukb-b-14746) (👉 📊) M17 Gonarthrosis [arthrosis of knee] Inverse variance weighted 25 -7.418121841 3.28551487 0.023956492
Cheese (ukb-b-1489) (👉 📊) M17 Gonarthrosis [arthrosis of knee] Weighted median 192 1.156759978 0.587227503 0.048853635
Ice-cream (ukb-b-17189) (👉 📊) M17 Gonarthrosis [arthrosis of knee] Inverse variance weighted 14 2.16527624 1.073625701 0.043717563
Cereal bar (ukb-b-18788) (👉 📊) M17 Gonarthrosis [arthrosis of knee] Weighted median 11 -2.805029398 1.297236479 0.030594171
Parsnip (ukb-b-2468) (👉 📊) M17 Gonarthrosis [arthrosis of knee] Inverse variance weighted 10 2.645831596 1.315923917 0.044364915
White pasta (ukb-b-2512) (👉 📊) M17 Gonarthrosis [arthrosis of knee] Inverse variance weighted 6 -2.844335062 1.344933351 0.034442559
Pure fruit/vegetable juice (ukb-b-337) (👉 📊) M17 Gonarthrosis [arthrosis of knee] Inverse variance weighted 6 2.818408817 1.365482896 0.039014098
Crumbed or deep-fried poultry (ukb-b-39) (👉 📊) M17 Gonarthrosis [arthrosis of knee] Inverse variance weighted 7 -6.516719711 2.433670539 0.00741223
Wholemeal pasta (ukb-b-4150) (👉 📊) M17 Gonarthrosis [arthrosis of knee] MR Egger 13 -13.49331655 4.701019641 0.015233462
Banana (ukb-b-5362) (👉 📊) M17 Gonarthrosis [arthrosis of knee] MR Egger 13 -2.806796805 1.18592284 0.037365005
Cucumber (ukb-b-588) (👉 📊) M17 Gonarthrosis [arthrosis of knee] Inverse variance weighted 10 2.134536951 0.923309828 0.020786958
Garlic bread (ukb-b-602) (👉 📊) M17 Gonarthrosis [arthrosis of knee] Inverse variance weighted 13 -3.993887604 1.459575714 0.006212781
Soft cheese (ukb-b-8007) (👉 📊) M17 Gonarthrosis [arthrosis of knee] MR Egger 13 -8.305351832 3.635299208 0.04318259

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Sweets (ukb-b-10217) M17 Gonarthrosis [arthrosis of knee] rs11038176 6.30580638652071 3.05201029107602 0.0388175559037619
Sweets (ukb-b-10217) M17 Gonarthrosis [arthrosis of knee] All - Inverse variance weighted 1.52419612906381 0.759454855530651 0.0447538364376132
Oily fish (ukb-b-10546) M17 Gonarthrosis [arthrosis of knee] All - Inverse variance weighted 2.43073300392125 1.18584272686478 0.0403845622757333
Bread (ukb-b-11348) M17 Gonarthrosis [arthrosis of knee] rs62272476 30.0056491446616 8.81411417066211 0.0006634046248516
Bread (ukb-b-11348) M17 Gonarthrosis [arthrosis of knee] rs6462253 16.8610190059024 7.11483908052095 0.0177958605434757
Bread (ukb-b-11348) M17 Gonarthrosis [arthrosis of knee] rs7211048 15.7615719484406 6.63516477910417 0.0175270674904653
Bread (ukb-b-11348) M17 Gonarthrosis [arthrosis of knee] All - MR Egger -4.25777603789165 2.00694861270496 0.0361033536575882
Fried potatoes (ukb-b-12836) M17 Gonarthrosis [arthrosis of knee] rs117525941 4.0508932715673 1.60543152798129 0.0116278141736561
Fried potatoes (ukb-b-12836) M17 Gonarthrosis [arthrosis of knee] rs72864648 4.673082647088 1.83926976882627 0.0110622208652742
Fried potatoes (ukb-b-12836) M17 Gonarthrosis [arthrosis of knee] All - MR Egger 3.49162212467376 1.38343667012654 0.0282798762517444
Vegetarian alternatives (ukb-b-14425) M17 Gonarthrosis [arthrosis of knee] rs10767356 29.6974977281883 12.0925962358187 0.0140555198235886
Vegetarian alternatives (ukb-b-14425) M17 Gonarthrosis [arthrosis of knee] All - MR Egger -296.960092578665 98.6217800643229 0.0395075389549249
Lobster/crab (ukb-b-14746) M17 Gonarthrosis [arthrosis of knee] rs3134489 -36.2289764694038 18.1801468710742 0.0462858838577876
Lobster/crab (ukb-b-14746) M17 Gonarthrosis [arthrosis of knee] All - Inverse variance weighted -7.41812184058923 3.28551487044782 0.0239564916836785
Cheese (ukb-b-1489) M17 Gonarthrosis [arthrosis of knee] rs10138053 -12.0895123695617 6.0887023808498 0.0470816820105651
Cheese (ukb-b-1489) M17 Gonarthrosis [arthrosis of knee] rs114964798 -17.8686111474217 5.96757051679161 0.0027508821119075
Cheese (ukb-b-1489) M17 Gonarthrosis [arthrosis of knee] rs117309393 -20.1607454263486 7.58038880058687 0.0078235236952451
Cheese (ukb-b-1489) M17 Gonarthrosis [arthrosis of knee] rs117371901 11.6234057817669 5.68266863486918 0.0408141326979876
Cheese (ukb-b-1489) M17 Gonarthrosis [arthrosis of knee] rs12666766 -15.0044447637092 6.51000745283612 0.0211762314692929
Cheese (ukb-b-1489) M17 Gonarthrosis [arthrosis of knee] rs1514755 13.7710764645891 4.82140348948696 0.004286934828185
Cheese (ukb-b-1489) M17 Gonarthrosis [arthrosis of knee] rs1806771 -11.0987189965096 5.08427892191613 0.0290396035246016
Cheese (ukb-b-1489) M17 Gonarthrosis [arthrosis of knee] rs2086504 13.8290703466057 4.97348451554305 0.0054265289945305
Cheese (ukb-b-1489) M17 Gonarthrosis [arthrosis of knee] rs28415940 10.1946541782153 3.70830545732581 0.0059751696175514
Cheese (ukb-b-1489) M17 Gonarthrosis [arthrosis of knee] rs4296548 16.323083419709 4.75795615954547 0.0006020431486357
Cheese (ukb-b-1489) M17 Gonarthrosis [arthrosis of knee] rs660240 -13.9236764728761 5.48468395587984 0.0111282041800735
Cheese (ukb-b-1489) M17 Gonarthrosis [arthrosis of knee] rs67967503 15.6807309561033 6.74879937089844 0.0201531375926652
Cheese (ukb-b-1489) M17 Gonarthrosis [arthrosis of knee] rs6857 -12.6439659489234 6.01494346783333 0.0355451970831599
Cheese (ukb-b-1489) M17 Gonarthrosis [arthrosis of knee] rs7299943 -9.74413909604054 4.87618969140126 0.0456830515029996
Ice-cream (ukb-b-17189) M17 Gonarthrosis [arthrosis of knee] rs2389921 9.47471746445012 3.38885185321274 0.0051763607621819
Ice-cream (ukb-b-17189) M17 Gonarthrosis [arthrosis of knee] All - Inverse variance weighted 2.16527623983299 1.07362570057303 0.0437175629587446
Cereal bar (ukb-b-18788) M17 Gonarthrosis [arthrosis of knee] rs117538197 12.0732510246059 5.15748051590117 0.0192362711580745
Parsnip (ukb-b-2468) M17 Gonarthrosis [arthrosis of knee] rs149187565 7.53943436870266 3.10213724847871 0.0150821673873323
Parsnip (ukb-b-2468) M17 Gonarthrosis [arthrosis of knee] All - Inverse variance weighted 2.64583159613974 1.31592391707072 0.0443649150517745
White pasta (ukb-b-2512) M17 Gonarthrosis [arthrosis of knee] All - Inverse variance weighted -2.84433506237858 1.34493335081125 0.0344425585142048
Pure fruit/vegetable juice (ukb-b-337) M17 Gonarthrosis [arthrosis of knee] All - Inverse variance weighted 2.81840881678199 1.36548289622781 0.03901409759021
Crumbed or deep-fried poultry (ukb-b-39) M17 Gonarthrosis [arthrosis of knee] rs117845922 -11.8273762449447 5.51987089224518 0.0321379394550619
Crumbed or deep-fried poultry (ukb-b-39) M17 Gonarthrosis [arthrosis of knee] rs4888614 -12.590143400536 6.03811120218831 0.0370590559614097
Crumbed or deep-fried poultry (ukb-b-39) M17 Gonarthrosis [arthrosis of knee] All - Inverse variance weighted -6.5167197109984 2.4336705385414 0.0074122296866012
Wholemeal pasta (ukb-b-4150) M17 Gonarthrosis [arthrosis of knee] rs3821340 17.9089452002172 8.22327897950803 0.0294183192994566
Wholemeal pasta (ukb-b-4150) M17 Gonarthrosis [arthrosis of knee] rs76962427 -11.5285359979613 5.08590769274944 0.0234048443003443
Wholemeal pasta (ukb-b-4150) M17 Gonarthrosis [arthrosis of knee] All - MR Egger -13.4933165455929 4.70101964115436 0.0152334621437485
Banana (ukb-b-5362) M17 Gonarthrosis [arthrosis of knee] rs76722032 -2.49605008419069 0.965040463456788 0.0096964063728341
Banana (ukb-b-5362) M17 Gonarthrosis [arthrosis of knee] All - MR Egger -2.80679680455489 1.18592283973189 0.0373650053409722
Cucumber (ukb-b-588) M17 Gonarthrosis [arthrosis of knee] rs9289020 6.63523452224528 2.36632915757493 0.0050469758540203
Cucumber (ukb-b-588) M17 Gonarthrosis [arthrosis of knee] All - Inverse variance weighted 2.13453695140195 0.923309828240498 0.0207869584796275
Garlic bread (ukb-b-602) M17 Gonarthrosis [arthrosis of knee] rs79896327 -13.3596261769625 4.31791957874785 0.0019748010701271
Garlic bread (ukb-b-602) M17 Gonarthrosis [arthrosis of knee] All - Inverse variance weighted -3.99388760379388 1.4595757138402 0.0062127808534155
Soft cheese (ukb-b-8007) M17 Gonarthrosis [arthrosis of knee] rs112482846 -14.5791935623218 5.61877491576466 0.009466575550914
Soft cheese (ukb-b-8007) M17 Gonarthrosis [arthrosis of knee] rs2284636 16.1654494605184 7.16276788417985 0.0240160812602914
Soft cheese (ukb-b-8007) M17 Gonarthrosis [arthrosis of knee] rs9645975 -20.7937489799578 9.0337958867869 0.0213479674545211
Soft cheese (ukb-b-8007) M17 Gonarthrosis [arthrosis of knee] All - MR Egger -8.30535183216567 3.63529920812089 0.0431825901931865